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  1. Article ; Online: The gene regulatory basis of bystander activation in CD8

    Watson, Neva B / Patel, Ravi K / Kean, Connor / Veazey, Janelle / Oyesola, Oyebola O / Laniewski, Nathan / Grenier, Jennifer K / Wang, Jocelyn / Tabilas, Cybelle / Yee Mon, Kristel J / McNairn, Adrian J / Peng, Seth A / Wesnak, Samantha P / Nzingha, Kito / Davenport, Miles P / Tait Wojno, Elia D / Scheible, Kristin M / Smith, Norah L / Grimson, Andrew /
    Rudd, Brian D

    Science immunology

    2024  Volume 9, Issue 92, Page(s) eadf8776

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Humans ; Adult ; Mice ; Animals ; CD8-Positive T-Lymphocytes ; Immunity, Innate ; Cytokines ; T-Lymphocyte Subsets ; Antigens
    Chemical Substances Cytokines ; Antigens
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adf8776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection.

    Hilt, Zachary T / Charles, Wisler / Cheng, Katarina E / Tabilas, Cybelle / Steinhilber, Megan / Wesnak, Samantha P / Smith, Norah L / Schaffer, Chris B / Rudd, Brian D

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 12, Page(s) 2281–2286

    Abstract: CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing ... ...

    Abstract CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9's ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine.
    MeSH term(s) Humans ; Receptors, CCR/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Intestine, Small/metabolism ; Cytomegalovirus Infections/metabolism ; Brain/metabolism
    Chemical Substances Receptors, CCR
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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  3. Article ; Online: Early microbial exposure shapes adult immunity by altering CD8+ T cell development.

    Tabilas, Cybelle / Iu, David S / Daly, Ciarán W P / Yee Mon, Kristel J / Reynaldi, Arnold / Wesnak, Samantha P / Grenier, Jennifer K / Davenport, Miles P / Smith, Norah L / Grimson, Andrew / Rudd, Brian D

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 49, Page(s) e2212548119

    Abstract: Microbial exposure during development can elicit long-lasting effects on the health of an individual. However, how microbial exposure in early life leads to permanent changes in the immune system is unknown. Here, we show that the microbial environment ... ...

    Abstract Microbial exposure during development can elicit long-lasting effects on the health of an individual. However, how microbial exposure in early life leads to permanent changes in the immune system is unknown. Here, we show that the microbial environment alters the set point for immune susceptibility by altering the developmental architecture of the CD8+ T cell compartment. In particular, early microbial exposure results in the preferential expansion of highly responsive fetal-derived CD8+ T cells that persist into adulthood and provide the host with enhanced immune protection against intracellular pathogens. Interestingly, microbial education of fetal-derived CD8+ T cells occurs during thymic development rather than in the periphery and involves the acquisition of a more effector-like epigenetic program. Collectively, our results provide a conceptual framework for understanding how microbial colonization in early life leads to lifelong changes in the immune system.
    MeSH term(s) CD8-Positive T-Lymphocytes ; Cell Differentiation ; Educational Status ; Epigenomics ; Fetus/immunology ; Fetus/microbiology ; Immunity
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2212548119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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