LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="West, Richard"
  2. AU="Lin, K. C."
  3. AU=Reddy Rohin K

Suchergebnis

Treffer 1 - 10 von insgesamt 220

Suchoptionen

  1. Artikel: Adapting to online placements.

    West, Richard

    British journal of nursing (Mark Allen Publishing)

    2021  Band 30, Heft 12, Seite(n) 694

    Mesh-Begriff(e) Humans ; Learning ; Students, Nursing
    Sprache Englisch
    Erscheinungsdatum 2021-06-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2021.30.12.694
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Buch: Eating disorders

    West, Richard

    anorexia nervosa and bulimia nervosa

    (Studies of current health problems ; 111)

    1994  

    Verfasserangabe Richard West
    Serientitel Studies of current health problems ; 111
    Überordnung
    Schlagwörter Eating Disorders / Great Britain / statistics
    Sprache Englisch
    Umfang 52 S.
    Verlag Office of Health Economics
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT007492250
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

  3. Buch: Obesity

    West, Richard

    (Studies of current health problems ; 112)

    1994  

    Verfasserangabe Richard West
    Serientitel Studies of current health problems ; 112
    Überordnung
    Schlagwörter Obesity
    Sprache Englisch
    Umfang 48 S.
    Verlag Office of Health Economics
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT008353851
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  4. Buch: Born imperfect

    West, Richard

    the role of genetic disease

    (Studies of current health problems ; 110)

    1993  

    Verfasserangabe Richard West
    Serientitel Studies of current health problems ; 110
    Überordnung
    Schlagwörter Hereditary Diseases ; Genetics, Medical ; Genetic Counseling
    Sprache Englisch
    Umfang 44 S.
    Verlag Office of Health Economics
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT008062017
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  5. Artikel: Mathematical model of intestinal lipolysis of a long-chain triglyceride.

    Rezhdo, Oljora / West, Richard / Kim, Myriel / Ng, Brandon / Saphier, Sigal / Carrier, Rebecca L

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Lipids are an important component of food and oral drug formulations. Upon release into gastrointestinal fluids, triglycerides, common components of foods and drug delivery systems, form emulsions and are digested into simpler amphiphilic lipids (e.g., ... ...

    Abstract Lipids are an important component of food and oral drug formulations. Upon release into gastrointestinal fluids, triglycerides, common components of foods and drug delivery systems, form emulsions and are digested into simpler amphiphilic lipids (e.g., fatty acids) that can associate with intestinal bile micelles and impact their drug solubilization capacity. Digestion of triglycerides is dynamic and dependent on lipid quantity and type, and quantities of other components in the intestinal environment (e.g., bile salts, lipases). The ability to predict lipid digestion kinetics in the intestine could enhance understanding of lipid impact on the fate of co-administered compounds (e.g., drugs, nutrients). In this study, we present a kinetic model that can predict the lipolysis of emulsions of triolein, a model long-chain triglyceride, as a function of triglyceride amount, droplet size, and quantity of pancreatic lipase in an intestinal environment containing bile micelles. The model is based on a Ping Pong Bi Bi mechanism coupled with quantitative analysis of partitioning of lipolysis products in colloids, including bile micelles, in solution. The agreement of lipolysis model predictions with experimental data suggests that the mechanism and proposed assumptions adequately represent triglyceride digestion in a simulated intestinal environment. In addition, we demonstrate the value of such a model over simpler, semi-mechanistic models reported in the literature. This lipolysis framework can serve as a basis for modeling digestion kinetics of different classes of triglycerides and other complex lipids as relevant in food and drug delivery systems.
    Sprache Englisch
    Erscheinungsdatum 2024-05-04
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.05.01.592066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Buch: Depression

    West, Richard

    (Studies of current health problems ; 105)

    1992  

    Verfasserangabe Richard West
    Serientitel Studies of current health problems ; 105
    Überordnung
    Schlagwörter Affective Disorders, Psychotic / Great Britain / statistics
    Sprache Englisch
    Umfang 40 S. : graph. Darst.
    Verlag Office of Health Economics
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT007492395
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

  7. Buch: Parkinson's disease

    West, Richard

    (Studies of current health problems ; 103)

    1991  

    Verfasserangabe Richard West
    Serientitel Studies of current health problems ; 103
    Überordnung
    Schlagwörter Parkinson Disease
    Sprache Englisch
    Umfang 40 S. : Ill.
    Verlag Office of Health Economics
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT006289836
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

  8. Buch: Organ transplantation

    West, Richard

    (Studies of current health problems ; 100)

    1991  

    Verfasserangabe Richard West
    Serientitel Studies of current health problems ; 100
    Überordnung
    Sprache Englisch
    Umfang 68 S. : graph. Darst.
    Verlag Office of Health Economics
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT010078093
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  9. Artikel ; Online: Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications.

    Nguyen, Thanh / Ahn, Sang Joon / West, Richard / Fancher, Ibra S

    Journal of visualized experiments : JoVE

    2022  , Heft 184

    Abstract: Vascular endothelial cells lining the wall of the vascular system play important roles in a variety of physiological processes, including vascular tone regulation, barrier functions, and angiogenesis. Endothelial cell dysfunction is a hallmark predictor ... ...

    Abstract Vascular endothelial cells lining the wall of the vascular system play important roles in a variety of physiological processes, including vascular tone regulation, barrier functions, and angiogenesis. Endothelial cell dysfunction is a hallmark predictor and major driver for the progression of severe cardiovascular diseases, yet the underlying mechanisms remain poorly understood. The ability to isolate and perform analyses on endothelial cells from various vascular beds in their native form will give insight into the processes of cardiovascular disease. This protocol presents the procedure for the dissection of mouse subcutaneous and mesenteric adipose tissues, followed by isolation of their respective arterial vasculature. The isolated arteries are then digested using a specific cocktail of digestive enzymes focused on liberating functionally viable endothelial cells. The digested tissue is assessed by flow cytometry analysis using CD31+/CD45- cells as markers for positive endothelial cell identification. Cells can be sorted for immediate downstream functional assays or used to generate primary cell lines. The technique of isolating and digesting arteries from different vascular beds will provide options for researchers to evaluate freshly isolated vascular cells from arteries of interest and allow them to perform a wide range of functional tests on specific cell types.
    Mesh-Begriff(e) Adipose Tissue ; Animals ; Cell Movement ; Endothelial Cells/metabolism ; Flow Cytometry ; Mice ; Neovascularization, Pathologic/metabolism ; Vascular Diseases/metabolism
    Sprache Englisch
    Erscheinungsdatum 2022-06-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/63999
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton.

    Ghosh, Arit / Coffin, Megan / West, Richard / Fowler, Velia M

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2022  Band 36, Heft 3, Seite(n) e22220

    Abstract: Erythroid differentiation (ED) is a complex cellular process entailing morphologically distinct maturation stages of erythroblasts during terminal differentiation. Studies of actin filament (F-actin) assembly and organization during terminal ED have ... ...

    Abstract Erythroid differentiation (ED) is a complex cellular process entailing morphologically distinct maturation stages of erythroblasts during terminal differentiation. Studies of actin filament (F-actin) assembly and organization during terminal ED have revealed essential roles for the F-actin pointed-end capping proteins, tropomodulins (Tmod1 and Tmod3). Tmods bind tropomyosins (Tpms), which enhance Tmod capping and F-actin stabilization. Tmods can also nucleate F-actin assembly, independent of Tpms. Tmod1 is present in the red blood cell (RBC) membrane skeleton, and deletion of Tmod1 in mice leads to a mild compensated anemia due to mis-regulated F-actin lengths and membrane instability. Tmod3 is not present in RBCs, and global deletion of Tmod3 leads to embryonic lethality in mice with impaired ED. To further decipher Tmod3's function during ED, we generated a Tmod3 knockout in a mouse erythroleukemia cell line (Mel ds19). Tmod3 knockout cells appeared normal prior to ED, but showed defects during progression of ED, characterized by a marked failure to reduce cell and nuclear size, reduced viability, and increased apoptosis. Tmod3 does not assemble with Tmod1 and Tpms into the Triton X-100 insoluble membrane skeleton during ED, and loss of Tmod3 had no effect on α1,β1-spectrin and protein 4.1R assembly into the membrane skeleton. However, F-actin, Tmod1 and Tpms failed to assemble into the membrane skeleton during ED in absence of Tmod3. We propose that Tmod3 nucleation of F-actin assembly promotes incorporation of Tmod1 and Tpms into membrane skeleton F-actin, and that this is integral to morphological maturation and cell survival during erythroid terminal differentiation.
    Mesh-Begriff(e) Actin Cytoskeleton/metabolism ; Animals ; Cell Line, Tumor ; Erythroblasts/cytology ; Erythroblasts/metabolism ; Erythropoiesis ; Leukemia, Erythroblastic, Acute/blood ; Leukemia, Erythroblastic, Acute/metabolism ; Mice ; Protein Multimerization ; Spectrin/metabolism ; Tropomodulin/genetics ; Tropomodulin/metabolism
    Chemische Substanzen Tmod1 protein, mouse ; Tmod3 protein, mouse ; Tropomodulin ; Spectrin (12634-43-4)
    Sprache Englisch
    Erscheinungsdatum 2022-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202101011R
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang