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  1. Article: Medical rehabilitation of chronic progressive disseminated encephalomyelitis (MS).

    Westarp, M E

    Journal of neurovirology

    2000  Volume 6 Suppl 2, Page(s) S176–8

    Abstract: Eight years after diagnosis, 40% of MS patients develop a chronically progressive form. Annually we treat approximately 200 patients with progressive MS. Treatment consists of medication, i.e. agents that help to prevent future impairment, or interferon- ... ...

    Abstract Eight years after diagnosis, 40% of MS patients develop a chronically progressive form. Annually we treat approximately 200 patients with progressive MS. Treatment consists of medication, i.e. agents that help to prevent future impairment, or interferon-beta injections, and intervals of mitoxantrone infusions (Novantrone(R)), and in some cases cyclic cyclophosphamide (Endoxan(R)) or nucleoside analogue cladribin (Leustatin(R)). Without clear scientific evidence, we recommend unsaturated fatty acids (thistle or sunflower oil), sufficient protein, and freshly prepared fruits and vegetables as a sound basis for remyelination. Remyelination profits from general prophylaxis in the use of ascorbic acid to help prevent urinary infections via acidification, autogenic training to reduce fatigue, improve ventilation of deeper airways, and stimulate vagotonic regeneration, and prevention of unnecessary immune stimulation caused by insects and some food. We recommend the use of sun hats and disencourage blood donation (Allain 1998). Physiotherapy can improve strength, reduce spasticity, and train the patient to compensate for dysbalance and ataxia; supported by beta blockers and good antispastics, tremor and gait disturbances can be positively influenced. Music and motion, speech therapy, realistic training of daily activities, and prudent psychotherapy complete the range of measurements to reconstitute as much as possible of the patient's individual freedom. In the individual, we eventually provide prudent technical aids and careful prognostic estimations. Cooperating with local and regional patient networks, we reinforce long-term disease management and spread up-to-date medical research results, and finally gather valuable contextual information and clinical data on an increasingly frequent idiopathic disease of the human central nervous system.
    MeSH term(s) Adult ; Age Factors ; Disease Progression ; Encephalomyelitis/rehabilitation ; Encephalomyelitis/therapy ; Humans ; Middle Aged ; Multiple Sclerosis, Chronic Progressive/rehabilitation ; Multiple Sclerosis, Chronic Progressive/therapy
    Language English
    Publishing date 2000-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Motor neuron disease.

    Westarp, M E / Kornhuber, H H

    Journal of neurology, neurosurgery, and psychiatry

    1995  Volume 58, Issue 2, Page(s) 269

    MeSH term(s) Humans ; Motor Neuron Disease/nursing ; Terminal Care/methods
    Language English
    Publishing date 1995-02
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp.58.2.269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neurologische Intensivmedizin.

    Westarp, M E / Wollinsky, K H

    Krankenpflege Journal

    1991  Volume 29, Issue 11, Page(s) 509

    Title translation Neurologic intensive care units.
    MeSH term(s) Humans ; Intensive Care Units/organization & administration ; Nervous System Diseases/nursing ; Nervous System Diseases/therapy
    Language German
    Publishing date 1991-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603227-8
    ISSN 0174-108X ; 0048-9549
    ISSN 0174-108X ; 0048-9549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Kopfschmerz--kernpunkte und Klassifikation.

    Westarp, M E / Keppler, I

    Krankenpflege Journal

    1990  Volume 28, Issue 10, Page(s) 516–519

    Title translation Headache--essential points and classification.
    MeSH term(s) Headache/classification ; Humans
    Language German
    Publishing date 1990-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603227-8
    ISSN 0174-108X ; 0048-9549
    ISSN 0174-108X ; 0048-9549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Vergiftung mit Desinfektionsmittel bei Vitamin-B12-Mangel.

    Westarp, M E / Wolf, H U

    Deutsche medizinische Wochenschrift (1946)

    1990  Volume 115, Issue 20, Page(s) 796–797

    Title translation Poisoning with disinfectants in vitamin B12 deficiency.
    MeSH term(s) Aged ; Disinfectants/poisoning ; Humans ; Vitamin B 12 Deficiency/metabolism
    Chemical Substances Disinfectants
    Language German
    Publishing date 1990-05-18
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Immunoglobulin-G isotype changes in human sporadic amyotrophic lateral sclerosis (ALS).

    Westarp, M E / Bartmann, P / Kornhuber, H H

    Neuroscience letters

    1994  Volume 173, Issue 1-2, Page(s) 124–126

    Abstract: Out of 50 patients with sporadic amyotrophic lateral sclerosis (sALS), excluding 8 patients with recent immunosuppressive medication or low total IgG, we examined all available 92 sera of 11 women and 31 men nephelometrically for serum immunoglobulin ... ...

    Abstract Out of 50 patients with sporadic amyotrophic lateral sclerosis (sALS), excluding 8 patients with recent immunosuppressive medication or low total IgG, we examined all available 92 sera of 11 women and 31 men nephelometrically for serum immunoglobulin concentrations including IgG isotypes IgG1-4. Mean serum levels of IgA and IgM remained within references in all cases. Isotypes IgG1 and IgG3 were the most frequently altered immunoglobulins. Without specific treatment, 34 out of 42 patients (= 80%) and 58 out of 92 sera (= 63%) demonstrated low IgG3 concentrations (< 0.41 g/l), while 14 patients (= 33%) and 20 sera (= 22%) demonstrated low IgG1 serum levels (< 4.22 g/l). In patients with normal total IgG, isotypes IgG1 and IgG2 often changed in a complementary way, and IgG1/IgG2 serum concentrations correlated significantly (rs = -0.518, P < 0.001). In four longitudinally monitored patients, the IgG3 isotype ranged from 1.3% to 8.2% of serum IgG and demonstrated a remarkable individual variability over time, corresponding to the relatively short half-life of IgG3. Since elevated circulating immune complexes may fluctuate rapidly, altered serum immunoglobulin isotypes could become more convenient parameters in a still enigmatic disease. To assess their role and relevance, their association with clinical course, cerebrospinal fluid and circulating immune complexes has to be examined.
    MeSH term(s) Adolescent ; Adult ; Aged ; Amyotrophic Lateral Sclerosis/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/immunology ; Isomerism ; Male ; Middle Aged ; Nephelometry and Turbidimetry
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 1994-05-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/0304-3940(94)90164-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Hypogammaglobulinemia in McArdle myopathy (glycogenosis type V).

    Westarp, M E / Schreiner, V / Kornhuber, H H

    European archives of psychiatry and clinical neuroscience

    1991  Volume 240, Issue 3, Page(s) 159–162

    Abstract: Glycogenosis type V (McArdle) was the first myopathy to be enzymatically defined myopathy and has been found in approximately 120 patients. It is characterized by a myophosphorylase defect. In 2 patients with completely missing phosphorylase activity, ... ...

    Abstract Glycogenosis type V (McArdle) was the first myopathy to be enzymatically defined myopathy and has been found in approximately 120 patients. It is characterized by a myophosphorylase defect. In 2 patients with completely missing phosphorylase activity, muscle fiber necrosis and creatinine kinase elevation, we found reproducibly low gammaglobulins and low immunoglobulin-G. Compared with 124 nonmyopathic control patients with hypogammaglobulinemia, we did not find any established cause for low gammaglobulins in either case of McArdle disease. Myopathies with selected laboratory features or histopathology in common did not show changes in gammaglobulins or immunoglobulins. Unaffected family members had normal gamma-globulins and immunoglobulins. Therefore, gammaglobulins indicate an immunologic involvement in phosphorylase deficiency, and a potential for genomic co-localization.
    MeSH term(s) Adult ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/immunology ; Diagnosis, Differential ; Electromyography ; Female ; Glycogen Storage Disease Type V/diagnosis ; Glycogen Storage Disease Type V/immunology ; Humans ; IgG Deficiency ; Male ; Middle Aged ; Myoglobinuria/diagnosis ; Myoglobinuria/immunology ; Phosphorylases/deficiency
    Chemical Substances Phosphorylases (EC 2.4.1.-)
    Language English
    Publishing date 1991
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0940-1334 ; 0175-758X
    ISSN (online) 1433-8491
    ISSN 0940-1334 ; 0175-758X
    DOI 10.1007/bf02190757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Three or more infantile febrile seizures and HHV-6.

    Westarp, M E / Kleiser, B / Bechinger, D / Kornhuber, H H

    Journal of neurovirology

    1995  Volume 1, Issue 3-4, Page(s) 321

    MeSH term(s) Herpesviridae Infections/complications ; Herpesvirus 6, Human/isolation & purification ; Humans ; Infant ; Seizures, Febrile/complications ; Seizures, Febrile/virology ; Spasms, Infantile/complications ; Spasms, Infantile/virology
    Language English
    Publishing date 1995-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.3109/13550289509114029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Selection of brain choline acetyltransferase synthetic peptides.

    Westarp, M E / Ostermann, C / Mäder, M

    Neuropeptides

    1990  Volume 16, Issue 3, Page(s) 149–155

    Abstract: Choline acetyltransferase (ChAT) of pig brain is a 640 amino acid enzyme. The sequence has recently been published (Berrard et al., 1988). We identified potentially antigenic epitopes on porcine ChAT by primary and secondary structure analysis. We used ... ...

    Abstract Choline acetyltransferase (ChAT) of pig brain is a 640 amino acid enzyme. The sequence has recently been published (Berrard et al., 1988). We identified potentially antigenic epitopes on porcine ChAT by primary and secondary structure analysis. We used 12 structural parameters derived from the amino acid sequence, especially surface antigenicity, internal repetitions and protease cleavage site clusters and superposed gliding averages for the complete ChAT protein. Four peptides from 13 to 21 amino acids in length were defined for antibody production. In detail, we describe a nine-step selection process and discuss costs of synthesis and purification.
    MeSH term(s) Amino Acid Sequence ; Animals ; Brain/enzymology ; Choline O-Acetyltransferase/immunology ; Epitopes/analysis ; Molecular Sequence Data ; Peptide Fragments/immunology ; Sequence Homology, Nucleic Acid ; Sindbis Virus/immunology ; Species Specificity ; Swine
    Chemical Substances Epitopes ; Peptide Fragments ; Choline O-Acetyltransferase (EC 2.3.1.6)
    Language English
    Publishing date 1990-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 9048-7
    ISSN 1532-2785 ; 0143-4179
    ISSN (online) 1532-2785
    ISSN 0143-4179
    DOI 10.1016/0143-4179(90)90127-k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Vergiftung mit Desinfektionsmittel bei Vitamin-B12-Mangel

    Westarp, M.E. / Wolf, H.U.

    Deutsche Medizinische Wochenschrift (Germany)

    1990  

    Institution Rehabilitationskrankenhaus, Ulm (Germany, F.R.). Neurologische Klinik
    Keywords Vitaminmangel ; Desinfektionsmittel ; Enzymaktivitaet ; Haemoglobin ; Vergiftung ; Symptom
    Language German
    Edition v. 115(20) p. 796-797
    Document type Article
    ISSN 0012-0472
    Database ELFIS - Nutrition, agriculture and forestry information system

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