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  1. Article ; Online: Circulating ketone bodies as signals for cardiovascular disease and mortality.

    Voorrips, Suzanne N / Westenbrink, B Daan

    European heart journal

    2023  Volume 44, Issue 18, Page(s) 1647–1649

    MeSH term(s) Humans ; Ketone Bodies ; Cardiovascular Diseases ; Cardiovascular System ; Heart
    Chemical Substances Ketone Bodies
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad176
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  2. Article ; Online: Reply to 'Exercise intolerance in heart failure: beyond mitochondrial dysfunction'. Letter regarding the article 'Exercise: a molecular tool to boost muscle growth and mitochondrial performance in heart failure?'

    Nijholt, Kirsten T / Westenbrink, B Daan

    European journal of heart failure

    2022  Volume 24, Issue 5, Page(s) 910–911

    MeSH term(s) Exercise/physiology ; Heart Failure/therapy ; Humans ; Mitochondria, Muscle ; Muscles
    Language English
    Publishing date 2022-04-03
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2494
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    Zs.A 5299: Show issues Location:
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  3. Article: Short-Chain Fatty Acids in the Metabolism of Heart Failure - Rethinking the Fat Stigma.

    Palm, Constantin L / Nijholt, Kirsten T / Bakker, Barbara M / Westenbrink, B Daan

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 915102

    Abstract: Heart failure (HF) remains a disease with immense global health burden. During the development of HF, the myocardium and therefore cardiac metabolism undergoes specific changes, with decreased long-chain fatty acid oxidation and increased anaerobic ... ...

    Abstract Heart failure (HF) remains a disease with immense global health burden. During the development of HF, the myocardium and therefore cardiac metabolism undergoes specific changes, with decreased long-chain fatty acid oxidation and increased anaerobic glycolysis, diminishing the overall energy yield. Based on the dogma that the failing heart is oxygen-deprived and on the fact that carbohydrates are more oxygen-efficient than FA, metabolic HF drugs have so far aimed to stimulate glucose oxidation or inhibit FA oxidation. Unfortunately, these treatments have failed to provide meaningful clinical benefits. We believe it is time to rethink the concept that fat is harmful to the failing heart. In this review we discuss accumulating evidence that short-chain fatty acids (SCFAs) may be an effective fuel for the failing heart. In contrast to long-chain fatty acids, SCFAs are readily taken up and oxidized by the heart and could serve as a nutraceutical treatment strategy. In addition, we discuss how SCFAs activate pathways that increase long chain fatty acid oxidation, which could help increase the overall energy availability. Another potential beneficial effect we discuss lies within the anti-inflammatory effect of SCFAs, which has shown to inhibit cardiac fibrosis - a key pathological process in the development of HF.
    Language English
    Publishing date 2022-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.915102
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  4. Article ; Online: Aortic regurgitation, a forgotten valve disease in hypertrophic cardiomyopathy?

    Westenbrink, B Daan / de Boer, Rudolf A / Vliegenthart, Rozemarijn

    European journal of radiology

    2020  Volume 126, Page(s) 108971

    MeSH term(s) Aortic Valve Insufficiency ; Cardiomyopathy, Hypertrophic ; Echocardiography ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2020-03-19
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2020.108971
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1630: Show issues Location:
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  5. Article ; Online: What You Did Not Know About Cardiac Ca

    Nijholt, Kirsten T / de Boer, Rudolf A / Westenbrink, B Daan

    Circulation

    2021  Volume 143, Issue 5, Page(s) 466–469

    MeSH term(s) Cyclic AMP-Dependent Protein Kinases/metabolism ; Humans ; Lysosomes/metabolism ; Ryanodine Receptor Calcium Release Channel
    Chemical Substances Ryanodine Receptor Calcium Release Channel ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.052677
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  6. Article: SGLT2 Inhibitors and Ketone Metabolism in Heart Failure.

    Saucedo-Orozco, Huitzilihuitl / Voorrips, Suzanne N / Yurista, Salva R / de Boer, Rudolf A / Westenbrink, B Daan

    Journal of lipid and atherosclerosis

    2022  Volume 11, Issue 1, Page(s) 1–19

    Abstract: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as powerful drugs that can be used to treat heart failure (HF) patients, both with preserved and reduced ejection fraction and in the presence or absence of type 2 diabetes. While the ... ...

    Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as powerful drugs that can be used to treat heart failure (HF) patients, both with preserved and reduced ejection fraction and in the presence or absence of type 2 diabetes. While the mechanisms underlying the salutary effects of SGLT2 inhibitors have not been fully elucidated, there is clear evidence for a beneficial metabolic effect of these drugs. In this review, we discuss the effects of SGLT2 inhibitors on cardiac energy provision secondary to ketone bodies, pathological ventricular remodeling, and inflammation in patients with HF. While the specific contribution of ketone bodies to the pleiotropic cardiovascular benefits of SGLT2 inhibitors requires further clarification, ketone bodies themselves may also be used as a therapy for HF.
    Language English
    Publishing date 2022-01-13
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3016001-7
    ISSN 2288-2561 ; 2287-2892
    ISSN (online) 2288-2561
    ISSN 2287-2892
    DOI 10.12997/jla.2022.11.1.1
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  7. Article ; Online: Ca2+/calmodulin-dependent kinase IIδC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak.

    Dewenter, Matthias / Seitz, Tilmann / Steinbrecher, Julia H / Westenbrink, B Daan / Ling, Haiyun / Lehnart, Stephan E / Wehrens, Xander H T / Backs, Johannes / Brown, Joan Heller / Maier, Lars S / Neef, Stefan

    ESC heart failure

    2024  

    Abstract: Aims: Hyperactivity of Ca: Methods and results: We crossbred CaMKIIδC overexpressing [transgenic (TG)] mice with RyR2-S2814A knock-in mice that are resistant to CaMKII-dependent RyR2 phosphorylation. Ca: Conclusions: S2814 phosphoresistance of ... ...

    Abstract Aims: Hyperactivity of Ca
    Methods and results: We crossbred CaMKIIδC overexpressing [transgenic (TG)] mice with RyR2-S2814A knock-in mice that are resistant to CaMKII-dependent RyR2 phosphorylation. Ca
    Conclusions: S2814 phosphoresistance of RyR2 prevents the CaMKII-dependent SR Ca
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14772
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  8. Article ; Online: Ketone bodies for the failing heart: fuels that can fix the engine?

    Yurista, Salva R / Nguyen, Christopher T / Rosenzweig, Anthony / de Boer, Rudolf A / Westenbrink, B Daan

    Trends in endocrinology and metabolism: TEM

    2021  Volume 32, Issue 10, Page(s) 814–826

    Abstract: Accumulating evidence suggests that the failing heart reverts energy metabolism toward increased utilization of ketone bodies. Despite many discrepancies in the literature, evidence from both bench and clinical research demonstrates beneficial effects of ...

    Abstract Accumulating evidence suggests that the failing heart reverts energy metabolism toward increased utilization of ketone bodies. Despite many discrepancies in the literature, evidence from both bench and clinical research demonstrates beneficial effects of ketone bodies in heart failure. Ketone bodies are readily oxidized by cardiomyocytes and can provide ancillary fuel for the energy-starved failing heart. In addition, ketone bodies may help to restore cardiac function by mitigating inflammation, oxidative stress, and cardiac remodeling. In this review, we hypothesize that a therapeutic approach intended to restore cardiac metabolism through ketone bodies could both refuel and 'repair' the failing heart.
    MeSH term(s) Energy Metabolism ; Heart Failure ; Humans ; Ketone Bodies ; Myocytes, Cardiac ; Oxidation-Reduction
    Chemical Substances Ketone Bodies
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2021.07.006
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    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Could SGLT2 Inhibitors Improve Exercise Intolerance in Chronic Heart Failure?

    Voorrips, Suzanne N / Saucedo-Orozco, Huitzilihuitl / Sánchez-Aguilera, Pablo I / De Boer, Rudolf A / Van der Meer, Peter / Westenbrink, B Daan

    International journal of molecular sciences

    2022  Volume 23, Issue 15

    Abstract: Despite the constant improvement of therapeutical options, heart failure (HF) remains associated with high mortality and morbidity. While new developments in guideline-recommended therapies can prolong survival and postpone HF hospitalizations, impaired ... ...

    Abstract Despite the constant improvement of therapeutical options, heart failure (HF) remains associated with high mortality and morbidity. While new developments in guideline-recommended therapies can prolong survival and postpone HF hospitalizations, impaired exercise capacity remains one of the most debilitating symptoms of HF. Exercise intolerance in HF is multifactorial in origin, as the underlying cardiovascular pathology and reactive changes in skeletal muscle composition and metabolism both contribute. Recently, sodium-related glucose transporter 2 (SGLT2) inhibitors were found to improve cardiovascular outcomes significantly. Whilst much effort has been devoted to untangling the mechanisms responsible for these cardiovascular benefits of SGLT2 inhibitors, little is known about the effect of SGLT2 inhibitors on exercise performance in HF. This review provides an overview of the pathophysiological mechanisms that are responsible for exercise intolerance in HF, elaborates on the potential SGLT2-inhibitor-mediated effects on these phenomena, and provides an up-to-date overview of existing studies on the effect of SGLT2 inhibitors on clinical outcome parameters that are relevant to the assessment of exercise capacity. Finally, current gaps in the evidence and potential future perspectives on the effects of SGLT2 inhibitors on exercise intolerance in chronic HF are discussed.
    MeSH term(s) Chronic Disease ; Diabetes Mellitus, Type 2/metabolism ; Heart Failure/metabolism ; Humans ; Muscle, Skeletal/metabolism ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23158631
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  10. Article ; Online: BNP in heart failure: even leucocytes cannot escape its influence.

    Karper, Jacco C / Westenbrink, B Daan

    European journal of heart failure

    2015  Volume 17, Issue 6, Page(s) 536–538

    MeSH term(s) Female ; Heart Failure/blood ; Humans ; Male ; Natriuretic Agents/pharmacology ; Natriuretic Peptide, Brain/pharmacology ; Neutrophils/drug effects ; Superoxides/metabolism
    Chemical Substances Natriuretic Agents ; Superoxides (11062-77-4) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.295
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