LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Fasting Plasma Ketone Bodies Are Associated with NT-proBNP: A Potential Mechanism to Provide Fuel for the Failing Heart.

    Palm, Constantin L / Shalaurova, Irina / Connelly, Margery A / Bakker, Stephan J L / Westenbrink, Berend Daan / Dullaart, Robin P F

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061541
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Mitochondrial therapy for doxorubicin cardiomyopathy: nuclear factor-κB to the rescue?

    Nijholt, Kirsten Theresa / Westenbrink, Berend Daan / de Boer, Rudolf Allert

    Cardiovascular research

    2020  Volume 116, Issue 6, Page(s) 1092–1094

    MeSH term(s) Cardiomyopathies ; Peptidyl-Prolyl Isomerase F ; Doxorubicin/adverse effects ; Humans ; Mitochondrial Permeability Transition Pore ; NF-kappa B
    Chemical Substances Peptidyl-Prolyl Isomerase F ; Mitochondrial Permeability Transition Pore ; NF-kappa B ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2020-01-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz344
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The value of echocardiographic measurement of epicardial adipose tissue in heart failure patients.

    van Woerden, Gijs / van Veldhuisen, Dirk J / Gorter, Thomas M / Ophuis, Bob / Saucedo-Orozco, Huitzilihuitl / van Empel, Vanessa P M / Willems, Tineke P / Geelhoed, Bastiaan / Rienstra, Michiel / Westenbrink, Berend Daan

    ESC heart failure

    2022  Volume 9, Issue 2, Page(s) 953–957

    Abstract: Aims: Epicardial adipose tissue (EAT) is increasingly recognized as an important factor in the pathophysiology of heart failure (HF). Cardiac magnetic resonance (CMR) imaging is the gold-standard imaging modality to evaluate EAT size, but in contrast to ...

    Abstract Aims: Epicardial adipose tissue (EAT) is increasingly recognized as an important factor in the pathophysiology of heart failure (HF). Cardiac magnetic resonance (CMR) imaging is the gold-standard imaging modality to evaluate EAT size, but in contrast to echocardiography, CMR is costly and not widely available. We investigated EAT thickness on echocardiography in relation to EAT volume on CMR, and we assessed the agreement between observers for measuring echocardiographic EAT.
    Methods and results: Patients with HF and left ventricular ejection fraction >40% were enrolled. All patients underwent CMR imaging and transthoracic-echocardiography. EAT volume was quantified on CMR short-axis cine-stacks. Echocardiographic EAT thickness was measured on parasternal long-axis and short-axis views. Linear regression analyses were used to assess the association between EAT volume on CMR and EAT thickness on echocardiography. Intraclass correlation coefficient (ICC) was used to assess the interobserver agreement as well as the intraobserver agreement. EAT on CMR and echocardiography was evaluated in 117 patients (mean age 71 ± 10 years, 49% women and mean left ventricular ejection fraction 54 ± 7%). Mean EAT volume on CMR was 202 ± 64 mL and ranged from 80 to 373 mL. Mean EAT thickness on echocardiography was 3.8 ± 1.5 mm and ranged from 1.7 to 10.2 mm. EAT volume on CMR and EAT thickness on echocardiography were significantly correlated (junior-observer: r = 0.62, P < 0.001, senior-observer: r = 0.33, P < 0.001), and up to one-third of the variance in EAT volume was explained by EAT thickness (R
    Conclusions: There was a modest correlation between EAT volume on CMR and EAT thickness on echocardiography. Limited agreement between junior and senior observers for measuring echocardiographic EAT was observed. EAT thickness on echocardiography is limited in estimating EAT volume.
    MeSH term(s) Adipose Tissue/diagnostic imaging ; Aged ; Aged, 80 and over ; Echocardiography/methods ; Female ; Heart Failure/diagnostic imaging ; Humans ; Male ; Middle Aged ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13828
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Nonalcoholic fatty liver disease, circulating ketone bodies and all-cause mortality in a general population-based cohort.

    Post, Adrian / Garcia, Erwin / van den Berg, Eline H / Flores-Guerrero, Jose L / Gruppen, Eke G / Groothof, Dion / Westenbrink, Berend Daan / Connelly, Margery A / Bakker, Stephan J L / Dullaart, Robin P F

    European journal of clinical investigation

    2021  Volume 51, Issue 12, Page(s) e13627

    Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of ... ...

    Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of NAFLD. We investigated the association between NAFLD and circulating ketone bodies and determined the extent to which NAFLD and circulating ketone bodies are associated with all-cause mortality.
    Methods: Plasma ketone bodies were measured by nuclear magnetic resonance spectroscopy in participants of the general population-based PREVEND study. A fatty liver index (FLI) ≥60 was regarded as a proxy of NAFLD. Associations of an elevated FLI and ketone bodies with all-cause mortality were investigated using Cox regression analyses.
    Results: The study included 6,297 participants aged 54 ± 12 years, of whom 1,970 (31%) had elevated FLI. Participants with elevated FLI had higher total ketone bodies (194 [153-259] vs 170 [133-243] µmol/L; P < .001) than participants without elevated FLI. During 7.9 [7.8-8.9] years of follow-up, 387 (6%) participants died. An elevated FLI was independently associated with an increased risk of mortality (HR: 1.34 [1.06-1.70]; P = .02). Higher total ketone bodies were also associated with an increased mortality risk (HR per doubling: 1.29 [1.12-1.49]; P < .001). Mediation analysis suggested that the association of elevated FLI with all-cause mortality was in part mediated by ketone bodies (proportion mediated: 10%, P < .001).
    Conclusion: Circulating ketone bodies were increased in participants with suspected NAFLD. Both suspected NAFLD and higher circulating ketone bodies are associated with an increased risk of all-cause mortality.
    MeSH term(s) Adult ; Aged ; Body Mass Index ; Cause of Death ; Female ; Humans ; Ketone Bodies/blood ; Male ; Middle Aged ; Mortality ; Non-alcoholic Fatty Liver Disease/blood ; Nuclear Magnetic Resonance, Biomolecular ; Proportional Hazards Models ; Triglycerides/blood ; Waist Circumference ; gamma-Glutamyltransferase/blood
    Chemical Substances Ketone Bodies ; Triglycerides ; gamma-Glutamyltransferase (EC 2.3.2.2)
    Language English
    Publishing date 2021-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13627
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Importance of epicardial adipose tissue localization using cardiac magnetic resonance imaging in patients with heart failure with mid-range and preserved ejection fraction.

    van Woerden, Gijs / van Veldhuisen, Dirk J / Gorter, Thomas M / van Empel, Vanessa P M / Hemels, Martin E W / Hazebroek, Eric J / van Veldhuisen, Sophie L / Willems, Tineke P / Rienstra, Michiel / Westenbrink, Berend Daan

    Clinical cardiology

    2021  Volume 44, Issue 7, Page(s) 987–993

    Abstract: Background: Epicardial adipose tissue (EAT) has been implicated in the pathophysiology of heart failure (HF) with left ventricular ejection fraction (LVEF) >40%, but whether this is due to a regional or global effect of EAT remains unclear.: ... ...

    Abstract Background: Epicardial adipose tissue (EAT) has been implicated in the pathophysiology of heart failure (HF) with left ventricular ejection fraction (LVEF) >40%, but whether this is due to a regional or global effect of EAT remains unclear.
    Hypothesis: Regional EAT is associated with alterations in local cardiac structure and function.
    Methods: Patients with HF and LVEF >40% were studied. Cardiac Magnetic Resonance imaging was used to localize EAT surrounding the right ventricle (RV) and LV separately, using anterior- and posterior interventricular grooves as boundaries. Atrial- and ventricular EAT were differentiated using the mitral-valve position. All EAT depots were related to the adjacent myocardial structure.
    Results: 102 consecutive HF patients were enrolled. The majority of EAT was present around the RV (42% of total EAT, p < .001). RV-EAT showed a strong association with increased RV mass (β = 0.60, p < .001) and remained associated with RV mass after adjusting for total EAT, sex, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), renal function and blood glucose. LV-EAT showed a similar association with LV mass in univariable analysis, albeit less pronounced (β = 0.24, p = .02). Atrial EAT was increased in patients with atrial fibrillation compared to those without atrial fibrillation (30 vs. 26 ml/m
    Conclusions: Regional EAT is strongly associated with local cardiac structure and function in HF patients with LVEF >40%. These data support the hypothesis that regional EAT is involved in the pathophysiology of HF with LVEF >40%.
    MeSH term(s) Adipose Tissue/diagnostic imaging ; Heart Failure/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Prognosis ; Stroke Volume ; Ventricular Function, Left
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391935-3
    ISSN 1932-8737 ; 0160-9289
    ISSN (online) 1932-8737
    ISSN 0160-9289
    DOI 10.1002/clc.23644
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Association of beta-hydroxybutyrate with development of heart failure: Sex differences in a Dutch population cohort.

    Flores-Guerrero, Jose L / Westenbrink, Berend Daan / Connelly, Margery A / Otvos, James D / Groothof, Dion / Shalaurova, Irina / Garcia, Erwin / Navis, Gerjan / de Boer, Rudolf A / Bakker, Stephan J L / Dullaart, Robin P F

    European journal of clinical investigation

    2020  Volume 51, Issue 5, Page(s) e13468

    Abstract: Background: In the failing heart, energy metabolism is shifted towards increased ketone body oxidation. Nevertheless, the association of beta-hydroxybutyrate (β-OHB) with development of heart failure (HF) remains unclear. We investigated the association ...

    Abstract Background: In the failing heart, energy metabolism is shifted towards increased ketone body oxidation. Nevertheless, the association of beta-hydroxybutyrate (β-OHB) with development of heart failure (HF) remains unclear. We investigated the association between plasma β-OHB and the risk of HF in a prospective population-based cohort.
    Design: Plasma β-OHB concentrations were measured in 6134 participants of the PREVEND study. Risk of incident HF with reduced (HFrEF) or preserved (HFpEF) ejection fraction was estimated using multivariable-adjusted Cox regression models.
    Results: During median follow-up for 8.2 years, 227 subjects were diagnosed with HF (137 with HFrEF; 90 with HFpEF). Cox regression analyses revealed a significant association of higher β-OHB concentrations with incident HF (HR per 1 standard deviation increase, 1.40 (95% CI: 1.21-1.63; P < .001), which was largely attributable to HFrEF. In women, the hazard ratio (HR) for HFrEF per 1 standard deviation increase in β-OHB was 1.73 (95% confidence interval (CI): 1.17-2.56, P = .005) in age, BMI, type 2 diabetes, hypertension, myocardial infarction, smoking, alcohol consumption, total cholesterol, HDL-C, triglycerides, glucose, eGFR and UAE adjusted analysis. In men, in the same fully adjusted analysis, the HR was 1.14 (CI: 0.86-1.53, P = .36) (P < .01 for sex interaction). In N-terminal pro-brain natriuretic peptide (NT-proBNP)-stratified analysis, the age-adjusted association with HF was significant in women with higher NT-proBNP levels (P = .008).
    Conclusions: This prospective study suggests that high plasma concentrations of β-OHB are associated with an increased risk of HFrEF, particularly in women. The mechanisms responsible for the sex differences of this association warrant further study.
    MeSH term(s) 3-Hydroxybutyric Acid/blood ; Adult ; Aged ; Cohort Studies ; Female ; Heart Failure/blood ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Netherlands ; Proportional Hazards Models ; Sex Factors ; Stroke Volume
    Chemical Substances 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13468
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.

    de Brouwer, Remco / Te Rijdt, Wouter P / Hoorntje, Edgar T / Amin, Ahmad / Asselbergs, Folkert W / Cox, Moniek G P J / van der Heijden, Jeroen F / Hillege, Hans / Karper, Jacco C / Mahmoud, Belend / van der Meer, Peter / Oomen, Anton / Te Riele, Anneline S J M / Silljé, Herman H W / Tan, Hanno L / van Tintelen, Jan Peter / van Veldhuisen, Dirk J / Westenbrink, Berend Daan / Wiesfeld, Ans C P /
    Willems, Tineke P / van der Zwaag, Paul A / Wilde, Arthur A M / de Boer, Rudolf A / van den Berg, Maarten P

    European heart journal

    2023  Volume 44, Issue 40, Page(s) 4284–4287

    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad292
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top