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  1. Article ; Online: Biomarkers in Acute Heart Failure: Diagnosis, Prognosis, and Treatment.

    Wettersten, Nicholas

    International journal of heart failure

    2021  Volume 3, Issue 2, Page(s) 81–105

    Abstract: Heart failure is a global health problem. An episode of acute heart failure (AHF) is a period of substantial morbidity and mortality with few advances in the management of an episode that have improved outcomes. The measurement of multiple biomarkers has ...

    Abstract Heart failure is a global health problem. An episode of acute heart failure (AHF) is a period of substantial morbidity and mortality with few advances in the management of an episode that have improved outcomes. The measurement of multiple biomarkers has become an integral adjunctive tool for the management of AHF. Many biomarkers are now well established in their ability to assist with diagnosis and prognostication of an AHF patient. There are also emerging biomarkers that are showing significant promise in the areas of diagnosis and prognosis. For improving the management of AHF, both established and novel biomarkers may assist in guiding medical therapy and subsequently improving outcomes. Thus, it is important to understand the different abilities and limitations of established and emerging biomarkers in AHF so that they may be correctly interpreted and integrated into clinical practice for AHF. This knowledge may improve the care of AHF patients. This review will summarize the evidence of both established and novel biomarkers for diagnosis, prognosis and management in AHF so that the treating clinician may become more comfortable incorporating these biomarkers into clinical practice in an evidence-based manner.
    Language English
    Publishing date 2021-02-15
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ISSN 2636-1558
    ISSN (online) 2636-1558
    DOI 10.36628/ijhf.2020.0036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Mounting Evidence for Permissive Hypercreatinemia in Acute Heart Failure: Adding Sodium Glucose Cotransporter Inhibitors to the List.

    Macedo, Etienne / Wettersten, Nicholas

    Kidney360

    2023  Volume 4, Issue 10, Page(s) 1347–1349

    MeSH term(s) Humans ; Heart Failure/drug therapy ; Canagliflozin ; Sodium-Glucose Transport Proteins
    Chemical Substances Canagliflozin (0SAC974Z85) ; Sodium-Glucose Transport Proteins
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Research Support, U.S. Gov't, Non-P.H.S. ; Editorial ; Comment
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 'Don't Throw the Baby out With the Bathwater' Urine Galectin-3 in Heart Failure With Chronic Kidney Disease: Another Tool to Distinguish Intrinsic Kidney Disease From Chronic, Functional Cardiorenal Syndrome?

    Wettersten, Nicholas / Murray, Patrick T

    Journal of cardiac failure

    2023  Volume 30, Issue 2, Page(s) 347–349

    MeSH term(s) Humans ; Heart Failure/diagnosis ; Cardio-Renal Syndrome/diagnosis ; Galectin 3 ; Body Fluids ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis
    Chemical Substances Galectin 3
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4340: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Aging: Not for the Faint of Heart.

    Wettersten, Nicholas

    JACC. Heart failure

    2019  Volume 7, Issue 12, Page(s) 1066–1068

    MeSH term(s) Aging ; Atrial Fibrillation ; Comorbidity ; Heart Failure/epidemiology ; Humans ; Stroke Volume
    Language English
    Publishing date 2019-11-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2019.10.002
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  5. Article ; Online: Diuretic Resistance-A Key to Identifying Clinically Significant Worsening Renal Function in Heart Failure?

    Wettersten, Nicholas / Duff, Stephen / Murray, Patrick T

    Mayo Clinic proceedings

    2022  Volume 97, Issue 9, Page(s) 1598–1600

    MeSH term(s) Diuretics/therapeutic use ; Furosemide ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Kidney/physiology
    Chemical Substances Diuretics ; Furosemide (7LXU5N7ZO5)
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advancements in biomarkers for cardiovascular disease: diagnosis, prognosis, and therapy.

    Wettersten, Nicholas / Horiuchi, Yu / Maisel, Alan

    Faculty reviews

    2021  Volume 10, Page(s) 34

    Abstract: Biomarkers are essential tools in the practice of cardiology. They assist with diagnosis, prognosis, and guiding therapy in many different cardiovascular diseases. Numerous biomarkers have become strongly associated with different cardiovascular ... ...

    Abstract Biomarkers are essential tools in the practice of cardiology. They assist with diagnosis, prognosis, and guiding therapy in many different cardiovascular diseases. Numerous biomarkers have become strongly associated with different cardiovascular conditions, such as troponin with acute coronary syndrome and natriuretic peptides with heart failure. Even though these biomarkers have been in practice for almost two decades, their uses continue to expand beyond their original roles. Additionally, many new biomarkers have been discovered with increasing utility in cardiovascular disease, including soluble suppression of tumorigenicity 2, galectin 3, and biomarkers of fibrosis, metabolism, and inflammation. How these old and new biomarkers are being expanded into clinical practice is constantly in evolution. This review will highlight some of the recent major advancements in the rapidly evolving field of biomarkers.
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/10-34
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  7. Article ; Online: Response by Horiuchi et al to Letter Regarding Article, "Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction".

    Horiuchi, Yu / Wettersten, Nicholas / Maisel, Alan

    Circulation

    2021  Volume 143, Issue 8, Page(s) e252–e253

    MeSH term(s) Anterior Wall Myocardial Infarction ; Biomarkers ; Humans ; Prognosis ; ST Elevation Myocardial Infarction
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.051634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Biomarker developments in heart failure: 2016 and beyond.

    Wettersten, Nicholas / Maisel, Alan S

    Current opinion in cardiology

    2019  Volume 34, Issue 2, Page(s) 218–224

    Abstract: Purpose of review: Biomarkers play a fundamental role in the management of heart failure. Both new and old biomarkers are evaluated every year with new information gained for their use in heart failure. Major advancements have been made in the past 2 ... ...

    Abstract Purpose of review: Biomarkers play a fundamental role in the management of heart failure. Both new and old biomarkers are evaluated every year with new information gained for their use in heart failure. Major advancements have been made in the past 2 years in key biomarkers that will surely become part of standard clinical management of heart failure. This review will focus on major developments since 2016.
    Recent findings: Soluble suppression of tumorigenicity 2 has had multiple breakthrough studies solidifying its prognostic use in both acute and chronic heart failure and with multiple studies showing a strong benefit with serial monitoring. High-sensitivity troponin has also recently been demonstrated to be a powerful prognostic biomarker in heart failure. Additionally, it may serve as a novel screening tool to identify patients at high risk for incident heart failure. Natriuretic peptides continue to show their resilience as the main prognostic biomarker in heart failure. Recent studies suggest natriuretic peptides may help identify certain patient populations that benefit from specific therapies and they can predict prognosis beyond in diseases other than heart failure.
    Summary: Although natriuretic peptides are well-established biomarkers in heart failure, the weight of evidence for soluble suppression of tumorigenicity 2 and high-sensitivity troponin has significantly grown since 2016 that these two biomarkers should be incorporated into regular practice and management of heart failure patients.
    MeSH term(s) Biomarkers/analysis ; Chronic Disease ; Heart Failure/diagnosis ; Humans ; Natriuretic Peptide, Brain/analysis ; Prognosis ; Troponin/analysis
    Chemical Substances Biomarkers ; Troponin ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2556: Show issues Location:
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  9. Article: Role of Cardiac Troponin Levels in Acute Heart Failure.

    Wettersten, Nicholas / Maisel, Alan

    Cardiac failure review

    2017  Volume 1, Issue 2, Page(s) 102–106

    Abstract: Cardiac troponin (cTn) is the primary biomarker for the diagnosis of myocardial necrosis in an acute coronary syndrome (ACS). cTn levels can also be elevated in many other conditions, including heart failure, with significant prognostic value. An ... ...

    Abstract Cardiac troponin (cTn) is the primary biomarker for the diagnosis of myocardial necrosis in an acute coronary syndrome (ACS). cTn levels can also be elevated in many other conditions, including heart failure, with significant prognostic value. An elevated cTn level can be found in both acute and chronic heart failure and its presence is believed to be due to multiple different pathophysiological processes. In acute decompensated heart failure (AHF), an elevated cTn level has been repeatedly shown to correlate with increased short- and long-term mortality and, to a lesser extent, readmission rates. These associations have been demonstrated with both I and T isoforms of cTn, as well as when troponin is measured with conventional assays or new high-sense assays. In multimarker models, cTn has repeatedly been found to be an independent predictive variable enhancing prognostic ability of the model. cTn is therefore an important biomarker for prognosis in AHF.
    Language English
    Publishing date 2017-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2960293-2
    ISSN 2057-7559 ; 2057-7540
    ISSN (online) 2057-7559
    ISSN 2057-7540
    DOI 10.15420/cfr.2015.1.2.102
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  10. Article ; Online: Mending the Soul When the Heart Is Broken.

    Adler, Eric D / Wettersten, Nicholas

    Journal of the American College of Cardiology

    2017  Volume 70, Issue 3, Page(s) 342–343

    MeSH term(s) Heart ; Heart Failure ; Humans ; Palliative Care
    Language English
    Publishing date 2017-07-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2017.05.058
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    Zs.MO 196: Show issues

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