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  1. Article ; Online: Kidney Transplantation in Patients With Monoclonal Gammopathy of Renal Significance.

    Sprangers, Ben / Hegenbart, Ute / Wetzels, Jack F M

    Transplantation

    2023  Volume 107, Issue 5, Page(s) 1056–1068

    Abstract: Monoclonal gammopathy of renal significance (MGRS) defines disorders characterized by direct or indirect kidney injury caused by a monoclonal immunoglobulin produced by a B-cell or plasma-cell clone that does not meet current hematologic criteria for ... ...

    Abstract Monoclonal gammopathy of renal significance (MGRS) defines disorders characterized by direct or indirect kidney injury caused by a monoclonal immunoglobulin produced by a B-cell or plasma-cell clone that does not meet current hematologic criteria for therapy. MGRS-associated kidney diseases are diverse and can result in the development of end-stage kidney disease. The current paradigm states that the underlying hematologic condition should be treated and in deep remission before kidney transplantation can be performed because recurrence has been reported for all MGRS-associated kidney diseases. However, we suggest that decisions regarding kidney transplantation in MGRS patients should be individualized considering many factors such as the subtype of MGRS-associated kidney disease, patient age and comorbidity, presence and risk of extrarenal complications, estimated waiting time, the availability of a living kidney donor, and previous hematological treatment and response. Thus, kidney transplantation should be considered even in treatment-naive patients, with hematological treatment initiated after successful kidney transplantation.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Kidney ; Paraproteinemias/complications ; Kidney Diseases/etiology ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/complications ; Monoclonal Gammopathy of Undetermined Significance/complications
    Language English
    Publishing date 2023-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004443
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  2. Article ; Online: Narrowing the knowledge gap in atypical HUS.

    van de Kar, Nicole C A J / Wetzels, Jack F M

    Blood

    2023  Volume 142, Issue 16, Page(s) 1334–1335

    MeSH term(s) Humans ; Atypical Hemolytic Uremic Syndrome ; Cohort Studies ; Complement System Proteins ; Antibodies, Monoclonal, Humanized
    Chemical Substances Complement System Proteins (9007-36-7) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021474
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  3. Article ; Online: The authors reply.

    Wetzels, Jack F M / Ronco, Pierre / Jha, Vivekanand

    Kidney international

    2022  Volume 101, Issue 1, Page(s) 187

    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.11.010
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  4. Article ; Online: Antibodies Against M-Type Phospholipase Receptor and Prediction of Outcome in Membranous Nephropathy: We are Not There Yet.

    Wetzels, Jack F M

    American journal of nephrology

    2018  Volume 48, Issue 6, Page(s) 434–437

    MeSH term(s) Autoantibodies ; Glomerulonephritis, Membranous ; Humans ; Phospholipases ; Receptors, Phospholipase A2
    Chemical Substances Autoantibodies ; Receptors, Phospholipase A2 ; Phospholipases (EC 3.1.-)
    Language English
    Publishing date 2018-11-23
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000494661
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  5. Article ; Online: Rituximab Is Preferable to Cyclophosphamide for Treatment of Membranous Nephropathy: CON.

    van de Logt, Anne-Els / Wetzels, Jack F

    Kidney360

    2021  Volume 2, Issue 11, Page(s) 1699–1701

    MeSH term(s) Cyclophosphamide/adverse effects ; Glomerulonephritis, Membranous/drug therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Rituximab/adverse effects
    Chemical Substances Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0001432021
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  6. Article ; Online: Blood pressure in early autosomal dominant polycystic kidney disease.

    Wetzels, Jack F

    The New England journal of medicine

    2015  Volume 372, Issue 10, Page(s) 975–976

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Benzimidazoles/therapeutic use ; Benzoates/therapeutic use ; Female ; Humans ; Hypertension/drug therapy ; Kidney/pathology ; Lisinopril/therapeutic use ; Male ; Polycystic Kidney, Autosomal Dominant/drug therapy
    Chemical Substances Antihypertensive Agents ; Benzimidazoles ; Benzoates ; Lisinopril (E7199S1YWR)
    Language English
    Publishing date 2015-03-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1500332#SA2
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  7. Article ; Online: Complement inhibitors are not useful in secondary hemolytic uremic syndromes.

    Duineveld, Caroline / Wetzels, Jack F M

    Kidney international

    2019  Volume 96, Issue 4, Page(s) 829–833

    MeSH term(s) Antibodies, Monoclonal, Humanized/economics ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Complement Activation/drug effects ; Complement Activation/immunology ; Complement Inactivating Agents/economics ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Cost-Benefit Analysis ; Early Termination of Clinical Trials ; Hemolytic-Uremic Syndrome/drug therapy ; Hemolytic-Uremic Syndrome/economics ; Hemolytic-Uremic Syndrome/immunology ; Hemolytic-Uremic Syndrome/microbiology ; Humans ; Patient Outcome Assessment ; Randomized Controlled Trials as Topic ; Shiga-Toxigenic Escherichia coli/immunology ; Standard of Care/economics ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement Inactivating Agents ; Complement System Proteins (9007-36-7) ; eculizumab (A3ULP0F556)
    Language English
    Publishing date 2019-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.08.001
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  8. Article: Antibodies Against M-Type Phospholipase Receptor and Prediction of Outcome in Membranous Nephropathy: We are Not There Yet

    Wetzels, Jack F.M.

    American Journal of Nephrology

    2018  Volume 48, Issue 6, Page(s) 434–437

    Institution Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands
    Language English
    Publishing date 2018-11-23
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Editorial ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000494661
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  9. Article ; Online: Ex Vivo Test of Complement Dysregulation in Atypical Hemolytic Uremic Syndrome Kidney Transplant patients: A Pilot Study.

    Duineveld, Caroline / Bouwmeester, Romy N / van den Heuvel, Lambertus P W J / van de Kar, Nicole C A J / Wetzels, Jack F M

    Kidney international reports

    2023  Volume 9, Issue 1, Page(s) 145–151

    Abstract: Introduction: In 2014, a complement assay, which evaluates C5b-9 deposition on endothelial cells, was proposed as a biomarker for atypical hemolytic uremic syndrome (aHUS). Early diagnosis and/or prediction of aHUS (relapse) is pivotal in aHUS kidney ... ...

    Abstract Introduction: In 2014, a complement assay, which evaluates C5b-9 deposition on endothelial cells, was proposed as a biomarker for atypical hemolytic uremic syndrome (aHUS). Early diagnosis and/or prediction of aHUS (relapse) is pivotal in aHUS kidney transplant recipients who do not receive eculizumab prophylaxis.
    Methods: In this pilot study, serum samples of transplanted patients with aHUS in remission without eculizumab and patients with other primary kidney diseases (controls) were blinded and evaluated in the complement assay.
    Results: We included 13 patients with aHUS (4 males, 9 females) of median age of 54 years (range: 35-69) and median of 5.9 years (range: 0.25-14.1) after transplantation; and 13 controls (7 males, 6 females) of median age of 42 years (range: 27-60) and median of 5.8 years (range: 1.6-11.7) after transplantation. There were no significant differences in C5b-9 deposits between patients with aHUS and controls on resting cells (median of 136% [range: 93%-382%] and 121% [range: 75%-200%], respectively) and activated cells (median of 196% [range: 99%-388%] and 170% [range: 113%-260%], respectively). Three patients with aHUS and 4 controls showed elevated C5b-9 deposits on resting cells, which should correspond to active aHUS. None of these patients had laboratory signs of thrombotic microangiopathy (TMA). During follow-up (15.8 months, range: 6-21), estimated glomerular filtration rate remained stable in all. In 5 patients with aHUS with a genetic variant, no increase in C5b-9 deposits was found on activated endothelial cells, which contrasts with the literature suggesting that the test should identify carriers of a genetic variant.
    Conclusion: Our data question the routine use of the
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.10.003
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  10. Article ; Online: Glomerular disease in 2016: New advances in the treatment of glomerular disease.

    Maas, Rutger J / Wetzels, Jack F

    Nature reviews. Nephrology

    2017  Volume 13, Issue 2, Page(s) 65–66

    MeSH term(s) Genetic Markers ; Genetic Testing ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/drug therapy ; Kidney Diseases/genetics ; Kidney Glomerulus ; Precision Medicine ; Urological Agents/therapeutic use
    Chemical Substances Genetic Markers ; Urological Agents
    Language English
    Publishing date 2017-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2016.195
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