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  1. Article ; Online: ASO Author Reflections: Sentinel Node Navigated Surgery as a New Treatment Strategy for High-Risk T1 Esophageal Adenocarcinoma.

    Frederiks, Charlotte N / Weusten, Bas L A M

    Annals of surgical oncology

    2023  Volume 30, Issue 7, Page(s) 4012–4013

    MeSH term(s) Humans ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Lymph Nodes/surgery ; Lymph Node Excision
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13382-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Esophageal Second Primary Tumors in Patients With Head and Neck Squamous Cell Carcinoma: Incidence, Risk Factors, and Overall Survival.

    Overwater, Anouk / Rueb, Kuna / Elias, Sjoerd G / de Bree, Remco / Weusten, Bas L A M

    The American journal of gastroenterology

    2022  Volume 117, Issue 5, Page(s) 794–797

    Abstract: Introduction: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC).: ... ...

    Abstract Introduction: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC).
    Methods: Outcomes were cumulative incidence and risk factors for ESPTs and its effect on overall survival.
    Results: A total of 47 ESPTs were observed in 1,708 patients with HNSCC, with 10-year cumulative incidence (95% confidence interval) of 2.9% (2.1-3.7). Alcohol and HNSCC location were significant predictors for ESPTs. ESPTs significantly increased the risk of dying (adjusted hazard ratio 3.36, 95% confidence interval 2.16-5.22).
    Discussion: Endoscopic esophageal surveillance of Western patients with HNSCC with high risk of ESPTs seems justified.
    MeSH term(s) Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/pathology ; Cohort Studies ; Esophageal Neoplasms/pathology ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/epidemiology ; Humans ; Incidence ; Neoplasms, Multiple Primary/pathology ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/pathology ; Risk Factors ; Squamous Cell Carcinoma of Head and Neck/epidemiology
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: En bloc resection: does it really matter?

    Weusten, Bas L A M

    Endoscopy

    2014  Volume 46, Issue 4, Page(s) 279–281

    MeSH term(s) Disease-Free Survival ; Dissection/methods ; Endoscopy, Gastrointestinal/methods ; Endoscopy, Gastrointestinal/mortality ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagoscopy/methods ; Female ; Gastric Mucosa/pathology ; Gastric Mucosa/surgery ; Gastroscopy/methods ; Humans ; Male ; Minimally Invasive Surgical Procedures/methods ; Minimally Invasive Surgical Procedures/mortality ; Patient Selection ; Risk Assessment ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2014-04
    Publishing country Germany
    Document type Comparative Study ; Editorial
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0034-1365404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endoscopic submucosal dissection for early esophageal squamous cell carcinoma: long-term results from a Western cohort.

    Beaufort, Ilse N / Frederiks, Charlotte N / Overwater, Anouk / Brosens, Lodewijk A A / Koch, Arjun D / Pouw, Roos E / Bergman, Jacques J G H M / Weusten, Bas L A M

    Endoscopy

    2024  Volume 56, Issue 5, Page(s) 325–333

    Abstract: Background: Although endoscopic submucosal dissection (ESD) is established as first-choice treatment for early esophageal squamous cell carcinoma (ESCC) worldwide, most data are derived from Asian studies. We aimed to evaluate the long-term outcomes of ... ...

    Abstract Background: Although endoscopic submucosal dissection (ESD) is established as first-choice treatment for early esophageal squamous cell carcinoma (ESCC) worldwide, most data are derived from Asian studies. We aimed to evaluate the long-term outcomes of ESD for patients with early ESCC in a Western cohort.
    Methods: In this retrospective cohort study, patients with early ESCC amenable to ESD were included from four tertiary referral hospitals in the Netherlands between 2012 and 2017. All ESD procedures were performed by experienced endoscopists, after which the decision for additional treatment was made on a per-patient basis. Outcomes were curative resection rate, ESCC-specific survival, and overall survival.
    Results: Of 68 included patients (mean age 69 years; 34 males), ESD was technically successful in 66 (97%; 95%CI 93%-100%), with curative resection achieved in 34/66 (52%; 95%CI 39%-64%). Among patients with noncurative resection, 15/32 (47%) underwent additional treatment, mainly esophagectomy (n = 10) or definitive chemoradiation therapy (n = 4). Endoscopic surveillance was preferred in 17/32 patients (53%), based on severe comorbidities or patient choice. Overall, 31/66 patients (47%) died during a median follow-up of 66 months; 8/31 (26%) were ESCC-related deaths. The 5-year overall and ESCC-specific survival probabilities were 62% (95%CI 52%-75%) and 86% (95%CI 77%-96%), respectively.
    Conclusion: In this Western cohort with long-term follow-up, the effectiveness and safety of ESD for early ESCC was confirmed, although the rate of noncurative resections was substantial. Irrespective of curative status, the long-term prognosis of these patients was limited mainly due to competing mortality.
    MeSH term(s) Humans ; Endoscopic Mucosal Resection/methods ; Endoscopic Mucosal Resection/adverse effects ; Male ; Female ; Aged ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Retrospective Studies ; Esophageal Squamous Cell Carcinoma/surgery ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Middle Aged ; Netherlands ; Esophagectomy/methods ; Esophagectomy/adverse effects ; Treatment Outcome ; Survival Rate ; Aged, 80 and over ; Neoplasm Staging
    Language English
    Publishing date 2024-02-07
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2245-7235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Updates in Cryotherapy for Barrett's Esophagus.

    Frederiks, Charlotte N / Canto, Marcia Irene / Weusten, Bas L A M

    Gastrointestinal endoscopy clinics of North America

    2020  Volume 31, Issue 1, Page(s) 155–170

    Abstract: Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is ... ...

    Abstract Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett's esophagus; however, larger prospective series with longer follow-up are warranted to determine the clinical utility of cryotherapy in the treatment of Barrett's esophagus.
    MeSH term(s) Ablation Techniques/methods ; Barrett Esophagus/therapy ; Cryotherapy/methods ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/therapy ; Esophagus/surgery ; Humans ; Nitrogen/administration & dosage ; Precancerous Conditions/pathology ; Precancerous Conditions/therapy
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313994-0
    ISSN 1558-1950 ; 1052-5157
    ISSN (online) 1558-1950
    ISSN 1052-5157
    DOI 10.1016/j.giec.2020.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cryoballoon ablation as salvage therapy after nonradical resection of a high-risk T1b esophageal adenocarcinoma: a case report.

    Frederiks, Charlotte N / van de Water, Jolanda M W / Ebrahimi, Gati / Weusten, Bas L A M

    European journal of gastroenterology & hepatology

    2021  Volume 34, Issue 3, Page(s) 354–357

    Abstract: Although esophagectomy with or without (neo)adjuvant chemoradiation therapy is the current standard of care for patients with early esophageal adenocarcinoma with high-risk features or after nonradical endoscopic resection of an early esophageal ... ...

    Abstract Although esophagectomy with or without (neo)adjuvant chemoradiation therapy is the current standard of care for patients with early esophageal adenocarcinoma with high-risk features or after nonradical endoscopic resection of an early esophageal adenocarcinoma, not all patients are eligible for surgery due to varying reasons. In these patients, cryoballoon ablation may serve as an alternative treatment option considering the potential of deeper tissue ablation as compared to heat-based ablation techniques. We report the first case in which cryoballoon ablation was successfully performed as salvage therapy with a curative intent for positive deep resection margins after an incomplete endoscopic resection of a recurrent early esophageal adenocarcinoma.
    MeSH term(s) Adenocarcinoma/pathology ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagoscopy/adverse effects ; Humans ; Neoplasm Staging ; Salvage Therapy
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000002242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The course of pain and dysphagia after radiofrequency ablation for Barrett's esophagus-related neoplasia.

    Overwater, Anouk / Elias, Sjoerd G / Schoon, Erik J / Bergman, Jacques J G H M / Pouw, Roos E / Weusten, Bas L A M

    Endoscopy

    2022  Volume 55, Issue 3, Page(s) 255–260

    Abstract: Background: Radiofrequency ablation (RFA) is effective for eradication of Barrett's esophagus (BE) neoplasia, but little is known on the course of pain and dysphagia after RFA. We aimed to describe the course of post-RFA symptoms and to identify ... ...

    Abstract Background: Radiofrequency ablation (RFA) is effective for eradication of Barrett's esophagus (BE) neoplasia, but little is known on the course of pain and dysphagia after RFA. We aimed to describe the course of post-RFA symptoms and to identify possible associated risk factors.
    Methods: In this multicenter, observational cohort study, all RFA procedures registered in a prospective database were included. Patient and treatment characteristics were collected from medical records and patients self-registered post-procedural symptoms in electronic symptom diaries for 14 days. Mixed model regression was used for the analyses.
    Results: In total, 255 diaries were completed. Post-RFA pain was reported for 95 % (95 %CI 93-98) of procedures (median duration 14 days; 25th-75th percentiles [p25-p75] 11-14) and major pain for 64 % (95 %CI 58-69; median duration 8 days, p25-p75 3-13). Post-procedural pain significantly increased with BE length, younger age, and no prior ablation. Dysphagia was present after 83 % (95 %CI 79-88) of procedures (median duration 13 days, p25-p75 9-14). The risk of dysphagia decreased with age and increased when patients experienced more pain.
    Conclusions: RFA treatment for BE-related neoplasia seems a significant burden for patients, and post-procedural symptoms should be taken into account when counseling patients before starting endoscopic eradication therapy.
    MeSH term(s) Humans ; Barrett Esophagus/surgery ; Deglutition Disorders/etiology ; Deglutition Disorders/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Treatment Outcome ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/etiology ; Radiofrequency Ablation/adverse effects ; Radiofrequency Ablation/methods ; Pain/etiology ; Esophagoscopy/methods
    Language English
    Publishing date 2022-09-07
    Publishing country Germany
    Document type Observational Study ; Multicenter Study ; Clinical Trial ; Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1929-1448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cryoablation in the management of Barrett's esophagus.

    Overwater, Anouk / Weusten, Bas L A M

    Current opinion in gastroenterology

    2017  Volume 33, Issue 4, Page(s) 261–269

    Abstract: Purpose of review: Providing an overview on types of cryotherapy for esophageal application and their role in the management of Barrett's esophagus.: Recent findings: Recent studies have involved multiple types of cryotherapy including cryospray ... ...

    Abstract Purpose of review: Providing an overview on types of cryotherapy for esophageal application and their role in the management of Barrett's esophagus.
    Recent findings: Recent studies have involved multiple types of cryotherapy including cryospray techniques that use either liquid nitrogen or carbon dioxide as the cryogenic fluid, and the CryoBalloon focal ablation device that uses nitrous oxide. Overall, studies report cryotherapy to be safe and effective in eradicating Barrett's epithelium. However, substantial variations among these studies in design and outcomes preclude direct comparisons of the results. Moreover, little is known of the long-term outcomes of cryotherapy, with only one report describing 5-year follow-up of patients treated with liquid nitrogen cryospray.
    Summary: The concept of cryotherapy is appealing. By preserving the extracellular matrix and inducing anesthetic effects, cryotherapy has the potential to enable deeper ablations with less pain and a lower rate of stricture formation than radiofrequency ablation. To date, however, these potential benefits remain unproved. Prospective studies with clearly defined endpoints and longer follow-up are necessary to determine the role of cryotherapy in the management of patients with Barrett's esophagus.
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pelvic insufficiency fractures and pelvic bone metastases after neoadjuvant (chemo)radiotherapy for rectal cancer.

    Rijpma-Jacobs, Lotte / van der Vlies, Ellen / Meek, David B / Bollen, Thomas L / Siersema, Peter D / Weusten, Bas L A M / Intven, Martijn / van Lelyveld, Niels / Los, Maartje

    Acta oncologica (Stockholm, Sweden)

    2023  Volume 62, Issue 10, Page(s) 1295–1300

    Abstract: Background: Pelvic insufficiency fractures (PIFs) are a late complication of radiotherapy for pelvic malignancies. We evaluated the incidence, radiologic findings, clinical course, and outcome of PIFs in patients treated with neoadjuvant (chemo) ... ...

    Abstract Background: Pelvic insufficiency fractures (PIFs) are a late complication of radiotherapy for pelvic malignancies. We evaluated the incidence, radiologic findings, clinical course, and outcome of PIFs in patients treated with neoadjuvant (chemo)radiotherapy ((C)RT) for rectal cancer.
    Material and methods: Data of patients diagnosed with rectal cancer from a large teaching hospital treated from 2002 to 2012 were extracted from the Dutch Cancer Registry. All hospital records were reviewed for the diagnosis of PIFs or pelvic bone metastases. An expert radiologist reassessed all imaging procedures of the lower back, abdomen, and pelvis.
    Results: A total of 513 rectal cancer patients were identified of whom 300 patients (58.5%) were treated with neoadjuvant (C)RT (long- vs. short-course radiotherapy: 91 patients [17.7%] vs. 209 [40.7%], respectively). Twelve PIFs were diagnosed initially according to hospital records and imaging reports of all 513 patients. These 12 patients were treated with neoadjuvant (C)RT. After reassessment of all pelvic imaging procedures done in this patient group (432 patients (84.2%)), 20 additional PIFs were detected in patients treated with neoadjuvant (C)RT, resulting in a 10.7% PIF rate in irradiated patients. One PIF was detected in the group of patients not treated with neoadjuvant (C)RT for rectal cancer. This patient had palliative radiotherapy for prostate cancer and is left out of the analysis. Median follow-up time of 32 PIF patients was 49 months. Median time between start of neoadjuvant (C)RT and diagnosis of PIF was 17 months (IQR 9-28). Overall median survival for patients with PIF was 63.5 months (IQR 44-120).
    Conclusion: PIFs are a relatively common late complication of neoadjuvant (C)RT for rectal cancer but are often missed or misdiagnosed as pelvic bone metastases. The differentiation of PIFs from pelvic bone metastases is important because of a different treatment and disease outcome.
    MeSH term(s) Male ; Humans ; Fractures, Stress/epidemiology ; Fractures, Stress/etiology ; Fractures, Stress/pathology ; Neoadjuvant Therapy/adverse effects ; Pelvic Bones/pathology ; Pelvis/pathology ; Rectal Neoplasms/pathology ; Chemoradiotherapy/adverse effects ; Retrospective Studies ; Neoplasm Staging
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2023.2252168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: En bloc resection: does it really matter?

    Weusten, Bas L. A. M.

    Endoscopy

    2014  Volume 46, Issue 04, Page(s) 279–281

    Language English
    Publishing date 2014-03-26
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0034-1365404
    Database Thieme publisher's database

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