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Book ; Thesis: Nanokolloidale Verschleißprodukte

Weuster, Matthias

Untersuchung der inflammatorischen und toxischen Effekte auf Makrophagen der Maus

2009

Author's details	vorgelegt von Matthias Weuster
Language	German
Size	91 Bl. : Ill., zahlr. graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Duisburg, Essen, Univ., Diss., 2010
HBZ-ID	HT016368828
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: The Vega advanced third generation posterior stabilized total knee arthroplasty system enables the restoration of range of motion for high demanding daily activities - A 5-years follow-up study.

Gerdesmeyer, Ludger / Glowalla, Claudio / Lasic, Igor / Al Muderis, Munjed / Weuster, Matthias / Klueter, Tim

PloS one

2024 Volume 19, Issue 5, Page(s) e0302885

Abstract: Background: The Vega System® PS (Aesculap AG, Tuttlingen, Germany) is an advanced, third generation fixed implant that aims to mimic natural knee kinematics by optimizing pivotal motion while reducing surface stress. This study evaluated mid-term ... ...

Abstract	Background: The Vega System® PS (Aesculap AG, Tuttlingen, Germany) is an advanced, third generation fixed implant that aims to mimic natural knee kinematics by optimizing pivotal motion while reducing surface stress. This study evaluated mid-term survival and clinical outcomes, including range of motion (ROM) of the modern posterior stabilized implant in order to analyse whether this biomechanically successful implant reaches good results in situ. Methods: The first 100 patients to receive the Vega PS System for total knee arthroplasty were invited to take part in this single centre, single surgeon study. Of these, 84 patients were clinically assessed 5-6 years postoperatively. Data which was obtained during this follow-up examination included revision data, range of motion and clinical scores. Results: The 5-year survival rate for exchange of any component was 97.6%, whereby two patients required replacement of the polyethylene gliding surface. Secondary patella resurfacing was performed in 7 patients. Significantly improved results in comparison to the preoperative state could be obtained at the follow-up: KOOS improved from 39.4 to 78.8, SF-12 PCS improved from 32.1 to 42 SF-12 MCS improved from 46 to 53.8 and patella pain improved from 2.7 to 0.3. The mean ROM of the 84 patients after 5 years was 133.1° and mean total KSS was 189.9. Discussion & conclusions: This study demonstrates a high survival rate of the Vega PS System® and significant improvements in clinical outcomes 5 years after implantation. The obtained mean ROM indicates that this implant provides good flexibility of the knee joint, allowing a high number of activities. However, due to the rate of secondary patella implantation, routine resurfacing of the patella for all PS TKA cases is highly recommended. Clinical trials registration: The study was registered at clinicaltrials.gov (NCT02802085).
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/methods ; Range of Motion, Articular ; Female ; Male ; Aged ; Follow-Up Studies ; Middle Aged ; Knee Prosthesis ; Knee Joint/surgery ; Knee Joint/physiopathology ; Aged, 80 and over ; Activities of Daily Living ; Biomechanical Phenomena ; Treatment Outcome ; Prosthesis Design
Language	English
Publishing date	2024-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302885
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Integrierung und Validierung der Hysteroskopie-Simulation mit dem HystSim® im Rahmen von Trainingskursen zur gynäkologischen Endoskopie

Skrzipczyk, Moritz [Verfasser] / Alkatout, Ibrahim [Akademischer Betreuer] / Weuster, Matthias [Gutachter]

2020

Author's details	Moritz Skrzipczyk ; Gutachter: Matthias Weuster ; Betreuer: Ibrahim Alkatout
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek Kiel
Publishing place	Kiel
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Retrospective Mid-Term Follow-Up of Posttraumatic and Iatrogenic Neurovascular Complications in Surgically Treated Paediatric Patients with Distal Humerus Fracture.

Gutwerk, Alexander / Behrendt, Peter / Vetter, Svenja / Menzdorf, Leif / Oates, Edward / Jazra, Sebastian / Lippross, Sebastian / Klüter, Tim / Seekamp, Andreas / Weuster, Matthias

Children (Basel, Switzerland)

2022 Volume 9, Issue 9

Abstract: Background: The purpose of the study was to investigate and describe neurovascular complications and mid-term clinical outcomes of operatively managed fractures of the distal humerus in a paediatric population. Neurovascular injuries are common in these ...

Abstract	Background: The purpose of the study was to investigate and describe neurovascular complications and mid-term clinical outcomes of operatively managed fractures of the distal humerus in a paediatric population. Neurovascular injuries are common in these fractures, but reports about their implications for mid-term clinical outcomes is sparse. Methods: A single-centre retrospective study was conducted at a university teaching hospital investigating paediatric patients who underwent operative management of a distal humerus fracture between 2014 and 2018. Patient demographics, fracture classification, pre-, peri- and postoperative neurovascular complications were investigated. Mid-term follow up clinical examination and functional scoring using QuickDASH, the Broberg and Morrey Score (BMS), the Mayo Elbow Performance Score (MEPS) and the Numeric Rating Scale were performed. Results: A total of 84 patients were identified, of which 34 met the inclusion criteria and were available for follow-up clinical examination. The average time to follow-up was 150 weeks (1049.44 days ± 448.54). Ten primary traumatic neurovascular complications were identified, the majority of which involved the median nerve. Primary traumatic dissection of the brachial artery was recorded in three patients. Secondary iatrogenic nerve injury was documented in five patients after previously normal clinical examination. At follow-up, the average QuickDASH score was 3.0 ± 4.3, BMS was 98.6 ± 3.4 and MEPS was 97.1 ± 3.3 points. Conclusions: The mid-term clinical outcome following surgical management of distal humerus fractures is excellent. There is, however, a considerable frequency of both primary and secondary neurovascular complications, which must be considered when opting to treat these injuries surgically.
Language	English
Publishing date	2022-09-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9091349
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Article ; Online: Predicting tracheostomy in multiple injured patients with severe thoracic injury (AIS ≥ 3) with the new T

Bläsius, Felix M / Wutzler, Sebastian / Störmann, Philipp / Lustenberger, Thomas / Frink, Michael / Maegele, Marc / Weuster, Matthias / Bayer, Jörg / Horst, Klemens / Caspers, Michael / Seekamp, Andreas / Marzi, Ingo / Hildebrand, Frank / Andruszkow, Hagen

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3260

Abstract: Multiple trauma patients with severe chest trauma are at increased risk for tracheostomy. While the risk factors associated with the need for tracheostomy are well established in the general critical care population, they have not yet been validated in a ...

Abstract	Multiple trauma patients with severe chest trauma are at increased risk for tracheostomy. While the risk factors associated with the need for tracheostomy are well established in the general critical care population, they have not yet been validated in a cohort of patients suffering severe thoracic trauma. This retrospective cohort study analysed data on patients aged 18 years or older who were admitted to one of the six participating academic level I trauma centres with multiple injuries, including severe thoracic trauma (AIS
MeSH term(s)	Adult ; Humans ; Tracheostomy ; Retrospective Studies ; Thoracic Injuries/complications ; Multiple Trauma/complications ; Sepsis/complications
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30461-x
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Article ; Online: In Vitro

Weitkamp, Jan-Tobias / Benz, Karin / Rolauffs, Bernd / Bayer, Andreas / Weuster, Matthias / Lucius, Ralph / Gülses, Aydin / Naujokat, Hendrik / Wiltfang, Jörg / Lippross, Sebastian / Hoffmann, Michael / Kurz, Bodo / Behrendt, Peter

Cartilage

2023 Volume 14, Issue 2, Page(s) 220–234

Abstract: Objective: In autologous chondrocyte implantation (ACI), there is no consensus about used bioscaffolds. The aim of this study was to perform an : Design: Monolayer expanded human chondrocytes (: Results: The shift of COL1/2 ratio toward COL2A1 was ...

Abstract	Objective: In autologous chondrocyte implantation (ACI), there is no consensus about used bioscaffolds. The aim of this study was to perform an Design: Monolayer expanded human chondrocytes ( Results: The shift of COL1/2 ratio toward COL2A1 was more pronounced in HA, and cells displayed a more spherical morphology compared with CS. BMP-2 and IL-10 significantly increased COL2A1, SOX9, and ACAN expression, which was paralleled by enhanced staining of glycosaminoglycans (GAGs) and type 2 collagen in histological sections of CS and HA. COL10A1 was not significantly expressed in HA and CS. Better interfacial integration and enhanced cell invasion was observed in CS. Push-out tests using CS showed higher bonding strength to native cartilage. Conclusion: HA-based hydrogel revealed a more chondrocyte-like phenotype but only allowed limited cell invasion, whereas CS were advantageous in terms of cellular invasion and interfacial adhesion. These differences may be clinically relevant when treating cartilaginous or osteochondral defects.
MeSH term(s)	Animals ; Cattle ; Humans ; Chondrocytes/metabolism ; Hydrogels ; Interleukin-10 ; Biocompatible Materials/pharmacology ; Tissue Scaffolds ; Cells, Cultured ; Collagen/metabolism
Chemical Substances	Hydrogels ; Interleukin-10 (130068-27-8) ; Biocompatible Materials ; Collagen (9007-34-5)
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035231154507
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Article ; Online: Correction: Percutaneous thoraco‑lumbar‑sacral pedicle screw placement accuracy results from a multi‑center, prospective clinical study using a skin marker‑based optical navigation system.

Scarone, Pietro / Chatterjea, Anindita / Jenniskens, Inge / Klüter, Tim / Weuster, Matthias / Lippross, Sebastian / Presilla, Stefano / Distefano, Daniela / Chianca, Vito / Sedaghat, Sam / Nelson, Melissa / Lampe, Finn / Seekamp, Andreas

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2023 Volume 32, Issue 12, Page(s) 4470

Language	English
Publishing date	2023-10-20
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-023-07989-7
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Book ; Online ; Thesis: Vergleich eines innovativen Lehrfilm-basierten versus klassischen Dozenten-basierten Konzepts in der Sonographie-Ausbildung von Studierenden

Duschek, Max Verfasser] / [Elke, Gunnar [Akademischer Betreuer] / Weuster, Matthias [Gutachter]

2019

Author's details	Max Duschek ; Gutachter: Matthias Weuster ; Betreuer: Gunnar Elke
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek Kiel
Publishing place	Kiel
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Long-term Efficacy of Percutaneous Epidural Neurolysis of Adhesions in Chronic Lumbar Radicular Pain: 10 Year Follow-up of a Randomized Controlled Trial.

Gerdesmeyer, Ludger / Noe, Carl / Prehn-Kristensen, Alexander / Harrasser, Norbert / Muderis, Munjed Al / Weuster, Matthias / Klueter, Tim

Pain physician

2021 Volume 24, Issue 5, Page(s) 359–367

Abstract: Background: No long-term follow-up data exist in any treatment for chronic radicular pain occurring with disc pathology and after failed back surgery. A previous randomized controlled trial (RCT) has proven efficacy in short-term follow-up as an ... ...

Abstract	Background: No long-term follow-up data exist in any treatment for chronic radicular pain occurring with disc pathology and after failed back surgery. A previous randomized controlled trial (RCT) has proven efficacy in short-term follow-up as an evidence-based effective therapeutic option. Objectives: Long term data is needed to determine the efficacy and cost- effectiveness of minimal invasive procedures. The present study reports 10 year follow-up results from the randomized trial. Study design: A prospective, randomized, placebo-controlled, interventional clinical trial. A power calculation was based on a previous feasibility trial. Setting: University medical centers. Methods: After a 4 year enrollment phase, 381 patients with chronic radicular pain persisting beyond 4 months, who failed conservative treatments, were screened. Ninety patients were enrolled. Patients were randomly assigned to receive percutaneous epidural lysis of adhesions or placebo with concealed allocation in permuted blocks of 4 to 8 patients each, and stratified by treatment center. The primary outcomes were a mean change of the Oswestry Disability Index (ODI) scores and Visual Analog Scale (VAS), one and 10 years after intervention. For each rating scale an analysis of variance with the within-patient factor time (baseline, one year follow-up, 10 year follow-up) and the between-patient factor treatment (lysis, placebo) was used. Results: Homogeneity was shown at baseline between the groups. The ODI and VAS scores were significantly better one and 10 years in the lysis group vs the control group. The ODI in the lysis group improved from 55.3 ± 11.6 to 9.6 ± 9.3 after one year and to 11.7 ± 14.2 after 10 years. The placebo group also improved from 55.4 ± 11.5 to 30.7 ± 14.2 after one year and to 24.8 ± 12.0 after 10 years. The VAS improved from 6.7 ± 1.1 to 1.2 ± 1.1 after one year and to 1.5 ± 1.4 after 10 years in the lysis group and from 6.7 ± 1.1 to 2.8 ± 1.5 after one year and to 2.9 ± 1.3 after 10 years after placebo intervention. The statistical difference of the ODI and VAS between the treatment and control groups remain significant up to 10 years. No treatment-related severe adverse effects occurred within the 10 years, but minor transient neurological effects were seen directly after the intervention. Limitations: The long-term effects of single treatment components cannot be specified as no imaging examination was performed at 10 year follow-up. A large variety of unanalyzed noninvasive treatments were done within the 10 years. Some patients did not clearly remember the intervention after 10 years. Uncontrolled effects such as higher inhomogeneity of biometric properties, concomitant therapies, pain tolerance level, or just social effects could occur, but were not analyzed in the trial. Conclusion: This is the first 10 year follow-up report of a placebo-controlled RCT showing efficacy of the minimally invasive percutaneous adhesiolysis procedure for patients with chronic lumbosacral radicular pain. No alternative evidence-based treatment modality with 10 year follow-up is available to be recommended. This procedure should be considered as the first treatment option for patients with chronic lumbosacral radicular pain.
MeSH term(s)	Back Pain/surgery ; Follow-Up Studies ; Humans ; Intervertebral Disc Displacement/surgery ; Low Back Pain ; Lumbar Vertebrae ; Nerve Block ; Pain Measurement ; Treatment Outcome
Language	English
Publishing date	2021-07-29
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2146393-1
ISSN	2150-1149 ; 1533-3159
ISSN (online)	2150-1149
ISSN	1533-3159
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Zs.A 5930: Show issues

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Article ; Online: Der Hybridoperationssaal : Anwendung in Unfallchirurgie und Orthopädie.

Braun, Frederic / Peh, Simon / Weuster, Matthias / Klueter, Tim / Seekamp, Andreas / Lippross, Sebastian

Der Unfallchirurg

2019 Volume 123, Issue 2, Page(s) 134–142

Abstract: Background: For some years now, more and more hospitals in Germany have acquired so-called hybrid operating rooms. In these operating rooms it is possible to produce three-dimensional imaging during the operation. Originally developed for cardiovascular ...

Title translation	Hybrid operating room : Application in trauma surgery and orthopaedics.
Abstract	Background: For some years now, more and more hospitals in Germany have acquired so-called hybrid operating rooms. In these operating rooms it is possible to produce three-dimensional imaging during the operation. Originally developed for cardiovascular surgery, these rooms are increasingly being used for interdisciplinary purposes. Previous experiences in the use for trauma surgery and orthopedics has shown that three-dimensional imaging can have a positive effect on the success of surgery. Objective: Can minimally invasive operations on the spine benefit intraoperatively from three-dimensional imaging with respect to operating times and results? Methods: Minimally invasive operations on the spine performed at the UKSH Campus Kiel between 2015 and 2018 in the hybrid operating room were considered. These were compared to minimally invasive spinal surgery performed in conventional operating rooms. Results: As is usual with the establishment of a new procedure, there are initially longer operating times. With regular use and appropriate training and experience of the personnel, the processes can be optimized. Conclusion: Due to the accuracy of the three-dimensional imaging, errors can be detected and eliminated at an early stage during the operation. Revisions are less frequent. In contrast, there is increased radiation exposure and sometimes longer operation and anesthesia times.
MeSH term(s)	Germany ; Humans ; Operating Rooms ; Orthopedic Procedures ; Orthopedics ; Radiation Exposure
Language	German
Publishing date	2019-05-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605965-x
ISSN	1433-044X ; 0177-5537
ISSN (online)	1433-044X
ISSN	0177-5537
DOI	10.1007/s00113-019-0657-1
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