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  1. Article ; Online: Non-perennial stream networks as directed acyclic graphs: The R-package streamDAG

    Aho, Ken / Kriloff, Cathy / Godsey, Sarah E. / Ramos, Rob / Wheeler, Chris / You, Yaqi / Warix, Sara / Derryberry, DeWayne / Zipper, Sam / Hale, Rebecca L. / Bond, Charles T. / Kuehn, Kevin A.

    Environmental Modelling and Software. 2023 Sept., v. 167 p.105775-

    2023  

    Abstract: Many conventional stream network metrics are poorly suited to non-perennial streams, which can vary substantially in space and time. To address this issue, we considered non-perennial stream networks as directed acyclic graphs (DAGs). DAG metrics allow: ... ...

    Abstract Many conventional stream network metrics are poorly suited to non-perennial streams, which can vary substantially in space and time. To address this issue, we considered non-perennial stream networks as directed acyclic graphs (DAGs). DAG metrics allow: 1) summarization of important non-perennial stream characteristics (e.g., complexity, connectedness, and nestedness) from both local (individual segment) and global stream network perspectives, and 2) tracking of these features as networks expand and contract. We review a large number of graph theoretic metrics, and introduce a new R package, streamDAG that codifies approaches we feel are most useful. The streamDAG package contains procedures for handling water presence data, and functions for both local and global analyses of both unweighted and weighted stream DAGs. We demonstrate streamDAG using two North American non-perennial streams: Murphy Creek, a simple drainage system in the Owyhee Mountains of southwestern Idaho, and Konza Prairie, a relatively complex network in central Kansas.
    Keywords computer software ; drainage systems ; nestedness ; space and time ; streams ; Idaho ; Kansas ; Non-perennial stream ; Graph theory ; Directed acyclic graph ; Network analysis ; Hydrologic connectivity ; R computational software
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1364-8152
    DOI 10.1016/j.envsoft.2023.105775
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Facilitators and barriers to the successful implementation of pediatric antibacterial drug trials: Findings from CTTI's survey of investigators.

    Corneli, Amy / Wheeler, Chris / Bradley, John / Gamel, Breck / Nambiar, Sumathi / Noel, Gary J / Lin, Li / Roberts, Jamie N / Benjamin, Daniel K

    Contemporary clinical trials communications

    2018  Volume 9, Page(s) 115–120

    Abstract: An urgent need exists to develop new antibacterial drugs for children. We conducted research with investigators of pediatric antibacterial drug trials to identify facilitators and barriers in the conduct of these trials. Seventy-three investigators ... ...

    Abstract An urgent need exists to develop new antibacterial drugs for children. We conducted research with investigators of pediatric antibacterial drug trials to identify facilitators and barriers in the conduct of these trials. Seventy-three investigators completed an online survey assessing the importance of 15 facilitators (grouped in 5 topical categories) and the severity of 36 barriers (grouped in 6 topical categories) to implementing pediatric antibacterial drug trials. Analysis focused on the identification of key factors that facilitate the successful implementation of pediatric antibacterial drug trials and the key barriers to implementation. Almost all investigators identified two factors as very important facilitators: having site personnel for enrollment and having adequate funding. Other top factors were related to staffing. Among the barriers, factors related to parent concerns and consent were prominent, particularly obtaining parental consent when there was disagreement between parents, concerns about the number of blood draws, and concerns about the number of invasive procedures. Having overly narrow eligibility criteria was also identified as a major barrier. The survey findings suggest three areas in which to focus efforts to help facilitate ongoing drug development: (1) improving engagement with parents of children who may be eligible to enroll in a pediatric antibacterial drug trial, (2) broadening inclusion criteria to allow more participants to enroll, and (3) ensuring adequate staffing and establishing sustainable financial strategies, such as funding pediatric trial networks. The pediatric antibacterial drug trials enterprise is likely to benefit from focused efforts by all stakeholders to remove barriers and enhance facilitation.
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2018.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Electronic medical records in long-term care

    Campbell, Josh / Coustasse, Alberto / Phillips, Krista / Wheeler, Chris

    Journal of hospital marketing & public relations Vol. 20, No. 2 , p. 131-142

    2010  Volume 20, Issue 2, Page(s) 131–142

    Author's details Krista Phillips; Chris Wheeler; Josh Campbell; Alberto Coustasse
    Language English
    Publisher Haworth Press
    Publishing place Binghamton, NY
    Document type Article
    ZDB-ID 2098451-0
    Database ECONomics Information System

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  4. Article ; Online: Electronic medical records in long-term care.

    Phillips, Krista / Wheeler, Chris / Campbell, Josh / Coustasse, Alberto

    Journal of hospital marketing & public relations

    2010  Volume 20, Issue 2, Page(s) 131–142

    Abstract: Long-term care (LTC) facilities possess unique characteristics in terms of implementation and utilization of electronic medical records (EMRs). The focus of LTC is on a population requiring care encompassing all aspects associated with quality of life ... ...

    Abstract Long-term care (LTC) facilities possess unique characteristics in terms of implementation and utilization of electronic medical records (EMRs). The focus of LTC is on a population requiring care encompassing all aspects associated with quality of life rather than simply acute treatment. Because this focus is of a larger scale than traditional medical facilities, the priorities in the implementation and utilization of EMRs are higher in accessing patient history information. The purpose of this study was to determine the EMR utilization in the chronic care settings. In conclusion, the literature review performed does not support the fact that EMRs are currently being effectively and widely used in the LTC facilities.
    MeSH term(s) Electronic Health Records/organization & administration ; Electronic Health Records/utilization ; Health Plan Implementation ; Humans ; Long-Term Care ; Nursing Homes ; United States
    Language English
    Publishing date 2010-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1539-0934
    ISSN (online) 1539-0934
    DOI 10.1080/15390942.2010.493377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative.

    Greenberg, Rachel G / Gamel, Breck / Bloom, Diane / Bradley, John / Jafri, Hasan S / Hinton, Denise / Nambiar, Sumathi / Wheeler, Chris / Tiernan, Rosemary / Smith, P Brian / Roberts, Jamie / Benjamin, Daniel K

    Contemporary clinical trials communications

    2017  Volume 9, Page(s) 33–39

    Abstract: Enrollment of children into pediatric clinical trials remains challenging. More effective strategies to improve recruitment of children into trials are needed. This study used in-depth qualitative interviews with parents who were approached to enroll ... ...

    Abstract Enrollment of children into pediatric clinical trials remains challenging. More effective strategies to improve recruitment of children into trials are needed. This study used in-depth qualitative interviews with parents who were approached to enroll their children in a clinical trial in order to gain an understanding of the barriers to pediatric clinical trial participation. Twenty-four parents whose children had been offered the opportunity to participate in a clinical trial were interviewed: 19 whose children had participated in at least 1 clinical trial and 5 who had declined participation in any trial. Each study aspect, from the initial explanation of the study to the end of the study, can affect the willingness of parents to consent to the proposed study and future studies. Establishing trust, appropriate timing, a transparent discussion of risks and benefits oriented to the layperson, and providing motivation for children to participate were key factors that impacted parents' decisions. In order for clinical trial accrual to be successful, parents' priorities and considerations must be a central focus, beginning with initial trial design. The recommendations from the parents who participated in this study can be used to support budget allocations that ensure adequate training of study staff and improved staffing on nights and weekends. Studies of parent responses in outpatient settings and additional inpatient settings will provide valuable information on the consent process from the child's and parent's perspectives. Further studies are needed to explore whether implementation of such strategies will result in improved recruitment for pediatric clinical trials.
    Language English
    Publishing date 2017-11-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2017.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative.

    Greenberg, Rachel G / Corneli, Amy / Bradley, John / Farley, John / Jafri, Hasan S / Lin, Li / Nambiar, Sumathi / Noel, Gary J / Wheeler, Chris / Tiernan, Rosemary / Smith, P Brian / Roberts, Jamie / Benjamin, Daniel K

    Contemporary clinical trials communications

    2017  Volume 9, Page(s) 7–12

    Abstract: Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to ... ...

    Abstract Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to recruitment of pediatric patients, but little is known regarding the specific barriers that limit pediatric providers from participating in and referring their patients to clinical trials. We conducted an online survey of pediatric providers from a wide variety of practice types across the United States to evaluate their attitudes and awareness of pediatric clinical trials. Using a 4-point Likert scale, providers described their perception of potential barriers to their practice serving as a site for pediatric clinical trials. Of the 136 providers surveyed, 52/136 (38%) had previously referred a pediatric patient to a trial, and only 17/136 (12%) had ever been an investigator for a pediatric trial. Lack of awareness of existing pediatric trials was a major barrier to patient referral by providers, in addition to consideration of trial risks, distance to the site, and time needed to discuss trial participation with parents. Overall, providers perceived greater challenges related to parental concerns and parent or child logistical barriers than study implementation and ethics or regulatory barriers as barriers to their practice serving as a trial site. Providers who had previously been an investigator for a pediatric trial were less likely to be concerned with potential barriers than non-investigators. Understanding the barriers that limit pediatric providers from collaboration or inhibit their participation is key to designing effective interventions to optimize pediatric trial participation.
    Language English
    Publishing date 2017-11-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2017.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Proposed Brain-, Spine-, and Mental- Health Screening Methodology (NEUROSCREEN) for Healthcare Systems: Position of the Society for Brain Mapping and Therapeutics.

    Nami, Mohammad / Thatcher, Robert / Kashou, Nasser / Lopes, Dahabada / Lobo, Maria / Bolanos, Joe F / Morris, Kevin / Sadri, Melody / Bustos, Teshia / Sanchez, Gilberto E / Mohd-Yusof, Alena / Fiallos, John / Dye, Justin / Guo, Xiaofan / Peatfield, Nicholas / Asiryan, Milena / Mayuku-Dore, Alero / Krakauskaite, Solventa / Soler, Ernesto Palmero /
    Cramer, Steven C / Besio, Walter G / Berenyi, Antal / Tripathi, Manjari / Hagedorn, David / Ingemanson, Morgan / Gombosev, Marinela / Liker, Mark / Salimpour, Yousef / Mortazavi, Martin / Braverman, Eric / Prichep, Leslie S / Chopra, Deepak / Eliashiv, Dawn S / Hariri, Robert / Tiwari, Ambooj / Green, Ken / Cormier, Jason / Hussain, Namath / Tarhan, Nevzat / Sipple, Daniel / Roy, Michael / Yu, John S / Filler, Aaron / Chen, Mike / Wheeler, Chris / Ashford, J Wesson / Blum, Kenneth / Zelinsky, Deborah / Yamamoto, Vicky / Kateb, Babak

    Journal of Alzheimer's disease : JAD

    2022  Volume 86, Issue 1, Page(s) 21–42

    Abstract: The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive issues. However, there is a lack of inexpensive and efficient brain evaluation and screening systems. As a result, a considerable fraction of patients with ... ...

    Abstract The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive issues. However, there is a lack of inexpensive and efficient brain evaluation and screening systems. As a result, a considerable fraction of patients with neurocognitive or psychobehavioral predicaments either do not get timely diagnosed or fail to receive personalized treatment plans. This is especially true in the elderly populations, wherein only 16% of seniors say they receive regular cognitive evaluations. Therefore, there is a great need for development of an optimized clinical brain screening workflow methodology like what is already in existence for prostate and breast exams. Such a methodology should be designed to facilitate objective early detection and cost-effective treatment of such disorders. In this paper we have reviewed the existing clinical protocols, recent technological advances and suggested reliable clinical workflows for brain screening. Such protocols range from questionnaires and smartphone apps to multi-modality brain mapping and advanced imaging where applicable. To that end, the Society for Brain Mapping and Therapeutics (SBMT) proposes the Brain, Spine and Mental Health Screening (NEUROSCREEN) as a multi-faceted approach. Beside other assessment tools, NEUROSCREEN employs smartphone guided cognitive assessments and quantitative electroencephalography (qEEG) as well as potential genetic testing for cognitive decline risk as inexpensive and effective screening tools to facilitate objective diagnosis, monitor disease progression, and guide personalized treatment interventions. Operationalizing NEUROSCREEN is expected to result in reduced healthcare costs and improving quality of life at national and later, global scales.
    MeSH term(s) Aged ; Brain/diagnostic imaging ; Brain Mapping ; COVID-19 ; Delivery of Health Care ; Humans ; Male ; Pandemics ; Quality of Life
    Language English
    Publishing date 2022-01-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-215240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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