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  1. Article ; Online: Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice.

    Whitaker-Fornek, Jessica R / Jenkins, Paul M / Levitt, Erica S

    Journal of neurophysiology

    2023  Volume 130, Issue 6, Page(s) 1578–1587

    Abstract: Rett syndrome (RTT) is a severe neurodevelopmental disorder that mainly affects females due to silencing mutations in the X- ... ...

    Abstract Rett syndrome (RTT) is a severe neurodevelopmental disorder that mainly affects females due to silencing mutations in the X-linked
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Female ; Rett Syndrome/genetics ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Synaptic Transmission/physiology ; Neurons/physiology ; Respiration ; Pons ; Disease Models, Animal
    Chemical Substances Methyl-CpG-Binding Protein 2
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00327.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.224: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Activation of orexin-2 receptors in the Kӧlliker-Fuse nucleus of anesthetized mice leads to transient slowing of respiratory rate.

    Varga, Adrienn G / Whitaker-Fornek, Jessica R / Maletz, Sebastian N / Levitt, Erica S

    Frontiers in physiology

    2022  Volume 13, Page(s) 977569

    Abstract: Orexins are neuropeptides originating from the hypothalamus that serve broad physiological roles, including the regulation of autonomic function, sleep-wake states, arousal and breathing. Lack of orexins may lead to narcolepsy and sleep disordered ... ...

    Abstract Orexins are neuropeptides originating from the hypothalamus that serve broad physiological roles, including the regulation of autonomic function, sleep-wake states, arousal and breathing. Lack of orexins may lead to narcolepsy and sleep disordered breathing. Orexinergic hypothalamic neurons send fibers to Kӧlliker-Fuse (KF) neurons that directly project to the rostroventral respiratory group, and phrenic and hypoglossal motor neurons. These connections indicate a potential role of orexin-modulated KF neurons in functionally linking the control of wakefulness/arousal and respiration. In a reduced preparation of juvenile rats Orexin B microinjected into the KF led to a transient increase in respiratory rate and hypoglossal output, however Orexin B modulation of the KF in intact preparations has not been explored. Here, we performed microinjections of the Orexin B mouse peptide and the synthetic Orexin 2 receptor agonist, MDK 5220, in the KF of spontaneously breathing, isoflurane anesthetized wild type mice. Microinjection of Orexin-2 receptor agonists into the KF led to transient slowing of respiratory rate, which was more exaggerated in response to Orexin-B than MDK 5220 injections. Our data suggest that Orexin B signaling in the KF may contribute to arousal-mediated respiratory responses.
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.977569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake.

    Dossat, Amanda M / Kokoska, Milayna M / Whitaker-Fornek, Jessica R / Sniffen, Sarah E / Kulkarni, Aishwarya S / Levitt, Erica S / Wesson, Daniel W

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 23, Page(s) 4251–4261

    Abstract: The gustatory cortex (GC) region of the insular cortex processes taste information in manners important for taste-guided behaviors, including food intake itself. In addition to oral gustatory stimuli, GC activity is also influenced by physiological ... ...

    Abstract The gustatory cortex (GC) region of the insular cortex processes taste information in manners important for taste-guided behaviors, including food intake itself. In addition to oral gustatory stimuli, GC activity is also influenced by physiological states including hunger. The specific cell types and molecular mechanisms that provide the GC with such abilities are unclear. Glucagon-like peptide 1 (GLP-1) is produced by neurons in the brain, where it can act on GLP-1 receptor-expressing (GLP-1R+) neurons found in several brain regions. In these brain regions, GLP-1R agonism suppresses homeostatic food intake and dampens the hedonic value of food. Here, we report in mice of both sexes that cells within the GC express
    MeSH term(s) Rats ; Male ; Female ; Mice ; Animals ; Eating/physiology ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Insular Cortex ; Rats, Sprague-Dawley ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide 1/pharmacology
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1668-22.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Classroom-Based Research Experiences to Support Underserved STEM Student Success: From Introductory Inquiry to Optogenetics in the Embryonic Chicken.

    Fromherz, Sylvia / Whitaker-Fornek, Jessica R / Sharp, Andrew A

    Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience

    2018  Volume 17, Issue 1, Page(s) A97–A110

    Abstract: In order to help overcome barriers to success for undergraduate STEM students from disadvantaged backgrounds, we developed two classroom-based research experiences (REs), ...

    Abstract In order to help overcome barriers to success for undergraduate STEM students from disadvantaged backgrounds, we developed two classroom-based research experiences (REs),
    Language English
    Publishing date 2018-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2577251-X
    ISSN 1544-2896
    ISSN 1544-2896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development and regulation of breathing rhythms in embryonic and hatchling birds.

    Whitaker-Fornek, Jessica R / Nelson, Jennie K / Lybbert, Casetin W / Pilarski, Jason Q

    Respiratory physiology & neurobiology

    2019  Volume 269, Page(s) 103246

    Abstract: For many, if not all, air-breathing vertebrates, breathing-like movements begin while the embryo is still ensconced in an aqueous environment. This is because primordial regions of the CNS become spontaneously active during early gestation and then must ... ...

    Abstract For many, if not all, air-breathing vertebrates, breathing-like movements begin while the embryo is still ensconced in an aqueous environment. This is because primordial regions of the CNS become spontaneously active during early gestation and then must functionally transform and specialize once air breathing commences. The degree to which the embryonic ventilatory control system is established and competent at birth is variable, however, even between different components of the respiratory system. Moreover, the embryological experiences of an individual can also affect the outcomes and responsiveness of ventilation to respiratory stimuli and these details have major clinical implications. The broad field of respiratory neurobiology still has much to learn about the ontogeny of breathing control systems, and the oviparity of birds provides a unique model to examine how early rhythms transform day-to-day as they become functional. This hybrid review and research article will highlight the contributions of birds to the study of breathing control during early development. We will detail what is currently known about the onset and maturation of respiratory rhythm generation and also provide novel data about the development of central chemosensitivity. Finally, we will review data regarding the development of peripheral afferent inputs during early development and discuss whole-animal reflex responsiveness to common respiratory stimuli, both chronic and acute, during the incubation period and following hatching.
    MeSH term(s) Animals ; Animals, Newborn ; Birds/embryology ; Birds/physiology ; Embryo, Nonmammalian ; Embryonic Development ; Respiration ; Rhombencephalon/embryology ; Rhombencephalon/physiology
    Language English
    Publishing date 2019-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2019.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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