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Article ; Online: Proton Exchange Membranes from Sulfonated Lignin Nanocomposites for Redox Flow Battery Applications.

Dos Santos, Fernanda Brito / McMichael, Philip Spencer / Whitbeck, Alex / Jalaee, Adel / Gyenge, Elod / Foster, E Johan

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2309459

Abstract: Redox flow batteries (RFBs) are increasingly being considered for a wide range of energy storage applications, and such devices rely on proton exchange membranes (PEMs) to function. PEMs are high-cost, petroleum-derived polymers that often possess ... ...

Abstract	Redox flow batteries (RFBs) are increasingly being considered for a wide range of energy storage applications, and such devices rely on proton exchange membranes (PEMs) to function. PEMs are high-cost, petroleum-derived polymers that often possess limited durability, variable electrochemical performance, and are linked to discharge of perfluorinated compounds. Alternative PEMs that utilize biobased materials, including lignin and sulfonated lignin (SL), low-cost byproducts of the wood pulping process, have struggled to balance electrochemical performance with dimensional stability. Herein, SL nanoparticles are demonstrated for use as a nature-derived, ion-conducting PEM material. SL nanoparticles (NanoSLs) can be synthesized for increased surface area, uniformity, and miscibility compared with macrosized lignin, improving proton conductivity. After addition of polyvinyl alcohol (PVOH) as a structural backbone, membranes with the highest NanoSL concentration demonstrated an ion exchange capacity of 1.26 meq g
Language	English
Publishing date	2024-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202309459
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Article ; Online: Risk of cardiovascular mortality with androgen deprivation therapy in prostate cancer: A secondary analysis of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Randomized Controlled Trial.

Butler, Santino S / Mahal, Brandon A / Moslehi, Javid J / Nohria, Anju / Dee, Edward C / Makkar, Rishi / Whitbeck, Amanda / Wangoe, Janet / Mouw, Kent W / Nguyen, Paul L / Muralidhar, Vinayak

Cancer

2021 Volume 127, Issue 13, Page(s) 2213–2221

Abstract: Background: For men with radiation-managed prostate cancer, there is conflicting evidence regarding the association between androgen deprivation therapy (ADT) and cardiovascular mortality (CVM), particularly among those who have with preexisting ... ...

Abstract	Background: For men with radiation-managed prostate cancer, there is conflicting evidence regarding the association between androgen deprivation therapy (ADT) and cardiovascular mortality (CVM), particularly among those who have with preexisting comorbidities. The objective of this study was to analyze the association between ADT and CVM across patient comorbidity status using prospectively collected data from a large clinical trial. Methods: In total, 1463 men were identified who were diagnosed with clinically localized, intermediate-risk/high-risk prostate cancer (T2b-T4, Gleason 7-10, or prostate-specific antigen >10 ng/mL) from 1993 to 2001 and managed with either radiation therapy (RT) alone or RT plus ADT during the randomized Prostate, Lung, Colon, and Ovarian (PLCO) Cancer Screening Trial. Adjusted hazard ratios (aHRs) for cause-specific mortality (prostate cancer-specific mortality vs other-cause mortality-including the primary end point of CVM [death from ischemic heart disease, cerebrovascular accident, or other circulatory disease]) were determined using Fine and Gray competing-risk regression analysis and stratified by comorbidity history. Results: There was no difference in the risk of 5-year CVM between ADT plus RT and RT alone (2.3% vs 3.3%, respectively; aHR, 0.69; 95% CI, 0.38-1.24; P = .21) overall or on subgroup analysis among men with a history of ≥1 preexisting comorbidities (3.2% vs 5.3%, respectively; aHR, 0.83; 95% CI, 0.43-1.60; P = .58), ≥2 preexisting comorbidities (6.9% vs 8.3%, respectively; aHR, 0.95; 95% CI, 0.40-2.25; P = .90), or cardiovascular disease/risk factors (3.6% vs 4.3%, respectively; aHR, 0.85; 95% CI, 0.44-1.65; P = .63). These results were all similar when each component of CVM was analyzed separately-either cardiac, stroke, or other vascular mortality (P > .05). Conclusions: This study provides prospectively collected evidence that the use of ADT plus RT, compared with RT alone, is not associated with an increased risk of CVM, even among subgroups of men who have preexisting comorbidities and cardiovascular disease.
MeSH term(s)	Androgen Antagonists/adverse effects ; Androgens ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Colorectal Neoplasms/drug therapy ; Follow-Up Studies ; Humans ; Lung ; Male ; Prostate ; Prostatic Neoplasms/therapy
Chemical Substances	Androgen Antagonists ; Androgens
Language	English
Publishing date	2021-04-27
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.33486
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Article ; Online: Validation of a subclassification for high-risk prostate cancer in a prospective cohort.

Butler, Santino S / Dee, Edward C / Lamba, Nayan / Sha, Sybil T / Mahal, Brandon A / Whitbeck, Amanda / Makkar, Rishi / Wangoe, Janet / Mouw, Kent W / Nguyen, Paul L / Muralidhar, Vinayak

Cancer

2020 Volume 126, Issue 10, Page(s) 2132–2138

Abstract: Background: A subgroup of men with favorable high-risk prostate cancer (T1c with either a Gleason score of 4 + 4 = 8 and a prostate-specific antigen [PSA] level ... 20 ng/mL) has been associated with ... ...

Abstract	Background: A subgroup of men with favorable high-risk prostate cancer (T1c with either a Gleason score of 4 + 4 = 8 and a prostate-specific antigen [PSA] level <10 ng/mL or a Gleason score of 6 and a PSA level >20 ng/mL) has been associated with improved outcomes in comparison with other standard high-risk patients. This study was designed to validate the prognostic utility of a subclassification for high-risk disease with a prospectively collected data set. Methods: This study identified 3033 men from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who had been diagnosed from 1993 to 2001 with clinically localized prostate cancer-either intermediate-risk disease (clinical stage T2b-c, a Gleason score of 7, or a PSA level of 10 to 20 ng/mL) or high-risk disease (clinical stage T3-T4, a Gleason score of 8-10, or a PSA level >20 ng/mL)-that was managed with radical prostatectomy or radiation therapy. Multivariable logistic regression was used to calculate adjusted odds ratios (aORs) for pathological T3 to T4 or N1 (pT3-T4/pN1) disease. Fine and Gray competing risks regression was used to determine adjusted hazard ratios (aHRs) of prostate cancer-specific mortality (PCSM). Results: The median follow-up was 5.7 years. Patients with favorable high-risk disease had lower 8-year PCSM in comparison with patients with standard high-risk disease (2.2% vs 10.8%; aHR, 0.26; 95% confidence interval [CI], 0.09-0.73; P = .01) but similar PCSM in comparison with patients with intermediate-risk disease (2.2% vs 2.2%; aHR, 0.90; 95% CI, 0.32-2.54; P = .84). Among those who underwent surgery, those with favorable high-risk disease had lower odds of pT3-T4/pN1 disease than those with standard high-risk disease (46.2% vs 63.3%; aOR, 0.50; 95% CI, 0.27-0.94; P = .03). Conclusions: This study validates the prognostic utility of a subclassification for high-risk disease in a prospectively collected patient cohort. Patients with favorable high-risk disease have PCSM similar to that of patients with intermediate-risk disease and significantly better than that of patients with standard high-risk disease. Future trials are needed to assess possible de-intensification of therapy for favorable high-risk disease.
MeSH term(s)	Aged ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Prognosis ; Prospective Studies ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Survival Analysis
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2020-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.32778
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Book ; Online: Dissecting Jets and Missing Energy Searches Using $n$-body Extended Simplified Models

Cohen, Timothy / Dolan, Matthew J. / Hedri, Sonia El / Hirschauer, James / Tran, Nhan / Whitbeck, Andrew

2016

Abstract: Simplified Models are a useful way to characterize new physics scenarios for the LHC. Particle decays are often represented using non-renormalizable operators that involve the minimal number of fields required by symmetries. Generalizing to a wider class ...

Abstract	Simplified Models are a useful way to characterize new physics scenarios for the LHC. Particle decays are often represented using non-renormalizable operators that involve the minimal number of fields required by symmetries. Generalizing to a wider class of decay operators allows one to model a variety of final states. This approach, which we dub the $n$-body extension of Simplified Models, provides a unifying treatment of the signal phase space resulting from a variety of signals. In this paper, we present the first application of this framework in the context of multijet plus missing energy searches. The main result of this work is a global performance study with the goal of identifying which set of observables yields the best discriminating power against the largest Standard Model backgrounds for a wide range of signal jet multiplicities. Our analysis compares combinations of one, two and three variables, placing emphasis on the enhanced sensitivity gain resulting from non-trivial correlations. Utilizing boosted decision trees, we compare and classify the performance of missing energy, energy scale and energy structure observables. We demonstrate that including an observable from each of these three classes is required to achieve optimal performance. This work additionally serves to establish the utility of $n$-body extended Simplified Models as a diagnostic for unpacking the relative merits of different search strategies, thereby motivating their application to new physics signatures beyond jets and missing energy. Comment: 31 + 28 pages, 11 + 10 figures; v2 references added, journal version
Keywords	High Energy Physics - Phenomenology ; High Energy Physics - Experiment
Subject code	621 ; 539
Publishing date	2016-05-04
Publishing country	us
Document type	Book ; Online
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Article: Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes.

Stoler, M H / Wolinsky, S M / Whitbeck, A / Broker, T R / Chow, L T

Virology

1989 Volume 172, Issue 1, Page(s) 331–340

Abstract: Human papillomaviruses (HPVs) infect specific human epithelial tissues. Because viral propagation in cultured cells has not been achieved, studies of HPV genetic activities have been difficult and rely largely on analyses of patient specimens by ... ...

Abstract	Human papillomaviruses (HPVs) infect specific human epithelial tissues. Because viral propagation in cultured cells has not been achieved, studies of HPV genetic activities have been difficult and rely largely on analyses of patient specimens by conventional biochemical methods. HPV type 6 and type 11 infections often result in genital warts (condylomata acuminata). Structural mapping of RNAs from such warts reveals that they use alternative promoters, splice sites, and polyadenylation sites to produce complex families of overlapping mRNAs that span multiple open reading frames. Based on the mRNA structures, we have developed message-specific subgenomic clones of HPV-6 and HPV-11 in pGEM vectors. Tritium-labeled, single-stranded RNA probes were synthesized in vitro and applied to serial thin sections of patient specimens for in situ hybridization. Our results reveal the qualitative and quantitative transcription patterns of different viral messages in relationship to one another, to viral DNA replication, and to cellular differentiation. The viral "E region" is transcribed before the onset of vegetative DNA replication and continues to be expressed in increasing amounts in the maturing epithelium. Even in mature epithelia, E region messengers are far more abundant than "L region" mRNAs. The L region messages encoding capsid proteins are truly late in that they appear concomitant with or after the onset of vegetative viral DNA replication and are only present in the superficial strata of the epithelium, which contain the oldest and most differentiated keratinocytes. Abundant intron material derived from processing E region transcripts accumulates in the nuclei. Strictly nuclear signals from the L region transcripts in the midepithelium suggest that regulation of their expression is at the level of transcription elongation.
MeSH term(s)	Condylomata Acuminata/genetics ; Condylomata Acuminata/microbiology ; DNA Replication ; Female ; Humans ; Nucleic Acid Hybridization ; Papillomaviridae/genetics ; RNA Probes ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Restriction Mapping ; Transcription, Genetic ; Vulva/microbiology
Chemical Substances	RNA Probes ; RNA, Messenger ; RNA, Viral
Language	English
Publishing date	1989-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/0042-6822(89)90135-9
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Article: Human papillomavirus type 16 and 18 gene expression in cervical neoplasias.

Stoler, M H / Rhodes, C R / Whitbeck, A / Wolinsky, S M / Chow, L T / Broker, T R

Human pathology

1992 Volume 23, Issue 2, Page(s) 117–128

Abstract: Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze ... ...

Abstract	Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed HPV type 16 and type 18 subgenomic clones from which 3H-labeled riboprobes specific to individual mRNA families can be generated in vitro. Using these probes for in situ hybridization, we examined serial sections of archival biopsy specimens of the spectrum of genital lesions. In low-grade squamous lesions, all viral open reading frames were expressed, and the most abundant transcription spanned the E4 and E5 open reading frames at the 3' end of the E region. L region transcription coding for the capsid proteins was restricted to terminally differentiated keratinocytes. As the grade of neoplasia increased, cellular differentiation and overall viral transcription decreased and, with few exceptions, the L2 and L1 transcripts ceased to exist. The E6-E7 transforming region was invariably derepressed. Interestingly, the patterns of HPV-16 gene expression suggested the coexistence of episomal and integrated viral DNAs. In contrast, in HPV-18 lesions, all the viral template DNA appeared to have integrated. Integration was deduced to have occurred near the boundary of the E1 and E2 open reading frames. Viral transcription patterns were similar in carcinomas in situ and in invasive carcinomas, regardless of the histologic cell types or the associated virus types, consistent with the notion that additional host gene alterations were necessary for progression. On the basis of viral gene expression in vivo and the E6 promoter regulation previously characterized in vitro, we discuss a molecular mechanism for HPV-associated carcinogenesis.
MeSH term(s)	Adenocarcinoma/microbiology ; Carcinoma in Situ/microbiology ; Carcinoma, Small Cell/microbiology ; Carcinoma, Squamous Cell/microbiology ; DNA Probes, HPV ; Female ; Gene Expression ; Genes, Viral/genetics ; Humans ; Papillomaviridae/genetics ; Tumor Virus Infections/genetics ; Uterine Cervical Neoplasms/microbiology
Chemical Substances	DNA Probes, HPV
Language	English
Publishing date	1992-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/0046-8177(92)90232-r
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Article: Cardiac carnitine acyltransferase activities in exercised normal and dystrophic hamsters.

Whitbeck, A A / Davis, A T / Carrow, R / Bieber, L L

Experimental pathology

1991 Volume 43, Issue 1-2, Page(s) 121–123

Abstract: Carnitine acyltransferase activities in the hearts of normal and dystrophic, sedentary and swim exercised hamsters were studied, in order to analyze the relationship between carnitine metabolism and exercise in cardiomyopathy. After 12 weeks, the mean ... ...

Abstract	Carnitine acyltransferase activities in the hearts of normal and dystrophic, sedentary and swim exercised hamsters were studied, in order to analyze the relationship between carnitine metabolism and exercise in cardiomyopathy. After 12 weeks, the mean specific activities of cardiac carnitine acetyltransferase (CAT), carnitine octanoyltransferase (COT) and carnitine palmitoyltransferase (CPT) were significantly higher in the dystrophic sedentary group, relative to the normal sedentary group (p less than 0.05). There was no significant effect of exercise on the mean specific activity of the carnitine acyltransferases, compared to the dystrophic or normal sedentary controls. Thus, the improvements in cardiac histopathology due to exercise noted previously are not associated with altered carnitine acyltransferase activity.
MeSH term(s)	Animals ; Cardiomyopathies/enzymology ; Carnitine Acyltransferases/metabolism ; Cricetinae ; Mesocricetus ; Myotonic Dystrophy/enzymology ; Physical Conditioning, Animal
Chemical Substances	Carnitine Acyltransferases (EC 2.3.1.-)
Language	English
Publishing date	1991
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604618-6
ISSN	0232-1513 ; 0014-4908
ISSN	0232-1513 ; 0014-4908
DOI	10.1016/s0232-1513(11)80158-1
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Article: Infectious cycle of human papillomavirus type 11 in human foreskin xenografts in nude mice.

Stoler, M H / Whitbeck, A / Wolinsky, S M / Broker, T R / Chow, L T / Howett, M K / Kreider, J W

Journal of virology

1990 Volume 64, Issue 7, Page(s) 3310–3318

Abstract: We have performed the first molecular analysis of a time course of infection by a papillomavirus. The Hershey isolate of the human papillomavirus type 11 was used to infect human foreskin tissues, which were then implanted under the renal capsules of ... ...

Abstract	We have performed the first molecular analysis of a time course of infection by a papillomavirus. The Hershey isolate of the human papillomavirus type 11 was used to infect human foreskin tissues, which were then implanted under the renal capsules of nude mice. The xenografts were recovered every 2 weeks for 14 weeks, fixed in formalin, and embedded in paraffin. Four-micrometer serial sections were examined by light microscopy for morphological changes, by immunocytochemistry for virion antigen production, and by in situ hybridization with 3H-labeled RNA probes for viral DNA replication and expression of the major mRNA species. After a lag period, probes spanning the E4 and E5 open reading frames, which are present in all E region viral mRNAs, generated the first detectable signals at week 4. Signals of other E region probes were minimally detected at week 6. Between weeks 6 and 8, there was an abrupt change in the implant such that cellular proliferation, viral DNA replication, and E and L region mRNA transcription were robust and reached a plateau. By weeks 10 to 12, the experimental condylomata were morphologically and histologically indistinguishable from naturally occurring condylomata acuminata. These findings suggest that cellular hyperproliferation and the morphologic features of condylomata are direct results of viral genetic activities. Unlike other DNA viruses, the E region transcripts increased with cell age and cellular differentiation and persisted throughout the entire experiment. In particular, the mRNA encoding the E1iE4 and perhaps E5 proteins remained overwhelmingly abundant. In contrast, viral DNA replication, L region mRNA synthesis, and virion antigen production were restricted to the most differentiated, superficial cells.
MeSH term(s)	Animals ; Capsid/metabolism ; Cloning, Molecular ; Gene Expression ; Humans ; In Vitro Techniques ; Mice ; Mice, Nude ; Nucleic Acid Hybridization ; Papillomaviridae/growth & development ; RNA Probes ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Time Factors ; Transcription, Genetic ; Transplantation, Heterologous ; Virus Replication
Chemical Substances	RNA Probes ; RNA, Messenger ; RNA, Viral
Language	English
Publishing date	1990-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.64.7.3310-3318.1990
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Article: Protein synthesis in isolated, beating rat atria.

Whitbeck, A A / Cohen, J

Experientia

1969 Volume 25, Issue 10, Page(s) 1029–1030

MeSH term(s)	Animals ; Carbon Dioxide/metabolism ; Carbon Isotopes ; Diaphragm ; Heart/physiology ; Heart Atria ; In Vitro Techniques ; Kidney/metabolism ; Leucine/metabolism ; Liver/metabolism ; Male ; Muscle Proteins/biosynthesis ; Myocardium/metabolism ; Puromycin/pharmacology ; Rats
Chemical Substances	Carbon Isotopes ; Muscle Proteins ; Carbon Dioxide (142M471B3J) ; Puromycin (4A6ZS6Q2CL) ; Leucine (GMW67QNF9C)
Language	English
Publishing date	1969-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1972-0
ISSN	0014-4754
ISSN	0014-4754
DOI	10.1007/bf01901405
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Article: Factitious changes in binding of oxygen to hemoglobin when based on extracellular pH in the presence of certain blood additives like radiographic contrast media.

Lichtman, M A / Whitbeck, A A / Murphy, M

Investigative radiology

1975 Volume 10, Issue 3, Page(s) 225–230

Abstract: Construction of oxygen-hemoglobin DISSOCIATION CURVES BASED ON EXTRACELLULAR PH and using blood tonometered with 5 per cent CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic ... ...

Abstract	Construction of oxygen-hemoglobin DISSOCIATION CURVES BASED ON EXTRACELLULAR PH and using blood tonometered with 5 per cent CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic molecules like sucrose of poorly penetrating anionic aompounds like radiographic contrast materials. False conclusions regarding the position of the oxygen-hemoglobin dissociation curve can result because of the disturbance of the normal pH gradient between plasma and red cell induced by such chemicals.
MeSH term(s)	Blood ; Contrast Media ; Diatrizoate ; Erythrocytes ; Hemoglobins ; Humans ; Hydrogen-Ion Concentration ; Oxygen/blood ; Protein Binding ; Sucrose ; Veins
Chemical Substances	Contrast Media ; Hemoglobins ; Diatrizoate (117-96-4) ; Sucrose (57-50-1) ; Oxygen (S88TT14065)
Language	English
Publishing date	1975-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/00004424-197505000-00006
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