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  1. Article ; Online: CCAAT enhancer binding protein gamma (C/EBP-γ): An understudied transcription factor.

    Renfro, Zachary / White, Bryan E / Stephens, Kimberly E

    Advances in biological regulation

    2022  Volume 84, Page(s) 100861

    Abstract: The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP-γ is the shortest C/EBP protein and lacks a canonical activation domain for the recruitment ...

    Abstract The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP-γ is the shortest C/EBP protein and lacks a canonical activation domain for the recruitment of transcriptional machinery. Despite its ubiquitous expression and ability to dimerize with other C/EBP proteins, C/EBP-γ has been studied far less than other C/EBP proteins, and, to our knowledge, no review of its functions has been written. This review seeks to integrate the current knowledge about C/EBP-γ and its physiologic roles, especially in cell proliferation, the integrated stress response, oncogenesis, hematopoietic and nervous system development, and metabolism, as well as to identify areas for future research.
    MeSH term(s) CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; Gene Expression Regulation ; Humans ; Promoter Regions, Genetic ; Protein Binding ; Transcription Factors/metabolism ; Transcription, Genetic
    Chemical Substances CCAAT-Enhancer-Binding Proteins ; Transcription Factors
    Language English
    Publishing date 2022-01-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2022.100861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.364: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Cellular Uptake of Gold Nanorods in Breast Cancer Cell Lines.

    White, Bryan E / White, Molly K / Nima Alsudani, Zeid A / Watanabe, Fumiya / Biris, Alexandru S / Ali, Nawab

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: Nanosized materials have been proposed for a wide range of biomedical applications, given their unique characteristics. However, how these nanomaterials interact with cells and tissues, as well as how they bio-distribute in organisms, is still under ... ...

    Abstract Nanosized materials have been proposed for a wide range of biomedical applications, given their unique characteristics. However, how these nanomaterials interact with cells and tissues, as well as how they bio-distribute in organisms, is still under investigation. Differences such as the nanoparticle size, shape, and surface chemistry affect the basic mechanisms of cellular uptake and responses, which, in turn, affects the nanoparticles' applicability for biomedical applications. Thus, it is vital to determine how a specific nanoparticle interacts with cells of interest before extensive
    Language English
    Publishing date 2022-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12060937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of Regulatory Elements in Primary Sensory Neurons Involved in Trauma-Induced Neuropathic Pain.

    Stephens, Kimberly E / Moore, Cedric / Vinson, David A / White, Bryan E / Renfro, Zachary / Zhou, Weiqiang / Ji, Zhicheng / Ji, Hongkai / Zhu, Heng / Guan, Yun / Taverna, Sean D

    Molecular neurobiology

    2023  Volume 61, Issue 3, Page(s) 1845–1859

    Abstract: Chronic pain is a significant public health issue that is often refractory to existing therapies. Here we use a multiomic approach to identify cis-regulatory elements that show differential chromatin accessibility and reveal transcription factor (TF) ... ...

    Abstract Chronic pain is a significant public health issue that is often refractory to existing therapies. Here we use a multiomic approach to identify cis-regulatory elements that show differential chromatin accessibility and reveal transcription factor (TF) binding motifs with functional regulation in the rat dorsal root ganglion (DRG), which contain cell bodies of primary sensory neurons, after nerve injury. We integrated RNA-seq to understand how differential chromatin accessibility after nerve injury may influence gene expression. Using TF protein arrays and chromatin immunoprecipitation-qPCR, we confirmed C/EBPγ binding to a differentially accessible sequence and used RNA-seq to identify processes in which C/EBPγ plays an important role. Our findings offer insights into TF motifs that are associated with chronic pain. These data show how interactions between chromatin landscapes and TF expression patterns may work together to determine gene expression programs in rat DRG neurons after nerve injury.
    MeSH term(s) Rats ; Animals ; Rats, Sprague-Dawley ; Chronic Pain/metabolism ; Neuralgia/metabolism ; Sensory Receptor Cells/metabolism ; Chromatin/metabolism ; Ganglia, Spinal/metabolism
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03673-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effects of a natural polyphenol on nicotine-induced pancreatic cancer cell proliferation.

    Chowdhury, Parimal / Jayroe, John J / White, Bryan E / Fenton, Ember R

    Tobacco induced diseases

    2018  Volume 16, Page(s) 50

    Abstract: Introduction: Resveratrol (: Methods: Cultured AR42J cells were incubated with 100 μM nicotine for 3 min and with 100 μM resveratrol for 30 min, either alone or in combination. Proliferation assays were conducted for a period of 0 to 96 h in serum ... ...

    Abstract Introduction: Resveratrol (
    Methods: Cultured AR42J cells were incubated with 100 μM nicotine for 3 min and with 100 μM resveratrol for 30 min, either alone or in combination. Proliferation assays were conducted for a period of 0 to 96 h in serum media, incubated with nicotine and resveratrol, and evaluated by MTT assay. Protein was measured in lysed cells and activation of MAPK signals was measured by western blot using purified p-ERK antibody. Co-localization of activated ERK signals was confirmed by FITC conjugated ERK antibody using immunofluorescence assay and confocal microscopy. Biomarker of lipid peroxidation was determined in cell lysates by malondialdehyde (MDA) bioassay.
    Results: Resveratrol significantly suppressed the nicotine-induced proliferation of acinar cells compared to untreated controls (p<0.05). Mitogen activated protein kinase (MAPK) analysis revealed up-regulation of p-ERK expression by nicotine (p<0.05) that was suppressed significantly by resveratrol (p<0.05). Co-localization of activated ERK signals was confirmed by FITC conjugated ERK antibody, and this response was reduced significantly by resveratrol. Nicotine-induced malondialdehyde formation was also suppressed by resveratrol (p<0.05).
    Conclusions: The data suggest that resveratrol suppressed nicotine-induced AR42J cell proliferation. The proliferation of AR42J cells by nicotine is associated with activation of MAPK signals and induction of protein oxidation. Resveratrol suppressed lipid peroxidation and P-ERK activated signals induced by nicotine. We conclude that resveratrol acts as an effective antioxidant in reversing the nicotine induced pancreatic cancer cell proliferation.
    Language English
    Publishing date 2018-10-24
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2194616-4
    ISSN 1617-9625 ; 2070-7266
    ISSN (online) 1617-9625
    ISSN 2070-7266
    DOI 10.18332/tid/95159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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