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  1. AU="White, Khendi"
  2. AU="Park, Joonsung"
  3. AU="Tcheroyan, Raya"
  4. AU="Campbell-Bell, Cherith M"
  5. AU="Bayne, Max"
  6. AU="Kavatagimath, Satish"
  7. AU="Nishino, Tomoya"

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  1. Article ; Online: Stress for a stressed out heart: Classic cardiac PET findings in takotsubo cardiomyopathy.

    Albert, Chonyang L / White, Khendi T / Cremer, Paul C / Jaber, Wael A

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 26, Issue 2, Page(s) 679–680

    MeSH term(s) Aged ; Atrial Fibrillation/diagnostic imaging ; Catheterization ; Echocardiography ; Female ; Fluorodeoxyglucose F18 ; Heart/diagnostic imaging ; Humans ; Perfusion ; Positron-Emission Tomography ; Rubidium Radioisotopes ; Takotsubo Cardiomyopathy/diagnostic imaging
    Chemical Substances Rubidium Radioisotopes ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Rubidium-82 (9K730EL8KU)
    Language English
    Publishing date 2018-05-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-1306-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: PCSK9 inhibition: A promise fulfilled?

    White, Khendi / Mohan, Chaitra / Rocco, Michael

    Cleveland Clinic journal of medicine

    2016  Volume 83, Issue 11 Suppl 2, Page(s) S36–S44

    Abstract: The association of reduced proprotein convertase subtilisin/kexin type 9 (PCSK9) activity with reduced cardiovascular disease (CVD) events--and the need for add-ons to statin therapy to achieve treatment goals--has led to the rapid development and US ... ...

    Abstract The association of reduced proprotein convertase subtilisin/kexin type 9 (PCSK9) activity with reduced cardiovascular disease (CVD) events--and the need for add-ons to statin therapy to achieve treatment goals--has led to the rapid development and US Food and Drug Administration (FDA) approval of monoclonal antibody therapies to inhibit PCSK9. Now that PCSK9 inhibitors are approved by the FDA for use in certain patients, data from ongoing long-term clinical trials addressing tolerability, safety, and proof of additional reduction in CVD events are eagerly awaited.
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.83.s2.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Identifying an Optimal Cutpoint for the Diagnosis of Hypertriglyceridemia in the Nonfasting State.

    White, Khendi T / Moorthy, M V / Akinkuolie, Akintunde O / Demler, Olga / Ridker, Paul M / Cook, Nancy R / Mora, Samia

    Clinical chemistry

    2015  Volume 61, Issue 9, Page(s) 1156–1163

    Abstract: Background: Nonfasting triglycerides are similar or superior to fasting triglycerides at predicting cardiovascular events. However, diagnostic cutpoints are based on fasting triglycerides. We examined the optimal cutpoint for increased nonfasting ... ...

    Abstract Background: Nonfasting triglycerides are similar or superior to fasting triglycerides at predicting cardiovascular events. However, diagnostic cutpoints are based on fasting triglycerides. We examined the optimal cutpoint for increased nonfasting triglycerides.
    Methods: We obtained baseline nonfasting (<8 h since last meal) samples from 6391 participants in the Women's Health Study who were followed prospectively for ≤17 years. The optimal diagnostic threshold for nonfasting triglycerides, determined by logistic regression models by use of c-statistics and the Youden index (sum of sensitivity and specificity minus 1), was used to calculate hazard ratios (HRs) for incident cardiovascular events. Performance was compared to thresholds recommended by the American Heart Association (AHA) and European guidelines.
    Results: The optimal threshold was 175 mg/dL (1.98 mmol/L), with a c-statistic of 0.656, statistically better than the AHA cutpoint of 200 mg/dL (c-statistic 0.628). For nonfasting triglycerides above and below 175 mg/dL, after adjusting for age, hypertension, smoking, hormone use, and menopausal status, the HR for cardiovascular events was 1.88 (95% CI 1.52-2.33, P < 0.001), and for triglycerides measured at 0-4 and 4-8 h since the last meal, 2.05 (1.54- 2.74) and 1.68 (1.21-2.32), respectively. We validated performance of this optimal cutpoint by use of 10-fold cross-validation and bootstrapping of multivariable models that included standard risk factors plus total and HDL cholesterol, diabetes, body mass index, and C-reactive protein.
    Conclusions: In this study of middle-aged and older apparently healthy women, we identified a diagnostic threshold for nonfasting hypertriglyceridemia of 175 mg/dL (1.98 mmol/L), with the potential to more accurately identify cases than the currently recommended AHA cutpoint.
    MeSH term(s) Cardiovascular Diseases/etiology ; Fasting ; Female ; Humans ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/diagnosis ; Middle Aged ; Postprandial Period ; ROC Curve ; Triglycerides/blood
    Chemical Substances Triglycerides
    Language English
    Publishing date 2015-06-12
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2015.241752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.171: Show issues Location:
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