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  1. Article ; Online: The ATLAS Trial: A Look Before We LeAAPS.

    Whitlock, Richard P / Belley-Côté, Emilie P

    Innovations (Philadelphia, Pa.)

    2022  Volume 17, Issue 6, Page(s) 459–460

    Language English
    Publishing date 2022-11-13
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 1559-0879
    ISSN (online) 1559-0879
    DOI 10.1177/15569845221130800
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  2. Article ; Online: What is the optimal prosthetic valve in dialysis?

    Kim, Kevin S / Belley-Côté, Emilie / Whitlock, Richard P

    European heart journal

    2022  Volume 43, Issue 44, Page(s) 4657–4659

    MeSH term(s) Humans ; Renal Dialysis ; Heart Valve Prosthesis ; Bioprosthesis ; Aortic Valve/surgery ; Heart Valve Prosthesis Implantation
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac396
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    Zs.A 1563: Show issues Location:
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  3. Article ; Online: Concomitant Surgical Left Atrial Appendage Occlusion: a Review.

    Whitlock, Richard P / Belley-Côté, Emilie P

    Current cardiology reports

    2022  Volume 24, Issue 7, Page(s) 823–828

    Abstract: Purpose of review: In this review, we discuss some of the observational studies that examined the impact of left atrial appendage occlusion on stroke, the Left Atrial Appendage Occlusion Study (LAAOS) III research program that provided definitive ... ...

    Abstract Purpose of review: In this review, we discuss some of the observational studies that examined the impact of left atrial appendage occlusion on stroke, the Left Atrial Appendage Occlusion Study (LAAOS) III research program that provided definitive evidence for the benefit of surgical left atrial appendage occlusion on ischemic stroke, and high priority studies in the field that should be pursued by the surgical community.
    Recent findings: Atrial fibrillation is common in patients undergoing cardiac surgery. Oral anticoagulants are effective at preventing strokes related to atrial fibrillation; they have been the standard of care for stroke prevention in patients with atrial fibrillation for decades. Most strokes in patients with atrial fibrillation originate from the left atrial appendage. LAAOS III, a large randomized controlled trial, has recently demonstrated that concomitant left atrial appendage occlusion in patients undergoing cardiac surgery for another indication reduces the risk of stroke or systemic embolism on top of oral anticoagulation. Surgical left atrial appendage occlusion reduces the risk of ischemic stroke and systemic embolism in patients with atrial fibrillation and a CHA
    MeSH term(s) Anticoagulants/therapeutic use ; Atrial Appendage/surgery ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Embolism ; Humans ; Ischemic Stroke ; Observational Studies as Topic ; Randomized Controlled Trials as Topic ; Stroke/complications ; Stroke/prevention & control ; Treatment Outcome
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-022-01705-5
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    Zs.A 5524: Show issues Location:
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  4. Article ; Online: Temporal presentations of heparin-induced thrombocytopenia following cardiac surgery: A single-center, retrospective cohort study.

    Warkentin, Theodore E / Sheppard, Jo-Ann I / Whitlock, Richard P

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 11, Page(s) 2601–2616

    Abstract: Background: Heparin-induced thrombocytopenia (HIT) is an important adverse drug reaction that can occur postcardiac surgery. Preoperative exposure to unfractionated heparin (UFH) is common, raising the issue of how frequently cardiac surgery-associated ... ...

    Abstract Background: Heparin-induced thrombocytopenia (HIT) is an important adverse drug reaction that can occur postcardiac surgery. Preoperative exposure to unfractionated heparin (UFH) is common, raising the issue of how frequently cardiac surgery-associated HIT occurs after immunizing preoperative exposure to heparin.
    Objective: To determine the frequency and clinical picture of HIT occurring within 4 days of cardiac surgery (early presentation) versus later presentations (typical, delayed).
    Methods: We identified patients with laboratory-confirmed HIT following cardiac surgery over 30 years in a single cardiac surgery center. Three different clinical presentations of HIT were identified: typical (HIT-related platelet count fall beginning between postoperative days [PODs] 5-10), delayed (patients with falls after POD10 or who presented following hospital discharge), and early (established before POD5, including during cardiac surgery [acute intraoperative HIT]).
    Results: Of 129 patients identified with HIT complicating cardiac surgery, 100 had typical and 16 had delayed presentation of HIT; only 13 patients (10.1%) presented with early HIT, all of whom had received exposure to UFH during the 10 days before cardiac surgery. No patient was identified in whom remote preoperative UFH exposure was implicated in explaining early HIT. Notably, five patients appeared to have had acute intraoperative HIT, without immediate adverse consequences.
    Conclusions: Approximately 90% of patients with HIT after cardiac surgery appear to develop this complication due to immunization triggered by cardiac surgery; however, in approximately 10% of patients, early presentation during the first four PODs (or intraoperatively) can be explained by recent immunizing exposure to heparin.
    MeSH term(s) Humans ; Heparin/adverse effects ; Retrospective Studies ; Anticoagulants/adverse effects ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Thrombocytopenia/complications ; Cardiac Surgical Procedures/adverse effects
    Chemical Substances Heparin (9005-49-6) ; Anticoagulants
    Language English
    Publishing date 2022-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15826
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    Zs.MO 295: Show issues

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  5. Article ; Online: Troponin I after Cardiac Surgery and 30-Day Mortality. Reply.

    Devereaux, P J / Lamy, Andre / Whitlock, Richard P

    The New England journal of medicine

    2022  Volume 386, Issue 24, Page(s) 2343

    MeSH term(s) Cardiac Surgical Procedures/mortality ; Humans ; Troponin I ; Troponin T
    Chemical Substances Troponin I ; Troponin T
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2204552
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  6. Article ; Online: Reply to Sex Differences in the Clinical Outcomes After Left Atrial Appendage: A Systematic Review and Meta-Analysis.

    Eagle, Gwen E / Whitlock, Richard P / Belley-Côté, Emilie P

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 41, Page(s) 177

    MeSH term(s) Atrial Appendage/diagnostic imaging ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Female ; Humans ; Male ; Sex Characteristics ; Stroke/etiology ; Stroke/prevention & control
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Systematic Review ; Comment
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.03.024
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    Zs.A 5562: Show issues Location:
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  7. Article ; Online: Reply to Left Atrial Appendage Closure During Cardiac Surgery for Atrial Fibrillation: A Meta-Analysis.

    Eagle, Gwen E / Whitlock, Richard P / Belley-Côté, Emilie P

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 40, Page(s) 204

    MeSH term(s) Anticoagulants ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures/adverse effects ; Humans
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Comment
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.02.014
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  8. Article ; Online: Reply to Standard Versus Higher Intensity Anticoagulation for Patients With Mechanical Aortic Valve Replacement and Additional Risk Factors for Thromboembolism.

    Eagle, Gwen E / Whitlock, Richard P / Belley-Côté, Emilie P

    The American journal of cardiology

    2022  Volume 168, Page(s) 172–173

    MeSH term(s) Anticoagulants/therapeutic use ; Aortic Valve/surgery ; Heart Valve Prosthesis/adverse effects ; Humans ; Risk Factors ; Thromboembolism/etiology ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2021.12.058
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  9. Article ; Online: Meta-Analysis of Surgical Left Atrial Appendage Occlusion During Cardiac Surgery.

    Eagle, Gwen E / Whitlock, Richard P / Belley-Côté, Emilie P

    The American journal of cardiology

    2022  Volume 166, Page(s) 145–146

    MeSH term(s) Atrial Appendage/surgery ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures ; Humans
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2021.12.002
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  10. Article ; Online: Invited Commentary.

    Jaffer, Iqbal H / Whitlock, Richard P

    The Annals of thoracic surgery

    2019  Volume 107, Issue 5, Page(s) 1581–1582

    MeSH term(s) Aortic Valve ; Bioprosthesis ; Fibrinolytic Agents ; Heart Valve Prosthesis
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2019-01-11
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2018.12.020
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