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  1. Article ; Online: The effectiveness of peer support from a person with lived experience of mental health challenges for young people with anxiety and depression: a systematic review.

    Simmons, Magenta B / Cartner, Sharla / MacDonald, Roxxanne / Whitson, Sarah / Bailey, Alan / Brown, Ellie

    BMC psychiatry

    2023  Volume 23, Issue 1, Page(s) 194

    Abstract: Background: Peer workers support individuals experiencing mental health challenges by drawing on their shared lived experience. Peer support has become increasingly popular for young people with anxiety and depression, but the evidence base is unclear. ... ...

    Abstract Background: Peer workers support individuals experiencing mental health challenges by drawing on their shared lived experience. Peer support has become increasingly popular for young people with anxiety and depression, but the evidence base is unclear. This systematic review aimed to understand the effectiveness of peer support for youth depression and anxiety (either primary or comorbid), and to understand in which contexts, for whom, and why peer support works.
    Methods: A systematic search was conducted with the Orygen Evidence Finder, Embase, MEDLINE, and PsycInfo from January 1980 to July 2022. Controlled trials of interventions to improve mental health in young people (mean age 14-24), delivered by a peer worker with lived experienced of mental health challenges were included. Outcomes related to depression or anxiety were extracted and descriptive synthesis was undertaken due to the heterogeneity of studies. Study quality was rated using the Critical Appraisal Skills Programme; reporting adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
    Results: Nine randomised controlled trials with 2,003 participants were included, with seven undertaken in high income countries. One targeted depression and anxiety, two stigma-distress (any mental disorder), one first episode psychosis, four studies preventing eating disorders and one drug misuse. One study successfully reduced anxiety and depression, another reduced depression only, four reported reductions in negative affect, with the final three measuring, but not having a significant impact on depression. Study quality was rated as 'good' overall.
    Discussion: Despite the uptake of youth peer support globally, there is limited evidence from controlled trials of the effect of peer support-related interventions on anxiety and depression. There is some effect on negative affect, especially for university students. Further rigorously designed trials of peer delivered interventions for young people need to be conducted with a focus on understanding the mechanisms of action underpinning peer support.
    MeSH term(s) Adolescent ; Humans ; Young Adult ; Adult ; Mental Health ; Depression/therapy ; Anxiety/therapy ; Anxiety Disorders/therapy ; Psychotic Disorders ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-023-04578-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Implementing a combined individual placement and support and vocational peer work program in integrated youth mental health settings.

    Simmons, Magenta B / Chinnery, Gina / Whitson, Sarah / Bostock, Sarah / Braybrook, Joshua / Hamilton, Matthew / Killackey, Eóin / Brushe, Mary

    Early intervention in psychiatry

    2023  Volume 17, Issue 4, Page(s) 412–421

    Abstract: Aim: To describe the implementation and outcomes of a combined individual placement and support (IPS) and vocational peer work program for young people with mental ill-health.: Methods: This uncontrolled pilot study co-located IPS workers and ... ...

    Abstract Aim: To describe the implementation and outcomes of a combined individual placement and support (IPS) and vocational peer work program for young people with mental ill-health.
    Methods: This uncontrolled pilot study co-located IPS workers and vocational peer workers within two integrated youth mental health services (provided to clients aged 15-25 years old). Employment outcomes included job placements (working 15 hours or more per week in a paid competitive job in the open employment market) and sustained employment (employed for at least 26 weeks). Participants who required additional assistance also received peer work.
    Results: Of the 326 young people enrolled, 195 (59.8%) achieved competitive employment, including 157 (48.2%) in funder-approved placements. Among those in approved placements, 87 (55.4%) achieved sustained employment. For the 116 participants additionally receiving vocational peer work, 54 (46.6%) worked in funder-approved placements, of whom 27 (50.0%) achieved sustained employment. Among 210 participants who did not receive peer work, 103 (49.0%) worked in funder-approved placements, of whom 60 (58.3%) achieved sustained employment.
    Conclusions: The program achieved positive vocational outcomes and good fidelity to the IPS model. Approximately half of young people had employment placements, with a relatively high proportion maintained over time. The similar proportion of placements for those who did and did not receive peer work was encouraging given the IPS team determined that the former group needed additional support. Recommendations include upskilling the workforce, a data linkage system to obtain placement evidence, and using implementation science methodologies to understand how IPS programs are successfully embedded. This demands a coordinated effort between governments and funders, policymakers, services, and professional bodies.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Rehabilitation, Vocational/methods ; Employment, Supported ; Mental Disorders/psychology ; Mental Health ; Pilot Projects
    Language English
    Publishing date 2023-01-22
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Decisional capacity in young people with first episode psychosis, major depressive disorder and no mental disorder.

    Killey, Chiara M J / Allott, Kelly / Whitson, Sarah / Francey, Shona M / Bryant, Christina / Simmons, Magenta B

    Schizophrenia research. Cognition

    2021  Volume 28, Page(s) 100228

    Abstract: We aimed to (1) examine decisional capacity for treatment in young people (aged 15 to 25 years) with first-episode psychosis (FEP), Major Depressive Disorder (MDD) and no mental disorder, and (2) determine which theoretically relevant factors are ... ...

    Abstract We aimed to (1) examine decisional capacity for treatment in young people (aged 15 to 25 years) with first-episode psychosis (FEP), Major Depressive Disorder (MDD) and no mental disorder, and (2) determine which theoretically relevant factors are associated with, and predict decisional capacity. We assessed decisional capacity (using MacArthur Competence Assessment Tool-Treatment; MacCAT-T), cognitive abilities, insight and symptom severity in young people with no mental disorder (
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800609-4
    ISSN 2215-0013
    ISSN 2215-0013
    DOI 10.1016/j.scog.2021.100228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 10 years of the Syrian conflict: a time to act and not merely to remember.

    Jabbour, Samer / Leaning, Jennifer / Nuwayhid, Iman / Ager, Alastair / Cammett, Melani / Dewachi, Omar / Fouad, Fouad M / Giacaman, Rita / Sapir, Debarati Guha / Hage, Ghassan / Majed, Ziad / Nasser, Rabie / Sparrow, Annie / Spiegel, Paul / Tarakji, Ahmad / Whitson, Sarah Leah / Yassin, Nasser

    Lancet (London, England)

    2021  Volume 397, Issue 10281, Page(s) 1245–1248

    MeSH term(s) COVID-19/therapy ; Humans ; Poverty ; Refugees/statistics & numerical data ; Syria ; War Exposure
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)00623-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Isolating the impact of antipsychotic medication on metabolic health: Secondary analysis of a randomized controlled trial of antipsychotic medication versus placebo in antipsychotic medication naïve first-episode psychosis (the STAGES study).

    O'Donoghue, Brian / Allott, Kelly / Harrigan, Susy / Scalzo, Franco / Ward, Janine / Mallawaarachchi, Sumudu / Whitson, Sarah / Baldwin, Lara / Graham, Jessica / Mullen, Edward / MacNeil, Craig / Alexander, Dylan / Wood, Stephen J / Berk, Michael / Alvarez-Jimenez, Mario / Thompson, Andrew / Fornito, Alex / Yuen, Hok Pan / Nelson, Barnaby /
    Francey, Shona M / McGorry, Patrick

    Early intervention in psychiatry

    2022  Volume 17, Issue 6, Page(s) 597–607

    Abstract: Background: Cardiovascular and metabolic diseases are the leading contributors to the early mortality associated with psychotic disorders. To date, it has not been possible to disentangle the effect of medication and non-medication factors on the ... ...

    Abstract Background: Cardiovascular and metabolic diseases are the leading contributors to the early mortality associated with psychotic disorders. To date, it has not been possible to disentangle the effect of medication and non-medication factors on the physical health of people with a first episode of psychosis (FEP). This study aimed to isolate the effects of antipsychotic medication on anthropometric measurements, fasting glucose and lipids.
    Methods: This study utilized data from a triple-blind randomized placebo-controlled trial comparing two groups of antipsychotic-naïve young people with a FEP who were randomized to receive a second-generation antipsychotic medication (FEP-medication group) or placebo (FEP-placebo group) for 6 months. Twenty-seven control participants were also recruited.
    Results: Eighty-one participants commenced the trial; 69.1% completed at least 3 months of the intervention and 33.3% completed the full 6 months. The FEP-placebo group gained a mean of 2.4 kg (±4.9) compared to 1.1 kg (±4.9) in the control participants (t = 0.76, p = .45). After controlling for multiple analyses, there was no difference in blood pressure, waist circumference or heart rate between the FEP-placebo group and controls. After 6 months, the FEP medication group had gained 4.1 kg (±4.5), higher than those receiving placebo but not statistically significant (t = 0.8, p = .44). There were no differences in fasting glucose or lipids between the FEP groups after 3 months.
    Conclusions: While limited by small numbers and high attrition, these findings indicate that some of the metabolic complications observed in psychotic disorders could be attributable to factors other than medication. This emphasizes the need to deliver physical health interventions early in the course of FEP.
    MeSH term(s) Humans ; Adolescent ; Antipsychotic Agents/adverse effects ; Psychotic Disorders/complications ; Lipids/therapeutic use ; Glucose
    Chemical Substances Antipsychotic Agents ; Lipids ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-10-04
    Publishing country Australia
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cognitive ability and metabolic physical health in first-episode psychosis.

    Whitson, Sarah / O'Donoghue, Brian / Hester, Robert / Baldwin, Lara / Harrigan, Susy / Francey, Shona / Graham, Jessica / Nelson, Barnaby / Ratheesh, Aswin / Alvarez-Jimenez, Mario / Fornito, Alex / Pantelis, Christos / Yuen, Hok Pan / Thompson, Andrew / Kerr, Melissa / Berk, Michael / Wood, Stephen J / McGorry, Patrick / Allott, Kelly

    Schizophrenia research. Cognition

    2021  Volume 24, Page(s) 100194

    Abstract: Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure. Individuals with chronic psychosis experience poorer physical health while taking antipsychotic medication, but health ... ...

    Abstract Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure. Individuals with chronic psychosis experience poorer physical health while taking antipsychotic medication, but health disparities may be evident at FEP onset, prior to antipsychotic exposure. Given the links between cognition and physical health in healthy populations, the aim was to explore whether cognition and physical health are associated in FEP, which could inform early physical health interventions for cognition in FEP. Participants were aged 15 to 25 and included 86 individuals experiencing FEP with limited antipsychotic exposure and duration of untreated psychosis of ≤six months, and 43 age- and sex-matched controls. Individuals with FEP performed significantly poorer than controls in most cognitive domains (Cohen's
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800609-4
    ISSN 2215-0013
    ISSN 2215-0013
    DOI 10.1016/j.scog.2021.100194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.

    Wannan, Cassandra M J / Nelson, Barnaby / Addington, Jean / Allott, Kelly / Anticevic, Alan / Arango, Celso / Baker, Justin T / Bearden, Carrie E / Billah, Tashrif / Bouix, Sylvain / Broome, Matthew R / Buccilli, Kate / Cadenhead, Kristin S / Calkins, Monica E / Cannon, Tyrone D / Cecci, Guillermo / Chen, Eric Yu Hai / Cho, Kang Ik K / Choi, Jimmy /
    Clark, Scott R / Coleman, Michael J / Conus, Philippe / Corcoran, Cheryl M / Cornblatt, Barbara A / Diaz-Caneja, Covadonga M / Dwyer, Dominic / Ebdrup, Bjørn H / Ellman, Lauren M / Fusar-Poli, Paolo / Galindo, Liliana / Gaspar, Pablo A / Gerber, Carla / Glenthøj, Louise Birkedal / Glynn, Robert / Harms, Michael P / Horton, Leslie E / Kahn, René S / Kambeitz, Joseph / Kambeitz-Ilankovic, Lana / Kane, John M / Kapur, Tina / Keshavan, Matcheri S / Kim, Sung-Wan / Koutsouleris, Nikolaos / Kubicki, Marek / Kwon, Jun Soo / Langbein, Kerstin / Lewandowski, Kathryn E / Light, Gregory A / Mamah, Daniel / Marcy, Patricia J / Mathalon, Daniel H / McGorry, Patrick D / Mittal, Vijay A / Nordentoft, Merete / Nunez, Angela / Pasternak, Ofer / Pearlson, Godfrey D / Perez, Jesus / Perkins, Diana O / Powers, Albert R / Roalf, David R / Sabb, Fred W / Schiffman, Jason / Shah, Jai L / Smesny, Stefan / Spark, Jessica / Stone, William S / Strauss, Gregory P / Tamayo, Zailyn / Torous, John / Upthegrove, Rachel / Vangel, Mark / Verma, Swapna / Wang, Jijun / Rossum, Inge Winter-van / Wolf, Daniel H / Wolff, Phillip / Wood, Stephen J / Yung, Alison R / Agurto, Carla / Alvarez-Jimenez, Mario / Amminger, Paul / Armando, Marco / Asgari-Targhi, Ameneh / Cahill, John / Carrión, Ricardo E / Castro, Eduardo / Cetin-Karayumak, Suheyla / Mallar Chakravarty, M / Cho, Youngsun T / Cotter, David / D'Alfonso, Simon / Ennis, Michaela / Fadnavis, Shreyas / Fonteneau, Clara / Gao, Caroline / Gupta, Tina / Gur, Raquel E / Gur, Ruben C / Hamilton, Holly K / Hoftman, Gil D / Jacobs, Grace R / Jarcho, Johanna / Ji, Jie Lisa / Kohler, Christian G / Lalousis, Paris Alexandros / Lavoie, Suzie / Lepage, Martin / Liebenthal, Einat / Mervis, Josh / Murty, Vishnu / Nicholas, Spero C / Ning, Lipeng / Penzel, Nora / Poldrack, Russell / Polosecki, Pablo / Pratt, Danielle N / Rabin, Rachel / Rahimi Eichi, Habiballah / Rathi, Yogesh / Reichenberg, Avraham / Reinen, Jenna / Rogers, Jack / Ruiz-Yu, Bernalyn / Scott, Isabelle / Seitz-Holland, Johanna / Srihari, Vinod H / Srivastava, Agrima / Thompson, Andrew / Turetsky, Bruce I / Walsh, Barbara C / Whitford, Thomas / Wigman, Johanna T W / Yao, Beier / Yuen, Hok Pan / Ahmed, Uzair / Byun, Andrew Jin Soo / Chung, Yoonho / Do, Kim / Hendricks, Larry / Huynh, Kevin / Jeffries, Clark / Lane, Erlend / Langholm, Carsten / Lin, Eric / Mantua, Valentina / Santorelli, Gennarina / Ruparel, Kosha / Zoupou, Eirini / Adasme, Tatiana / Addamo, Lauren / Adery, Laura / Ali, Munaza / Auther, Andrea / Aversa, Samantha / Baek, Seon-Hwa / Bates, Kelly / Bathery, Alyssa / Bayer, Johanna M M / Beedham, Rebecca / Bilgrami, Zarina / Birch, Sonia / Bonoldi, Ilaria / Borders, Owen / Borgatti, Renato / Brown, Lisa / Bruna, Alejandro / Carrington, Holly / Castillo-Passi, Rolando I / Chen, Justine / Cheng, Nicholas / Ching, Ann Ee / Clifford, Chloe / Colton, Beau-Luke / Contreras, Pamela / Corral, Sebastián / Damiani, Stefano / Done, Monica / Estradé, Andrés / Etuka, Brandon Asika / Formica, Melanie / Furlan, Rachel / Geljic, Mia / Germano, Carmela / Getachew, Ruth / Goncalves, Mathias / Haidar, Anastasia / Hartmann, Jessica / Jo, Anna / John, Omar / Kerins, Sarah / Kerr, Melissa / Kesselring, Irena / Kim, Honey / Kim, Nicholas / Kinney, Kyle / Krcmar, Marija / Kotler, Elana / Lafanechere, Melanie / Lee, Clarice / Llerena, Joshua / Markiewicz, Christopher / Matnejl, Priya / Maturana, Alejandro / Mavambu, Aissata / Mayol-Troncoso, Rocío / McDonnell, Amelia / McGowan, Alessia / McLaughlin, Danielle / McIlhenny, Rebecca / McQueen, Brittany / Mebrahtu, Yohannes / Mensi, Martina / Hui, Christy Lai Ming / Suen, Yi Nam / Wong, Stephanie Ming Yin / Morrell, Neal / Omar, Mariam / Partridge, Alice / Phassouliotis, Christina / Pichiecchio, Anna / Politi, Pierluigi / Porter, Christian / Provenzani, Umberto / Prunier, Nicholas / Raj, Jasmine / Ray, Susan / Rayner, Victoria / Reyes, Manuel / Reynolds, Kate / Rush, Sage / Salinas, Cesar / Shetty, Jashmina / Snowball, Callum / Tod, Sophie / Turra-Fariña, Gabriel / Valle, Daniela / Veale, Simone / Whitson, Sarah / Wickham, Alana / Youn, Sarah / Zamorano, Francisco / Zavaglia, Elissa / Zinberg, Jamie / Woods, Scott W / Shenton, Martha E

    Schizophrenia bulletin

    2024  Volume 50, Issue 3, Page(s) 496–512

    Abstract: This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of ... ...

    Abstract This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.
    MeSH term(s) Humans ; Psychotic Disorders ; Schizophrenia ; Prospective Studies ; Adult ; Prodromal Symptoms ; Young Adult ; International Cooperation ; Adolescent ; Research Design/standards ; Male ; Female
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbae011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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