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  1. Article ; Online: Is there a correlation between antibiotic use and the severity or post-infection conditions of COVID-19 and other viral infections?

    Au, Tsz Yuen / Assavarittirong, Chanika / Benjamin, Shamiram / Wiśniewski, Oskar Wojciech

    Clinical and experimental medicine

    2023  Volume 23, Issue 8, Page(s) 4123–4128

    Abstract: Antibiotics are one of the most frequently prescribed medications in modern medicine; besides treating bacterial infections, they may often be utilized for prophylactic purposes, including during select viral infections. It has been shown that 74.9% of ... ...

    Abstract Antibiotics are one of the most frequently prescribed medications in modern medicine; besides treating bacterial infections, they may often be utilized for prophylactic purposes, including during select viral infections. It has been shown that 74.9% of COVID-19 patients received antibiotics as a part of their treatment regimen during the pandemic. However, studies suggest that the actual incidence of bacterial coinfection was relatively uncommon with a mere 3.5% of overall cases reported. A recent study revealed that antibiotic administration would not improve disease progression or shorten the length of hospitalization in COVID-19 patients; additionally, some antibiotics, such as linezolid, promote the production of free radicals that might be responsible for exacerbated clinical symptoms during and post-infection. Notably, antibiotic use disturbs the normal gut microbiome, and this interference impedes antiviral immune response enhancing severity and susceptibility to a list of viral infections. Thus, resultant augmented severity of these infections may be a consequence of higher susceptibility to respiratory viral co-infection.
    MeSH term(s) Humans ; Anti-Bacterial Agents/adverse effects ; COVID-19 ; Bacterial Infections/drug therapy ; Bacterial Infections/diagnosis ; Bacterial Infections/microbiology ; Linezolid/therapeutic use ; Disease Progression ; Coinfection/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Linezolid (ISQ9I6J12J)
    Language English
    Publishing date 2023-08-31
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01171-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Nutritional Behavior in European Countries during COVID-19 Pandemic-A Review.

    Wiśniewski, Oskar Wojciech / Czyżniewski, Bartłomiej / Żukiewicz-Sobczak, Wioletta / Gibas-Dorna, Magdalena

    Nutrients

    2023  Volume 15, Issue 15

    Abstract: COVID-19 is highly linked with hyperinflammation and dysfunction of the immune cells. Studies have shown that adequate nutrition, a modifiable factor affecting immunity and limiting systemic inflammation, may play an adjunct role in combating the ... ...

    Abstract COVID-19 is highly linked with hyperinflammation and dysfunction of the immune cells. Studies have shown that adequate nutrition, a modifiable factor affecting immunity and limiting systemic inflammation, may play an adjunct role in combating the negative consequences of SARS-CoV-2 infection. Due to the global lockdown conditions, the COVID-19 pandemic has contributed, among others, to restrictions on fresh food availability and changes in lifestyle and eating behaviors. The aim of this paper was to review the data regarding eating habits in European countries within the general population of adults and some specific subpopulations, including obese, diabetic, and psychiatric patients, during the COVID-19 pandemic. The PubMed database and the official websites of medical organizations and associations were searched for the phrases "COVID" and "eating habits". Papers regarding the pediatric population, non-European countries, presenting aggregated data from different countries worldwide, and reviews were excluded. During the COVID-19 pandemic, unhealthy lifestyles and eating behaviors were commonly reported. These included increased snacking, intake of caloric foods, such as sweets, pastries, and beverages, and a decline in physical activity. Data suggest that poor eating habits that create a positive energy balance have persisted over time as an additional post-COVID negative consequence.
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15153451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: G6PD deficiency-does it alter the course of COVID-19 infections?

    Au, Tsz Yuen / Wiśniewski, Oskar Wojciech / Benjamin, Shamiram / Kubicki, Tadeusz / Dytfeld, Dominik / Gil, Lidia

    Annals of hematology

    2023  Volume 102, Issue 7, Page(s) 1629–1636

    Abstract: Despite the existence of well-founded data around the relationship between reactive oxygen species (ROS) and glucose-6-phosphate dehydrogenase (G6PD), current research around G6PD-deficient patients with viral infections, and limitations as a result of ... ...

    Abstract Despite the existence of well-founded data around the relationship between reactive oxygen species (ROS) and glucose-6-phosphate dehydrogenase (G6PD), current research around G6PD-deficient patients with viral infections, and limitations as a result of their condition, are inadequate. Here, we analyze existing data around immunological risks, complications, and consequences of this disease, particularly in relation to COVID-19 infections and treatment. The relationship between G6PD deficiency and elevated ROS leading to increased viral load suggests that these patients may confer heightened infectivity. Additionally, worsened prognoses and more severe complications of infection may be realized in class I G6PD-deficient individuals. Though more research is demanded on the topic, preliminary studies suggest that antioxidative therapy which reduces ROS levels in these patients could prove beneficial in the treatment of viral infections in G6PD-deficient individuals.
    MeSH term(s) Humans ; Glucosephosphate Dehydrogenase Deficiency ; Reactive Oxygen Species ; COVID-19 ; Glucosephosphate Dehydrogenase
    Chemical Substances Reactive Oxygen Species ; Glucosephosphate Dehydrogenase (EC 1.1.1.49)
    Language English
    Publishing date 2023-03-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05164-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Hiponatremia w świetle najnowszych wytycznych – diagnostyka i różnicowanie.

    Wiśniewski, Oskar Wojciech / Łącka, Katarzyna

    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

    2018  Volume 45, Issue 268, Page(s) 168–172

    Abstract: Hyponatremia is still considered as a challenge of today's medicine. It is an independent factor responsible for the increased mortality among hyponatremic population and its clinical expression might be made up of threatening neurological symptoms, e.g. ...

    Title translation Hyponatremia in the light of the most recent guidelines - diagnostics and differential diagnosis.
    Abstract Hyponatremia is still considered as a challenge of today's medicine. It is an independent factor responsible for the increased mortality among hyponatremic population and its clinical expression might be made up of threatening neurological symptoms, e.g. brain oedema. Moreover, inappropriate treatment of hyponatremia may be followed with grievous consequences in the form of osmotic demyelination syndrome. Hyponatremia could also arise from iatrogenic origins. Thus, education concerning issues related to hyponatremia as the most frequent, though often underestimated, waterelectrolyte imbalance seems to be fundamental. This paper is a review of the current state of knowledge about hyponatremia with regard to its causes, diagnostics and differential diagnosis based on the prevailing guidelines elaborated by American and European experts independently.
    MeSH term(s) Diagnosis, Differential ; Humans ; Hyponatremia/diagnosis ; Hyponatremia/etiology ; Practice Guidelines as Topic
    Language Polish
    Publishing date 2018-10-29
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 1388406-2
    ISSN 1426-9686
    ISSN 1426-9686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4780: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Severe hyponatremia as the first sign of late-onset Schmidt's syndrome: A case report.

    Wiśniewski, Oskar Wojciech / Matuszak, Paulina / Kasprzak, Agnieszka / Łącka, Katarzyna

    Caspian journal of internal medicine

    2021  Volume 12, Issue Suppl 2, Page(s) S392–S396

    Abstract: Background: Schmidt's syndrome (SS) is a rare endocrine disorder (14-20:1000000), which consists of autoimmune thyroiditis (AIT) and autoimmune Addison's disease (aAD), and usually occurs in young adults. Here, we report a unique case of late-onset SS ... ...

    Abstract Background: Schmidt's syndrome (SS) is a rare endocrine disorder (14-20:1000000), which consists of autoimmune thyroiditis (AIT) and autoimmune Addison's disease (aAD), and usually occurs in young adults. Here, we report a unique case of late-onset SS manifesting initially with isolated severe hyponatremia and present the hazardous outcomes of preliminary misdiagnosis.
    Case presentation: A 78-year-old female presented to the emergency department with a two-day history of diarrhea, emesis and disturbances in consciousness. She also reported general fatigue and increasing weakness in the last month. Urgent laboratory findings revealed isolated severe hyponatremia (serum sodium=108 mmol/l) and initial treatment with active sodium infusions was started, although with no improvement in the patient's neurological status after 5 days (serum sodium=127 mmol/l). Meanwhile, the patient developed recurring episodes of hypoglycemia and symptoms portending adrenal crisis (blood pressure=105/58 mmHg, heart rate=96 bpm, severe whole-body muscle pain, two loose stools), which required immediate i.e. hydrocortisone treatment. Reduced blood cortisol, elevated adrenocorticotropic hormone (ACTH) and atrophic morphology of the adrenal glands in computed tomography imaging contributed to the final diagnosis of aAD and SS consequently, since the patient had a past medical history of AIT.
    Conclusion: Isolated severe hyponatremia should not be underestimated as the first sign of aAD. Appropriate cause-specific treatment is crucial in managing hyponatremia.
    Language English
    Publishing date 2021-10-21
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.12.0.392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Risk Factors Predisposing to Angina in Patients with Non-Obstructive Coronary Arteries: A Retrospective Analysis.

    Wiśniewski, Oskar Wojciech / Dydowicz, Franciszek / Salamaga, Szymon / Skulik, Przemysław / Migaj, Jacek / Kałużna-Oleksy, Marta

    Journal of personalized medicine

    2022  Volume 12, Issue 7

    Abstract: No hemodynamically significant atherosclerotic plaques are observed in up to 30% of patients reporting angina and undergoing coronary angiography. To investigate risk factors associated with non-obstructive coronary artery disease (NOCAD), we analyzed ... ...

    Abstract No hemodynamically significant atherosclerotic plaques are observed in up to 30% of patients reporting angina and undergoing coronary angiography. To investigate risk factors associated with non-obstructive coronary artery disease (NOCAD), we analyzed the medical records of, consecutively, 136 NOCAD subjects and 128 patients with significant stenosis in at least one coronary artery (the OCAD group). The blood concentrations of the TC (4.40 [3.78−5.63] mmol/L vs. 4.12 [3.42−5.01] mmol/L; p = 0.026), LDL-C (2.32 [1.80−3.50] mmol/L vs. 2.10 [1.50−2.70] mmol/L; p = 0.003), non-HDL-C (2.89 [2.29−4.19] mmol/L vs. 2.66 [2.06−3.39] mmol/L; p = 0.045), as well as the LDL-C/HDL-C ratio (1.75 [1.22−2.60] vs. 1.50 [1.10−1.95]; p = 0.018) were significantly increased in the NOCAD patients compared to the OCAD group due to the lower prevalence and intensity of the statin therapy in the NOCAD individuals (p < 0.001). Moreover, the abovementioned lipid parameters appeared to be valuable predictors of NOCAD, with the LDL-C (OR = 1.44; 95%CI = 1.14−1.82) and LDL-C/HDL-C (OR = 1.51; 95%CI = 1.13−2.02) showing the highest odds ratios. Furthermore, multivariable logistic regression models determined female sex as the independent risk factor for NOCAD (OR = 2.37; 95%CI = 1.33−4.20). Simultaneously, arterial hypertension substantially lowered the probability of NOCAD (OR = 0.21; 95%CI = 0.10−0.43). To conclude, female sex, the absence of arterial hypertension, as well as increased TC, LDL-C, non-HDL, and LDL-C/HDL-C ratio are risk factors for NOCAD in patients reporting angina, potentially as a result of poor hypercholesterolemia management.
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12071049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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