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  1. Article ; Online: Therapeutic Benefit of

    Asante, Du-Bois / Wiafe, Gideon Akuamoah

    Journal of diabetes research

    2023  Volume 2023, Page(s) 3159352

    Abstract: Diabetes mellitus (DM), a complex heterogeneous metabolic disorder characterized by a defect in the function of insulin, is on the rapid rise globally. Sustained hyperglycemia which is a major sign of DM is linked to the generation of reactive oxygen ... ...

    Abstract Diabetes mellitus (DM), a complex heterogeneous metabolic disorder characterized by a defect in the function of insulin, is on the rapid rise globally. Sustained hyperglycemia which is a major sign of DM is linked to the generation of reactive oxygen species which promotes adverse complications of the disorder. Traditional herbal treatment of DM is a common practice in Africa and other tropical parts of the world.
    MeSH term(s) Vernonia/chemistry ; Plant Extracts/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Insulin ; Antioxidants/therapeutic use ; Plant Leaves ; Diabetes Mellitus/drug therapy
    Chemical Substances Plant Extracts ; Hypoglycemic Agents ; Insulin ; Antioxidants
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2023/3159352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Dynamics of pre-shift and post-shift lung function parameters among wood workers in Ghana.

    Ekman, John / Quartey, Philip / Ussif, Abdala Mumuni / Ricklund, Niklas / Egbenya, Daniel Lawer / Wiafe, Gideon Akuamoah / Tsegah, Korantema Mawuena / Karikari, Akua / Löfstedt, Håkan / Djankpa, Francis Tanam

    Annals of occupational and environmental medicine

    2023  Volume 35, Page(s) e39

    Abstract: Background: Diseases affecting the lungs and airways contribute significantly to the global burden of disease. The problem in low- and middle-income countries appears to be exacerbated by a shift in global manufacturing base to these countries and ... ...

    Abstract Background: Diseases affecting the lungs and airways contribute significantly to the global burden of disease. The problem in low- and middle-income countries appears to be exacerbated by a shift in global manufacturing base to these countries and inadequate enforcement of environmental and safety standards. In Ghana, the potential adverse effects on respiratory function associated with occupational wood dust exposure have not been thoroughly investigated.
    Methods: Sixty-four male sawmill workers and 64 non-woodworkers participated in this study. The concentration of wood dust exposure, prevalence and likelihood of association of respiratory symptoms with wood dust exposure and changes in pulmonary function test (PFT) parameters in association with wood dust exposure were determined from dust concentration measurements, symptoms questionnaire and lung function test parameters.
    Results: Sawmill workers were exposed to inhalable dust concentration of 3.09 ± 0.04 mg/m
    Conclusions: Wood dust exposure at the study site was associated with acute respiratory symptoms and acute changes in some PFT parameters. This calls for institution and enforcement of workplace and environmental safety policies to minimise exposure at sawmill operating sites, and ultimately, decrease the burden of respiratory diseases.
    Language English
    Publishing date 2023-09-12
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2729723-8
    ISSN 2052-4374
    ISSN 2052-4374
    DOI 10.35371/aoem.2023.35.e39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Assessment of corn starch as substitute for agarose in DNA gel electrophoresis.

    Djankpa, Francis Tanam / Wiafe, Gideon Akuamoah / Boateng, Bernard Ntim / Tsegah, Korantema Mawuena / Essien-Baidoo, Samuel / Ulanja, Mark Bilinyi / Affram, Kwame Ofori / Ussif, Abdala Mumuni / Agyeman, Desmond Owusu / Asante, Gabriel

    BMC research notes

    2021  Volume 14, Issue 1, Page(s) 73

    Abstract: Objective: The use of agarose in nucleic acid electrophoresis is the gold standard. However, agarose is very expensive and not readily available in resource limited developing countries like Ghana. Hence, finding a more affordable and readily available ... ...

    Abstract Objective: The use of agarose in nucleic acid electrophoresis is the gold standard. However, agarose is very expensive and not readily available in resource limited developing countries like Ghana. Hence, finding a more affordable and readily available alternative to agarose will be a major boost to molecular research in developing countries. This study was aimed at investigating the use of corn starch as a potential substitute for agarose in DNA gel electrophoresis.
    Results: Genomic deoxyribonucleic acid (DNA) extracted from Plasmodium falciparum and primers were obtained from the West African Centre for Cell Biology of Infectious Pathogens and amplified using polymerase chain reaction. The amplicon was run on agarose gel to ascertain the molecular weight (as a positive control). When visualized under both blue light and ultraviolet light, the DNA and ladder showed clear and clean bands with the expected molecular weight. Corn starch was then modified with sodium borate buffer, casted into a gel and used to run the same DNA sample. Our findings indicated that similar to agarose, the DNA sample and ladder migrated successfully through the modified starch gel but no bands were visible when visualized under blue and ultra-violet light.
    MeSH term(s) DNA/genetics ; Electrophoresis, Agar Gel ; Ghana ; Sepharose ; Starch ; Zea mays/genetics
    Chemical Substances Starch (9005-25-8) ; DNA (9007-49-2) ; Sepharose (9012-36-6)
    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-021-05483-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of in utero exposure to monosodium glutamate on locomotion, anxiety, depression, memory and KCC2 expression in offspring.

    Biney, Robert Peter / Djankpa, Francis Tanam / Osei, Silas Acheampong / Egbenya, Daniel Lawer / Aboagye, Benjamin / Karikari, Akua Afriyie / Ussif, Abdala / Wiafe, Gideon Akuamoah / Nuertey, David

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

    2021  Volume 82, Issue 1, Page(s) 50–62

    Abstract: In pregnancy, there is a significant risk for developing embryos to be adversely affected by everyday chemicals such as food additives and environmental toxins. In recent times, several studies have documented the detrimental effect of exposure to such ... ...

    Abstract In pregnancy, there is a significant risk for developing embryos to be adversely affected by everyday chemicals such as food additives and environmental toxins. In recent times, several studies have documented the detrimental effect of exposure to such chemicals on the behaviour and neurodevelopment of the offspring. This study evaluated the influence of the food additive, monosodium glutamate (MSG), on behaviour and development in mice. Pregnant dams were exposed to MSG 2 or 4 g/kg or distilled water from gestation day 10-20. On delivery, postnatal day 1 (PN 1), 3 pups were sacrificed and whole brain samples assayed for KCC2 expression by western blot. The remaining pups were housed until PN 43 before commencing behavioural assessment. Their weights were measured at birth and at 3 days intervals until PN 42. The impact of prenatal exposure to MSG on baseline exploratory, anxiety and depression behaviours as well as spatial and working memory was assessed. In utero exposure to 4 g/kg MSG significantly reduced exploratory drive and increased depression-like behaviours but did not exert any significant impact on anxiety-like behaviours (p < 0.01). Additionally, there was a two-fold increase in KCC2 expression in both 2 and 4 g/kg MSG-exposed offspring. CONCLUSION: This study indicates that, in utero exposure to MSG increases the expression of KCC2 and causes significant effect on locomotion and depression-like behaviours but only marginally affects memory function.
    MeSH term(s) Animals ; Anxiety/chemically induced ; Depression/chemically induced ; Female ; Locomotion ; Mice ; Pregnancy ; Sodium Glutamate/toxicity ; Symporters/pharmacology
    Chemical Substances Symporters ; Sodium Glutamate (W81N5U6R6U)
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605533-3
    ISSN 1873-474X ; 0736-5748
    ISSN (online) 1873-474X
    ISSN 0736-5748
    DOI 10.1002/jdn.10158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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