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  1. Article: Reply to Bareille et al. Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on "Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.

    Volod, Oksana / Bunch, Connor M / Miller, Joseph / Moore, Ernest E / Moore, Hunter B / Kwaan, Hau C / Patel, Shivani S / Wiarda, Grant / Aboukhaled, Michael / Thomas, Scott G / Fulkerson, Daniel / Erdman, Lee / Tincher, Anna / Walsh, Mark M

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: We are pleased to see that Bareille et al. have written a Commentary: "Are viscoelastometric assays of old generation ready for disposal?" [ ... ]. ...

    Abstract We are pleased to see that Bareille et al. have written a Commentary: "Are viscoelastometric assays of old generation ready for disposal?" [...].
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Use of Thromboelastography and Rotational Thromboelastometry in Otolaryngology: A Narrative Review.

    Marsee, Mathew K / Shariff, Faisal S / Wiarda, Grant / Watson, Patrick J / Sualeh, Ali H / Brenner, Toby J / McCoy, Max L / Al-Fadhl, Hamid D / Jones, Alexander J / Davis, Patrick K / Zimmer, David / Folsom, Craig

    Journal of clinical medicine

    2022  Volume 11, Issue 4

    Abstract: In the field of otolaryngology-head and neck surgery (ENT), coagulopathies present unique diagnostic and therapeutic challenges. In both hyper- and hypocoagulable patients, management of coagulopathies requires intricate attention to the nature of ... ...

    Abstract In the field of otolaryngology-head and neck surgery (ENT), coagulopathies present unique diagnostic and therapeutic challenges. In both hyper- and hypocoagulable patients, management of coagulopathies requires intricate attention to the nature of hemostatic competence. Common coagulation tests (CCTs) offer only a snapshot of hemostatic competence and do not provide a clear insight into the patient's real-time hemostatic condition. Viscoelastic tests (VETs) offer a holistic and concurrent picture of the coagulation process. Although VETs have found prominent utilization in hepatic transplants, obstetrics, and emergent surgical settings, they have not been fully adopted in the realm of otolaryngology. The objective of this manuscript is to provide an overview of the literature evaluating the current utilization and possible future uses of VETs in the field of otolaryngology. The authors performed a comprehensive literature search of the utilization of VETs in otolaryngology and identified applicable studies that included descriptions of viscoelastic testing. Twenty-five studies were identified in this search, spanning topics from head and neck oncology, microvascular free flap reconstruction, obstructive sleep apnea, adenotonsillectomy, facial trauma, and epistaxis. The applicability of VETs has been demonstrated in head and neck oncology and microvascular free flap management, although their pervasiveness in practice is limited. Underutilization of VETs in the field of otolaryngology may be due to a lack of familiarity of the tests amongst practitioners. Instead, most otolaryngologists continue to rely on CCTs, including PT, PTT, INR, CBC, fibrinogen levels, and thrombin time. Learning to perform, interpret, and skillfully employ VETs in clinical and operative practice can greatly improve the management of coagulopathic patients who are at increased risk of bleeding or thrombosis.
    Language English
    Publishing date 2022-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11041119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Case Series of Thromboelastography-Guided Anticoagulation in COVID-19 Patients with Inherited and Acquired Hypercoagulable States.

    Thomas, Anthony V / Lin, Kevin P / Stillson, John E / Bunch, Connor M / Speybroeck, Jacob / Wiarda, Grant / Al-Fadhl, Hamid / Gillespie, Laura / Zamlut, Mahmud / Fulkerson, Daniel H / Khan, Rashid Z / Kwaan, Hau C / Walsh, Mark M

    Case reports in medicine

    2021  Volume 2021, Page(s) 5568982

    Abstract: One of the complications of the novel coronavirus disease 2019 (COVID-19) is hypercoagulability. For this reason, patients presenting with COVID-19 are often put on therapeutic or intermediate anticoagulation upon hospitalization. A common issue of this ... ...

    Abstract One of the complications of the novel coronavirus disease 2019 (COVID-19) is hypercoagulability. For this reason, patients presenting with COVID-19 are often put on therapeutic or intermediate anticoagulation upon hospitalization. A common issue of this anticoagulation is the progression to hypocoagulability resulting in hemorrhage. Therefore, monitoring the hemostatic integrity of critically ill COVID-19 patients is of utmost importance. In this case series, we present the cases of three coagulopathic COVID-19 patients whose anticoagulation was guided by thromboelastography (TEG). In each case, TEG permitted the clinical team to simultaneously prevent thrombotic and hemorrhagic events, a difficult task for COVID-19 patients admitted to the intensive care unit. The first two cases illustrate the utility of TEG to guide anticoagulant dosing for COVID-19 patients when the activated partial thromboplastin time (aPTT) is inaccurate. The first case was a severely ill COVID-19 patient with end-stage renal disease and a falsely elevated aPTT secondary to hypertriglyceridemia. The second case was a severely ill COVID-19 patient with chronic pulmonary disease who demonstrated a falsely elevated aPTT due to polycythemia and hemoconcentration. In both cases, TEG was sensitive to the hypercoagulability caused by the metabolic derangements which enabled the goal-directed titration of anticoagulants. The last case depicts a severely ill COVID-19 patient with an inherited factor V Leiden mutation who required abnormally high dosing to achieve therapeutic anticoagulation, guided by TEG. Hypercoagulopathic COVID-19 patients are difficult to anticoagulate without development of hypocoagulopathy. Treatment of these patients demands goal-directed therapy by diligent laboratory monitoring. This can be accomplished by the use of TEG coupled with aPTT to guide anticoagulation. This case series illustrates the necessity for active hemostatic monitoring of critically ill COVID-19 patients.
    Language English
    Publishing date 2021-07-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2502642-2
    ISSN 1687-9635 ; 1687-9627
    ISSN (online) 1687-9635
    ISSN 1687-9627
    DOI 10.1155/2021/5568982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Tension pneumomediastinum and diffuse subcutaneous emphysema with severe acute respiratory syndrome coronavirus 2 infection requiring operative management for impending airway collapse: A case report.

    Lin, Kevin P / Stefaniak, Christopher / Bunch, Connor M / March, Robert / Zamlut, Mahmud / Raza, Syed / Osorio, Walter / Korzan, Josh / Show, Jeffery / Mjaess, Nicolas / Patel, Shivani / Zackariya, Sufyan / Sualeh, Ali / Wiarda, Grant / Al-Fadhl, Hamid / Thomas, Anthony V / Khan, Rashid Z / Gillespie, Laura / Walsh, Mark M

    Clinical case reports

    2021  Volume 9, Issue 8, Page(s) e04656

    Abstract: Tension pneumomediastinum is a rare complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that has increased in incidence with the novel coronavirus disease 2019 pandemic. Although traditionally managed with conservative ... ...

    Abstract Tension pneumomediastinum is a rare complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that has increased in incidence with the novel coronavirus disease 2019 pandemic. Although traditionally managed with conservative measures, we present the indications and methods for the first operative management of tension pneumomediastinum with concomitant SARS-CoV-2 infection.
    Language English
    Publishing date 2021-08-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.

    Volod, Oksana / Bunch, Connor M / Zackariya, Nuha / Moore, Ernest E / Moore, Hunter B / Kwaan, Hau C / Neal, Matthew D / Al-Fadhl, Mahmoud D / Patel, Shivani S / Wiarda, Grant / Al-Fadhl, Hamid D / McCoy, Max L / Thomas, Anthony V / Thomas, Scott G / Gillespie, Laura / Khan, Rashid Z / Zamlut, Mahmud / Kamphues, Peter / Fries, Dietmar /
    Walsh, Mark M

    Journal of clinical medicine

    2022  Volume 11, Issue 3

    Abstract: Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become an essential method for assaying hemostatic competence in liver transplantation, cardiac surgery, and most recently, trauma surgery involving hemorrhagic shock. It ... ...

    Abstract Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become an essential method for assaying hemostatic competence in liver transplantation, cardiac surgery, and most recently, trauma surgery involving hemorrhagic shock. It has taken more than three-quarters of a century of research and clinical application for this technology to become mainstream in these three clinical areas. Within the last decade, the cup and pin legacy devices, such as thromboelastography (TEG
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11030860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness.

    Grobbelaar, Lize M / Kruger, Arneaux / Venter, Chantelle / Burger, Este M / Laubscher, Gert J / Maponga, Tongai G / Kotze, Maritha J / Kwaan, Hau C / Miller, Joseph B / Fulkerson, Daniel / Huff, Wei / Chang, Eric / Wiarda, Grant / Bunch, Connor M / Walsh, Mark M / Raza, Syed / Zamlut, Mahmud / Moore, Hunter B / Moore, Ernest E /
    Neal, Matthew D / Kell, Douglas B / Pretorius, Etheresia

    Seminars in thrombosis and hemostasis

    2022  Volume 48, Issue 7, Page(s) 858–868

    Abstract: Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an extensive formation of fibrin amyloid microclots, which are considered to contribute to the pathology of the coronavirus 2019 disease (COVID-19). The newer omicron ... ...

    Abstract Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an extensive formation of fibrin amyloid microclots, which are considered to contribute to the pathology of the coronavirus 2019 disease (COVID-19). The newer omicron variants appear to be far more transmissible, but less virulent, even when taking immunity acquired from previous infections or vaccination into account. We here show that while the clotting parameters associated with omicron variants are significantly raised over those of healthy, matched controls, they are raised to levels significantly lower than those seen with more severe variants such as beta and delta. We also observed that individuals infected with omicron variants manifested less extensive microclot formation in platelet-poor plasma compared with those harboring the more virulent variants. The measurement of clotting effects between the different variants acts as a kind of "internal control" that demonstrates the relationship between the extent of coagulopathies and the virulence of the variant of interest. This adds to the evidence that microclots may play an important role in reflecting the severity of symptoms observed in COVID-19.
    MeSH term(s) Humans ; SARS-CoV-2 ; Fibrin ; COVID-19
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation.

    Bunch, Connor M / Moore, Ernest E / Moore, Hunter B / Neal, Matthew D / Thomas, Anthony V / Zackariya, Nuha / Zhao, Jonathan / Zackariya, Sufyan / Brenner, Toby J / Berquist, Margaret / Buckner, Hallie / Wiarda, Grant / Fulkerson, Daniel / Huff, Wei / Kwaan, Hau C / Lankowicz, Genevieve / Laubscher, Gert J / Lourens, Petrus J / Pretorius, Etheresia /
    Kotze, Maritha J / Moolla, Muhammad S / Sithole, Sithembiso / Maponga, Tongai G / Kell, Douglas B / Fox, Mark D / Gillespie, Laura / Khan, Rashid Z / Mamczak, Christiaan N / March, Robert / Macias, Rachel / Bull, Brian S / Walsh, Mark M

    Frontiers in surgery

    2022  Volume 9, Page(s) 889999

    Abstract: Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies prioritized transmissibility-based precautions and hospital capacity as the foundation for delay of elective procedures. As elective surgical volumes increased, ... ...

    Abstract Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies prioritized transmissibility-based precautions and hospital capacity as the foundation for delay of elective procedures. As elective surgical volumes increased, convalescent COVID-19 patients faced increased postoperative morbidity and mortality and clinicians had limited evidence for stratifying individual risk in this population. Clear evidence now demonstrates that those recovering from COVID-19 have increased postoperative morbidity and mortality. These data-in conjunction with the recent American Society of Anesthesiologists guidelines-offer the evidence necessary to expand the early pandemic guidelines and guide the surgeon's preoperative risk assessment. Here, we argue elective surgeries should still be delayed on a personalized basis to maximize postoperative outcomes. We outline a framework for stratifying the individual COVID-19 patient's fitness for surgery based on the symptoms and severity of acute or convalescent COVID-19 illness, coagulopathy assessment, and acuity of the surgical procedure. Although the most common manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is COVID-19 pneumonitis, every system in the body is potentially afflicted by an endotheliitis. This endothelial derangement most often manifests as a hypercoagulable state on admission with associated occult and symptomatic venous and arterial thromboembolisms. The delicate balance between hyper and hypocoagulable states is defined by the local immune-thrombotic crosstalk that results commonly in a hemostatic derangement known as fibrinolytic shutdown. In tandem, the hemostatic derangements that occur during acute COVID-19 infection affect not only the timing of surgical procedures, but also the incidence of postoperative hemostatic complications related to COVID-19-associated coagulopathy (CAC). Traditional methods of thromboprophylaxis and treatment of thromboses after surgery require a tailored approach guided by an understanding of the pathophysiologic underpinnings of the COVID-19 patient. Likewise, a prolonged period of risk for developing hemostatic complications following hospitalization due to COVID-19 has resulted in guidelines from differing societies that recommend varying periods of delay following SARS-CoV-2 infection. In conclusion, we propose the perioperative, personalized assessment of COVID-19 patients' CAC using viscoelastic hemostatic assays and fluorescent microclot analysis.
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.889999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness

    Grobbelaar, Lize M. / Kruger, Arneaux / Venter, Chantelle / Burger, Este M. / Laubscher, Gert J. / Maponga, Tongai G. / Kotze, Maritha J. / Kwaan, Hau C. / Miller, Joseph B. / Fulkerson, Daniel / Huff, Wei / Chang, Eric / Wiarda, Grant / Bunch, Connor M. / Walsh, Mark M. / Raza, Syed / Zamlut, Mahmud / Moore, Hunter B. / Moore, Ernest E. /
    Neal, Matthew D. / Kell, Douglas B. / Pretorius, Etheresia

    Seminars in Thrombosis and Hemostasis

    (Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge To Conventional Coagulation Tests?)

    2022  Volume 48, Issue 07, Page(s) 858–868

    Abstract: Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an extensive formation of fibrin amyloid microclots, which are considered to contribute to the pathology of the coronavirus 2019 disease (COVID-19). The newer omicron ... ...

    Series title Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge To Conventional Coagulation Tests?
    Abstract Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an extensive formation of fibrin amyloid microclots, which are considered to contribute to the pathology of the coronavirus 2019 disease (COVID-19). The newer omicron variants appear to be far more transmissible, but less virulent, even when taking immunity acquired from previous infections or vaccination into account. We here show that while the clotting parameters associated with omicron variants are significantly raised over those of healthy, matched controls, they are raised to levels significantly lower than those seen with more severe variants such as beta and delta. We also observed that individuals infected with omicron variants manifested less extensive microclot formation in platelet-poor plasma compared with those harboring the more virulent variants. The measurement of clotting effects between the different variants acts as a kind of “internal control” that demonstrates the relationship between the extent of coagulopathies and the virulence of the variant of interest. This adds to the evidence that microclots may play an important role in reflecting the severity of symptoms observed in COVID-19.
    Keywords COVID-19 ; variants ; Omicron ; coagulation ; fluorescence microscopy ; microclots
    Language English
    Publishing date 2022-09-29
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756306
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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