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  1. Book ; Conference proceedings: Book of abstracts 12th Meeting of the European Association of Neuro-Oncology

    Wick, Wolfgang

    October 12-16, 2016, Mannheim/Heidelberg, Germany

    (Neuro-oncology ; volume 18, supplement 4 (2016))

    2016  

    Event/congress EANO Meeting (12., 2016, Mannheim)
    Author's details co-editors: Wolfgang Wick, Michael Weller
    Series title Neuro-oncology ; volume 18, supplement 4 (2016)
    Neuro-Oncology
    Collection Neuro-Oncology
    Language English
    Size iv98 Seiten
    Publisher Oxford University Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT019195893
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Sprunginnovationen in der Neuromedizin.

    Wick, Wolfgang

    Der Nervenarzt

    2022  Volume 93, Issue 10, Page(s) 975–976

    Title translation Disruptive innovations in neuromedicine.
    Language German
    Publishing date 2022-10-05
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-022-01381-4
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  3. Article: "Die Behandlung von primären Hirntumoren erfordert intelligente und komplexe Therapiekonzepte". Im Gespräch mit Wolfgang Wick

    Wick, Wolfgang

    Trillium-Krebsmedizin

    2020  Volume 29, Issue 7, Page(s) 570

    Language German
    Document type Article
    ZDB-ID 2768536-6
    ISSN 2198-9818
    Database Current Contents Medicine

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  4. Article ; Online: Performance of Large Language Models on a Neurology Board-Style Examination.

    Schubert, Marc Cicero / Wick, Wolfgang / Venkataramani, Varun

    JAMA network open

    2023  Volume 6, Issue 12, Page(s) e2346721

    Abstract: Importance: Recent advancements in large language models (LLMs) have shown potential in a wide array of applications, including health care. While LLMs showed heterogeneous results across specialized medical board examinations, the performance of these ... ...

    Abstract Importance: Recent advancements in large language models (LLMs) have shown potential in a wide array of applications, including health care. While LLMs showed heterogeneous results across specialized medical board examinations, the performance of these models in neurology board examinations remains unexplored.
    Objective: To assess the performance of LLMs on neurology board-style examinations.
    Design, setting, and participants: This cross-sectional study was conducted between May 17 and May 31, 2023. The evaluation utilized a question bank approved by the American Board of Psychiatry and Neurology and was validated with a small question cohort by the European Board for Neurology. All questions were categorized into lower-order (recall, understanding) and higher-order (apply, analyze, synthesize) questions based on the Bloom taxonomy for learning and assessment. Performance by LLM ChatGPT versions 3.5 (LLM 1) and 4 (LLM 2) was assessed in relation to overall scores, question type, and topics, along with the confidence level and reproducibility of answers.
    Main outcomes and measures: Overall percentage scores of 2 LLMs.
    Results: LLM 2 significantly outperformed LLM 1 by correctly answering 1662 of 1956 questions (85.0%) vs 1306 questions (66.8%) for LLM 1. Notably, LLM 2's performance was greater than the mean human score of 73.8%, effectively achieving near-passing and passing grades in the neurology board examination. LLM 2 outperformed human users in behavioral, cognitive, and psychological-related questions and demonstrated superior performance to LLM 1 in 6 categories. Both LLMs performed better on lower-order than higher-order questions, with LLM 2 excelling in both lower-order and higher-order questions. Both models consistently used confident language, even when providing incorrect answers. Reproducible answers of both LLMs were associated with a higher percentage of correct answers than inconsistent answers.
    Conclusions and relevance: Despite the absence of neurology-specific training, LLM 2 demonstrated commendable performance, whereas LLM 1 performed slightly below the human average. While higher-order cognitive tasks were more challenging for both models, LLM 2's results were equivalent to passing grades in specialized neurology examinations. These findings suggest that LLMs could have significant applications in clinical neurology and health care with further refinements.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Reproducibility of Results ; Neurologic Examination ; Language ; Neurology
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.46721
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  5. Article ; Online: Evaluation of risdiplam efficacy in 5q spinal muscular atrophy: A systematic comparison of electrophysiologic with clinical outcome measures.

    Kessler, Tobias / Sam, Georges / Wick, Wolfgang / Weiler, Markus

    European journal of neurology

    2023  Volume 31, Issue 1, Page(s) e16099

    Abstract: Background: To assess compound muscle action potential (CMAP) amplitudes as electrophysiologic markers in relation to clinical outcome in adult patients with 5q-linked spinal muscular atrophy (SMA) before and during treatment with risdiplam.: Methods!# ...

    Abstract Background: To assess compound muscle action potential (CMAP) amplitudes as electrophysiologic markers in relation to clinical outcome in adult patients with 5q-linked spinal muscular atrophy (SMA) before and during treatment with risdiplam.
    Methods: In this monocentric longitudinal cohort study, CMAP of 18 adult patients with SMA type 2 or 3 were assessed at baseline (T
    Results: During a pharmacotherapy-naive pre-treatment period of 328 ± 46 days, Revised Upper Limb Module (RULM) score and peroneal nerve CMAP amplitudes decreased, while CMAP of tibial and upper limb nerves remained unchanged. CMAP amplitudes positively correlated with clinical scores (Hammersmith Functional Motor Scale-Expanded [HFMSE], RULM) at T
    Conclusions: Median nerve CMAP amplitudes increase with risdiplam treatment in adult SMA patients, and should be further evaluated as potential easy-to-use electrophysiologic markers in assessing and monitoring clinical response to therapy.
    MeSH term(s) Adult ; Child ; Infant ; Humans ; Longitudinal Studies ; Muscular Atrophy, Spinal/drug therapy ; Spinal Muscular Atrophies of Childhood/drug therapy ; Outcome Assessment, Health Care
    Chemical Substances Risdiplam (76RS4S2ET1)
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16099
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    Zs.MO 592: Show issues

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  6. Article: Neue Therapien in der Neuroonkologie. Hirntumore bei Erwachsenen / CME-Fragen

    Wick, Wolfgang

    InFo Neurologie & Psychiatrie

    2019  Volume 21, Issue 6, Page(s) 40/52

    Language German
    Document type Article
    ZDB-ID 2008542-4
    ISSN 1437-062X
    Database Current Contents Medicine

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  7. Article: Primäre Hirntumoren erfordern intelligente Behandlungsstrategien. Interview mit Wolfgang Wick

    Wick, Wolfgang

    Onkologie heute

    2019  Volume 18, Issue 2, Page(s) 34

    Language German
    Document type Article
    ZDB-ID 2147741-3
    ISSN 1612-006X
    Database Current Contents Medicine

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  8. Article ; Online: Oncolytic virotherapy: Potentially a game-changing tumor treatment.

    Kessler, Tobias / Wick, Wolfgang

    Cancer cell

    2021  Volume 39, Issue 6, Page(s) 753–755

    Abstract: A two-center phase I trial published in the New England Journal of Medicine shows safety and feasibility of locally administered oncolytic herpes simplex virus-1 virus plus 5 Gy radiation for progressive pediatric high-grade gliomas. Patients seemed to ... ...

    Abstract A two-center phase I trial published in the New England Journal of Medicine shows safety and feasibility of locally administered oncolytic herpes simplex virus-1 virus plus 5 Gy radiation for progressive pediatric high-grade gliomas. Patients seemed to have an unusually good clinical course and showed immune activation in post-treatment tissues.
    MeSH term(s) Child ; Glioma/therapy ; Humans ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.05.014
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  9. Article ; Online: TTFields: where does all the skepticism come from?

    Wick, Wolfgang

    Neuro-oncology

    2016  Volume 18, Issue 3, Page(s) 303–305

    MeSH term(s) Brain Neoplasms/therapy ; Clinical Trials as Topic ; Combined Modality Therapy ; Humans
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/now012
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  10. Book: Neurologie

    Schwab, Stefan / Bendszus, Martin / Poeck, Klaus / Wick, Wolfgang / Hacke, Werner

    (Springer-Lehrbuch)

    2019  

    Author's details Werner Hacke (Hrsg.) ; Begründet von Klaus Poeck † ; unter Mitarbeit von Wolfgang Wick [und 3 weiteren]
    Series title Springer-Lehrbuch
    MeSH term(s) Nervous System Diseases ; Neurology
    Keywords Nervous System Diseases ; Neurologe ; Gehirn ; Zentrales Nervensystem ; Schlaganfall ; Neurologie ; Prüfungsvorbereitung ; Ärztliche Prüfung ; Assistenzarzt ; Medizinstudent ; Staatsexamen ; ZNS ; Klinischer Abschnitt ; Stroke ; Medizinstudium ; Läsion ; Psychologie ; Psychosomatik ; zerebral ; Psychiatrie ; Hirnstimulation ; Nervenkrankheit ; Nervensystem ; Krankheit ; Medizinische Staatsprüfung ; Abschnitt 2
    Subject Zweiter Abschnitt ; Ärztliche Staatsprüfung ; Medizinisches Staatsexamen ; Ärztliche Prüfung ; Seelenheilkunde ; Klinische Neurologie ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS ; Nervenkrankheiten ; Neurologische Erkrankung ; Neurologische Krankheit ; Nervensystem ; Nervensystemkrankheit ; Nervous disease
    Language German
    Size XXV, 1038 Seiten, Illustrationen, Diagramme, 27 cm
    Edition 14. überarbeitete Auflage ; korrigierte Publikation
    Publisher Springer
    Publishing place Berlin ; Heidelberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT018770366
    ISBN 978-3-662-46891-3 ; 9783662468920 ; 3-662-46891-3 ; 3662468921
    Database Catalogue ZB MED Medicine, Health

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