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  1. Article ; Online: Using gamification to enhance clinical trial start-up activities.

    Lane, Karen / Majkowski, Ryan / Gruber, Joshua / Amirault, Daniel / Hillery, Shannon / Wieber, Cortney / Thompson, Dixie D / Huvane, Jacqueline / Bridges, Jordan / Ryu, E Paul / Eyzaguirre, Lindsay M / Gildea, Marianne / Thompson, Richard E / Ford, Daniel E / Hanley, Daniel

    Journal of clinical and translational science

    2022  Volume 6, Issue 1, Page(s) e75

    Abstract: Background: The Trial Innovation Network (TIN) is a collaborative initiative within the National Center for Advancing Translational Science (NCATS) Clinical and Translational Science Awards (CTSA) Program. To improve and innovate the conduct of clinical ...

    Abstract Background: The Trial Innovation Network (TIN) is a collaborative initiative within the National Center for Advancing Translational Science (NCATS) Clinical and Translational Science Awards (CTSA) Program. To improve and innovate the conduct of clinical trials, it is exploring the uses of gamification to better engage the trial workforce and improve the efficiencies of trial activities. The gamification structures described in this article are part of a TIN website gamification toolkit, available online to the clinical trial scientific community.
    Methods: The game designers used existing electronic trial platforms to gamify the tasks required to meet trial start-up timelines to create friendly competitions. Key indicators and familiar metrics were mapped to scoreboards. Webinars were organized to share and applaud trial and game performance.
    Results: Game scores were significantly associated with an increase in achieving start-up milestones in activation, institutional review board (IRB) submission, and IRB approval times, indicating the probability of completing site activation faster by using games. Overall game enjoyment and feelings that the game did not apply too much pressure appeared to be an important moderator of performance in one trial but had little effect on performance in a second.
    Conclusion: This retrospective examination of available data from gaming experiences may be a first-of-kind use in clinical trials. There are signals that gaming may accelerate performance and increase enjoyment during the start-up phase of a trial. Isolating the effect of gamification on trial outcomes will depend on a larger sampling from future trials, using well-defined, hypothesis-driven statistical analysis plans.
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2022.405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development, implementation, and dissemination of operational innovations across the trial innovation network.

    Palm, Marisha E / Edwards, Terri L / Wieber, Cortney / Kay, Marie T / Marion, Eve / Boone, Leslie / Nanni, Angeline / Jones, Michelle / Pham, Eilene / Hildreth, Meghan / Lane, Karen / McBee, Nichol / Benjamin, Daniel K / Bernard, Gordon R / Dean, J Michael / Dwyer, Jamie P / Ford, Daniel E / Hanley, Daniel F / Harris, Paul A /
    Wilkins, Consuelo H / Selker, Harry P

    Journal of clinical and translational science

    2023  Volume 7, Issue 1, Page(s) e251

    Abstract: Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are ... ...

    Abstract Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuccessful. The National Center for Advancing Translational Science launched the Trial Innovation Network to address critical roadblocks in multi-center trials by leveraging existing infrastructure and developing operational innovations. We provide an overview of the roadblocks that led to opportunities for operational innovation, our work to develop, define, and map innovations across the network, and how we implemented and disseminated mature innovations.
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2023.658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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