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  1. Article ; Online: Response to Huang et al regarding "Riociguat and balloon pulmonary angioplasty improve prognosis in patients with inoperable chronic thromboembolic pulmonary hypertension".

    Wiedenroth, Christoph B / Guth, Stefan

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2023  Volume 42, Issue 11, Page(s) 1635

    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Letter
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2023.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multimodality treatment for chronic thromboembolic pulmonary hypertension.

    Wiedenroth, Christoph B

    International journal of cardiology

    2018  Volume 278, Page(s) 238–239

    MeSH term(s) Angioplasty ; Endarterectomy ; Humans ; Hypertension, Pulmonary ; Lung
    Language English
    Publishing date 2018-12-29
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.12.067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pulmonary endarterectomy reoperation: frequency, risk factors and outcomes.

    Guth, Stefan / Wiedenroth, Christoph B / Mayer, Eckhard

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 2, Page(s) 166–168

    Language English
    Publishing date 2022-03-20
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-pte-140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Therapie der chronisch thromboembolischen pulmonalen Hypertonie

    Wiedenroth, Christoph B. / Mayer, Eckhard / Guth, Stefan

    Aktuelle Kardiologie

    2023  Volume 12, Issue 01, Page(s) 34–38

    Abstract: Die chronisch thromboembolische pulmonale Hypertonie (CTEPH) ist eine wichtige und oft gut behandelbare Form der pulmonalen Hypertonie. Es stehen aktuell 3 Therapiemodalitäten zur Verfügung: die pulmonale Endarteriektomie, die pulmonale ... ...

    Abstract Die chronisch thromboembolische pulmonale Hypertonie (CTEPH) ist eine wichtige und oft gut behandelbare Form der pulmonalen Hypertonie. Es stehen aktuell 3 Therapiemodalitäten zur Verfügung: die pulmonale Endarteriektomie, die pulmonale Ballonangioplastie und die gezielte medikamentöse Behandlung. Das therapeutische Konzept hängt maßgeblich von der Lokalisation der zugrunde liegenden pulmonalarteriellen fibrösen Obstruktionen ab. Die pulmonale Endarteriektomie ist der Goldstandard in der Behandlung der CTEPH. Für inoperable Patienten stehen mittlerweile 2 zugelassene Substanzen (Riociguat und Treprostinil) zur Verfügung. Daneben wird bei Vorhandensein entsprechender Zielgebiete die interventionelle Therapie empfohlen. Evaluation und Behandlung von CTEPH-Patienten sollte in entsprechend erfahrenen Zentren erfolgen.
    Keywords chronisch thromboembolische pulmonale Hypertonie ; pulmonale Endarteriektomie ; pulmonale Ballonangioplastie ; chronic thromboembolic pulmonary hypertension ; pulmonary endarterectomy ; balloon pulmonary angioplasty
    Language German
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2654127-0
    ISSN 2193-5211 ; 2193-5203
    ISSN (online) 2193-5211
    ISSN 2193-5203
    DOI 10.1055/a-1953-5670
    Database Thieme publisher's database

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  5. Article: Pulmonary endarterectomy: technique and pitfalls.

    Guth, Stefan / Mayer, Eckhard / Prüfer, Diethard / Wiedenroth, Christoph B

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 2, Page(s) 180–188

    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) remains a rare and underdiagnosed disease. After one or several episodes of acute pulmonary embolism, around 3% of patients develop CTEPH and two-thirds of these patients are potential surgical ... ...

    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) remains a rare and underdiagnosed disease. After one or several episodes of acute pulmonary embolism, around 3% of patients develop CTEPH and two-thirds of these patients are potential surgical candidates. Besides surgery, additional treatment modalities are pulmonary arterial hypertension medication and balloon pulmonary angioplasty. Patients should be evaluated in CTEPH expert centers to ensure the most appropriate therapy. Pulmonary endarterectomy (PEA) is a complex, but standardized surgical procedure aiming to clear the obstructed pulmonary arteries completely. For optimal visualization, deep hypothermic circulatory arrest is a prerequisite. This article will give an overview of the evaluation, indication and surgical management of patients with CTEPH.
    Language English
    Publishing date 2022-03-19
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-pte-185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Analysis of Electrocardiographic Criteria of Right Ventricular Hypertrophy in Patients with Chronic Thromboembolic Pulmonary Hypertension before and after Balloon Pulmonary Angioplasty.

    Ley, Lukas / Wiedenroth, Christoph B / Ghofrani, Hossein Ardeschir / Hoeltgen, Reinhard / Bandorski, Dirk

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background: Chronic thromboembolic pulmonary hypertension (CTEPH) may lead to typical electrocardiographic changes that can be reversed by balloon pulmonary angioplasty (BPA). The aim of this study was to investigate the significance of rarely used ... ...

    Abstract Background: Chronic thromboembolic pulmonary hypertension (CTEPH) may lead to typical electrocardiographic changes that can be reversed by balloon pulmonary angioplasty (BPA). The aim of this study was to investigate the significance of rarely used electrocardiogram (ECG) parameters, possible electrocardiographic differences between residual and significantly improved CTEPH and the role of electrocardiographic parameters in low mPAP (mean pulmonary arterial pressure) ranges since the mPAP threshold for the definition of pulmonary hypertension has recently been adjusted (≥25 mmHg to >20 mmHg).
    Material and methods: Between March 2014 and October 2020, 140 patients with CTEPH and 10 with CTEPD (chronic thromboembolic pulmonary disease) without pulmonary hypertension (PH) were retrospectively enrolled (12-lead ECG and right heart catheterization before and 6 months after BPA). The ECG parameters of right heart strain validated by studies and clinical experience were evaluated. Special attention was paid to six specific ECG parameters. After BPA, the cohort was divided into subgroups to investigate possible electrocardiographic differences with regard to the haemodynamic result.
    Results: The present study confirmed that the typical electrocardiographic signs of CTEPH can be found on an ECG, can regress after BPA and partially correlate well with haemodynamic parameters. "R V1, V2 + S I, aVL - S V1" was a parameter of particular note. BPA reduced its frequency (47% vs. 29%) statistically significantly after Bonferroni correction (
    Conclusion: "R V1, V2 + S I, aVL - S V1" seems to be able to support the diagnosis of CTEPH, indicate therapeutic improvement and estimate haemodynamics. It also seems capable of predicting a (persistent) severe disease with probably increased need for therapy and increased mortality. Mild PH has been observed to have either no or few mild ECG changes. This might complicate the (early) detection of PH.
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chronisch thromboembolische pulmonale Hypertonie.

    Adameit, Miriam S D / Wiedenroth, Christoph B / Omlor, Albert / Schäfers, Hans-Joachim / Guth, Stefan / Wilkens, Heinrike

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 23, Page(s) 1514–1523

    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease, but an important late sequela after acute pulmonary embolism. Therefore, follow-up after at least three months of sufficient anticoagulation is recommended. Patients with suspected ... ...

    Title translation Chronic thromboembolic pulmonary hypertension.
    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease, but an important late sequela after acute pulmonary embolism. Therefore, follow-up after at least three months of sufficient anticoagulation is recommended. Patients with suspected CTEPH should be referred to specialized CTEPH centers for further evaluation and treatment.Three treatment modalities are available: pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA) and pulmonary hypertension-targeted drugs. The indication for surgery depends mainly on the localization of the pulmonary arterial obstructions. Severe comorbidities as well as advanced age need individual evaluation, but do not present strict exclusion criteria. Multimodal treatments are common practice in inoperable CTEPH. However, treatment decision making in an experienced multidisciplinary team is mandatory.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Chronic Disease ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/therapy ; Pulmonary Artery ; Angioplasty, Balloon ; Endarterectomy
    Language German
    Publishing date 2023-11-10
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2012-0899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Chronic thromboembolic pulmonary hypertension-medical, interventional, and surgical therapy.

    Wiedenroth, Christoph B / Pruefer, Diethard / Adameit, Miriam S D / Mayer, Eckhard / Guth, Stefan

    Herz

    2023  Volume 48, Issue 4, Page(s) 280–284

    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is an important late sequela of pulmonary embolism and a common form of pulmonary hypertension. Currently, three specific treatment modalities are available: pulmonary endarterectomy, balloon ... ...

    Title translation Chronische thromboembolische pulmonale Hypertonie – medikamentöse, interventionelle und chirurgische Behandlung.
    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is an important late sequela of pulmonary embolism and a common form of pulmonary hypertension. Currently, three specific treatment modalities are available: pulmonary endarterectomy, balloon pulmonary angioplasty, and targeted medical therapy. The treatment decision depends mainly on the exact localization of the underlying pulmonary arterial obstructions. Pulmonary endarterectomy is the gold standard treatment of CTEPH. For inoperable patients, riociguat and treprostinil are approved. In addition, interventional therapy is recommended if appropriate target lesions are proven. Evaluation and treatment of patients with CTEPH in experienced centers are mandatory.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/surgery ; Chronic Disease ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/surgery ; Pulmonary Artery ; Angioplasty, Balloon/adverse effects
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    DOI 10.1007/s00059-023-05172-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chronisch thromboembolische pulmonale Hypertonie

    Adameit, Miriam S. D. / Wiedenroth, Christoph B. / Omlor, Albert / Schäfers, Hans-Joachim / Guth, Stefan / Wilkens, Heinrike

    DMW - Deutsche Medizinische Wochenschrift

    2023  Volume 148, Issue 23, Page(s) 1514–1523

    Keywords CTEPH ; CTEPD ; pulmonale Hypertonie ; PEA ; BPA ; CTEPH ; CTEPD ; pulmonary hypertension ; PEA ; BPA
    Language German
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2012-0899
    Database Thieme publisher's database

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  10. Article ; Online: Native hepatic T1-time as a non-invasive predictor of diastolic dysfunction and a monitoring tool for disease progression and treatment response in patients with pulmonary hypertension.

    Kremer, Nils / Roller, Fritz C / Kremer, Sarah / Schäfer, Simon / Kryvenko, Vitalii / Rako, Zvonimir A / Brito da Rocha, Bruno R / Yogeswaran, Athiththan / Seeger, Werner / Guth, Stefan / Wiedenroth, Christoph B / Tello, Khodr

    International journal of cardiology

    2024  , Page(s) 132189

    Abstract: Aims: Hepatic T1-time derived from cardiac magnetic resonance imaging (cMRI) reflects venous congestion and may provide a simple alternative to invasive end-diastolic elastance (Eed) for assessment of right ventricular (RV) diastolic function. We ... ...

    Abstract Aims: Hepatic T1-time derived from cardiac magnetic resonance imaging (cMRI) reflects venous congestion and may provide a simple alternative to invasive end-diastolic elastance (Eed) for assessment of right ventricular (RV) diastolic function. We investigated the association of native hepatic T1-time with single-beat Eed and the value of hepatic T1-time for longitudinal monitoring in pulmonary hypertension (PH).
    Methods and results: We retrospectively enrolled 85 patients with suspected PH (59% female; 78 with PH diagnosed; 7 with PH excluded) who underwent standard right heart catheterization and cMRI within 24 h between 2015 and 2020. Hepatic T1-time showed moderate to strong correlations (rho >0.3, P ≤ 0.002) with pulmonary vascular resistance, native myocardial T1-time, Eed, RV size and function, brain natriuretic peptide (BNP) level, and 6-min walk distance, and a significant association with functional class (Kruskal-Wallis P < 0.001). Eed, myocardial T1-time, and BNP were independently linked to hepatic T1-time in multivariable regression. Hepatic T1-time > 598 ms predicted elevated Eed with 72.9% sensitivity and 82.1% specificity. Hepatic T1-time was superior to Eed in predicting clinical worsening. In 16 patients with follow-up assessments, those with decreasing hepatic T1-time (7 patients) showed significant hemodynamic improvements, whereas those with increasing hepatic T1-time (9 patients) did not. In a second retrospective cohort of 27 patients with chronic thromboembolic PH undergoing balloon pulmonary angioplasty, hepatic T1-time decreased significantly and hemodynamics improved after the procedure.
    Conclusions: Hepatic T1-time predicts RV diastolic dysfunction and prognosis, and may be useful for monitoring disease progression and treatment response in PH.
    Language English
    Publishing date 2024-05-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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