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  1. AU="Wiegersma, Aline Marileen"
  2. AU=Mehta Yatin
  3. AU="Ki Hwan Kim"
  4. AU="Gulati, Rajiv"
  5. AU="Sullivan, Christopher"
  6. AU="Meier-Stephenson, Vanessa C"
  7. AU=Kim Joo Seop
  8. AU="Mortensen, Jennifer L"
  9. AU="Manthey, Helga D"
  10. AU="Baker, Susan"
  11. AU="Gunasegaram, James R"
  12. AU="Jung, Steffen"
  13. AU="Cairns, Anita"
  14. AU="Fox, Lindsay"

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  1. Artikel ; Online: Prenatal Exposure to the 1944-45 Dutch Famine and Risk for Dementia up to Age 75: An Analysis of Primary Care Data.

    Wiegersma, Aline Marileen / Boots, Amber / van Bussel, Emma F / Lissenberg, Birgit I / Nielen, Mark M J / Roseboom, Tessa J / de Rooij, Susanne R

    Current Alzheimer research

    2024  

    Abstract: Background: A poor prenatal environment adversely affects brain development. Studies investigating long-term consequences of prenatal exposure to the 1944-45 Dutch famine have shown that those exposed to famine in early gestation had poorer selective ... ...

    Abstract Background: A poor prenatal environment adversely affects brain development. Studies investigating long-term consequences of prenatal exposure to the 1944-45 Dutch famine have shown that those exposed to famine in early gestation had poorer selective attention, smaller brain volumes, poorer brain perfusion, older appearing brains, and increased reporting of cognitive problems, all indicative of increased dementia risk.
    Objective: In the current population-based study, we investigated whether dementia incidence up to age 75 was higher among individuals who had been prenatally exposed to famine.
    Methods: We included men (n=6,714) and women (n=7,051) from the Nivel Primary Care Database who had been born in seven cities affected by the Dutch famine. We used Cox regression to compare dementia incidence among individuals exposed to famine during late (1,231), mid (1,083), or early gestation (601) with those unexposed (born before or conceived after the famine).
    Results: We did not observe differences in dementia incidence for those exposed to famine in mid or early gestation compared to those unexposed. Men and women exposed to famine in late gestation had significantly lower dementia rates compared to unexposed individuals (HR 0.52 [95%CI 0.30-0.89]). Sex-specific analyses showed a lower dementia rate in women exposed to famine in late gestation (HR 0.39 [95%CI 0.17-0.86]) but not in men (HR 0.68 [95%CI 0.33-1.41]).
    Conclusion: Although prenatal exposure to the Dutch famine has previously been associated with measures of accelerated brain aging, the present population-based study did not show increased dementia incidence up to age 75 in those exposed to famine during gestation.
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/0115672050290699240422050036
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age.

    Wiegersma, Aline Marileen / Boots, Amber / Roseboom, Tessa J / de Rooij, Susanne R

    Nutrients

    2023  Band 15, Heft 2

    Abstract: People exposed to the 1944-1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer ... ...

    Abstract People exposed to the 1944-1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer cognitive functioning in older age and a higher rate of cognitive decline. We tested this hypothesis in the Dutch famine birth cohort in men and women combined and separately. We assessed cognitive function using a Stroop-like, trail-making and 15-word task (at ages 68 and 74) and the Montreal cognitive assessment as well as self-perceived cognitive problems (at age 74) in 73 men (
    Mesh-Begriff(e) Male ; Pregnancy ; Humans ; Female ; Aged ; Middle Aged ; Starvation/complications ; Famine ; Cohort Studies ; Malnutrition/complications ; Malnutrition/epidemiology ; Cognition ; Prenatal Exposure Delayed Effects ; Netherlands/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-01-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15020293
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age.

    Wiegersma, Aline Marileen / Boots, Amber / Roseboom, Tessa J / de Rooij, Susanne R

    BMC geriatrics

    2022  Band 22, Heft 1, Seite(n) 176

    Abstract: Background: Undernutrition during critical periods of neurodevelopment can hinder the developing brain with lasting negative consequences for brain size, structure and function. In this study, we describe self-perceived cognitive problems of men and ... ...

    Abstract Background: Undernutrition during critical periods of neurodevelopment can hinder the developing brain with lasting negative consequences for brain size, structure and function. In this study, we describe self-perceived cognitive problems of men and women who were born around the time of the Dutch famine of 1944-45.
    Methods: We compared self-perceived cognitive problems between men and women who had been exposed to the 1944-45 Dutch famine in late, mid or early gestation and those who were born before or conceived after the famine (and had thus not been exposed prenatally). We included 595 participants aged 71-74 years.
    Results: Women who had been exposed to famine in late gestation more often reported cognitive problems compared to those who had not been exposed (OR 2.2 [95% CI 1.1-4.4]), whereas for men, this was the case for those exposed in early gestation (OR 2.3 [0.9-5.5]). Furthermore, men and women exposed in early gestation more often reported consulting a healthcare practitioner for cognitive problems in the past 12 months (OR 3.2 [1.3-8.1]). Especially men exposed in early gestation reported having consulted a healthcare practitioner more often than unexposed men (OR 4.4 [1.2-16.0]).
    Conclusions: These findings suggest that prenatal undernutrition does not only have lasting effects on brain size, but also on its function, with more self-perceived cognitive problems at older age, which also require more medical attention. Also, the effects of undernutrition depend on sex and its timing during gestation.
    Mesh-Begriff(e) Aged ; Cognition ; Cohort Studies ; Famine ; Female ; Humans ; Male ; Netherlands/epidemiology ; Pregnancy ; Prenatal Exposure Delayed Effects/epidemiology ; Starvation/complications ; Starvation/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2022-03-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-02820-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Correction: Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age.

    Wiegersma, Aline Marileen / Boots, Amber / Roseboom, Tessa J / de Rooij, Susanne R

    BMC geriatrics

    2022  Band 22, Heft 1, Seite(n) 413

    Sprache Englisch
    Erscheinungsdatum 2022-05-10
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-03023-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia.

    Wiegersma, Aline Marileen / Boots, Amber / Langendam, Miranda W / Limpens, Jacqueline / Shenkin, Susan D / Korosi, Aniko / Roseboom, Tessa J / de Rooij, Susanne R

    Social psychiatry and psychiatric epidemiology

    2023  

    Abstract: Purpose: Prenatal factors such as maternal stress, infection and nutrition affect fetal brain development and may also influence later risk for dementia. The purpose of this systematic review was to provide an overview of all studies which investigated ... ...

    Abstract Purpose: Prenatal factors such as maternal stress, infection and nutrition affect fetal brain development and may also influence later risk for dementia. The purpose of this systematic review was to provide an overview of all studies which investigated the association between prenatal factors and later risk for dementia.
    Methods: We systematically searched MEDLINE and Embase for original human studies reporting on associations between prenatal factors and dementia from inception to 23 November 2022. Prenatal factors could be any factor assessed during pregnancy, at birth or postnatally, provided they were indicative of a prenatal exposure. Risk of bias was assessed using the Newcastle Ottawa Scale. We followed PRISMA guidelines for reporting.
    Results: A total of 68 studies met eligibility criteria (including millions of individuals), assessing maternal age (N = 30), paternal age (N = 22), birth order (N = 15), season of birth (N = 16), place of birth (N = 13), prenatal influenza pandemic (N = 1) or Chinese famine exposure (N = 1), birth characteristics (N = 3) and prenatal hormone exposure (N = 4). We observed consistent results for birth in a generally less optimal environment (e.g. high infant mortality area) being associated with higher dementia risk. Lower and higher birth weight and prenatal famine exposure were associated with higher dementia risk. The studies on season of birth, digit ratio, prenatal influenza pandemic exposure, parental age and birth order showed inconsistent results and were hampered by relatively high risk of bias.
    Conclusion: Our findings suggest that some prenatal factors, especially those related to a suboptimal prenatal environment, are associated with an increased dementia risk. As these associations may be confounded by factors such as parental socioeconomic status, more research is needed to examine the potential causal role of the prenatal environment in dementia.
    Sprache Englisch
    Erscheinungsdatum 2023-04-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 623071-4
    ISSN 1433-9285 ; 0037-7813 ; 0933-7954
    ISSN (online) 1433-9285
    ISSN 0037-7813 ; 0933-7954
    DOI 10.1007/s00127-023-02471-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders.

    Wiegersma, Aline Marileen / Dalman, Christina / Lee, Brian K / Karlsson, Håkan / Gardner, Renee M

    JAMA psychiatry

    2019  Band 76, Heft 12, Seite(n) 1294–1304

    Abstract: Importance: Given the critical role that iron plays in neurodevelopment, an association between prenatal iron deficiency and later risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder ( ... ...

    Abstract Importance: Given the critical role that iron plays in neurodevelopment, an association between prenatal iron deficiency and later risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID), is plausible.
    Objective: To test the a priori hypothesis that anemia diagnosed in mothers during pregnancy is associated with an increased risk of ASD, ADHD, and ID in offspring and that the magnitude of the risk varies with regard to the timing of anemia in pregnancy.
    Design, setting, and participants: This cohort study used health and population register data from the Stockholm Youth Cohort to evaluate 532 232 nonadoptive children born from January 1, 1987, to December 31, 2010, in Sweden, with follow-up in health registers until December 31, 2016. Data analysis was performed from January 15, 2018, to June 20, 2018.
    Exposures: Registered diagnoses of anemia during pregnancy. Gestational timing of the first recorded anemia diagnosis (≤30 weeks or >30 weeks) was considered to assess potential critical windows of development.
    Main outcomes and measures: Registered diagnoses of ASD, ADHD, or ID or co-occurring combinations of these disorders.
    Results: The cohort included 532 232 individuals (272 884 [51.3%] male) between 6 and 29 years of age at the end of follow-up (mean [SD] age, 17.6 [7.1] years) and their 299 768 mothers. The prevalence of ASD, ADHD, and ID was higher among children born to mothers diagnosed with anemia within the first 30 weeks of pregnancy (4.9% ASD, 9.3% ADHD, and 3.1% ID) compared with mothers with anemia diagnosed later in pregnancy (3.8% ASD, 7.2% ADHD, and 1.1% ID) or mothers not diagnosed with anemia (3.5% ASD, 7.1% ADHD, and 1.3% ID). Anemia diagnosed during the first 30 weeks of pregnancy but not later was associated with increased risk of diagnosis of ASD (odds ratio [OR], 1.44; 95% CI, 1.13-1.84), ADHD (OR, 1.37; 95% CI, 1.14-1.64), and ID (OR, 2.20; 95% CI, 1.61-3.01) in offspring in models that included socioeconomic, maternal, and pregnancy-related factors. Early anemia diagnosis was similarly associated with risk of ASD (OR, 2.25; 95% CI, 1.24-4.11) and ID (OR, 2.59; 95% CI, 1.08-6.22) in a matched sibling comparison. Considering mutually exclusive diagnostic groups, we observed the strongest association between anemia and ID without co-occurring ASD (OR, 2.72; 95% CI, 1.84-4.01). Associations of these disorders with anemia diagnosed later in pregnancy were greatly diminished.
    Conclusions and relevance: In contrast to maternal anemia diagnosed toward the end of pregnancy, anemia diagnosed earlier in pregnancy was associated with increased risk of the development of ASD, ADHD, and particularly ID in offspring. Given that iron deficiency and anemia are common among women of childbearing age, our findings emphasize the importance of early screening for iron status and nutritional counseling in antenatal care.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Anemia/epidemiology ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Autism Spectrum Disorder/epidemiology ; Child ; Cohort Studies ; Female ; Gestational Age ; Humans ; Intellectual Disability/epidemiology ; Middle Aged ; Mothers ; Pregnancy ; Pregnancy Complications, Hematologic/epidemiology ; Registries ; Risk ; Sweden/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2019-08-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2019.2309
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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