Article ; Online: Altered functional connectivity among frontal eye fields, thalamus and cerebellum in bipolar disorder.
2020 Volume 54, Issue 3, Page(s) 487–497
Abstract: Objectives: The aim of our study is to evaluate functional connectivity of cerebellothalamo-cortical networks linking frontal eye fields (FEF) and cerebellar regions associated with oculomotor control: nodulus (X), uvula (IX), flocculus (H X) and ... ...
Title translation | Zaburzenia połączeń funkcjonalnych między czołowymi polami okoruchowymi, wzgórzem a móżdżkiem w chorobie afektywnej dwubiegunowej. |
---|---|
Abstract | Objectives: The aim of our study is to evaluate functional connectivity of cerebellothalamo-cortical networks linking frontal eye fields (FEF) and cerebellar regions associated with oculomotor control: nodulus (X), uvula (IX), flocculus (H X) and ventral paraflocculus (H IX) in bipolar disorder (BD) with the use of resting state functional magnetic resonance imaging (rsfMRI). Methods: 19 euthymic BD patients and 14 healthy controls underwent rsfMRI examination. Functional connectivity between bilateral FEF, thalamus and cerebellar regions associated with oculomotor control was evaluated. Results: BD patients revealed decreased functional connectivity between following structures: right FEF and bilateral thalamus, flocculus (H X), uvula (IX); right thalamus and right FEF; between right flocculus (H X) and right FEF, left thalamus; between left thalamus and bilateral FEF and right flocculus (H X). Conclusions: BD patients presented decreased functional connectivity among FEF, thalamus and cerebellar structures associated with eye movements control. Oculomotor evaluation of BD patients assessed with rsfMRI may help to determine whether altered functional connectivity observed in our study is associated with eye movements deficits in BD. |
MeSH term(s) | Adult ; Bipolar Disorder/pathology ; Bipolar Disorder/physiopathology ; Case-Control Studies ; Female ; Frontal Lobe/pathology ; Frontal Lobe/physiopathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neural Pathways/pathology ; Thalamus/pathology ; Thalamus/physiopathology |
Language | Polish |
Publishing date | 2020-06-30 |
Publishing country | Poland |
Document type | Journal Article |
ZDB-ID | 415518-x |
ISSN | 2391-5854 ; 0033-2674 |
ISSN (online) | 2391-5854 |
ISSN | 0033-2674 |
DOI | 10.12740/PP/OnlineFirst/104445 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.B 374: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.