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  1. Book ; Online ; Thesis: Untersuchung einer potenziell immunmodulatorischen Wirkung von Moxifloxacin in der schweren murinen Pneumokokkenpneumonie

    Wienhold, Sandra-Maria

    2015  

    Title variant Investigation of potential immunomodulatory effects of moxifloxacin in severe murine pneumococcal pneumonia
    Author's details vorgelegt von Sandra-Maria Wienhold
    Language German
    Size Online-Ressource (PDF-Datei: XI, 120 S.), graph. Darst.
    Publisher Mensch und Buch Verl
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Freie Univ., Diss.--Berlin, 2015
    ISBN 9783863876234 ; 3863876237
    Database Special collection on veterinary medicine and general parasitology

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  2. Book ; Thesis: Untersuchung einer potenziell immunmodulatorischen Wirkung von Moxifloxacin in der schweren murinen Pneumokokkenpneumonie

    Wienhold, Sandra-Maria

    2015  

    Author's details vorgelegt von Sandra-Maria Wienhold
    Keywords Streptococcus pneumoniae ; Tiermodell ; Lungenentzündung ; Immunmodulation ; Moxifloxacin
    Language German
    Size XI, 120 S., graph. Darst, 21 cm
    Publisher Mensch-und-Buch-Verl
    Publishing place Berlin
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freie Univ., Diss.--Berlin, 2015
    ISBN 9783863876234 ; 3863876237
    Database Special collection on veterinary medicine and general parasitology

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  3. Article ; Online: Towards Inhaled Phage Therapy in Western Europe.

    Wienhold, Sandra-Maria / Lienau, Jasmin / Witzenrath, Martin

    Viruses

    2019  Volume 11, Issue 3

    Abstract: The emergence of multidrug-resistant bacteria constitutes a great challenge for modern medicine, recognized by leading medical experts and politicians worldwide. Rediscovery and implementation of bacteriophage therapy by Western medicine might be one ... ...

    Abstract The emergence of multidrug-resistant bacteria constitutes a great challenge for modern medicine, recognized by leading medical experts and politicians worldwide. Rediscovery and implementation of bacteriophage therapy by Western medicine might be one solution to the problem of increasing antibiotic failure. In some Eastern European countries phage therapy is used for treating infectious diseases. However, while the European Medicines Agency (EMA) advised that the development of bacteriophage-based therapies should be expedited due to its significant potential, EMA emphasized that phages cannot be recommended for approval before efficacy and safety have been proven by appropriately designed preclinical and clinical trials. More evidence-based data is required, particularly in the areas of pharmacokinetics, repeat applications, immunological reactions to the application of phages as well as the interactions and effects on bacterial biofilms and organ-specific environments. In this brief review we summarize advantages and disadvantages of phage therapy and discuss challenges to the establishment of phage therapy as approved treatment for multidrug-resistant bacteria.
    MeSH term(s) Administration, Inhalation ; Animals ; Bacteria/drug effects ; Bacteria/virology ; Bacterial Infections/therapy ; Bacteriophages/physiology ; Clinical Trials as Topic ; Drug Resistance, Multiple, Bacterial ; Europe ; Humans ; Mice ; Phage Therapy/methods
    Language English
    Publishing date 2019-03-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11030295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Untersuchung einer potenziell immunmodulatorischen Wirkung von Moxifloxa-cin in der schweren murinen Pneumokokkenpneumonie

    Wienhold, Sandra-Maria [Verfasser]

    2015  

    Author's details Sandra-Maria Wienhold
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language German
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia.

    Goekeri, Cengiz / Pennitz, Peter / Groenewald, Wibke / Behrendt, Ulrike / Kirsten, Holger / Zobel, Christian M / Berger, Sarah / Heinz, Gitta A / Mashreghi, Mir-Farzin / Wienhold, Sandra-Maria / Dietert, Kristina / Dorhoi, Anca / Gruber, Achim D / Scholz, Markus / Rohde, Gernot / Suttorp, Norbert / Capnetz Study Group / Witzenrath, Martin / Nouailles, Geraldine

    Cells

    2023  Volume 12, Issue 6

    Abstract: Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when ... ...

    Abstract Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when dysregulated. Here we aimed at understanding the role of microRNA-223 in orchestrating pulmonary inflammation during pneumococcal pneumonia. Serum microRNA-223 was measured in patients with pneumococcal pneumonia and in healthy subjects. Pulmonary inflammation in wild-type and microRNA-223-knockout mice was assessed in terms of disease course, histopathology, cellular recruitment and evaluation of inflammatory protein and gene signatures following pneumococcal infection. Low levels of serum microRNA-223 correlated with increased disease severity in pneumococcal pneumonia patients. Prolonged neutrophilic influx into the lungs and alveolar spaces was detected in pneumococci-infected microRNA-223-knockout mice, possibly accounting for aggravated histopathology and acute lung injury. Expression of microRNA-223 in wild-type mice was induced by pneumococcal infection in a time-dependent manner in whole lungs and lung neutrophils. Single-cell transcriptome analyses of murine lungs revealed a unique profile of antimicrobial and cellular maturation genes that are dysregulated in neutrophils lacking microRNA-223. Taken together, low levels of microRNA-223 in human pneumonia patient serum were associated with increased disease severity, whilst its absence provoked dysregulation of the neutrophil transcriptome in murine pneumococcal pneumonia.
    MeSH term(s) Animals ; Humans ; Mice ; Inflammation/genetics ; Inflammation/microbiology ; Inflammation/pathology ; Lung/pathology ; Mice, Knockout ; MicroRNAs/genetics ; Pneumonia, Pneumococcal/genetics ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/pathology ; Streptococcus pneumoniae
    Chemical Substances MicroRNAs ; MIRN223 microRNA, human ; MIRN223 microRNA, mouse
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12060959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Repetitive Exposure to Bacteriophage Cocktails against

    Weissfuss, Chantal / Wienhold, Sandra-Maria / Bürkle, Magdalena / Gaborieau, Baptiste / Bushe, Judith / Behrendt, Ulrike / Bischoff, Romina / Korf, Imke H E / Wienecke, Sarah / Dannheim, Antonia / Ziehr, Holger / Rohde, Christine / Gruber, Achim D / Ricard, Jean-Damien / Debarbieux, Laurent / Witzenrath, Martin / Nouailles, Geraldine

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern. In ... ...

    Abstract Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern. In this study, we investigated the innate and adaptive immune responses to two different phage cocktails targeting either
    MeSH term(s) Animals ; Mice ; Mice, Inbred C57BL ; Immunity, Humoral ; Pseudomonas aeruginosa ; Bacteriophages ; Escherichia coli
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.

    Dörner, Patrick J / Anandakumar, Harithaa / Röwekamp, Ivo / Fiocca Vernengo, Facundo / Millet Pascual-Leone, Belén / Krzanowski, Marta / Sellmaier, Josua / Brüning, Ulrike / Fritsche-Guenther, Raphaela / Pfannkuch, Lennart / Kurth, Florian / Milek, Miha / Igbokwe, Vanessa / Löber, Ulrike / Gutbier, Birgitt / Holstein, Markus / Heinz, Gitta Anne / Mashreghi, Mir-Farzin / Schulte, Leon N /
    Klatt, Ann-Brit / Caesar, Sandra / Wienhold, Sandra-Maria / Offermanns, Stefan / Mack, Matthias / Witzenrath, Martin / Jordan, Stefan / Beule, Dieter / Kirwan, Jennifer A / Forslund, Sofia K / Wilck, Nicola / Bartolomaeus, Hendrik / Heimesaat, Markus M / Opitz, Bastian

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2788

    Abstract: Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains incompletely ...

    Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains incompletely understood. Here, we demonstrate that antibiotic therapy in hospitalized patients is associated with decreased diversity of the gut microbiome and depletion of short-chain fatty acid (SCFA) producers. Infection experiments with mice transplanted with patient fecal material reveal that these antibiotic-induced microbiota perturbations impair pulmonary defense against MDR Klebsiella pneumoniae. This is dependent on inflammatory monocytes (IMs), whose fatty acid receptor (FFAR)2/3-controlled and phagolysosome-dependent antibacterial activity is compromized in mice transplanted with antibiotic-associated patient microbiota. Collectively, we characterize how clinically relevant antibiotics affect antimicrobial defense in the context of human microbiota, and reveal a critical impairment of IM´s antimicrobial activity. Our study provides additional arguments for the rational use of antibiotics and offers mechanistic insights for the development of novel prophylactic strategies to protect high-risk patients from HAP.
    MeSH term(s) Humans ; Mice ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Monocytes ; Anti-Infective Agents/pharmacology ; Klebsiella pneumoniae ; Lung
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47149-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia.

    Tabeling, Christoph / Wienhold, Sandra-Maria / Birnhuber, Anna / Brack, Markus C / Nouailles, Geraldine / Kershaw, Olivia / Firsching, Theresa C / Gruber, Achim D / Lienau, Jasmin / Marsh, Leigh M / Olschewski, Andrea / Kwapiszewska, Grazyna / Witzenrath, Martin

    American journal of physiology. Lung cellular and molecular physiology

    2021  Volume 320, Issue 5, Page(s) L916–L925

    Abstract: Idiopathic pulmonary fibrosis (IPF) is a deadly condition characterized by progressive respiratory dysfunction. Exacerbations due to airway infections are believed to promote disease progression, and presence ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is a deadly condition characterized by progressive respiratory dysfunction. Exacerbations due to airway infections are believed to promote disease progression, and presence of
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00505.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 2749: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Book ; Online: Supplementary scRNA data for manuscript "MicroRNA-223 dampens neutrophil-mediated lung inflammation during pneumococcal pneumonia" ; Regulation of acute lung inflammation by microRNA-223

    Gökeri, Cengiz / Pennitz, Peter / Groenewald, Wibke / Behrendt, Ulrike / Kirsten, Holger / Zobel, Christian M. / Berger, Sarah / Heinz, Gitta A. / Mashreghi, Mir-Farzin / Wienhold, Sandra-Maria / Dietert, Kristina / Gruber, Achim D. / Scholz, Markus / Rohde, Gernot / Suttorp, Norbert / CAPNETZ Study Group / Witzenrath, Martin / Nouailles, Geraldine

    2023  

    Keywords PhysicalObject ; ddc:570 ; microRNA-223 -- pneumonia -- Streptococcus pneumoniae -- inflammation
    Language English
    Publishing date 2023-01-31
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia

    Goekeri, Cengiz / Pennitz, Peter / Groenewald, Wibke / Behrendt, Ulrike / Kirsten, Holger / Zobel, Christian M. / Berger, Sarah / Heinz, Gitta A. / Mashreghi, Mir-Farzin / Wienhold, Sandra-Maria / Dietert, Kristina / Dorhoi, Anca / Gruber, Achim D. / Scholz, Markus / Rohde, Gernot / Suttorp, Norbert / CAPNETZ Study Group: / Witzenrath, Martin / Nouailles, Geraldine

    2023  

    Abstract: Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when ... ...

    Abstract Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when dysregulated. Here we aimed at understanding the role of microRNA-223 in orchestrating pulmonary inflammation during pneumococcal pneumonia. Serum microRNA-223 was measured in patients with pneumococcal pneumonia and in healthy subjects. Pulmonary inflammation in wild-type and microRNA-223-knockout mice was assessed in terms of disease course, histopathology, cellular recruitment and evaluation of inflammatory protein and gene signatures following pneumococcal infection. Low levels of serum microRNA-223 correlated with increased disease severity in pneumococcal pneumonia patients. Prolonged neutrophilic influx into the lungs and alveolar spaces was detected in pneumococci-infected microRNA-223-knockout mice, possibly accounting for aggravated histopathology and acute lung injury. Expression of microRNA-223 in wild-type mice was induced by pneumococcal infection in a time-dependent manner in whole lungs and lung neutrophils. Single-cell transcriptome analyses of murine lungs revealed a unique profile of antimicrobial and cellular maturation genes that are dysregulated in neutrophils lacking microRNA-223. Taken together, low levels of microRNA-223 in human pneumonia patient serum were associated with increased disease severity, whilst its absence provoked dysregulation of the neutrophil transcriptome in murine pneumococcal pneumonia.
    Keywords Text ; ddc:570 ; microRNA-223 -- pneumonia -- Streptococcus pneumoniae -- neutrophils -- inflammation
    Subject code 610
    Language English
    Publishing date 2023-03-21
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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