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  1. Book ; Thesis: Zytokinprofil (IL-6,IL-8,IL10,IL-15,TGF-beta1,HGF) von Alveolarmakrophagen bei Patienten mit Pneumonie und Patienten mit chronisch-obstruktiver Lungenerkrankungen

    Wiesner, Olaf

    2001  

    Author's details vorgelegt von Olaf Wiesner
    Language German
    Size 108 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Magdeburg, Univ., Diss., 2002
    HBZ-ID HT013440407
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 3596 order for loan Magazin

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  2. Article ; Online: Therapie schwerer COVID-19-Verläufe in der Intensivmedizin.

    Wiesner, O / Busch, M / David, S

    Der Internist

    2020  Volume 61, Issue 8, Page(s) 804–812

    Abstract: The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention. The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of ... ...

    Title translation Treatment of severe COVID-19 courses in intensive care medicine.
    Abstract The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention. The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of intensive medical care end. In the routine intensive medical care practice, the challenges due to the special features of infections with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its treatment become obvious. These occur in the development and treatment of respiratory and multiorgan failure as well as the severe inflammatory syndrome. For these severe courses there is still only little evidence available as to which interventions are the most effective. In addition to the knowledge that can be gained from the rapid performance of clinical trials, the treatment is therefore based on analogies to other syndromes, such as sepsis and macrophage activation syndrome.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Critical Care ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language German
    Publishing date 2020-07-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-020-00850-9
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  3. Article: Therapie schwerer COVID-19-Verläufe in der Intensivmedizin.

    Busch, M / Wiesner, O / David, S

    Der Gastroenterologe : Zeitschrift fur Gastroenterologie und Hepatologie

    2020  Volume 15, Issue 6, Page(s) 477–486

    Abstract: The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention. The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of ... ...

    Title translation Treatment of severe COVID-19 courses in intensive care medicine.
    Abstract The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention. The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of intensive medical care end. In the routine intensive medical care practice, the challenges due to the special features of infections with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its treatment become obvious. These occur in the development and treatment of respiratory and multiorgan failure as well as the severe inflammatory syndrome. For these severe courses there is still only little evidence available as to which interventions are the most effective. In addition to the knowledge that can be gained from the rapid performance of clinical trials, the treatment is therefore based on analogies to other syndromes, such as sepsis and macrophage activation syndrome.
    Keywords covid19
    Language German
    Publishing date 2020-10-15
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2240307-3
    ISSN 1861-969X ; 1861-9681
    ISSN (online) 1861-969X
    ISSN 1861-9681
    DOI 10.1007/s11377-020-00478-z
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  4. Article ; Online: Fomepizol, Ethanol oder Dialyse bei lebensbedrohlicher Ethylenglykolvergiftung?

    Drick, N / Schmidt, J J / Wiesner, O / Kielstein, J T

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2020  Volume 116, Issue 8, Page(s) 698–701

    Abstract: The EXTRIP (EXtracorporeal Treatments In Poisoning) workgroup is a collaborative international effort of pharmacologists, toxicologists, critical care physicians and nephrologists reviewing all available evidence in extracorporeal procedures for the ... ...

    Title translation Fomepizole, ethanol or dialysis in the case of life-threatening ethylenglycol intoxication?
    Abstract The EXTRIP (EXtracorporeal Treatments In Poisoning) workgroup is a collaborative international effort of pharmacologists, toxicologists, critical care physicians and nephrologists reviewing all available evidence in extracorporeal procedures for the treatment of intoxications in a standardized way to distill treatment recommendations for the physician at the bedside. The second round of guidelines will include recommendations for ethylenglycol intoxication. The case reported here is of a 60-year old man with a body weight of 65 kg who ingested approximately half a bottle (500 mL) of Aral Antifreeze in a suicidal attempt and presented around 12 h later with severe metabolic acidosis (venous blood gas analysis: pH 7.13; lactate 30 mmol/l, anion gap 23.3 mmol/l). As fomepizole, the inhibitor of the alcohol dehydrogenase, was not readily available, therapy with intermittent hemodialysis was started, as well as ethanol infusion. The first available ethylenglycol concentration before prolonged intermittent hemodialysis was 1230 mg/L. The total removed amount of ethylenglycol during intermittent hemodialysis, as well as following prolonged intermittent renal replacement therapy, was quantified (102 and 65 g). Based on this case report, the new EXRIP recommendations for the role of extracorporeal treatment in the case of ethylenglycol intoxication are discussed.
    MeSH term(s) Critical Care ; Ethanol ; Fomepizole ; Humans ; Male ; Middle Aged ; Renal Dialysis ; Suicide, Attempted
    Chemical Substances Ethanol (3K9958V90M) ; Fomepizole (83LCM6L2BY)
    Language German
    Publishing date 2020-08-20
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-020-00718-8
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  5. Article ; Online: Das hypoxämische Lungenversagen.

    David, S / Wiesner, O

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2016  Volume 111, Issue 3, Page(s) 186–195

    Abstract: Hypoxic lung failure is among the major indications for patients' referral to intensive care units either for surveillance or if necessary therapy. There are a vast number of pathophysiological causes of lung failure and the optimal treatment highly ... ...

    Title translation Hypoxic lung failure.
    Abstract Hypoxic lung failure is among the major indications for patients' referral to intensive care units either for surveillance or if necessary therapy. There are a vast number of pathophysiological causes of lung failure and the optimal treatment highly depends on the underlying pathology; therefore, no standard algorithm exists. So-called acute respiratory distress syndrome (ARDS) represents a very severe manifestation of hypoxemic lung failure that is of particular relevance for intensivists and is therefore the focus of this review. In addition to fundamental pathophysiology of lung injury, the article also focuses on established and modern treatment strategies. Moreover, we will briefly highlight innovative concepts of ARDS treatment that might become relevant in the future.
    MeSH term(s) Adult ; Critical Care/methods ; Humans ; Hypercapnia/etiology ; Hypercapnia/physiopathology ; Hypercapnia/therapy ; Hypoxia/etiology ; Hypoxia/physiopathology ; Hypoxia/therapy ; Infant ; Middle Aged ; Oxygen Inhalation Therapy/methods ; Pulmonary Gas Exchange/physiology ; Respiration, Artificial/methods ; Respiratory Distress Syndrome, Adult/etiology ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/therapy ; Ventilation-Perfusion Ratio/physiology
    Language German
    Publishing date 2016-03-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-016-0146-z
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  6. Article: [Treatment of severe COVID-19 courses in intensive care medicine]

    Busch, M. / Wiesner, O. / David, S.

    Gastroenterologe

    Abstract: The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of ... ...

    Abstract The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of intensive medical care end In the routine intensive medical care practice, the challenges due to the special features of infections with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its treatment become obvious These occur in the development and treatment of respiratory and multiorgan failure as well as the severe inflammatory syndrome For these severe courses there is still only little evidence available as to which interventions are the most effective In addition to the knowledge that can be gained from the rapid performance of clinical trials, the treatment is therefore based on analogies to other syndromes, such as sepsis and macrophage activation syndrome Publisher: Abstract available from the publisher ger
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #882400
    Database COVID19

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  7. Article: Therapie schwerer COVID-19-Verläufe in der Intensivmedizin./ [Treatment of severe COVID-19 courses in intensive care medicine]

    Wiesner, O / Busch, M / David, S

    Internist (Berl)

    Abstract: The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention. The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of ... ...

    Abstract The pandemic triggered by coronavirus disease 2019 (COVID-19) has put intensive care medicine into the focus of public attention. The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of intensive medical care end. In the routine intensive medical care practice, the challenges due to the special features of infections with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its treatment become obvious. These occur in the development and treatment of respiratory and multiorgan failure as well as the severe inflammatory syndrome. For these severe courses there is still only little evidence available as to which interventions are the most effective. In addition to the knowledge that can be gained from the rapid performance of clinical trials, the treatment is therefore based on analogies to other syndromes, such as sepsis and macrophage activation syndrome.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #710552
    Database COVID19

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  8. Article ; Online: Therapie schwerer COVID-19-Verläufe in der Intensivmedizin

    Wiesner, O. / Busch, M. / David, S.

    Der Internist

    2020  Volume 61, Issue 8, Page(s) 804–812

    Keywords Internal Medicine ; covid19
    Language German
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-020-00850-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Conference proceedings: Dimethyl fumarate (DMF) inhibits proliferation and induce specific cell death in hepatocellular carcinoma (HCC)

    Michalski, M / Wiesner, O / Müller-Schilling, M / Gülow, K

    Zeitschrift für Gastroenterologie

    2021  Volume 59, Issue 01

    Event/congress 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Münster, 2021-01-29
    Language English
    Publishing date 2021-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0040-1722062
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  10. Article ; Conference proceedings: Dimethyfumarat (DMF) Behandlung inhibiert Proliferation und Migration von hepatozellulären Karzinom-Zelllinien

    Michalski, M / Wiesner, O / Müller-Schilling, M / Gülow, K

    Zeitschrift für Gastroenterologie

    2021  Volume 59, Issue 06

    Event/congress 48. Jahrestagung der Gesellschaft für Gastroenterologie in Bayern e.V. Information und Programm: www.gfgb.org, virtuell, 2021-07-01
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0040-1705781
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