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  1. Article ; Online: „Und Zebras gibt es doch!“ : Pulmonale Nokardiose: Fallserie und Übersicht.

    Schröder, Julia / Calligaris-Maibach, Romana / Beer, Hans-Jürg / Wiggli, Benedikt

    Innere Medizin (Heidelberg, Germany)

    2023  Volume 65, Issue 3, Page(s) 286–289

    Abstract: Nocardiosis is a rare disease that occurs primarily in patients with predisposing factors (immunosuppression/chronic lung disease). It is caused by aerobic, Gram-positive bacteria that are ubiquitous in soil. Cutaneous and pulmonary manifestations are ... ...

    Title translation "And zebras do exist after all"! : Pulmonary nocardiosis: case series and overview.
    Abstract Nocardiosis is a rare disease that occurs primarily in patients with predisposing factors (immunosuppression/chronic lung disease). It is caused by aerobic, Gram-positive bacteria that are ubiquitous in soil. Cutaneous and pulmonary manifestations are most common, but disseminated forms also occur. In terms of treatment, long-term antibiotic therapy is usually necessary. The prognosis for the cutaneous or pulmonary form is generally good.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Lung Diseases/diagnosis ; Nocardia Infections/diagnosis
    Chemical Substances Anti-Bacterial Agents
    Language German
    Publishing date 2023-08-07
    Publishing country Germany
    Document type Case Reports ; English Abstract ; Journal Article ; Review
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-023-01566-2
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  2. Article ; Online: A rare and dangerous hand infection caused by Francisella tularensis after a mouse bite.

    Mijuskovic, Barbara / Wiggli, Benedikt / Kaempfen, Alexandre

    The Journal of hand surgery, European volume

    2018  Volume 43, Issue 8, Page(s) 891–893

    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Bites and Stings/complications ; Debridement ; Hand/microbiology ; Hand/surgery ; Hospitalization ; Humans ; Infusions, Intravenous ; Male ; Mice/microbiology ; Piperacillin ; Soft Tissue Infections/microbiology ; Soft Tissue Infections/therapy ; Tazobactam ; Tularemia/diagnosis ; Tularemia/drug therapy ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; Tazobactam (SE10G96M8W) ; Piperacillin (X00B0D5O0E)
    Language English
    Publishing date 2018-04-02
    Publishing country England
    Document type Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193418769023
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  3. Article ; Online: Analysis of Diagnostic Modalities in Hospital-admitted Patients Evaluated for COVID-19.

    Gereke, Benedict / Friedl, Andree / Niemann, Tilo / Calligaris-Maibach, Romana / Schmid, Hans-Rudolf / Vanetta, Chiara / Rutishauser, Jonas / Wiggli, Benedikt

    In vivo (Athens, Greece)

    2022  Volume 36, Issue 3, Page(s) 1316–1324

    Abstract: Background/aim: To assess the diagnostic performance of reverse transcriptase polymerase chain reaction (RT-PCR), low-dose chest computed tomography (CT), and serological testing, alone and in combinations, as well as routine inflammatory markers in ... ...

    Abstract Background/aim: To assess the diagnostic performance of reverse transcriptase polymerase chain reaction (RT-PCR), low-dose chest computed tomography (CT), and serological testing, alone and in combinations, as well as routine inflammatory markers in patients evaluated for COVID-19 during the first wave in early 2020.
    Patients and methods: We retrospectively analyzed data of all patients who were admitted to the emergency department due to fever and/or respiratory symptoms. CT scans were rated using the COVID-19 Reporting and Data System (CO-RADS) suspicion score. True disease status (COVID-19 - positive vs. negative) was adjudicated by two independent clinicians. Receiver-operating characteristic curves and areas under the curves were calculated for inflammatory markers. Sensitivities and specificities were calculated for RT-PCR, CT, and serology alone, as well as the combinations of RT-PCR+CT, RT-PCR+serology, CT+serology, and all three modalities.
    Results: Of 221 patients with a median age of 72 years, 113 were classified as COVID-19 positive. Among 180 patients from which data on CT and RT-PCR were available, RT-PCR had the highest sensitivity to detect COVID-19 (0.87; 95%CI=0.78-0.93). Notably, the addition of CT in the analysis increased sensitivity to 0.89 (95%CI=0.8-0.94), but lowered specificity from 1 (95%CI=0.96-1) to 0.9 (95%CI=0.83-0.95). The combination of RT-PCR, CT and serology (n=60 patients with complete dataset) yielded a sensitivity of 0.83 (95%CI=0.61-0.94) and specificity of 0.86 (95%CI=0.72-0.93).
    Conclusion: RT-PCR was the best single test in patients evaluated for COVID-19. Conversely, the routine performance of chest CT adds little sensitivity and decreases specificity.
    MeSH term(s) Aged ; COVID-19/diagnosis ; Hospitalization ; Hospitals ; Humans ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2022-04-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12832
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  4. Article ; Online: Early recognition of thiamine deficiency: ocular motor deficits in a patient with nutritional deprivation due to persistent antibiotic-related nausea.

    Wiggli, Benedikt / Kapitza, Sandra / Ahlhelm, Frank / Tarnutzer, Alexander A

    Infection

    2019  Volume 48, Issue 1, Page(s) 137–140

    Abstract: Case description: A 73-year-old male presented with new onset dizziness and a 22-kg weight loss due to antibiotic-induced nausea/vomiting. Due to gaze-evoked nystagmus (GEN), thiamine deficiency was suspected. Within 12 h after replacement, his GEN ... ...

    Abstract Case description: A 73-year-old male presented with new onset dizziness and a 22-kg weight loss due to antibiotic-induced nausea/vomiting. Due to gaze-evoked nystagmus (GEN), thiamine deficiency was suspected. Within 12 h after replacement, his GEN decreased.
    Conclusion: In patients with nutritional deprivation, new onset GEN should prompt further diagnostics and immediate thiamine supplementation to avoid disease progression.
    MeSH term(s) Aged ; Anti-Bacterial Agents/adverse effects ; Humans ; Male ; Malnutrition/etiology ; Nausea/chemically induced ; Nausea/complications ; Nystagmus, Pathologic/chemically induced ; Thiamine Deficiency/chemically induced ; Thiamine Deficiency/diagnosis ; Thiamine Deficiency/therapy ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-10-12
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-019-01363-w
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  5. Article: Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19.

    Jurisic, Stjepan / Komminoth, Mathis / Todorov, Atanas / Bertschi, Daniela A / Jurisic, Martin / Vranjic, Ivica / Wiggli, Benedikt / Schmid, Hansruedi / Gebhard, Catherine / Gebhard, Caroline E / Heidecker, Bettina / Beer, Jürg-Hans / Patriki, Dimitri

    Journal of clinical medicine

    2023  Volume 12, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12082925
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  6. Article ; Online: Detection and characterization of COVID-19 findings in chest CT: Feasibility and applicability of an AI-based software tool.

    Gashi, Andi / Kubik-Huch, Rahel A / Chatzaraki, Vasiliki / Potempa, Anna / Rauch, Franziska / Grbic, Sasa / Wiggli, Benedikt / Friedl, Andrée / Niemann, Tilo

    Medicine

    2021  Volume 100, Issue 41, Page(s) e27478

    Abstract: Abstract: The COVID-19 pandemic has challenged institutions' diagnostic processes worldwide. The aim of this study was to assess the feasibility of an artificial intelligence (AI)-based software tool that automatically evaluates chest computed ... ...

    Abstract Abstract: The COVID-19 pandemic has challenged institutions' diagnostic processes worldwide. The aim of this study was to assess the feasibility of an artificial intelligence (AI)-based software tool that automatically evaluates chest computed tomography for findings of suspected COVID-19.Two groups were retrospectively evaluated for COVID-19-associated ground glass opacities of the lungs (group A: real-time polymerase chain reaction positive COVID patients, n = 108; group B: asymptomatic pre-operative group, n = 88). The performance of an AI-based software assessment tool for detection of COVID-associated abnormalities was compared with human evaluation based on COVID-19 reporting and data system (CO-RADS) scores performed by 3 readers.All evaluated variables of the AI-based assessment showed significant differences between the 2 groups (P < .01). The inter-reader reliability of CO-RADS scoring was 0.87. The CO-RADS scores were substantially higher in group A (mean 4.28) than group B (mean 1.50). The difference between CO-RADS scoring and AI assessment was statistically significant for all variables but showed good correlation with the clinical context of the CO-RADS score. AI allowed to predict COVID positive cases with an accuracy of 0.94.The evaluated AI-based algorithm detects COVID-19-associated findings with high sensitivity and may support radiologic workflows during the pandemic.
    MeSH term(s) Aged ; Aged, 80 and over ; Artificial Intelligence/standards ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Nucleic Acid Testing/standards ; Feasibility Studies ; Female ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Middle Aged ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000027478
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  7. Article ; Online: Preoperative chest computed tomography in emergency surgery during COVID-19 pandemic.

    Chatzaraki, Vasiliki / Kubik-Huch, Rahel A / Potempa, Anna / Gashi, Andi / Friedl, Andrée / Heesen, Michael / Wiggli, Benedikt / Nocito, Antonio / Niemann, Tilo

    Journal of perioperative practice

    2021  , Page(s) 17504589211024405

    Abstract: Background: The COVID-19 pandemic challenges the recommendations for patients' preoperative assessment for preventing severe acute respiratory syndrome coronavirus type 2 transmission and COVID-19-associated postoperative complications and morbidities.!# ...

    Abstract Background: The COVID-19 pandemic challenges the recommendations for patients' preoperative assessment for preventing severe acute respiratory syndrome coronavirus type 2 transmission and COVID-19-associated postoperative complications and morbidities.
    Purpose: To evaluate the contribution of chest computed tomography for preoperatively assessing patients who are not suspected of being infected with COVID-19 at the time of referral.
    Methods: Candidates for emergency surgery screened via chest computed tomography from 8 to 27 April 2020 were retrospectively evaluated. Computed tomography images were analysed for the presence of COVID-19-associated intrapulmonary changes. When applicable, laboratory and recorded clinical symptoms were extracted.
    Results: Eighty-eight patients underwent preoperative chest computed tomography; 24% were rated as moderately suspicious and 11% as highly suspicious on computed tomography. Subsequent reverse transcription polymerase chain reaction (RT-PCR) was performed for seven patients, all of whom tested negative for COVID-19. Seven patients showed COVID-19-associated clinical symptoms, and most were classified as being mildly to moderately severe as per the clinical classification grading system. Only one case was severe. Four cases underwent RT-PCR with negative results.
    Conclusion: In a cohort without clinical suspicion of COVID-19 infection upon referral, preoperative computed tomography during the COVID-19 pandemic can yield a high suspicion of infection, even if the patient lacks clinical symptoms and is RT-PCR-negative. No recommendations can be made based on our results but contribute to the debate.
    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2226186-2
    ISSN 2515-7949 ; 1750-4589
    ISSN (online) 2515-7949
    ISSN 1750-4589
    DOI 10.1177/17504589211024405
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  8. Article ; Online: Prediction of Patient Management in COVID-19 Using Deep Learning-Based Fully Automated Extraction of Cardiothoracic CT Metrics and Laboratory Findings.

    Weikert, Thomas / Rapaka, Saikiran / Grbic, Sasa / Re, Thomas / Chaganti, Shikha / Winkel, David J / Anastasopoulos, Constantin / Niemann, Tilo / Wiggli, Benedikt J / Bremerich, Jens / Twerenbold, Raphael / Sommer, Gregor / Comaniciu, Dorin / Sauter, Alexander W

    Korean journal of radiology

    2021  Volume 22, Issue 6, Page(s) 994–1004

    Abstract: Objective: To extract pulmonary and cardiovascular metrics from chest CTs of patients with coronavirus disease 2019 (COVID-19) using a fully automated deep learning-based approach and assess their potential to predict patient management.: Materials ... ...

    Abstract Objective: To extract pulmonary and cardiovascular metrics from chest CTs of patients with coronavirus disease 2019 (COVID-19) using a fully automated deep learning-based approach and assess their potential to predict patient management.
    Materials and methods: All initial chest CTs of patients who tested positive for severe acute respiratory syndrome coronavirus 2 at our emergency department between March 25 and April 25, 2020, were identified (n = 120). Three patient management groups were defined: group 1 (outpatient), group 2 (general ward), and group 3 (intensive care unit [ICU]). Multiple pulmonary and cardiovascular metrics were extracted from the chest CT images using deep learning. Additionally, six laboratory findings indicating inflammation and cellular damage were considered. Differences in CT metrics, laboratory findings, and demographics between the patient management groups were assessed. The potential of these parameters to predict patients' needs for intensive care (yes/no) was analyzed using logistic regression and receiver operating characteristic curves. Internal and external validity were assessed using 109 independent chest CT scans.
    Results: While demographic parameters alone (sex and age) were not sufficient to predict ICU management status, both CT metrics alone (including both pulmonary and cardiovascular metrics; area under the curve [AUC] = 0.88; 95% confidence interval [CI] = 0.79-0.97) and laboratory findings alone (C-reactive protein, lactate dehydrogenase, white blood cell count, and albumin; AUC = 0.86; 95% CI = 0.77-0.94) were good classifiers. Excellent performance was achieved by a combination of demographic parameters, CT metrics, and laboratory findings (AUC = 0.91; 95% CI = 0.85-0.98). Application of a model that combined both pulmonary CT metrics and demographic parameters on a dataset from another hospital indicated its external validity (AUC = 0.77; 95% CI = 0.66-0.88).
    Conclusion: Chest CT of patients with COVID-19 contains valuable information that can be accessed using automated image analysis. These metrics are useful for the prediction of patient management.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Automation ; COVID-19/diagnosis ; COVID-19/diagnostic imaging ; COVID-19/virology ; Deep Learning ; Female ; Humans ; Logistic Models ; Lung/physiopathology ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Thorax/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2021-02-24
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2020.0994
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  9. Article ; Online: Survival from methicillin-sensitive Staphylococcus aureus bloodstream infections over 20 years: a cohort of 1328 patients.

    Wiggli, Benedikt J / Frei, Reno / Laffer, Reto / Tschudin Sutter, Sarah / Widmer, Andreas F-X

    Swiss medical weekly

    2017  Volume 147, Page(s) w14508

    Abstract: Purpose: Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding ... ...

    Abstract Purpose: Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MSSA) strains. In the unusual setting of a very low MRSA prevalence institution, we investigated incidence, mortality and trends of BSI caused by MSSA over the last 20 years.
    Objective: To evaluate and demonstrate trends in incidence and mortality of MSSA BSI as well as risk factors for mortality.
    Methods: Retrospective, observational analysis of the prospective bloodstream infection cohort at the University Hospital Basel between January 1993 and December 2013. All patients with blood cultures positive for MSSA were included. All patients were analysed regarding pertinent demographic, clinical and antimicrobial treatment data. We calculated incidence, temporal trends and mortality of MSSA BSI.
    Results: 1328 episodes of MSSA BSI were identified, accounting for a yearly incidence ranging from 2.1 to 4.5 per 10 000 patient-days (p = 0.2 for trend). Overall mortality was 19.3% and did not improve over time. Community-acquired MSSA BSI significantly increased over time, while nosocomial cases decreased (p <0.05).
    Conclusions: Mortality related to MSSA BSI remains high and unchanged over the last 20 years. Despite advances in treatment and supportive care in medicine during the last 20 years survival did not improve and, therefore, new approaches are required to lower mortality in MSSA BSI.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cross Infection/prevention & control ; Hospital Mortality ; Hospitals ; Humans ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Prospective Studies ; Risk Factors ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Switzerland/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2017.14508
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  10. Article ; Online: Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

    Kohler, Philipp / Babouee Flury, Baharak / Güsewell, Sabine / Egger, Thomas / Leal, Onicio / Brucher, Angela / Lemmenmeier, Eva / Meier Kleeb, Dorette / Möller, J Carsten / Ortner, Manuela / Rieder, Philip / Ruetti, Markus / Schmid, Hans-Ruedi / Stocker, Reto / Vuichard-Gysin, Danielle / Speer, Oliver / Wiggli, Benedikt / Besold, Ulrike / McGeer, Allison /
    Risch, Lorenz / Friedl, Andrée / Schlegel, Matthias / Vernazza, Pietro / Kahlert, Christian R / Kuster, Stefan P

    Influenza and other respiratory viruses

    2023  Volume 17, Issue 6, Page(s) e13167

    Abstract: The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid ... ...

    Abstract The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.
    MeSH term(s) Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; Breakthrough Infections ; Dizziness ; Prospective Studies ; Vaccination ; Health Personnel ; Pain ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.13167
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