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  1. Article ; Online: The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators.

    van Zeelst, L J / Derksen, R / Wijers, C H W / Hegeman, J / Berry, R / de Wilt, J H W / Strobbe, L J A

    The breast journal

    2022  Volume 2022, Page(s) 1863519

    Abstract: Background: The rate of inpatient mastectomies remains high despite multiple studies reporting favourably on outpatient mastectomies. Outpatient mastectomies do not compromise quality of patient care and are more efficient than inpatient care. The ... ...

    Abstract Background: The rate of inpatient mastectomies remains high despite multiple studies reporting favourably on outpatient mastectomies. Outpatient mastectomies do not compromise quality of patient care and are more efficient than inpatient care. The objective of this study was to evaluate the feasibility of outpatient mastectomy.
    Materials and methods: Implementation of an outpatient mastectomy program was evaluated in a retrospective study. All patients who underwent mastectomy between January 2019 and September 2021 were included.
    Results: 213 patients were enrolled in the study: 62.4% (
    Conclusions: Outpatient mastectomy is shown to be feasible and safe with a steady increase during the study period. A barrier to outpatient mastectomy was bilateral mastectomy. Incidence of unplanned return to care or complications did not differ significantly between the outpatient and inpatient cohorts.
    MeSH term(s) Breast Neoplasms/surgery ; COVID-19 ; Female ; Humans ; Mastectomy ; Outpatients ; Retrospective Studies
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1155/2022/1863519
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4483: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Haemorrhagic stroke related to the use of 4-fluoroamphetamine.

    Wijers, C H W / Visser, M C / van Litsenburg, R T H / Niesink, R J M / Willemse, R B / Croes, Esther A

    Journal of neurology

    2018  Volume 265, Issue 7, Page(s) 1607–1611

    Abstract: Introduction: The use of the new psychoactive substance 4-fluoroamphetamine (4-FA) and the number of 4-FA-related intoxications substantially increased in The Netherlands in recent years. We describe two patients with severe 4-FA-related complications ... ...

    Abstract Introduction: The use of the new psychoactive substance 4-fluoroamphetamine (4-FA) and the number of 4-FA-related intoxications substantially increased in The Netherlands in recent years. We describe two patients with severe 4-FA-related complications and the characteristics of a large sample of 4-FA-intoxicated patients.
    Methods: Information on patients with 4-FA-related intoxications between January 2009 and June 2017 was available from the Monitor Drug-related Incidents. Detailed clinical information was obtained of two patients with haemorrhagic stroke after toxicologically confirmed 4-FA use.
    Results: We report on two patients who presented with headache and mild hypertension after 4-FA use. Patient A developed one-sided weakness and decreased consciousness after a few hours. A computed tomography scan showed a left-sided intracerebral haemorrhage. Because of life-threatening cerebral herniation, haematoma evacuation was performed. Postoperatively, she suffered from a right-sided hemiparalysis and severe aphasia, requiring clinical rehabilitation. Patient B had a subarachnoid haemorrhage without neurological deficits. In total, 939 4-FA-intoxicated patients were registered. These patients used 4-FA alone (44%) or in combination with alcohol (13%) and/or other drugs (43%).
    Discussion: Patients using 4-FA are at risk for life-threatening health problems, including intracranial haemorrhage. Additional brain imaging should be considered in 4-FA-intoxicated patients, not only in the presence of neurological deficits, but also in the case of severe headache.
    MeSH term(s) Adolescent ; Adult ; Amphetamines/adverse effects ; Female ; Frontal Lobe/diagnostic imaging ; Humans ; Intracranial Hemorrhages/chemically induced ; Intracranial Hemorrhages/complications ; Intracranial Hemorrhages/diagnostic imaging ; Intracranial Hemorrhages/epidemiology ; Male ; Retrospective Studies ; Street Drugs/adverse effects ; Stroke/chemically induced ; Stroke/complications ; Stroke/diagnostic imaging ; Stroke/epidemiology ; Young Adult
    Chemical Substances Amphetamines ; Street Drugs ; 4-fluoroamphetamine (S5744XYR1Z)
    Language English
    Publishing date 2018-05-08
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-018-8888-6
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    Ui II Zs.40: Show issues Location:
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  3. Article ; Online: Preoperative PSMA-PET/CT as a predictor of biochemical persistence and early recurrence following radical prostatectomy with lymph node dissection.

    Baas, D J H / Schilham, M / Hermsen, R / de Baaij, J M S / Vrijhof, H J E J / Hoekstra, R J / Sedelaar, J P M / Küsters-Vandevelde, H V N / Gotthardt, M / Wijers, C H W / van Basten, J P / Somford, D M

    Prostate cancer and prostatic diseases

    2021  Volume 25, Issue 1, Page(s) 65–70

    Abstract: Background: This study aims to evaluate the predictive value of lymph nodes (LN) suspicious for metastases on preoperative prostate-specific membrane antigen (PSMA) PET/CT for biochemical persistence (BCP) and early biochemical recurrence (BCR) ... ...

    Abstract Background: This study aims to evaluate the predictive value of lymph nodes (LN) suspicious for metastases on preoperative prostate-specific membrane antigen (PSMA) PET/CT for biochemical persistence (BCP) and early biochemical recurrence (BCR) following robotic-assisted radical prostatectomy (RARP) with extended pelvic LN dissection (ePLND).
    Methods: We evaluated 213 patients with intermediate and high-risk prostate cancer (PCa) who underwent clinical staging with preoperative
    Results: Forty patients (19%) were PSMA+. The overall incidence of pN1 was 23%. Sensitivity, specificity, PPV and NPV on a per patient level for the detection of pN1 was 29%, 84%, 35%, and 80% respectively. BCP was observed in 26 of 211 patients (12%) and early BCR in 23 of 110 patients (21%). The presence of PSMA+ was a significant predictor for BCP (OR 7.1, 2.9-17.1 95% CI) and BCR (OR 8.1, 2.9-22.6 95% CI).
    Conclusion: Preoperative PSMA-PET/CT may be a valuable tool for patient counseling for RARP and ePLND as it is a significant predictor for the risk of postoperative BCP and early BCR. We conclude that an ePLND should not be avoided in men with intermediate or high-risk PCa and preoperative negative PSMA-PET/CT, as 20% have microscopic LN metastasis.
    MeSH term(s) Gallium Radioisotopes ; Humans ; Lymph Node Excision ; Male ; Positron Emission Tomography Computed Tomography ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery
    Chemical Substances Gallium Radioisotopes ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-021-00452-y
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    Zs.A 5277: Show issues Location:
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  4. Article ; Online: Anorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regions.

    Wijers, C H W / van Rooij, I A L M / Bakker, M K / Marcelis, C L M / Addor, M C / Barisic, I / Béres, J / Bianca, S / Bianchi, F / Calzolari, E / Greenlees, R / Lelong, N / Latos-Bielenska, A / Dias, C M / McDonnell, R / Mullaney, C / Nelen, V / O'Mahony, M / Queisser-Luft, A /
    Rankin, J / Zymak-Zakutnia, N / de Blaauw, I / Roeleveld, N / de Walle, H E K

    BJOG : an international journal of obstetrics and gynaecology

    2013  Volume 120, Issue 9, Page(s) 1066–1074

    Abstract: Objective: To identify pregnancy-related risk factors for different manifestations of congenital anorectal malformations (ARMs).: Design: A population-based case-control study.: Setting: Seventeen EUROCAT (European Surveillance of Congenital ... ...

    Abstract Objective: To identify pregnancy-related risk factors for different manifestations of congenital anorectal malformations (ARMs).
    Design: A population-based case-control study.
    Setting: Seventeen EUROCAT (European Surveillance of Congenital Anomalies) registries, 1980-2008.
    Population: The study population consisted of 1417 cases with ARM, including 648 cases of isolated ARM, 601 cases of ARM with additional congenital anomalies, and 168 cases of ARM-VACTERL (vertebral, anal, cardiac, tracheo-esophageal, renal, and limb defects), along with 13 371 controls with recognised syndromes or chromosomal abnormalities.
    Methods: Multiple logistic regression analyses were used to calculate adjusted odds ratios (ORs) for potential risk factors for ARM, such as fertility treatment, multiple pregnancy, primiparity, maternal illnesses during pregnancy, and pregnancy-related complications.
    Main outcome measures: Adjusted ORs for pregnancy-related risk factors for ARM.
    Results: The ARM cases were more likely to be firstborn than the controls (OR 1.6, 95% CI 1.4-1.8). Fertility treatment and being one of twins or triplets seemed to increase the risk of ARM in cases with additional congenital anomalies or VACTERL (ORs ranging from 1.6 to 2.5). Maternal fever during pregnancy and pre-eclampsia were only associated with ARM when additional congenital anomalies were present (OR 3.9, 95% CI 1.3-11.6; OR 3.4, 95% CI 1.6-7.1, respectively), whereas maternal epilepsy during pregnancy resulted in a five-fold elevated risk of all manifestations of ARM (OR 5.1, 95% CI 1.7-15.6).
    Conclusions: This large European study identified maternal epilepsy, fertility treatment, multiple pregnancy, primiparity, pre-eclampsia, and maternal fever during pregnancy as potential risk factors primarily for complex manifestations of ARM with additional congenital anomalies and VACTERL.
    MeSH term(s) Abnormalities, Multiple/epidemiology ; Abortion, Induced/statistics & numerical data ; Anorectal Malformations ; Anus, Imperforate/epidemiology ; Case-Control Studies ; Epilepsy/complications ; Epilepsy/epidemiology ; Europe/epidemiology ; Female ; Fever/complications ; Fever/epidemiology ; Humans ; Infant, Newborn ; Odds Ratio ; Parity ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Complications ; Pregnancy, Twin/statistics & numerical data ; Reproductive Techniques, Assisted/adverse effects ; Reproductive Techniques, Assisted/statistics & numerical data ; Risk Factors
    Language English
    Publishing date 2013-04-10
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.12235
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    Um I Zs.121: Show issues Location:
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