Article ; Online: Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study.
Transactions of the Royal Society of Tropical Medicine and Hygiene
2022 Volume 116, Issue 12, Page(s) 1129–1137
Abstract: Background: Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic ... ...
| Abstract | Background: Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic approach to management. There are sparse data from the South Asian region on the outcomes of hospital-discharged COVID-19 patients. We assessed the posthospital discharge outcomes of a cohort of Sri Lankan COVID-19 patients and explored the factors that influenced these outcomes. Methods: Data were prospectively collected from patients who were discharged following an admission to the Nawaloka Hospital, Sri Lanka with COVID-19 from March to June 2021. At discharge, their demographic, clinical and laboratory findings were recorded. The patients were categorised as having mild, moderate and severe COVID-19, based on the Sri Lanka Ministry of Health COVID-19 guidelines. Following discharge, information on health status, complications and outcomes was collected through clinic visits and preplanned telephone interviews. A validated (in Sri Lanka) version of the Short Form 36 health survey questionnaire (SF-36) was used to assess multi-item dimensions health status of the patients at 1, 2 and 3 mo postdischarge. Results: We collected data on 203 patients (male, n=111 [54.7%]). The level of vaccination was significantly associated with disease severity (p<0.001). Early recovery was seen in the mild group compared with the moderate and severe groups. At 3 mo, on average 98% of mild and 90% of moderate/severe patients had recovered. Based on the SF-36, physical functioning dimensions, role limitation due to physical and emotional health, energy/ fatigue, emotional well-being, social functioning, pain and general health were significantly different in the moderate/severe vs mild COVID-19 groups at 1, 2 and 3 mo postdischarge (p<0.05). Twenty-three patients developed complications, of which the most common were myocardial infarction with heart failure (n=6/23; 26.1%), cerebrovascular accident (n=6/23; 26.1%) and respiratory tract infections (n=3/23; 13.01%) and there were six deaths. Conclusions: In our cohort, receiving two doses of the COVID-19 vaccine was associated with reduced disease severity. Those with mild disease recovered faster than those with moderate/severe disease. At 3 mo posthospital discharge, >90% had recovered. |
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| MeSH term(s) | Humans ; Male ; COVID-19/epidemiology ; Prospective Studies ; Patient Discharge ; SARS-CoV-2 ; COVID-19 Vaccines ; Aftercare ; Sri Lanka/epidemiology |
| Chemical Substances | COVID-19 Vaccines |
| Language | English |
| Publishing date | 2022-04-28 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 441375-1 |
| ISSN | 1878-3503 ; 0035-9203 |
| ISSN (online) | 1878-3503 |
| ISSN | 0035-9203 |
| DOI | 10.1093/trstmh/trac039 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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