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  1. Article: Exercise as medicine: Providing practitioner guidance on exercise prescription.

    Kyei-Frimpong, Jamie / Blood-Siegfried, Jane / Wijetilaka, Ruvini / Gendler, Abigail

    Preventive medicine reports

    2021  Volume 22, Page(s) 101323

    Abstract: The purpose of this study was to examine the effect of a practitioner education program (consisting of education on exercise guidelines and exercise prescription) on practitioner (i) confidence in prescribing exercise and (ii) rate of prescribing ... ...

    Abstract The purpose of this study was to examine the effect of a practitioner education program (consisting of education on exercise guidelines and exercise prescription) on practitioner (i) confidence in prescribing exercise and (ii) rate of prescribing exercise. A pre-post study design was utilized. A two-session practitioner education and a toolbox of resources was developed and implemented in January 2020, targeting 12 eligible practitioners at a large primary care and functional medicine office in New York City. A three-question confidence survey was given pre and post. Fifty randomly selected charts were reviewed at baseline (pre), and 25 charts were reviewed monthly for 3 months (February - April 2020) post. There were significant increases and a large effect size in both confidence in prescribing exercise (30% to 89% [
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2021.101323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria.

    Baker, Rosanna P / Wijetilaka, Ruvini / Urban, Sinisa

    PLoS pathogens

    2006  Volume 2, Issue 10, Page(s) e113

    Abstract: Invasion of host cells by the malaria pathogen Plasmodium relies on parasite transmembrane adhesins that engage host-cell receptors. Adhesins must be released by cleavage before the parasite can enter the cell, but the processing enzymes have remained ... ...

    Abstract Invasion of host cells by the malaria pathogen Plasmodium relies on parasite transmembrane adhesins that engage host-cell receptors. Adhesins must be released by cleavage before the parasite can enter the cell, but the processing enzymes have remained elusive. Recent work indicates that the Toxoplasma rhomboid intramembrane protease TgROM5 catalyzes this essential cleavage. However, Plasmodium does not encode a direct TgROM5 homolog. We examined processing of the 14 Plasmodium falciparum adhesins currently thought to be involved in invasion by both model and Plasmodium rhomboid proteases in a heterologous assay. While most adhesins contain aromatic transmembrane residues and could not be cleaved by nonparasite rhomboid proteins, including Drosophila Rhomboid-1, Plasmodium falciparum rhomboid protein (PfROM)4 (PFE0340c) was able to process these adhesins efficiently and displayed novel substrate specificity. Conversely, PfROM1 (PF11_0150) shared specificity with rhomboid proteases from other organisms and was the only PfROM able to cleave apical membrane antigen 1 (AMA1). PfROM 1 and/or 4 was thus able to cleave diverse adhesins including TRAP, CTRP, MTRAP, PFF0800c, EBA-175, BAEBL, JESEBL, MAEBL, AMA1, Rh1, Rh2a, Rh2b, and Rh4, but not PTRAMP, and cleavage relied on the adhesin transmembrane domains. Swapping transmembrane regions between BAEBL and AMA1 switched the relative preferences of PfROMs 1 and 4 for these two substrates. Our analysis indicates that PfROMs 1 and 4 function with different substrate specificities that together constitute the specificity of TgROM5 to cleave diverse adhesins. This is the first enzymatic analysis of Plasmodium rhomboid proteases and suggests an involvement of PfROMs in all invasive stages of the malaria lifecycle, in both the vertebrate host and the mosquito vector.
    MeSH term(s) Animals ; Base Sequence ; Cell Adhesion Molecules/metabolism ; Drosophila Proteins/metabolism ; Host-Parasite Interactions/physiology ; Insect Hormones/metabolism ; Membrane Proteins/metabolism ; Molecular Sequence Data ; Peptide Hydrolases/metabolism ; Plasmodium falciparum/enzymology ; Plasmodium falciparum/pathogenicity ; Protozoan Proteins/metabolism ; Substrate Specificity
    Chemical Substances Cell Adhesion Molecules ; Drosophila Proteins ; Insect Hormones ; Membrane Proteins ; Protozoan Proteins ; Rho protein, Drosophila ; Peptide Hydrolases (EC 3.4.-) ; ROM4 protein, Plasmodium falciparum (EC 3.4.-)
    Language English
    Publishing date 2006-10-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.0020113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complement factor B activation in patients with preeclampsia.

    Velickovic, Ivan / Dalloul, Mudar / Wong, Karen A / Bakare, Olufunke / Schweis, Franz / Garala, Maya / Alam, Amit / Medranda, Giorgio / Lekovic, Jovana / Shuaib, Waqas / Tedjasukmana, Andreas / Little, Perry / Hanono, Daniel / Wijetilaka, Ruvini / Weedon, Jeremy / Lin, Jun / Toledano, Roulhac d'Arby / Zhang, Ming

    Journal of reproductive immunology

    2015  Volume 109, Page(s) 94–100

    Abstract: Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators. ... ...

    Abstract Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators. We hypothesized that the disagreement in findings may be due to the racial/ethnic differences among various study groups, and that fB activation is significant in women of an ethnic minority with preeclampsia. We investigated the maternal and fetal levels of Bb (the activated fB fragment) in pregnant women of an ethnic minority with or without preeclampsia. We enrolled 291 pregnant women (96% of an ethnic minority, including 78% African-American). Thirteen percent of these were diagnosed with preeclampsia. Maternal venous blood was collected from all participants together with fetal umbilical cord blood samples from 154 deliveries in the 291 women. The results were analyzed using the Mann-Whitney U test and multivariate analyses. Maternal Bb levels were significantly higher in the preeclamptic group than in the nonpreeclamptic group. Levels of Bb in fetal cord blood were similar in both groups. Subgroup analyses of African-American patients' results confirmed the study hypothesis that there would be a significant increase in Bb in the maternal blood of the preeclamptic group and no increase in Bb in the fetal cord blood of this group. These results suggest that a maternal immune response through complement fB might play a role in the development of preeclampsia, particularly in African-American patients.
    MeSH term(s) Adult ; African Americans ; Complement Activation/immunology ; Complement Factor B/immunology ; Complement Factor B/metabolism ; Female ; Fetal Blood/immunology ; Fetal Blood/metabolism ; Humans ; Pre-Eclampsia/blood ; Pre-Eclampsia/ethnology ; Pre-Eclampsia/immunology ; Pre-Eclampsia/mortality ; Pregnancy
    Chemical Substances Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2015-06
    Publishing country Ireland
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2014.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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