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  1. Book ; Thesis: Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy

    Wilczek, Adriana Luisa / Thum, Thomas

    2021  

    Institution Medizinische Hochschule Hannover
    Institut für Molekulare und Translationale Therapiestrategien
    Author's details vorgelegt von Adriana Luisa Wilczek ; aus dem Institut für Molekulare und Translationale Therapiestrategien der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. Dr. med. Thomas Thum, PhD
    Language German ; English
    Size 52 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    Note Text auf Deutsch, Sonderabdruck auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus „Scientific Reports", Jg. 9 (2019)
    HBZ-ID HT021687183
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2023 E 33 order for loan Magazin

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  2. Article ; Online: Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy.

    Sonnenschein, Kristina / Wilczek, Adriana Luisa / de Gonzalo-Calvo, David / Pfanne, Angelika / Derda, Anselm Arthur / Zwadlo, Carolin / Bavendiek, Udo / Bauersachs, Johann / Fiedler, Jan / Thum, Thomas

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 20350

    Abstract: Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and is associated with a high risk of sudden cardiac death. HCM is characterized by pronounced hypertrophy of cardiomyocytes, fiber disarray and development of fibrosis ...

    Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and is associated with a high risk of sudden cardiac death. HCM is characterized by pronounced hypertrophy of cardiomyocytes, fiber disarray and development of fibrosis and can be divided into a non-obstructive (HNCM) and obstructive form (HOCM) therefore requiring personalized therapeutic therapies. In the present study, we investigated the expression patterns of several circulating circular RNAs (circRNAs) as potential biomarkers in patients with HCM. We included 64 patients with HCM and 53 healthy controls to the study and quantitatively measured the expression of a set of circRNAs already known to be associated with cardiac diseases (circDNAJC6) and/or being highly abundant in blood (circTMEM56 and circMBOAT2). Abundancy of circRNAs was then correlated to relevant clinical parameters. Serum expression levels of circRNAs DNAJC6, TMEM56 and MBOAT2 were downregulated in patients with HCM. The inverse association between circRNA levels and HCM remained unchanged even after adjusting for confounding factors. All circRNAs, evaluated separately or in combination, showed a robust discrimination capacity when comparing control subjects with HCM, HNCM or HOCM patients (AUC from 0.722 to 0.949). Two circRNAs, circTMEM56 and circDNAJC6, significantly negatively correlated with echocardiographic parameters for HOCM. Collectively, circulating circRNAs DNAJC6, TMEM56 and MBOAT2 can distinguish between healthy and HCM patients. In addition, circTMEM56 and circDNAJC6 could serve as indicators of disease severity in patients with HOCM. Thus, circRNAs emerge as novel biomarkers for HCM facilitating the clinical decision making in a personalized manner.
    MeSH term(s) Biomarkers ; Cardiomyopathy, Hypertrophic/blood ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/genetics ; Case-Control Studies ; Cell-Free Nucleic Acids ; Echocardiography ; Female ; Heart Function Tests ; Humans ; Male ; Odds Ratio ; RNA, Circular/blood ; ROC Curve
    Chemical Substances Biomarkers ; Cell-Free Nucleic Acids ; RNA, Circular
    Language English
    Publishing date 2019-12-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-56617-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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