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  1. Article ; Online: The EBM+ movement.

    Wilde, Michael

    The international journal of biostatistics

    2023  Volume 19, Issue 2, Page(s) 283–293

    Abstract: In this paper, I provide an introduction for biostatisticians and others to some recent work in the philosophy of medicine. Firstly, I give an overview of some philosophical arguments that are thought to create problems for a prominent approach towards ... ...

    Abstract In this paper, I provide an introduction for biostatisticians and others to some recent work in the philosophy of medicine. Firstly, I give an overview of some philosophical arguments that are thought to create problems for a prominent approach towards establishing causal claims in medicine, namely, the Evidence-Based Medicine (EBM) approach. Secondly, I provide an overview of further recent work in the philosophy of medicine, which argues that mechanistic studies can help to address these problems. Lastly, I describe a novel approach for establishing causal claims in medicine that has been informed by this recent work in the philosophy of medicine, namely, the EBM+ approach.
    MeSH term(s) Humans ; Philosophy, Medical ; Evidence-Based Medicine ; Philosophy ; Movement ; Research Personnel
    Language English
    Publishing date 2023-02-20
    Publishing country Germany
    Document type Journal Article
    ISSN 1557-4679
    ISSN (online) 1557-4679
    DOI 10.1515/ijb-2022-0126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures

    Parkkinen, Veli-Pekka / Wallmann, Christian / Wilde, Michael / Clarke, Brendan / Illari, Phyllis / Kelly, Michael P / Norell, Charles / Russo, Federica / Shaw, Beth / Williamson, Jon

    2018  

    Keywords Philosophy ; Philosophy: epistemology & theory of knowledge ; Medicine-Philosophy ; Epistemology
    Size 1 electronic resource (125 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021028826
    ISBN 978-3-319-94610-8 ; 3-319-94610-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Evaluating Evidence of Mechanisms in Medicine

    Parkkinen, Veli-Pekka / Wallmann, Christian / Wilde, Michael / Clarke, Brendan / Illari, Phyllis / Kelly, Michael P. / Norell, Charles / Russo, Federica / Shaw, Beth / Williamson, Jon

    Principles and Procedures

    (SpringerBriefs in Philosophy)

    2018  

    Author's details by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson
    Series title SpringerBriefs in Philosophy
    Keywords Philosophy ; Epistemology ; Medicine/Philosophy
    Subject code 610.1
    Language English
    Size 1 Online-Ressource (XVIII, 125 p. 14 illus)
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT019767239
    ISBN 978-3-319-94610-8 ; 9783319946092 ; 3-319-94610-2 ; 3319946099
    DOI 10.1007/978-3-319-94610-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Endotyping Asthma: Profiling the Metabolic Dimension?

    Wilde, Michael J / Siddiqui, Salman

    American journal of respiratory and critical care medicine

    2021  Volume 205, Issue 3, Page(s) 261–263

    MeSH term(s) Asthma ; Humans ; Phenotype
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202111-2605ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: If speed is of the essence: rapid analysis of ambergris by APCI compact mass spectrometry.

    Rowland, Steven J / Wilde, Michael J / Sutton, Paul A / Blackbird, Sabena J / Wolff, George A

    Natural product research

    2024  , Page(s) 1–7

    Abstract: The use of atmospheric pressure chemical ionisation (APCI) compact mass spectrometry (CMS) was investigated for the analysis of jetsam and museum-archived ambergris and of ambergris components in perfumes. The data were compared with those from existing ... ...

    Abstract The use of atmospheric pressure chemical ionisation (APCI) compact mass spectrometry (CMS) was investigated for the analysis of jetsam and museum-archived ambergris and of ambergris components in perfumes. The data were compared with those from existing methods. Authentic samples of some individual ambergris constituents (ambrein, coprostanol, epicoprostanol and coprostanone), were also examined. Rapid APCI CMS was achieved using either a solids probe or a probe with solutions held in capillary melting point tubes. Interpretation is made of the spectra of the principal natural product components, the relative ion responses were measured and the elemental composition of key ions in the spectra confirmed using high resolution accurate mass APCI MS. Rapid analysis of ambergris by APCI CMS may prove to be a further convenient method of identifying ambrein, of measuring the relative ratios of ambrein and steroids in ambergris and even of quantifying the latter, with minimal sample preparation.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2321496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Audio / Video ; Online: Akkerbouwdag 9 - Kansen voor biologisch ondernemerschap (onderdeel van de Biokennisweek). CIV Groen, Praktijkcluster Agro, 13 januari 2022

    Wilde, Michael / Simons, Marlijn

    2022  

    Abstract: Negende Akkerbouwdag van CIV Groen Praktijkcluster Agro (webinar) met als thema: Kansen voor biologisch ondernemerschap. Dit webinar is ook onderdeel van de Biokennisweek 2022. Met 2 sprekers: Michael Wilde, Directeur Bionext, en Marlijn Simons, PLUS ... ...

    Abstract Negende Akkerbouwdag van CIV Groen Praktijkcluster Agro (webinar) met als thema: Kansen voor biologisch ondernemerschap. Dit webinar is ook onderdeel van de Biokennisweek 2022. Met 2 sprekers: Michael Wilde, Directeur Bionext, en Marlijn Simons, PLUS retail. In 2030 gebruiken we ten minste 25% van de landbouwgrond voor biologische landbouw. Dat is één van de doelen die de Europese Commissie stelt met de Farm to Fork Strategy. Wat voor perspectief biedt de biologische landbouw aan de ondernemer van de toekomst? Hoe ziet de markt eruit en wat betekent het voor de ondernemer om om te schakelen naar biologisch? Biologisch is een sterk keurmerk, wat meerwaarde oplevert voor de ondernemer. Maar het vraagt ook veel van de ondernemer: in de teelt, in de wijze van dieren houden, maar ook in het realiseren van de afzet. Directeur Bionext, Michael Wilde gaat in op de trends en ontwikkelingen binnen biologisch. Hoe ontwikkelt de markt zich, zowel binnen Nederland als Europa? Want groei van de sector is alleen mogelijk met een groeiende vraag vanuit de consument. En wat is de rol van de Europese en de Nederlandse overheid hierbij? Jack Mikkers, burgemeester Den Bosch en voorzitter AgrifoodCapital interviewt samen met MBO-Yuverta Boxtel studenten Stefano en Stijn jonge biologische ondernemers. Zij vertellen over hun ervaringen met het biologisch ondernemerschap. Waarom hebben ze hiervoor gekozen en wat vinden zij de voor- en nadelen van het biologisch zijn? Hoe hebben ze hun afzet geregeld en wat zijn hun plannen voor de toekomst? De ondernemers: Bas Antonissen, biologisch varkenshouder BoerBas in Rucphen (oud student MBO veehouderij Breda Prinsentuin), Maartje Verhulst, biologisch melkveehoudster op de Hillekenshoeve in Etten-Leur (geen agrarische opleiding, zij -instromer), Johannes Straver, landbouwbedrijf Straver (gangbaar en bio akkerbouwbedrijf en loonwerk) te Almkerk, Oud student HAS Den Bosch. Marlijn Simons, Manager Corporate Communicatie en MVO, Plus retail vertelt over de visie van PLUS op biologisch. PLUS heeft de ...
    Keywords "Organics" in general
    Publisher Praktijkcluster Agro
    Publishing country dk
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Bologna backstage - experiences from behind the scenes of the reforms of the Basel medical curriculum.

    Voigt, Gabriele / Wilde, Michael

    GMS journal for medical education

    2019  Volume 36, Issue 5, Page(s) Doc63

    Abstract: Based on a six-year degree in medical studies which was characterized by a series of lectures without an over-arching concept, Basel decided to embark on reforms in 1995. The first wave of reforms (1998-2003) produced a hybrid curriculum structure with ... ...

    Abstract Based on a six-year degree in medical studies which was characterized by a series of lectures without an over-arching concept, Basel decided to embark on reforms in 1995. The first wave of reforms (1998-2003) produced a hybrid curriculum structure with PbL teaching units, organized according to organ systems, in years 1-4 of medical studies, which met the demand for "clinical content in the pre-clinical phase". A focus on General Practice medicine was achieved by implementing the "One to one tutorial" in the 3
    MeSH term(s) Curriculum/standards ; Curriculum/trends ; Education, Medical, Undergraduate/methods ; Faculty, Medical/education ; Faculty, Medical/trends ; Germany ; Humans ; Models, Educational ; Problem-Based Learning ; Quality Improvement/legislation & jurisprudence ; Quality Improvement/trends
    Language English
    Publishing date 2019-10-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-5017
    ISSN (online) 2366-5017
    DOI 10.3205/zma001271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reinforced reasoning in medicine.

    Auker-Howlett, Daniel / Wilde, Michael

    Journal of evaluation in clinical practice

    2019  Volume 26, Issue 2, Page(s) 458–464

    Abstract: Some philosophers have argued that evidence of underlying mechanisms does not provide evidence for the effectiveness of a medical intervention. One such argument appeals to the unreliability of mechanistic reasoning. However, mechanistic reasoning is not ...

    Abstract Some philosophers have argued that evidence of underlying mechanisms does not provide evidence for the effectiveness of a medical intervention. One such argument appeals to the unreliability of mechanistic reasoning. However, mechanistic reasoning is not the only way that evidence of mechanisms might provide evidence of effectiveness. A more reliable type of reasoning may be distinguished by appealing to recent work on evidential pluralism in the epistemology of medicine. A case study from virology provides an example of this so-called reinforced reasoning in medicine. It is argued that in this case study, the available evidence of underlying mechanisms did in fact play a role in providing evidence in favour of a medical intervention. This paper therefore adds a novel and recent case study to the literature in support of evidential pluralism in medicine.
    MeSH term(s) Cultural Diversity ; Evidence-Based Medicine ; Humans ; Knowledge ; Problem Solving
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1327355-3
    ISSN 1365-2753 ; 1356-1294
    ISSN (online) 1365-2753
    ISSN 1356-1294
    DOI 10.1111/jep.13269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bologna backstage – experiences from behind the scenes of the reforms of the Basel medical curriculum

    Voigt, Gabriele / Wilde, Michael

    GMS Journal for Medical Education, Vol 36, Iss 5, p Doc

    2019  Volume 63

    Abstract: Based on a six-year degree in medical studies which was characterized by a series of lectures without an over-arching concept, Basel decided to embark on reforms in 1995. The first wave of reforms (1998-2003) produced a hybrid curriculum structure with ... ...

    Abstract Based on a six-year degree in medical studies which was characterized by a series of lectures without an over-arching concept, Basel decided to embark on reforms in 1995. The first wave of reforms (1998-2003) produced a hybrid curriculum structure with PbL teaching units, organized according to organ systems, in years 1-4 of medical studies, which met the demand for “clinical content in the pre-clinical phase”. A focus on General Practice medicine was achieved by implementing the “One to one tutorial” in the 3 and 4 year of studies. Fixed weekly schedules provided space for instruction in the three learning dimensions – cognitive, affective and psychomotor learning – implemented in four longitudinal competence strands. The compulsory elective subject area “Early patient contact” was integrated into the elective degree courses of the Bachelor’s degree by creating projects.From 2006 to 2012, the demands of the Bologna Declaration were implemented and a Bachelor’s and a “consecutive” Master’s degree program developed and then implemented. The PbL teaching units which had come in for criticism were replaced in the Master's Degree by the “Clinical Case” and in the Bachelor’s degree by the “Tutorial on Scientific and Clinical Reasoning”. To strengthen scientific competences, the “Science Month” and the compulsory elective subject area “Scientific Competences – Flexible Offers (WIKO.flex)” were introduced. Further curricular adjustments resulted in the development of an externally accredited integrated emergency curriculum, the establishment of feedback OSCEs and the intensification of the Skills Lab offer. In addition to content, organizational framework conditions for curricular development were key: Thus, the massive expansion of places on medical degree courses also had an impact on curriculum structure and examinations.In 2017, PROFILES, the new Swiss competence framework, was published, which presents curriculum planning with new challenges as a result of the introduction of the EPA concept. Due to the flexible ...
    Keywords reform efforts ; topical blocks based on organ systems ; hybrid curriculum ; core studies and elective degree courses ; general practice ; european higher education reform ; Bologna Declaration ; resistance to change ; structural implementation of the Bologna demands ; cognitive affective psychomotor ; longitudinal curricula ; accreditation ; PROFILES ; Special aspects of education ; LC8-6691 ; Medicine ; R
    Subject code 370
    Language German
    Publishing date 2019-10-01T00:00:00Z
    Publisher German Medical Science GMS Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Bologna backstage – experiences from behind the scenes of the reforms of the Basel medical curriculum

    Voigt, Gabriele / Wilde, Michael

    GMS Journal for Medical Education

    2019  Volume 36, Issue 5, Page(s) 63

    Abstract: Ausgehend von einem sechsjährigen Medizinstudium, welches von diversen Magistralvorlesungen geprägt war, die sich konzeptionslos aneinander reihten, wurde in Basel 1995 beschlossen, eine Reform in Angriff zu nehmen. Die erste Reformwelle (1998-2003) ... ...

    Title translation Bologna Backstage – ein Erfahrungsbericht von hinter den Kulissen der Reform des Basler Medizincurriculums
    Abstract Ausgehend von einem sechsjährigen Medizinstudium, welches von diversen Magistralvorlesungen geprägt war, die sich konzeptionslos aneinander reihten, wurde in Basel 1995 beschlossen, eine Reform in Angriff zu nehmen. Die erste Reformwelle (1998-2003) brachte in den Studienjahren 1-4 eine nach Organsystemen geordnete hybride Curriculumsstruktur mit PbL-Lehreinheiten hervor, in denen der Forderung nach „Klinik in die Vorklinik“ entsprochen wurde. Eine Schwerpunktsetzung auf Hausarztmedizin gelang durch die Implementierung des “Einzeltutoriates“ im 3. und 4. Studienjahr. Festgelegte Wochenplanstrukturen schafften Raum für Unterrichte in den drei Lerndimensionen kognitiv, affektiv und psychomotorisch, umgesetzt in den vier longitudinalen Kompetenzsträngen. In das Mantelstudium des Bachelors wurde mit der Schaffung von Projekten der Wahlpflichtbereich gelegt, in dem der frühe Patientenkontakt umgestzt wurde.
    Ab 2006 bis 2012 wurden die Forderungen der Bologna-Deklaration umgesetzt und ein Bachelor- und ein „konsekutives“ Masterstudium entwickelt und sukzessive implementiert. Dabei wurden in den Masterjahren die in die Kritik geratenen PbL-Lehreinheiten durch den „Klinischen Fall“, in den Bachelorjahren durch das „Tutorial of Scientific and Clinical Reasoning“ ersetzt. Zur Stärkung der wissenschaftlichen Kompetenz wurde der „Wissenschaftsmonat“ und der Wahlpflichtbereich „Wissenschaftliche Kompetenzen – flexible Angebote (WIKO.flex)“ eingeführt. Weitere curriculare Anpassungen führten zum Aufbau eines extern akkreditierten integrierten Notfall-Curriculums, zur Einrichtung von Feedback-OSCEs und Intensivierung des Skills-Lab-Angebotes. Neben inhaltlichen waren auch organisatorische Rahmenbedingungen für curriculare Entwicklungen ausschlaggebend: So hatte die massive Erweiterung der Medizinstudienplätze auch Folgen für die Curriculumsstruktur und Prüfungen.
    2017 ist PROFILES, der neue Schweizer Kompetenzrahmen, erschienen, der mit der Vorgabe des EPA-Konzepts die Curriculumsplanung vor neue Aufgaben stellt. Aufgrund der flexiblen Struktur des Curriculums kann die Fakultät diesen Herausforderungen gelassen entgegensehen. Die Reakkreditierung des Studiengangs 2018 gab als wichtige Impulse die Stärkung von interprofessioneller Lehre und einen Fokus auf den kompetenten Umgang mit verstärkten Patientenwünschen nach komplementärmedizinischen Behandlungen auf den Weg.

    Based on a six-year degree in medical studies which was characterized by a series of lectures without an over-arching concept, Basel decided to embark on reforms in 1995. The first wave of reforms (1998-2003) produced a hybrid curriculum structure with PbL teaching units, organized according to organ systems, in years 1-4 of medical studies, which met the demand for “clinical content in the pre-clinical phase”. A focus on General Practice medicine was achieved by implementing the “One to one tutorial” in the 3rd and 4th year of studies. Fixed weekly schedules provided space for instruction in the three learning dimensions – cognitive, affective and psychomotor learning – implemented in four longitudinal competence strands. The compulsory elective subject area “Early patient contact” was integrated into the elective degree courses of the Bachelor’s degree by creating projects.
    From 2006 to 2012, the demands of the Bologna Declaration were implemented and a Bachelor’s and a “consecutive” Master’s degree program developed and then implemented. The PbL teaching units which had come in for criticism were replaced in the Master's Degree by the “Clinical Case” and in the Bachelor’s degree by the “Tutorial on Scientific and Clinical Reasoning”. To strengthen scientific competences, the “Science Month” and the compulsory elective subject area “Scientific Competences – Flexible Offers (WIKO.flex)” were introduced. Further curricular adjustments resulted in the development of an externally accredited integrated emergency curriculum, the establishment of feedback OSCEs and the intensification of the Skills Lab offer. In addition to content, organizational framework conditions for curricular development were key: Thus, the massive expansion of places on medical degree courses also had an impact on curriculum structure and examinations.
    In 2017, PROFILES, the new Swiss competence framework, was published, which presents curriculum planning with new challenges as a result of the introduction of the EPA concept. Due to the flexible structure of the curriculum, the faculty feels confident it will be able to handle these challenges. The re-accreditation of the degree program in 2018 provided important stimuli for the strengthening of interprofessional teaching and a focus on the competent handling of an increasing number of patients asking for complementary medical treatments.
    Keywords Medizin, Gesundheit ; reform efforts ; topical blocks based on organ systems ; hybrid curriculum ; core studies and elective degree courses ; general practice ; european higher education reform ; Bologna Declaration ; resistance to change ; structural implementation of the Bologna demands ; cognitive affective psychomotor ; longitudinal curricula ; accreditation ; PROFILES ; Reformbemühungen ; Themenblöcke nach Organsystemen ; Hybridcurriculum ; Kern- und Mantelstudium ; Hausarztmedizin ; Europäische Hochschulreformbewegung ; Bologna-Deklaration ; Resistance to Change ; strukturelle Umsetzung der Bolognavorgaben ; kognitiv-affektiv-psychomotorisch ; longitudinale Curricula ; Akkreditierung ; PROFILES ; Curriculum Overview ; Gesamtdarstellung Studiengang
    Publishing date 2019-10-15
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Article ; Online
    ISSN 2366-5017
    ISSN (online) 2366-5017
    DOI 10.3205/zma001271
    Database German Medical Science

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