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  1. Book ; Thesis: Entwicklung einer minimalinvasiven Osteosynthese

    Kayhan, Leos / Wildemann, Britt / Kleber, Christian / Matziolis, Georgios

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Leos Nihat Kayhan
    Keywords Oberschenkelbruch
    Subject Oberschenkelfraktur ; Femurfraktur ; Hüftfraktur
    Language German
    Size 94 Seiten, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 04.07.2023
    HBZ-ID HT030630308
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 181 order for loan Magazin

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  2. Book ; Thesis: Stellenwert der Sonikation im Rahmen eines diagnostischen Polyethylen-Lagerwechsels am Kniegelenk bei Verdacht einer periprothetischen Infektion

    Singer, Hannes / Matziolis, Georgios / Wildemann, Britt / Roth, Andreas

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Hannes Adolf Fabian Singer
    Language German
    Size 116 Blätter, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 05.12.2023
    HBZ-ID HT030666252
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 402 order for loan Magazin

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  3. Book ; Thesis: Untersuchung des altersabhängigen systemischen Einflusses spezieller Fettsäuren auf Inflammation und Knochenstoffwechsel bei Parodontitis im Mausmodell

    Domuncu, Anton / Schulze-Späte, Ulrike / Wildemann, Britt / Becker, Jürgen

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Anton Sava Domuncu
    Language German
    Size 91 Blätter, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 05.12.2023
    HBZ-ID HT030704318
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 545 Magazin

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  4. Book ; Thesis: Impact of patient's frailty and adverse events on the outcome of multiple myeloma

    Brioli, Annamaria / Hochhaus, Andreas / Wildemann, Britt / Engelhardt, Monika

    2021  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Dr. Annamaria Brioli
    Keywords Plasmozytom ; Therapie ; Polyneuropathie ; Infektion
    Subject Ansteckung ; Erstinfektion ; Infektionen ; Polyneuropathia ; PNP ; Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Kahler-Krankheit ; Kahler-Bozzolo-Krankheit ; Malignes Plasmom ; Multiples Myelom ; Myelom ; Plasmocytom ; Plasmocytoma ; Plasmom ; Plasmozytisches Lymphom
    Language English
    Size Illustrationen, Diagramme
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Friedrich-Schiller-Universität Jena, 2021
    Note Zeitschriftenaufsätze in englischer Sprache ; Kumulative Habilitationsschrift, enthält Zeitschriftenaufsätze. - Tag der Verteidigung: 11.05.2021
    HBZ-ID HT021864490
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 673 order for loan Magazin

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  5. Article: Mechanical overload decreases tenogenic differentiation compared to physiological load in bioartificial tendons.

    Pentzold, Stefan / Wildemann, Britt

    Journal of biological engineering

    2022  Volume 16, Issue 1, Page(s) 5

    Abstract: Background: Tenocytes as specialised fibroblasts and inherent cells of tendons require mechanical load for their homeostasis. However, how mechanical overload compared to physiological load impacts on the tenogenic differentiation potential of ... ...

    Abstract Background: Tenocytes as specialised fibroblasts and inherent cells of tendons require mechanical load for their homeostasis. However, how mechanical overload compared to physiological load impacts on the tenogenic differentiation potential of fibroblasts is largely unknown.
    Methods: Three-dimensional bioartificial tendons (BATs) seeded with murine fibroblasts (cell line C3H10T1/2) were subjected to uniaxial sinusoidal elongation at either overload conditions (0-16%, Ø 8%) or physiological load (0-8%, Ø 4%). This regime was applied for 2 h a day at 0.1 Hz for 7 days. Controls were unloaded, but under static tension.
    Results: Cell survival did not differ among overload, physiological load and control BATs. However, gene expression of tenogenic and extra-cellular matrix markers (Scx, Mkx, Tnmd, Col1a1 and Col3a1) was significantly decreased in overload versus physiological load and controls, respectively. In contrast, Mmp3 was significantly increased at overload compared to physiological load, and significantly decreased under physiological load compared to controls. Mkx and Tnmd were significantly increased in BATs subjected to physiological load compared to controls. Proinflammatory interleukin-6 showed increased protein levels comparing load (both over and physiological) versus unloaded controls. Alignment of the cytoskeleton in strain direction was decreased in overload compared to physiological load, while other parameters such as nuclear area, roundness or cell density were less affected.
    Conclusions: Mechanical overload decreases tenogenic differentiation and increases ECM remodelling/inflammation in 3D-stimulated fibroblasts, whereas physiological load may induce opposite effects.
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2391582-1
    ISSN 1754-1611
    ISSN 1754-1611
    DOI 10.1186/s13036-022-00283-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanobiology of bacterial biofilms: Implications for orthopedic infection.

    Blondel, Margaux / Machet, Camille / Wildemann, Britt / Abidine, Yara / Swider, Pascal

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2024  

    Abstract: Postoperative bacterial infections are prevalent complications in both human and veterinary orthopedic surgery, particularly when a biofilm develops. These infections often result in delayed healing, early revision, permanent functional loss, and, in ... ...

    Abstract Postoperative bacterial infections are prevalent complications in both human and veterinary orthopedic surgery, particularly when a biofilm develops. These infections often result in delayed healing, early revision, permanent functional loss, and, in severe cases, amputation. The diagnosis and treatment pose significant challenges, and bacterial biofilm further amplifies the therapeutic difficulty as it confers protection against the host immune system and against antibiotics which are usually administered as a first-line therapeutic option. However, the inappropriate use of antibiotics has led to the emergence of numerous multidrug-resistant organisms, which largely compromise the already imperfect treatment efficiency. In this context, the study of bacterial biofilm formation allows to better target antibiotic use and to evaluate alternative therapeutic strategies. Exploration of the roles played by mechanical factors on biofilm development is of particular interest, especially because cartilage and bone tissues are reactive environments that are subjected to mechanical load. This review delves into the current landscape of biofilm mechanobiology, exploring the role of mechanical factors on biofilm development through a multiscale prism starting from bacterial microscopic scale to reach biofilm mesoscopic size and finally the macroscopic scale of the fracture site or bone-implant interface.
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Diabetes - osteoarthritis and joint pain.

    Eitner, Annett / Wildemann, Britt

    Bone & joint research

    2021  Volume 10, Issue 5, Page(s) 307–309

    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.105.BJR-2021-0119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes-A Mini-Review.

    Wildemann, Britt / Jandt, Klaus D

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 19

    Abstract: Implants and materials are indispensable in trauma and orthopedic surgery. The continuous improvements of implant design have resulted in an optimized mechanical function that supports tissue healing and restoration of function. One of the still unsolved ...

    Abstract Implants and materials are indispensable in trauma and orthopedic surgery. The continuous improvements of implant design have resulted in an optimized mechanical function that supports tissue healing and restoration of function. One of the still unsolved problems with using implants and materials is infection. Trauma and material implantation change the local inflammatory situation and enable bacterial survival and material colonization. The main pathogen in orthopedic infections is
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14195834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Allografts for partial meniscus repair: an

    Dabaghi, Mohammad / Eras, Volker / Kaltenhaeuser, Daniel / Ahmed, Norus / Wildemann, Britt

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1268176

    Abstract: The purpose of this study was to evaluate the treatment potential of a human-derived demineralized scaffold, ... ...

    Abstract The purpose of this study was to evaluate the treatment potential of a human-derived demineralized scaffold, Spongioflex
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1268176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial of Special Issue: Biological Basis of Musculoskeletal Regeneration 2019.

    Klatte-Schulz, Franka / Wildemann, Britt

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: The Special Issue "Biological Basis of Musculoskeletal Regeneration 2019" aimed to collect research and review articles that cover various aspects of the molecular and cellular mechanisms of bone, cartilage, tendon/ligament, and muscle regeneration [ ... ]. ...

    Abstract The Special Issue "Biological Basis of Musculoskeletal Regeneration 2019" aimed to collect research and review articles that cover various aspects of the molecular and cellular mechanisms of bone, cartilage, tendon/ligament, and muscle regeneration [...].
    MeSH term(s) Animals ; Bone Regeneration ; Humans ; Muscle, Skeletal/physiology ; Musculoskeletal Diseases/therapy ; Regenerative Medicine/methods ; Tissue Engineering/methods
    Language English
    Publishing date 2020-08-19
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21175968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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