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  1. Book: Tinnitus lindern durch Laserlicht

    Wilden, Lutz / Fritsch, Michaela

    die neue Kombinationstherapie bei Ohrgeräuschen, Hörsturz und Gleichgewichtsstörungen

    1994  

    Author's details Lutz Wilden ; Michaela Fritsch
    Keywords Tinnitus / radiotherapy / popular works ; Tinnitus / drug therapy / popular works ; Lasers / therapeutic use / popular works ; Combined Modality Therapy / popular works ; Plant Extracts / therapeutic use / popular works ; Ohrgeräusch ; Lasertherapie ; Kombinationstherapie
    Subject Laserbestrahlung ; Ohrensausen ; Tinnitus aurium ; Ratgeberliteratur
    Language German
    Size 106 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Jopp
    Publishing place Wiesbaden
    Document type Book
    HBZ-ID HT006411264
    ISBN 3-926955-69-4 ; 978-3-926955-69-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1995 B 617 order for loan Magazin

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  2. Book ; Thesis: DER SOZIALHYGIENISCHE ASPEKT DER SOGSCHWANGERSCHAFTSRITEN

    Wilden, Lutz

    UEBER EINIGE SCHWANGERSCHAFTSRITEN BEI NATURVOELKERN, VERGLEICHE ZU ERKENNTNISSEN D. HEUTIGEN SCHWANGERSCHAFTSVORSORGE

    1982  

    Title variant SOZIALHYGIENISCHE ASPEKT DER SOGENANNTEN SCHWANGERSCHAFTSRITEN
    Size 79, 5 BL.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis HEIDELBERG, UNIV., DISS., 1982 (NICHT F.D. AUSTAUSCH)
    HBZ-ID HT002603590
    Database Catalogue ZB MED Medicine, Health

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    83 E 787 order for loan Magazin

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  3. Article: Import of radiation phenomena of electrons and therapeutic low-level laser in regard to the mitochondrial energy transfer.

    Wilden, L / Karthein, R

    Journal of clinical laser medicine & surgery

    1998  Volume 16, Issue 3, Page(s) 159–165

    Abstract: Objective: The authors describe a consistent theoretical model of the cellular energy transfer (respiratory chain) by taking into consideration the radiation phenomena of electrons and therapeutic low level laser.: Summary background data: ... ...

    Abstract Objective: The authors describe a consistent theoretical model of the cellular energy transfer (respiratory chain) by taking into consideration the radiation phenomena of electrons and therapeutic low level laser.
    Summary background data: Biochemical models of the cellular energy transfer regard the classical corpuscular aspect of electrons as the responsible energy carriers, thereby ignoring the wave-particle dualism of the electrons and the import of radiation energy in this process.
    Methods: The authors show the influence of radiation phenomena on the cellular energy transfer, explaining consistently some of the intermediate steps of this complex process.
    Results: Because of the inherent wave-particle dualism of the electrons, it is appropriate to regard radiation phenomena to explain the cellular energy transfer. The classical biochemical models use only the particle part of the electrons as energy carriers. The connection between energy transport by radiation and the order in structures may be understood if, for instance, structurally bound energy is released during the dissolution of structures (oxidation of foodstuffs) or is again manifested (final reduction of oxygen to water). With a attention to the energy values relevant for the respiratory chain, the import of electromagnetic radiation of characteristic ranges of wavelengths on the cellular energy transfer becomes evident. Depending on its wavelength, electromagnetic radiation in the form of light can stimulate macromolecules and can initiate conformation changes in proteins or can transfer energy to electrons. Low level laser from the red and the near infrared region corresponds well with the characteristic energy and absorption levels of the relevant components of the respiratory chain. This laser stimulation vitalizes the cell by increasing the mitochondrial ATP(adenosine-tri-phosphate)-production.
    Conclusions: With regard to radiation phenomena and its inhanced electron flow in the cellular energy transfer (respiratory chain), it is possible to explain the experimentally found increase of ATP-production by means of low-level laser light on a cellular level. Intense research for this biostimulative effect is still necessary.
    MeSH term(s) Adenosine Triphosphate/biosynthesis ; Electron Transport/radiation effects ; Energy Transfer/radiation effects ; Infrared Rays ; Lasers ; Mitochondria/metabolism ; Mitochondria/physiology ; Mitochondria/radiation effects ; Models, Chemical ; NADH Dehydrogenase/metabolism ; Physical Phenomena ; Physics ; Protein Conformation/radiation effects
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; NADH Dehydrogenase (EC 1.6.99.3)
    Language English
    Publishing date 1998-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1024481-5
    ISSN 1044-5471
    ISSN 1044-5471
    DOI 10.1089/clm.1998.16.159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Der Wirkungsmechanismus von Low-Level-Laser-Strahlung auf Zellen

    Wilden, Lutz / Karthein, Rainer

    Laserzahnmedizin

    2010  Volume 11, Issue -, Page(s) 21

    Language German
    Document type Article
    ZDB-ID 2483319-8
    Database Current Contents Medicine

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  5. Article: Der Wirkungsmechanismus von Low-Level-Laser-Strahlung auf Zellen

    Karthein, Rainer / Wilden, Lutz

    Laserzahnmedizin

    2009  Volume -, Issue -, Page(s) 46

    Language German
    Document type Article
    ZDB-ID 2483319-8
    Database Current Contents Medicine

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  6. Article: Zur Wirkung von Low Level Laser Strahlung auf den zellulären Energietransfer

    WILDEN, L. / KARTHEIN, R.

    Laser-Medizin

    2000  Volume 15, Issue 1/2, Page(s) 33

    Language German
    Document type Article
    ZDB-ID 1077742-8
    Database Current Contents Medicine

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  7. Article: Patientenbefragung zur Low-Level-Laser-Therapie (LLLT)

    ELLERBROCK, D. / WILDEN, L.

    Laser-Medizin

    2000  Volume 15, Issue 3, Page(s) 139

    Language German
    Document type Article
    ZDB-ID 1077742-8
    Database Current Contents Medicine

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  8. Article ; Online: Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing.

    Vollbrecht, Claudia / Mairinger, Fabian Dominik / Koitzsch, Ulrike / Peifer, Martin / Koenig, Katharina / Heukamp, Lukas Carl / Crispatzu, Giuliano / Wilden, Laura / Kreuzer, Karl-Anton / Hallek, Michael / Odenthal, Margarete / Herling, Carmen Diana / Buettner, Reinhard

    PloS one

    2015  Volume 10, Issue 6, Page(s) e0129544

    Abstract: Background: High resolution molecular studies have demonstrated that the clonal acquisition of gene mutations is an important mechanism that may promote rapid disease progression and drug resistance in chronic lymphocytic leukemia (CLL). Therefore, the ... ...

    Abstract Background: High resolution molecular studies have demonstrated that the clonal acquisition of gene mutations is an important mechanism that may promote rapid disease progression and drug resistance in chronic lymphocytic leukemia (CLL). Therefore, the early and sensitive detection of such mutations is an important prerequisite for future predictive CLL diagnostics in the clinical setting.
    Material & methods: Here, we describe a novel, target-specific next generation sequencing (NGS) approach, which combines multiplex PCR-based target enrichment and library generation with ultra-deep high-throughput parallel sequencing using a MiSeq platform. We designed a CLL specific target panel, covering hotspots or complete coding regions of 15 genes known to be recurrently mutated and/or related to B-cell receptor signaling.
    Results: High-throughput sequencing was performed using as little as 40 ng of peripheral blood B-cell DNA from 136 CLL patients and a dilution series of two ATM- or TP53-mutated cell lines, the latter of which demonstrated a limit of mutation detection below 5%. Using a stringent functional assessment algorithm, 102 mutations in 8 genes were identified in CLL patients, including hotspot regions of TP53, SF3B1, NOTCH1, ATM, XPO1, MYD88, DDX3X and the B-cell receptor signaling regulator PTPN6. The presence of mutations was significantly associated with an advanced disease status und molecular markers of an inferior prognosis, such as an unmutated IGHV mutation status or positivity for ZAP70 by flow cytometry.
    Conclusion: In summary, targeted sequencing using an amplicon based library technology allows a resource-efficient and sensitive mutation analysis for diagnostic or exploratory purposes and facilitates molecular subtyping of patient sets with adverse prognosis.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Gene Library ; Genetic Association Studies ; Genetic Variation ; High-Throughput Nucleotide Sequencing ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction/methods ; Multiplex Polymerase Chain Reaction/standards ; Mutation ; Prognosis ; Sensitivity and Specificity
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0129544
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  9. Article: Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease.

    Sanchez-Ruiz, Monica / Wilden, Laura / Müller, Werner / Stenzel, Werner / Brunn, Anna / Miletic, Hrvoje / Schlüter, Dirk / Deckert, Martina

    Journal of immunology (Baltimore, Md. : 1950)

    2008  Volume 180, Issue 12, Page(s) 8421–8433

    Abstract: To identify basic mechanisms of how infections may induce a neuron-specific autoimmune response, we generated mice expressing OVA as neuronal autoantigen under control of the neuron-specific enolase promoter (NSE-OVA mice). Intracerebral, but not ... ...

    Abstract To identify basic mechanisms of how infections may induce a neuron-specific autoimmune response, we generated mice expressing OVA as neuronal autoantigen under control of the neuron-specific enolase promoter (NSE-OVA mice). Intracerebral, but not systemic, infection with attenuated Listeria monocytogenes-secreting OVA induced an atactic-paretic neurological syndrome in NSE-OVA mice after bacterial clearance from the brain, whereas wild-type mice remained healthy. Immunization with attenuated Listeria monocytogenes-secreting OVA before intracerebral infection strongly increased the number of intracerebral OVA-specific CD8 T cells aggravating neurological disease. T cell depletion and adoptive transfer experiments identified CD8 T cells as decisive mediators of the autoimmune disease. Importantly, NSE-OVA mice having received OVA-specific TCR transgenic CD8 T cells developed an accelerated, more severe, and extended neurological disease. Adoptively transferred pathogenic CD8 T cells specifically homed to OVA-expressing MHC class I(+) neurons and, corresponding to the clinical symptoms, approximately 30% of neurons in the anterior horn of the spinal cord became apoptotic. Thus, molecular mimicry between a pathogen and neurons can induce a CD8 T cell-mediated neurological disease, with its severity being influenced by the frequency of specific CD8 T cells, and its induction, but not its symptomatic phase, requiring the intracerebral presence of the pathogen.
    MeSH term(s) Adoptive Transfer ; Animals ; Autoantigens/administration & dosage ; Autoantigens/genetics ; Autoantigens/immunology ; Brain Diseases/enzymology ; Brain Diseases/genetics ; Brain Diseases/immunology ; Brain Diseases/microbiology ; CD4-Positive T-Lymphocytes/enzymology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/enzymology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/microbiology ; CD8-Positive T-Lymphocytes/transplantation ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Chickens ; Humans ; Listeria monocytogenes/genetics ; Listeria monocytogenes/immunology ; Listeriosis/enzymology ; Listeriosis/genetics ; Listeriosis/immunology ; Listeriosis/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular Mimicry/immunology ; Nervous System Autoimmune Disease, Experimental/enzymology ; Nervous System Autoimmune Disease, Experimental/genetics ; Nervous System Autoimmune Disease, Experimental/microbiology ; Nervous System Autoimmune Disease, Experimental/pathology ; Neurons/enzymology ; Neurons/immunology ; Neurons/metabolism ; Neurons/microbiology ; Ovalbumin/administration & dosage ; Ovalbumin/biosynthesis ; Ovalbumin/genetics ; Ovalbumin/metabolism ; Phosphopyruvate Hydratase/administration & dosage ; Phosphopyruvate Hydratase/biosynthesis ; Phosphopyruvate Hydratase/genetics ; Promoter Regions, Genetic ; Rats
    Chemical Substances Autoantigens ; Ovalbumin (9006-59-1) ; Phosphopyruvate Hydratase (EC 4.2.1.11)
    Language English
    Publishing date 2008-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.180.12.8421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: La Belgique illustrée

    Dumont-Wilden, Louis / Frank, Louis / Verhaeren, Emile

    1915  

    Author's details par Louis Dumont-Wilden. Préface d' Emile Verhaeren. Conclusion par Louis Frank
    Language French
    Size 302 S., zahlr. Ill., graph. Darst., Kt.
    Publisher Larousse
    Publishing place Paris
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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