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  1. AU="Wildman, D"
  2. AU="Manghi, Manoel"
  3. AU="van Dinther, Maarten"
  4. AU="Adams, Ashley L"
  5. AU="Zhang, Er-Bin"
  6. AU="Diuk-Wasser, Maria A"
  7. AU="Chowdhury, Muhtamim"
  8. AU="Rivas, Manuel A"
  9. AU="Mangelis, Anastasios"
  10. AU="Simpson, Tina Y"
  11. AU="Li, Peirang"
  12. AU="Zhang, Zhao-Liang"
  13. AU="Perner, Sven"
  14. AU=Suwanwongse Kulachanya AU=Suwanwongse Kulachanya
  15. AU="Rose, Jacqueline"
  16. AU="E Lostis"

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  1. Artikel ; Online: The prevalence and risk factors of PTSD symptoms among nurses during the COVID-19 pandemic-A systematic review and meta-analysis.

    Hernández-Bojorge, Santiago / Campos, Adriana / Parikh, Jeegan / Beckstead, Jason / Lajeunesse, Marc / Wildman, Derek

    International journal of mental health nursing

    2023  

    Abstract: Since the first reported outbreak in China, the Coronavirus disease 2019 (COVID-19) has raised serious concerns globally. The COVID-19 pandemic has caused a severe psychological impact on healthcare workers (HCWs), and especially nurses, who are the most ...

    Abstract Since the first reported outbreak in China, the Coronavirus disease 2019 (COVID-19) has raised serious concerns globally. The COVID-19 pandemic has caused a severe psychological impact on healthcare workers (HCWs), and especially nurses, who are the most numerous and exposed frontline group. This systematic review and meta-analysis aims to summarise extant literature on the effects of the COVID-19 pandemic on the psychological health of nurses, particularly concerning the prevalence and risk factors for post-traumatic stress disorder (PTSD). A systematic search was conducted on PubMed, Embase and PsycInfo from March 2020 to July 2023. Articles were included/excluded on predetermined eligibility criteria. A random-effect meta-analysis was performed using proportions to determine the pooled prevalence for PTSD among nurses. Subgroup analyses were also performed, and heterogeneity across studies was analysed using meta-regression. Relatively high prevalence rates of PTSD were reported among nurse populations during the COVID-19 pandemic in twenty-six different countries, globally. Risk factors associated with PTSD include having prior mental health co-morbidities, being a female, having high exposure/contact with COVID-19 patients, having insufficient protective conditions and having intensive workloads. The overall pooled prevalence was 29.1% (95% C.I. = 23.5%, 35.5%) using a random-effects model in 55 studies. The regression test of funnel plot asymmetry indicated a significant level of publication bias among studies. The COVID-19 pandemic is associated with significant levels of PTSD among frontline nurses globally. A high level of heterogeneity was observed across studies. Psychological, social and administrative interventions should be implemented to mitigate heavy psychological distress in nurses.
    Sprache Englisch
    Erscheinungsdatum 2023-12-07
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2076760-2
    ISSN 1447-0349 ; 1445-8330
    ISSN (online) 1447-0349
    ISSN 1445-8330
    DOI 10.1111/inm.13257
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Special issue: Morris Goodman memorial.

    Wildman, Derek

    Molecular phylogenetics and evolution

    2013  Band 66, Heft 2, Seite(n) 441

    Mesh-Begriff(e) Evolution, Molecular ; History, 20th Century ; Periodicals as Topic ; Phylogeny
    Sprache Englisch
    Erscheinungsdatum 2013-02
    Erscheinungsland United States
    Dokumenttyp Biography ; Editorial ; Historical Article
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2012.12.008
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  3. Artikel ; Online: Editorial for 25

    Zimmer, Elizabeth / Wildman, Derek

    Molecular phylogenetics and evolution

    2017  Band 117, Seite(n) 1

    Sprache Englisch
    Erscheinungsdatum 2017-12
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2017.10.024
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  4. Artikel ; Online: Visualization of Porous Composite Battery Electrode Fabrication Dynamics for Different Formulations and Conditions Using Hard X-ray Microradiography.

    Higa, Kenneth / Zhang, Buyi / Chandrasiri, Dilni Kaveendi / Tan, Denny / Collins-Wildman, Daniel / Bloemhard, Patricius / Lizotte, Eric / Martin-Nyenhuis, Gabriela / Parkinson, Dilworth Y / Prasher, Ravi / Battaglia, Vincent S

    ACS applied energy materials

    2024  Band 7, Heft 7, Seite(n) 2989–3008

    Abstract: Porous composite battery electrode performance is influenced by a large number of manufacturing decisions. While it is common to evaluate only finished electrodes when making process adjustments, one must then make inferences about the fabrication ... ...

    Abstract Porous composite battery electrode performance is influenced by a large number of manufacturing decisions. While it is common to evaluate only finished electrodes when making process adjustments, one must then make inferences about the fabrication process dynamics from static results, which makes process optimization very costly and time-consuming. To get information about the dynamics of the manufacturing processes of these composites, we have built a miniature coating and drying apparatus capable of fabricating lab-scale electrode laminates while operating within an X-ray beamline hutch. Using this tool, we have collected the first radiography image sequences of lab-scale battery electrode coatings in profile, taken throughout drying processes conducted under industrially relevant conditions. To assist with interpretation of these image sequences, we developed an automated image analysis program. Here, we discuss our observations of battery electrode slurry samples, including stratification and long-term fluid flow, and their relevance to composite electrode manufacturing.
    Sprache Englisch
    Erscheinungsdatum 2024-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2574-0962
    ISSN (online) 2574-0962
    DOI 10.1021/acsaem.4c00402
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  5. Artikel ; Online: Review: Toward an integrated evolutionary understanding of the mammalian placenta.

    Wildman, D E

    Placenta

    2011  Band 32 Suppl 2, Seite(n) S142–5

    Abstract: The placenta is fundamentally important for the success of pregnancy. Disruptions outside the normal range for placental function can result in pregnancy failure and other complications. The anatomy of the placenta varies greatly across mammals, as do ... ...

    Abstract The placenta is fundamentally important for the success of pregnancy. Disruptions outside the normal range for placental function can result in pregnancy failure and other complications. The anatomy of the placenta varies greatly across mammals, as do key parameters in pregnancy such as neonatal body mass, length of gestation and number of offspring per pregnancy. An accurate understanding of the evolution of the mammalian placenta will require at minimum the integration of anatomical, developmental, physiological, genetic, and epigenetic data. Currently available data suggest that the placenta is a dynamic organ that has evolved rapidly in a lineage specific manner. Examination of the placenta from the perspective of human evolution shows that many anatomical features of the human placenta are relatively conserved. Despite the anatomical conservation of the human placenta there are many recently evolved placenta-specific genes (e.g. CGB, LGALS13, GH2) that are important in the development and function of the human placenta. Other mammalian genomes have also evolved specific suites of placenta-expressed genes. For example, rodents have undergone expansions of the cathepsin and prolactin families, and artiodactyls have expanded their suite of pregnancy-associated glycoproteins. In addition to lineage specific birth and death of gene family members, the pattern of imprinted loci varies greatly among species. Taken together, these studies suggest that a strategy reliant upon the sampling of placentally expressed and imprinted genes from a phylogenetically diverse range of species is appropriate for unraveling the conserved and derived aspects of placental biology.
    Mesh-Begriff(e) Animals ; Biological Evolution ; Female ; Genomic Imprinting/genetics ; Humans ; Mammals/anatomy & histology ; Mammals/physiology ; Phylogeny ; Placenta/anatomy & histology ; Placenta/physiology ; Pregnancy
    Sprache Englisch
    Erscheinungsdatum 2011-02-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2011.01.005
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  6. Buch ; Online: Design and High Power Testing of 52.809 MHz RF Cavities for Slip Stacking in the Fermilab Recycler

    Madrak, R. / Wildman, D.

    2014  

    Abstract: For NOvA and future experiments requiring high intensity proton beams, Fermilab is in the process of upgrading the existing accelerator complex for increased proton production. One such improvement is to reduce the Main Injector cycle time, by performing ...

    Abstract For NOvA and future experiments requiring high intensity proton beams, Fermilab is in the process of upgrading the existing accelerator complex for increased proton production. One such improvement is to reduce the Main Injector cycle time, by performing slip stacking, previously done in the Main Injector, in the now repurposed Recycler Ring. Recycler slip stacking requires two new RF cavities operating at slightly different frequencies (df = 1260Hz). These are copper, coaxial, quarter wave cavities with R/Q =13 ohms. They operate at a peak gap voltage of 150 kV with 150 kW peak drive power (60% duty factor), and are resonant at 52.809 MHz with a 10 kHz tuning range. Two have been completed and installed. The design, high power test results, and status of the cavities are presented.

    Comment: 3 p. Presented at North American Particle Accelerator Conference (PAC 2013) Conference
    Schlagwörter Physics - Accelerator Physics
    Thema/Rubrik (Code) 621
    Erscheinungsdatum 2014-09-19
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort.

    Xue, Fei / Tang, Xiwei / Kim, Grace / Koenen, Karestan C / Martin, Chantel L / Galea, Sandro / Wildman, Derek / Uddin, Monica / Qu, Annie

    Journal of the American Statistical Association

    2022  Band 117, Heft 540, Seite(n) 1669–1683

    Abstract: DNA methylation (DNAm) has been suggested to play a critical role in post-traumatic stress disorder (PTSD), through mediating the relationship between trauma and PTSD. However, this underlying mechanism of PTSD for African Americans still remains unknown. ...

    Abstract DNA methylation (DNAm) has been suggested to play a critical role in post-traumatic stress disorder (PTSD), through mediating the relationship between trauma and PTSD. However, this underlying mechanism of PTSD for African Americans still remains unknown. To fill this gap, in this article, we investigate how DNAm mediates the effects of traumatic experiences on PTSD symptoms in the Detroit Neighborhood Health Study (DNHS) (2008-2013) which involves primarily African Americans adults. To achieve this, we develop a new mediation analysis approach for high-dimensional potential DNAm mediators. A key novelty of our method is that we consider heterogeneity in mediation effects across subpopulations. Specifically, mediators in different subpopulations could have opposite effects on the outcome, and thus could be difficult to identify under a traditional homogeneous model framework. In contrast, the proposed method can estimate heterogeneous mediation effects and identifies subpopulations in which individuals share similar effects. Simulation studies demonstrate that the proposed method outperforms existing methods for both homogeneous and heterogeneous data. We also present our mediation analysis results of a dataset with 125 participants and more than 450,000 CpG sites from the DNHS study. The proposed method finds three subgroups of subjects and identifies DNAm mediators corresponding to genes such as
    Sprache Englisch
    Erscheinungsdatum 2022-07-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2064981-2
    ISSN 1537-274X ; 0162-1459 ; 0003-1291
    ISSN (online) 1537-274X
    ISSN 0162-1459 ; 0003-1291
    DOI 10.1080/01621459.2022.2089572
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  8. Artikel: Differentially Expressed Heterogeneous Overdispersion Genes Testing for Count Data.

    Yuan, Yubai / Xu, Qi / Wani, Agaz / Dahrendor, Jan / Wang, Chengqi / Donglasan, Janelle / Burgan, Sarah / Graham, Zachary / Uddin, Monica / Wildman, Derek / Qu, Annie

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The mRNA-seq data analysis is a powerful technology for inferring information from biological systems of interest. Specifically, the sequenced RNA fragments are aligned with genomic reference sequences, and we count the number of sequence fragments ... ...

    Abstract The mRNA-seq data analysis is a powerful technology for inferring information from biological systems of interest. Specifically, the sequenced RNA fragments are aligned with genomic reference sequences, and we count the number of sequence fragments corresponding to each gene for each condition. A gene is identified as differentially expressed (DE) if the difference in its count numbers between conditions is statistically significant. Several statistical analysis methods have been developed to detect DE genes based on RNA-seq data. However, the existing methods could suffer decreasing power to identify DE genes arising from overdispersion and limited sample size. We propose a new differential expression analysis procedure: heterogeneous overdispersion genes testing (DEHOGT) based on heterogeneous overdispersion modeling and a post-hoc inference procedure. DEHOGT integrates sample information from all conditions and provides a more flexible and adaptive overdispersion modeling for the RNA-seq read count. DEHOGT adopts a gene-wise estimation scheme to enhance the detection power of differentially expressed genes. DEHOGT is tested on the synthetic RNA-seq read count data and outperforms two popular existing methods, DESeq and EdgeR, in detecting DE genes. We apply the proposed method to a test dataset using RNAseq data from microglial cells. DEHOGT tends to detect more differently expressed genes potentially related to microglial cells under different stress hormones treatments.
    Sprache Englisch
    Erscheinungsdatum 2023-02-22
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.02.21.529455
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  9. Artikel ; Online: A genetic perspective on glucose consumption in the cerebral cortex during human development.

    Caravas, J / Wildman, D E

    Diabetes, obesity & metabolism

    2014  Band 16 Suppl 1, Seite(n) 21–25

    Abstract: As the major glucose-consuming organ in the human body, the dynamics of glucose metabolism in the brain deserve special attention. It has been shown that the brain's energy allocation as a percentage of the total energy budget of the individual peaks ... ...

    Abstract As the major glucose-consuming organ in the human body, the dynamics of glucose metabolism in the brain deserve special attention. It has been shown that the brain's energy allocation as a percentage of the total energy budget of the individual peaks during childhood and declines through adolescence until reaching the stable allocation level seen in the adult. This pattern of glucose consumption has not been observed in other species, including our close primate relatives, and is therefore potentially either a driver or a consequence of human cognition. Furthermore, the allocation of glucose usage in the brain changes as the individual ages, with a surprising amount dedicated to glycolysis rather than oxidative phosphorylation pathway. This suggests that, at certain developmental stages, glucose-fuelled anabolic pathways, in addition to ATP generation, are the driving forces behind the brain's high energy requirement. In this study, we explore the most recent work pertaining to the dynamic glucose uptake and allocation of the developing human brain and investigate several genes that may play a role in regulating these processes.
    Mesh-Begriff(e) Aging ; Animals ; Cerebral Cortex/growth & development ; Cerebral Cortex/metabolism ; Energy Metabolism ; Gene Expression Regulation, Developmental ; Glucose/metabolism ; Glycolysis ; Humans ; Models, Neurological ; Neocortex/growth & development ; Neocortex/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurogenesis ; Neurons/cytology ; Neurons/metabolism ; Organ Specificity ; Oxidative Phosphorylation
    Chemische Substanzen Nerve Tissue Proteins ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2014-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.12333
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  10. Artikel: Sources for comparative studies of placentation. II. Genomic resources.

    Wildman, D E

    Placenta

    2007  Band 29, Heft 2, Seite(n) 144–147

    Abstract: The genomes of over a dozen placental mammal species are now publicly available. These genome sequences have the potential to provide insight into the development and evolution of the placenta. In particular, the variable anatomy of the placenta has ... ...

    Abstract The genomes of over a dozen placental mammal species are now publicly available. These genome sequences have the potential to provide insight into the development and evolution of the placenta. In particular, the variable anatomy of the placenta has likely been affected by natural selection on the genomes of living and extinct mammals. In this note the current availability of mammal genome sequences is reviewed, and strengths and limitations of these data are discussed. Additionally, museums, zoos, and commercial entities are available to provide genomic resources to the placental research community. Recommendations for tissue storage conditions of placentas in genomic research are given.
    Mesh-Begriff(e) Animals ; Databases, Genetic ; Female ; Genome ; Genomics/methods ; Humans ; Models, Biological ; Physiology, Comparative/methods ; Placentation/genetics ; Placentation/physiology ; Pregnancy ; Tissue Banks/supply & distribution ; Tissue Preservation/methods
    Sprache Englisch
    Erscheinungsdatum 2007-12-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2007.11.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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