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  1. Article: Acute Pneumocystis jirovecii Pneumonia Due to Absolute Lymphopenia.

    Hilker, Eric / Patil, Sachin M / Wilhite, Rodger / Holliday, Zach

    Cureus

    2022  Volume 14, Issue 3, Page(s) e22768

    Abstract: ... ...

    Abstract Pneumocystis
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diffuse Alveolar Hemorrhage: An Uncommon Manifestation of Vaping-associated Lung Injury.

    Wilhite, Rodger / Patel, Tarang / Karle, Ethan / Shankar, Shyam / Krvavac, Armin

    Cureus

    2019  Volume 11, Issue 12, Page(s) e6519

    Abstract: Vaping involves the use of a device to deliver aerosolized nicotine and tetrahydrocannabinol (THC) oils to the lungs. Vaping continues to increase in popularity; however, because it is a novel drug delivery system there is little evidence regarding its ... ...

    Abstract Vaping involves the use of a device to deliver aerosolized nicotine and tetrahydrocannabinol (THC) oils to the lungs. Vaping continues to increase in popularity; however, because it is a novel drug delivery system there is little evidence regarding its safety and long-term consequences. Here, we present a 22-year-old Caucasian male who was admitted with acute hypoxic respiratory failure and massive hemoptysis. Contrasted computed tomography of the chest demonstrated ground glass opacities throughout all lung fields and bilateral pulmonary emboli. Bronchoalveolar lavage revealed increased red blood cell counts in serial aliquots, consistent with the diagnosis of diffuse alveolar hemorrhage (DAH). An extensive workup did not reveal an etiology for the DAH. However, further history was obtained, and the patient divulged daily vaping of THC. E-cigarette, or vaping, product use associated lung injury (EVALI) consists of a myriad of different lung injury patterns. Our case illustrates an uncommon presentation of EVALI with DAH and multiple pulmonary emboli.
    Language English
    Publishing date 2019-12-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.6519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.

    Wilhite, Rodger / Sage, Jessica M / Bouzid, Abdurrahman / Primavera, Tyler / Agbas, Abdulbaki

    Future science OA

    2017  Volume 3, Issue 4, Page(s) FSO238

    Abstract: Aim: Alzheimer's disease (AD) and other forms of dementia create a noncurable disease population in world's societies. To develop a blood-based biomarker is important so that the remedial or disease-altering therapeutic intervention for AD patients ... ...

    Abstract Aim: Alzheimer's disease (AD) and other forms of dementia create a noncurable disease population in world's societies. To develop a blood-based biomarker is important so that the remedial or disease-altering therapeutic intervention for AD patients would be available at the early stage.
    Materials & methods: TDP-43 levels were analyzed in postmortem brain tissue and platelets of AD and control subjects.
    Results: We observed an increased TDP-43 (<60%) in postmortem AD brain regions and similar trends were also observed in patient's platelets.
    Conclusion: Platelet TDP-43 could be used as a surrogate biomarker that is measurable, reproducible and sensitive for screening the patients with some early clinical signs of AD and can be used to monitor disease prognosis.
    Language English
    Publishing date 2017-08-16
    Publishing country England
    Document type Journal Article
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.4155/fsoa-2017-0090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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