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Article ; Online: Some Non-Obvious Consequences of Non-Extensiveness of Entropy.

Wilk, Grzegorz / Włodarczyk, Zbigniew

2023 Volume 25, Issue 3

Abstract: Non-additive (or non-extensive) entropies have long been intensively studied and used in various fields of scientific research. This was due to the desire to describe the commonly observed quasi-power rather than the exponential nature of various ... ...

Abstract	Non-additive (or non-extensive) entropies have long been intensively studied and used in various fields of scientific research. This was due to the desire to describe the commonly observed quasi-power rather than the exponential nature of various distributions of the variables of interest when considered in the full available space of their variability. In this work we will concentrate on the example of high energy multiparticle production processes and will limit ourselves to only one form of non-extensive entropy, namely the Tsallis entropy. We will discuss some points not yet fully clarified and present some non-obvious consequences of non-extensiveness of entropy when applied to production processes.
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25030474
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Acute daily exposure to ambient air pollution impairs endothelium-dependent vasodilator responses in young, healthy individuals.

Jasiewicz-Honkisz, B / Osmenda, G / Wilk, G / Urbanski, K / Luc, K / Guzik, B / Mikołajczyk, T P / Guzik, T J

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2023 Volume 74, Issue 4

Abstract: Exposure to ambient air pollution influences cardiovascular (CV) morbidity and mortality. The differential effects of changing particulate or gaseous air pollution on endothelial function in young healthy individuals remain unclear. The aim of this study ...

Abstract	Exposure to ambient air pollution influences cardiovascular (CV) morbidity and mortality. The differential effects of changing particulate or gaseous air pollution on endothelial function in young healthy individuals remain unclear. The aim of this study was to evaluate the relationships between exposures to different pollutants and vascular function in a group of 39 young (33±11 years old) subjects with low CV risk. Flow-mediated dilatation (FMD) and nitroglycerin-mediated dilatation (NMD) were performed, when air pollution reached highest levels (heating period) and repeated in a subgroup of 18 participants a few months later (just before the heating period starts). Daily mean concentrations of PM2.5 and PM10 were inversely correlated with FMD, and this relationship remained significant after adjusting for factors known to affect vascular dysfunction. Endothelial function did not differ between the two time points studied. However, we observed a strong inverse association between the change in the concentration of particulate matter (deltaPM2.5 and deltaPM10) and the change in FMD (deltaFMD) between the two visits (R= -0.65, p= 0.02; R= -0.64, p= 0.02, respectively). In summary, we provide evidence that the concentration of PM2.5 and PM10, but not SO
MeSH term(s)	Humans ; Young Adult ; Adult ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Endothelium-Dependent Relaxing Factors ; Vasodilator Agents ; Air Pollution/adverse effects ; Air Pollution/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Endothelium-Dependent Relaxing Factors ; Vasodilator Agents ; Particulate Matter
Language	English
Publishing date	2023-10-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2023.4.03
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: regQTLs: Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors.

Wilk, Gary / Braun, Rosemary

PLoS genetics

2018 Volume 14, Issue 12, Page(s) e1007837

Abstract: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA ...

Abstract	Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Here we investigate the functional properties of genetic variants and their effects on miRNA regulation of gene expression in cancer. Our analysis is motivated by the hypothesis that distinct alleles may cause differential binding (from miRNAs to mRNAs or from transcription factors to DNA) and change the expression of genes. We previously identified pathways-systems of genes conferring specific cell functions-that are dysregulated by miRNAs in cancer, by comparing miRNA-pathway associations between healthy and tumor tissue. We draw on these results as a starting point to assess whether SNPs on dysregulated pathways are responsible for miRNA dysregulation of individual genes in tumors. Using an integrative regression analysis that incorporates miRNA expression, mRNA expression, and SNP genotype data, we identify functional SNPs that we term "regulatory QTLs (regQTLs)": loci whose alleles impact the regulation of genes by miRNAs. We apply the method to breast, liver, lung, and prostate cancer data from The Cancer Genome Atlas, and provide a tool to explore the findings.
MeSH term(s)	Alleles ; Binding Sites/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Quantitative Trait Loci ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism
Chemical Substances	MicroRNAs ; RNA, Neoplasm
Language	English
Publishing date	2018-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1007837
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrative analysis reveals disrupted pathways regulated by microRNAs in cancer.

Wilk, Gary / Braun, Rosemary

Nucleic acids research

2017 Volume 46, Issue 3, Page(s) 1089–1101

Abstract: MicroRNAs (miRNAs) are small endogenous regulatory molecules that modulate gene expression post-transcriptionally. Although differential expression of miRNAs have been implicated in many diseases (including cancers), the underlying mechanisms of action ... ...

Abstract	MicroRNAs (miRNAs) are small endogenous regulatory molecules that modulate gene expression post-transcriptionally. Although differential expression of miRNAs have been implicated in many diseases (including cancers), the underlying mechanisms of action remain unclear. Because each miRNA can target multiple genes, miRNAs may potentially have functional implications for the overall behavior of entire pathways. Here, we investigate the functional consequences of miRNA dysregulation through an integrative analysis of miRNA and mRNA expression data using a novel approach that incorporates pathway information a priori. By searching for miRNA-pathway associations that differ between healthy and tumor tissue, we identify specific relationships at the systems level which are disrupted in cancer. Our approach is motivated by the hypothesis that if an miRNA and pathway are associated, then the expression of the miRNA and the collective behavior of the genes in a pathway will be correlated. As such, we first obtain an expression-based summary of pathway activity using Isomap, a dimension reduction method which can articulate non-linear structure in high-dimensional data. We then search for miRNAs that exhibit differential correlations with the pathway summary between phenotypes as a means of finding aberrant miRNA-pathway coregulation in tumors. We apply our method to cancer data using gene and miRNA expression datasets from The Cancer Genome Atlas and compare ∼105 miRNA-pathway relationships between healthy and tumor samples from four tissues (breast, prostate, lung and liver). Many of the flagged pairs we identify have a biological basis for disruption in cancer.
MeSH term(s)	Atlases as Topic ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Metabolic Networks and Pathways/genetics ; MicroRNAs/classification ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Phenotype ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	MicroRNAs ; RNA, Messenger ; Tumor Suppressor Protein p53
Language	English
Publishing date	2017-12-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkx1250
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A study of the symmetry of roots and root canal morphology in mandibular anterior teeth using cone-beam computed tomographic imaging in a Polish population.

Sroczyk-Jaszczyńska, M / Kołecki, J / Lipski, M / Puciło, M / Wilk, G / Falkowski, A / Kot, K / Nowicka, A

Folia morphologica

2019 Volume 79, Issue 4, Page(s) 835–844

Abstract: Background: The purpose of the study was to analyse mandibular anterior teeth in a Polish population and determine the symmetry of root and root canal morphology between the right and left side using cone-beam computed tomography (CBCT) scanning.: ... ...

Abstract	Background: The purpose of the study was to analyse mandibular anterior teeth in a Polish population and determine the symmetry of root and root canal morphology between the right and left side using cone-beam computed tomography (CBCT) scanning. Materials and methods: From 111 CBCT examinations, 303 pairs of equivalent mandibular anterior teeth were analysed on the right and left sides to evaluate symmetry. Axial, sagittal, and cross-sectional slices with a thickness of 0.2-0.25 mm were used. The number of root canals and their internal patterns were classified following Vertucci's criteria. Results: All incisors in this study had 1 root. Canines usually had a single root and much less often had 2 roots. Type I and III root canal configurations were found most often, while type V and II configurations were less frequent. Significant compatibility between the left and right side was observed in all evaluated variables. Incisors had the highest symmetry with regard to the number of roots (100%). Second canals were observed more often in males than females, but only the results in lateral incisors were significant. Conclusions: This study provides supplemental information for dentists and should help them to better predict the morphology of mandibular anterior teeth in complicated cases in the Polish population. Symmetry was observed in roots and root canal morphology in all examined parameters.
MeSH term(s)	Cone-Beam Computed Tomography ; Cross-Sectional Studies ; Dental Pulp Cavity/diagnostic imaging ; Female ; Humans ; Male ; Mandible/diagnostic imaging ; Poland ; Tooth Root/diagnostic imaging
Language	English
Publishing date	2019-12-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	419361-1
ISSN	1644-3284 ; 0015-5659
ISSN (online)	1644-3284
ISSN	0015-5659
DOI	10.5603/FM.a2019.0128
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Stellenbeschreibungen und Anforderungsprofile

Wilk, Gabriele

2011 , Page(s) 199 S.

Language	German
Document type	Book
ISBN	978-3-648-01278-9
Database	OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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Book ; Online: Stellenbeschreibungen und Anforderungsprofile

Wilk, Gabriele

(Haufe Praxisratgeber)

2011

Abstract: Präzise Stellenbeschreibungen und klare Anforderungsprofile sind die Basis effektiver Personalarbeit. Dieser Praxisratgeber bietet Ihnen Formulierungshilfen und Textbausteine, damit Sie Kandidaten finden, deren Kompetenzen zur Unternehmensstrategie ... ...

Author's details	Gabriele Wilk
Series title	Haufe Praxisratgeber
Abstract	Präzise Stellenbeschreibungen und klare Anforderungsprofile sind die Basis effektiver Personalarbeit. Dieser Praxisratgeber bietet Ihnen Formulierungshilfen und Textbausteine, damit Sie Kandidaten finden, deren Kompetenzen zur Unternehmensstrategie passen. Dieses Buch gibt Ihnen leistungsfähige Werkzeuge zur strategischen Personalbeschaffung in die Hand. Nutzen Sie die Formulierungshilfen und Textbausteine, um aussagekräftige Stellenbeschreibungen und passgenaue Anforderungsprofile zu verfassen. Werden Sie zum attraktiven Arbeitgeber für die kompetentesten Bewerber. INHALTE: - Der effiziente Weg zur strategischen Personalbeschaffung. - Zeitsparend individuelle Ausschreibungsunterlagen erstellen. - Der kompetente und kostengünstige Helfer für jede Personalabteilung. AUF CD-ROM (Inhalte auf Anfrage): - Textbausteine, Formulierungshilfen, Checklisten und Mustervorlagen.
Keywords	Wirtschaft # Personal
Language	German
Size	Online-Ressource
Edition	1. Aufl.
Publisher	Haufe Verlag
Publishing place	Freiburg u.a.
Document type	Book ; Online
ISBN	3648012789 ; 9783648012789
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online: Stellenbeschreibungen und Anforderungsprofile

Wilk, Gabriele

(Haufe Praxisratgeber)

2011

Author's details	Gabriele Wilk
Series title	Haufe Praxisratgeber
Abstract	Präzise Stellenbeschreibungen und klare Anforderungsprofile sind die Basis effektiver Personalarbeit. Dieser Praxisratgeber bietet Ihnen Formulierungshilfen und Textbausteine, damit Sie Kandidaten finden, deren Kompetenzen zur Unternehmensstrategie passen. Dieses Buch gibt Ihnen leistungsfähige Werkzeuge zur strategischen Personalbeschaffung in die Hand. Nutzen Sie die Formulierungshilfen und Textbausteine, um aussagekräftige Stellenbeschreibungen und passgenaue Anforderungsprofile zu verfassen. Werden Sie zum attraktiven Arbeitgeber für die kompetentesten Bewerber. INHALTE: - Der effiziente Weg zur strategischen Personalbeschaffung. - Zeitsparend individuelle Ausschreibungsunterlagen erstellen. - Der kompetente und kostengünstige Helfer für jede Personalabteilung. AUF CD-ROM (Inhalte auf Anfrage): - Textbausteine, Formulierungshilfen, Checklisten und Mustervorlagen.
Keywords	Wirtschaft Personal
Language	German
Size	Online-Ressource
Edition	1. Aufl.
Publisher	Haufe Verlag
Publishing place	Freiburg u.a.
Document type	Book ; Online
ISBN	3648012789 ; 9783648012789
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients-Observational Study.

Sutkowska, Edyta / Stanek, Agata / Madziarska, Katarzyna / Jakubiak, Grzegorz K / Sokołowski, Janusz / Madziarski, Marcin / Sutkowska-Stępień, Karolina / Biernat, Karolina / Mazurek, Justyna / Borowkow-Bulek, Adrianna / Czyżewski, Jakub / Wilk, Gabriela / Jagasyk, Arkadiusz / Marciniak, Dominik

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: Background and aim: Physical activity (PA) can modulate the immune response, but its impact on infectious disease severity is unknown. We assess if the PA level impacts the severity of COVID-19.: Methods: Prospective, cohort study for adults ... ...

Abstract	Background and aim: Physical activity (PA) can modulate the immune response, but its impact on infectious disease severity is unknown. We assess if the PA level impacts the severity of COVID-19. Methods: Prospective, cohort study for adults hospitalized due to COVID-19, who filled out the International Physical Activity Questionnaire (IPAQ). Disease severity was expressed as death, transfer to intensive care unit (ICU), oxygen therapy (OxTh), hospitalization length, complications, C-reactive protein, and procalcitonin level. Results: Out of 326 individuals, 131 (57; 43.51% women) were analyzed: age: median-70; range: 20-95; BMI: mean-27.18 kg/m²; and SD: ±4.77. During hospitalization: 117 (83.31%) individuals recovered, nine (6.87%) were transferred to ICU, five (3.82%) died, and 83 (63.36%) needed OxTh. The median for the hospital stay was 11 (range: 3-49) for discharged patients, and mean hospitalization length was 14 (SD: ±5.8312) for deaths and 14.22 days (SD: ±6.92) for ICU-transferred patients. The median for MET-min/week was 660 (range: 0-19,200). Sufficient or high PA was found in recovered patients but insufficient PA was observed in dead or ICU-transferred patients ( Conclusion: A higher level of PA is associated with a milder course of COVID-19.
Language	English
Publishing date	2023-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12124046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Standardizing Care of Neuro-oncology Patients Using a Customized Electronic Medical Record Toolkit.

Merrell, Ryan T / Simon, Kelly Claire / Martinez, Nina / Vazquez, Rosa Maria / Hadsell, Bryce / Epshteyn, Alexander / Wilk, Gary / Frigerio, Roberta / Maraganore, Demetrius M

Mayo Clinic proceedings. Innovations, quality & outcomes

2021 Volume 5, Issue 3, Page(s) 625–634

Abstract: Objective: To develop and implement a customized toolkit within the electronic medical record (EMR) to standardize care of patients with brain tumors.: Patients and methods: We built a customized structured clinical documentation support toolkit to ... ...

Abstract	Objective: To develop and implement a customized toolkit within the electronic medical record (EMR) to standardize care of patients with brain tumors. Patients and methods: We built a customized structured clinical documentation support toolkit to capture standardized data at office visits. We detail the process by which this toolkit was conceptualized and developed. Toolkit development was a physician-led process to determine a work flow and necessary elements to support best practices as defined by the neuro-oncology clinical team. Results: We have developed in our EMR system a customized work flow for clinical encounters with neuro-oncology patients. In addition to providing a road map for clinical care by our neuro-oncology team, the toolkit is designed to maximize discrete data capture. Several hundred fields of discrete data are captured through the toolkit in the context of our routine office visits. We describe the characteristics of patients seen at our clinic, the adoption of the toolkit, current initiatives supported by the toolkit, and future applications. Conclusion: The EMR can be effectively structured to standardize office visits and improve discrete data capture. This toolkit can be leveraged to support quality improvement and practice-based research initiatives at the point of care in a neuro-oncology practice.
Language	English
Publishing date	2021-06-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4548
ISSN (online)	2542-4548
DOI	10.1016/j.mayocpiqo.2021.04.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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