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  1. Article ; Online: Correction to: Comment on "Understanding the Training of Psychiatric Mental Health Nurse Practitioners".

    Dragonetti, Joseph D / Wilkes, Sean

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2023  Volume 47, Issue 6, Page(s) 702

    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-023-01888-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on "Understanding the Training of Psychiatric Mental Health Nurse Practitioners".

    Dragonetti, Joseph D / Wilkes, Sean

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2023  Volume 47, Issue 6, Page(s) 692–693

    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-023-01867-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Boy in the Borstal: Gene Hunting, Dopaminergic Dogma, and the Science of Schizophrenia.

    Wilkes, Sean L / Ross, David A

    Biological psychiatry

    2023  Volume 93, Issue 4, Page(s) e7–e9

    MeSH term(s) Humans ; Male ; Dopamine ; Schizophrenia/genetics
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2022.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impacts of rTMS on Refractory Depression and Comorbid PTSD Symptoms at a Military Treatment Facility.

    Wilkes, Sean / Ona, Celia / Yang, Michael / Liu, Pingyang / Benton, Amber / Lustik, Michael / Coleman, John

    Military medicine

    2020  Volume 185, Issue 9-10, Page(s) e1420–e1427

    Abstract: Introduction: Repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression has been studied for over two decades. Repetitive TMS was approved by the Food and Drug Administration in 2008 for the treatment of depression after at least ...

    Abstract Introduction: Repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression has been studied for over two decades. Repetitive TMS was approved by the Food and Drug Administration in 2008 for the treatment of depression after at least one failed trial of an antidepressant medication of adequate dose and duration. This study evaluated whether rTMS treatments may be associated with measurable improvements in depression and post-traumatic stress disorder (PTSD) symptoms for treated military beneficiaries in Hawaii suffering from depression. It also examined the number of failed medication trials that patients underwent before rTMS treatment.
    Materials and methods: A retrospective chart review of 77 rTMS patients who received and completed treatment between January 1, 2010 and October 31, 2016 was performed. Under a typical treatment regimen, patients receive rTMS for 6 weeks as well as weekly psychiatric assessments, which included completion of Beck's Depression Inventory (BDI) and PTSD Checklist (PCL). A mixed model repeated measures analysis was done assuming an autoregressive order one covariance structure to evaluate changes over time. Adjusted analyses were done to assess whether changes over time differed by age, prior diagnosis of PTSD, active duty status, and gender.
    Results: The majority of patients were from the army (74%) and 56% were on active duty. Just over half (53%) were male. Most patients (52%) had completed trials of three or more different antidepressant medications before initiation of treatment with rTMS. The mean number of antidepressant trials was 2.7. BDI and PCL scores were significantly lower at end of treatment on average compared to the pretreatment baseline scores. Mean differences for BDI and PCL were significant with P < 0.001 15, 30, and 45 days after TMS treatment was initiated. Overall, 44% of patients experienced a reduction ≥10 points on BDI, and 38% experienced a reduction ≥10 points on PCL. Additionally, scores fell similarly regardless of whether or not patients had a comorbid diagnosis of PTSD.
    Conclusions: Our research suggests that rTMS treatments may produce a reduction in symptoms of both depression and PTSD in patients with refractory depression and comorbid PTSD. It may be a useful alternative to antidepressants in the treatment of depression in the military population, including those with comorbid PTSD. Broader implementation of this treatment modality may prove beneficial for the purposes of military readiness, given current policies and restrictions on service members who are initiated on antidepressant medications.
    MeSH term(s) Depressive Disorder, Treatment-Resistant ; Hawaii ; Humans ; Male ; Military Personnel ; Retrospective Studies ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/therapy ; Transcranial Magnetic Stimulation ; Treatment Outcome
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usaa148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Impact of Near-Peer Teaching on Medical Students' Transition to Clerkships.

    Knobloch, Alexander C / Ledford, Christy J W / Wilkes, Sean / Saperstein, Adam K

    Family medicine

    2018  Volume 50, Issue 1, Page(s) 58–62

    Abstract: Background and objectives: The transition to clerkships is one of the most challenging times during medical school. To help students better cope, many schools have established transition-to-clerkship curricula. Such curricula may optimally prepare ... ...

    Abstract Background and objectives: The transition to clerkships is one of the most challenging times during medical school. To help students better cope, many schools have established transition-to-clerkship curricula. Such curricula may optimally prepare students through increasing their self-efficacy and response efficacy. We hypothesized that a small-group, near-peer-led format would be ideally suited to help students achieve these outcomes.
    Methods: During process improvement for a transition-to-clerkship curriculum, we conducted an informal focus group and subsequent survey of postclerkship students to guide curricular innovation, including incorporation of third- and fourth-year students as near-peer instructors in a seminar format. Seminars included three sequential small-group discussions focused on discrete topic areas and concluded with a large-group session highlighting salient discussion points. To evaluate the impact of this educational strategy, near-peer learners were surveyed before and after the seminars.
    Results: Junior student participants reported feeling more prepared to integrate into the health care team, develop a clerkship study plan, and access applicable, valuable study materials, both immediately following the seminars and 6 months later, demonstrating increased self-efficacy. These students placed equal or greater value on these topics as compared to students in previous year groups, demonstrating similar response efficacy.
    Conclusions: This study demonstrated an increase in student self-efficacy that persisted 6 months postintervention, in addition to similar response efficacy. Future research could be directed toward: (1) investigating whether improvements in self-efficacy among students transitioning to clerkships are associated with improved clerkship performance and (2) studying outcomes for near-peer teachers.
    MeSH term(s) Adult ; Clinical Clerkship ; Clinical Competence ; Curriculum ; Educational Measurement/methods ; Female ; Focus Groups ; Humans ; Internet ; Male ; Peer Group ; Self Efficacy ; Students, Medical/psychology ; Surveys and Questionnaires ; Teaching
    Language English
    Publishing date 2018-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639374-3
    ISSN 1938-3800 ; 0742-3225
    ISSN (online) 1938-3800
    ISSN 0742-3225
    DOI 10.22454/FamMed.2018.745428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lumbosacral lipomyelomeningocele with anomalous osseous limb in a 3-month-old female.

    Wilkes, Sean L / Choi, Jay J / Rooks, Veronica J

    Radiology case reports

    2015  Volume 10, Issue 1, Page(s) 1051

    Abstract: A patient with lipomyelomeningocele (known in utero) presented for MRI characterization prior to surgical procedure at three months of age. Cross-sectional imaging revealed a spinal dysraphism of the lower lumbar spine, with a posterior spinal defect ... ...

    Abstract A patient with lipomyelomeningocele (known in utero) presented for MRI characterization prior to surgical procedure at three months of age. Cross-sectional imaging revealed a spinal dysraphism of the lower lumbar spine, with a posterior spinal defect spanning L4 to S2 subcutaneous fat intrusion, and distal spinal cord extrusion. An osseous excrescence was also appreciated, articulating with the left iliac bone. This case demonstrates the youngest known lipomyelomeningocele with accessory limb and the abnormal growth of multiple tissue types at the site of spinal dysraphism-a potential consequence of dedifferentiated cell proliferation originating from a secondary neural tube defect or rachipagus parasitic twinning.
    Language English
    Publishing date 2015-12-03
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.2484/rcr.v10i1.1051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evolution of Traumatic Parenchymal Intracranial Hematomas (ICHs): Comparison of Hematoma and Edema Components.

    Wilkes, Sean / McCormack, Erin / Kenney, Kimbra / Stephens, Brian / Passo, Ross / Harburg, Leah / Silverman, Erika / Moore, Carol / Bogoslovsky, Tanya / Pham, Dzung / Diaz-Arrastia, Ramon

    Frontiers in neurology

    2018  Volume 9, Page(s) 527

    Abstract: This study seeks to quantitatively assess evolution of traumatic ICHs over the first 24 h and investigate its relationship with functional outcome. Early expansion of traumatic intracranial hematoma (ICH) is common, but previous studies have focused on ... ...

    Abstract This study seeks to quantitatively assess evolution of traumatic ICHs over the first 24 h and investigate its relationship with functional outcome. Early expansion of traumatic intracranial hematoma (ICH) is common, but previous studies have focused on the high density (blood) component. Hemostatic therapies may increase the risk of peri-hematoma infarction and associated increased cytotoxic edema. Assessing the magnitude and evolution of ICH and edema represented by high and low density components on computerized tomography (CT) may be informative for designing therapies targeted at traumatic ICH. CT scans from participants in the COBRIT (Citicoline Brain Injury Trial) study were analyzed using MIPAV software. CT scans from patients with non-surgical intraparenchymal ICHs at presentation and approximately 24 h later (±12 h) were selected. Regions of high density and low density were quantitatively measured. The relationship between volumes of high and low density were compared to several outcome measures, including Glasgow Outcome Score-Extended (GOSE) and Disability Rating Score (DRS). Paired scans from 84 patients were analyzed. The median time between the first and second scan was 22.79 h (25%ile 20.11 h; 75%ile 27.49 h). Over this time frame, hematoma and edema volumes increased >50% in 34 (40%) and 46 (55%) respectively. The correlation between the two components was low (
    Language English
    Publishing date 2018-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2018.00527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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