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  1. Article ; Online: Attention-Deficit/Hyperactivity Disorder and Academic Functioning: Reading, Writing, and Math Abilities in a Community Sample of Youth with and without ADHD.

    Trane, Francesca E / Willcutt, Erik G

    Research on child and adolescent psychopathology

    2022  Volume 51, Issue 4, Page(s) 583–596

    Abstract: Previous studies have shown that Attention-Deficit/Hyperactivity disorder (ADHD) is marked by impairments in academic functioning in reading, writing, and mathematics. Yet, virtually no studies have examined academic functioning in terms of both basic ... ...

    Abstract Previous studies have shown that Attention-Deficit/Hyperactivity disorder (ADHD) is marked by impairments in academic functioning in reading, writing, and mathematics. Yet, virtually no studies have examined academic functioning in terms of both basic skills (e.g., word recognition, handwriting/spelling, arithmetic calculations) and more complex advanced skills (e.g., reading comprehension, writing composition, and mathematical problem-solving) within the same sample. In the present study, 518 children with ADHD were compared to a control group of 851 children without ADHD (ages 8-18) and assessed on a comprehensive battery of reading, writing, and math assessments. It was hypothesized that ADHD diagnostic status would uniquely predict performance on advanced skill measures even after controlling for performance on basic skills in that academic domain. ADHD status was associated with worse performance across all academic tests. Results also indicated that ADHD independently predicted performance for measures of writing composition and one measure of reading comprehension, even after controlling for performance on basic skills in those domains. However, ADHD did not independently predict mathematical problem-solving performance. These findings add to the literature on ADHD and academic functioning and indicate that inattention may weaken skills necessary for effective reading comprehension and writing composition.
    MeSH term(s) Child ; Humans ; Adolescent ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Reading ; Cognition ; Mathematics ; Handwriting
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3041907-4
    ISSN 2730-7174 ; 2730-7166
    ISSN (online) 2730-7174
    ISSN 2730-7166
    DOI 10.1007/s10802-022-01004-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Behavior and Molecular Genetic Approaches to Comorbidity.

    Willcutt, Erik G

    Current developmental disorders reports

    2019  Volume 6, Issue 2, Page(s) 31–36

    Abstract: Purpose of review: This review provides an overview of studies that used behavioral genetic methods to understand the genetic and environmental influences that lead to comorbidity, the co-occurrence of two or more developmental disorders in the same ... ...

    Abstract Purpose of review: This review provides an overview of studies that used behavioral genetic methods to understand the genetic and environmental influences that lead to comorbidity, the co-occurrence of two or more developmental disorders in the same individual.
    Recent findings: Comorbidity is primarily explained by shared genetic influences for most pairs of disorders that have been studied, including attention deficit hyperactivity disorder (ADHD) and learning disabilities, conduct disorder and ADHD, anxiety and depression, and anxiety and autism spectrum disorder (ASD). Molecular genetic studies indicate that the etiologies of developmental disorders are highly multifactorial, with dozens or even hundreds of genes acting in combination with environmental risk factors to lead to each individual disorder and the extensive comorbidity between disorders. Due to this complexity, current state-of-the-art studies are now combining molecular genetic data from multiple large samples to begin to achieve adequate statistical power to identify the specific genetic polymorphisms that lead to comorbidity.
    Summary: An extensive literature demonstrates the pervasiveness and potential importance of comorbidity between developmental disorders, and results of family, twin, and molecular genetic studies indicate that these comorbidities may be largely explained by shared genetic influences. Additional studies are ongoing to identify the specific genetic polymorphisms that increase risk for each developmental disorder and comorbidity between disorders.
    Language English
    Publishing date 2019-05-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2196-2987
    ISSN 2196-2987
    DOI 10.1007/s40474-019-00162-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sluggish Cognitive Tempo and Neuropsychological Functioning.

    Creque, Chava A / Willcutt, Erik G

    Research on child and adolescent psychopathology

    2021  Volume 49, Issue 8, Page(s) 1001–1013

    Abstract: Sluggish cognitive tempo (SCT) is marked by impairments across social, emotional, and academic functioning, but few studies have examined the association between SCT and neuropsychological functioning. The present study examined the associations between ... ...

    Abstract Sluggish cognitive tempo (SCT) is marked by impairments across social, emotional, and academic functioning, but few studies have examined the association between SCT and neuropsychological functioning. The present study examined the associations between SCT and measures of processing speed, executive function, attention, and reaction time. From a larger sample of 8,238 children and adolescents, a subsample of 928 children were overselected for symptoms of SCT or attention-deficit/hyperactivity disorder (ADHD) and compared to a matched control sample of 652 individuals without elevations of ADHD or SCT (age range = 5.9-15.4 years). Multiple regression analyses revealed that symptoms of SCT were independently associated with deficits in nearly all domains assessed by a battery of neuropsychological assessments, including slower processing speed, poorer working memory, decreased inhibition, poorer vigilance, and increased reaction time. Further, weaknesses in all five of these domains remained significant even after symptoms of ADHD-inattention, anxiety, and depression were controlled. These findings add to literature that supports the validity of SCT as a symptom profile separate from ADHD-inattention symptoms.
    MeSH term(s) Adolescent ; Attention ; Attention Deficit Disorder with Hyperactivity ; Child ; Child, Preschool ; Cognition ; Executive Function ; Humans ; Neuropsychological Tests
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3041907-4
    ISSN 2730-7174 ; 2730-7166
    ISSN (online) 2730-7174
    ISSN 2730-7166
    DOI 10.1007/s10802-021-00810-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood.

    Breunig, Sophie / Lawrence, Jeremy M / Foote, Isabelle F / Gebhardt, Hannah J / Willcutt, Erik G / Grotzinger, Andrew D

    Biological psychiatry global open science

    2024  Volume 4, Issue 3, Page(s) 100307

    Abstract: Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with diagnostic criteria requiring symptoms to begin in childhood. We investigated whether individuals diagnosed as children differ from those diagnosed in ... ...

    Abstract Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with diagnostic criteria requiring symptoms to begin in childhood. We investigated whether individuals diagnosed as children differ from those diagnosed in adulthood with respect to shared and unique architecture at the genome-wide and gene expression level of analysis.
    Methods: We used genomic structural equation modeling (SEM) to investigate differences in genetic correlations (
    Results: Compared with the childhood subgroup, adulthood-diagnosed ADHD exhibited a significantly larger negative
    Conclusions: This study demonstrated that ADHD diagnosed later in life shows much stronger genetic overlap with internalizing disorders and related traits. This may indicate the potential clinical relevance of distinguishing these subgroups or increased misdiagnosis for those diagnosed later in life. Top transcriptome-wide SEM results implicated genes related to neuronal function and clinical characteristics (e.g., sleep).
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2667-1743
    ISSN (online) 2667-1743
    DOI 10.1016/j.bpsgos.2024.100307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Processing Speed is Related to the General Psychopathology Factor in Youth.

    Kramer, Eliza / Willcutt, Erik G / Peterson, Robin L / Pennington, Bruce F / McGrath, Lauren M

    Research on child and adolescent psychopathology

    2023  Volume 51, Issue 8, Page(s) 1179–1193

    Abstract: The relationship between the p factor and cognition in youth has largely focused on general cognition (IQ) and executive functions (EF). Another cognitive construct, processing speed (PS), is dissociable from IQ and EF, but has received less research ... ...

    Abstract The relationship between the p factor and cognition in youth has largely focused on general cognition (IQ) and executive functions (EF). Another cognitive construct, processing speed (PS), is dissociable from IQ and EF, but has received less research attention despite being related to many different mental health symptoms. The present sample included 795 youth, ages 11-16 from the Colorado Learning Disabilities Research Center (CLDRC) sample. Confirmatory factor analyses tested multiple p factor models, with the primary model being a second-order, multi-reporter p factor. We then tested the correlation between the p factor and a latent PS factor. There was a significant, negative correlation between the p factor and PS (r(87) = -0.42, p < .001), indicating that slower processing speed is associated with higher general mental health symptoms. This association is stronger than previously reported associations with IQ or EF. This finding was robust across models that used different raters (youth and caregiver) and modeling approaches (second-order vs. bifactor). Our findings indicate that PS is related to general psychopathology symptoms. This research points to processing speed as an important transdiagnostic construct that warrants further exploration across development.
    MeSH term(s) Humans ; Adolescent ; Processing Speed ; Psychopathology ; Mental Disorders/diagnosis ; Mental Disorders/psychology ; Executive Function ; Cognition
    Language English
    Publishing date 2023-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3041907-4
    ISSN 2730-7174 ; 2730-7166
    ISSN (online) 2730-7174
    ISSN 2730-7166
    DOI 10.1007/s10802-023-01049-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advancing the study of sluggish cognitive tempo via DSM, RDoC, and hierarchical models of psychopathology.

    Becker, Stephen P / Willcutt, Erik G

    European child & adolescent psychiatry

    2018  Volume 28, Issue 5, Page(s) 603–613

    Abstract: Sluggish cognitive tempo (SCT) is separable from attention-deficit/hyperactivity disorder (ADHD) and other psychopathologies, and growing evidence demonstrates SCT to be associated with impairment in both children and adults. However, it remains unclear ... ...

    Abstract Sluggish cognitive tempo (SCT) is separable from attention-deficit/hyperactivity disorder (ADHD) and other psychopathologies, and growing evidence demonstrates SCT to be associated with impairment in both children and adults. However, it remains unclear how SCT should optimally be conceptualized. In this article, we argue that multiple models of psychopathology should be leveraged to make substantive advances to our understanding of SCT. Both categorical and dimensional approaches should be used, including the Diagnostic and Statistical Manual of Mental Disorders (DSM) nosology, the Research Domain Criteria (RDoC) initiative, and hierarchical models of psychopathology. Studies are needed to determine whether individuals categorized with SCT can be reliably identified and differentiated from individuals without SCT in pathophysiological, neuropsychological, behavioral, and daily life functioning. Studies are also needed to evaluate the validity and utility of SCT as a transdiagnostic and dimensional construct. In considering SCT as a dimensional and potentially transdiagnostic construct, we describe ways in which SCT might be examined within the RDoC framework, including negative valence systems, cognitive systems, and arousal/regulatory systems, as well as within hierarchical models of psychopathology. Conceptualizing SCT within both categorical and dimensional models of psychopathology will help to better understand the causes, developmental pathways, and clinical implications of SCT, both as a construct in its own right and also in relation to other psychopathologies.
    MeSH term(s) Cognition Disorders/diagnosis ; Cognition Disorders/pathology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Male ; Psychopathology/methods
    Language English
    Publishing date 2018-03-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-018-1136-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modeling the Speeded Determinants of Adolescents' Academic and Attentional Functioning.

    Wakeman, Holly N / Leopold, Daniel R / Olson, Richard K / Willcutt, Erik G

    Developmental neuropsychology

    2021  Volume 47, Issue 2, Page(s) 61–77

    Abstract: The current study utilized a large, unselected sample of adolescent twins to examine whether processing speed (PS) is an important shared predictor that accounts for covariance among reading, math, ADHD, and rapid naming (RN). The best fitting model ... ...

    Abstract The current study utilized a large, unselected sample of adolescent twins to examine whether processing speed (PS) is an important shared predictor that accounts for covariance among reading, math, ADHD, and rapid naming (RN). The best fitting model included correlated but distinguishable latent measures of PS, RN, reading, math, inattention, hyperactivity/impulsivity, and academic fluency. PS was a shared predictor across all outcomes, while RN was uniquely associated with reading, fluency, and (albeit weakly) math. The results add to a growing literature suggesting that PS and RN may be important components of comprehensive neuropsychological models of academics, ADHD, and their covariation.
    MeSH term(s) Adolescent ; Attention ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Cognition ; Humans ; Mathematics ; Reading
    Language English
    Publishing date 2021-12-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Twin Study
    ZDB-ID 632665-1
    ISSN 1532-6942 ; 8756-5641
    ISSN (online) 1532-6942
    ISSN 8756-5641
    DOI 10.1080/87565641.2021.2010735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Heritability and Clinical Characteristics of Neuropsychological Profiles in Youth With and Without Elevated ADHD Symptoms.

    Arnett, Anne B / McGrath, Lauren M / Flaherty, Brian P / Pennington, Bruce F / Willcutt, Erik G

    Journal of attention disorders

    2022  Volume 26, Issue 11, Page(s) 1422–1436

    Abstract: Objective: In the last decade, there has been an increase in research that aims to parse heterogeneity in attention deficit hyperactivity disorder (ADHD). The current study tests heritability of latent class neuropsychological subtypes.: Method: ... ...

    Abstract Objective: In the last decade, there has been an increase in research that aims to parse heterogeneity in attention deficit hyperactivity disorder (ADHD). The current study tests heritability of latent class neuropsychological subtypes.
    Method: Latent class analysis was used to derive subtypes in a sample of school-age twins (
    Results: Five neuropsychological profiles replicated across twin 1 and twin 2 datasets. Latent class membership was heritable overall, but heritability varied by profile and was lower than heritability of ADHD status. Variability in neuropsychological performance across domains was the strongest predictor of elevated ADHD symptoms. Neuropsychological profiles showed distinct associations with age, psychiatric symptoms and reading ability.
    Conclusion: Neuropsychological profiles are associated with unique neurocognitive presentations, but are not strong candidate endophenotypes for ADHD diagnosis.
    MeSH term(s) Adolescent ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/genetics ; Attention Deficit Disorder with Hyperactivity/psychology ; Cognition ; Humans ; Twins/genetics
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Historical Article
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547221075842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Compounding Effects of Domain-General Cognitive Weaknesses and Word Reading Difficulties on Anxiety Symptoms in Youth.

    Anderson, Nina J / Rozenman, Michelle / Pennington, Bruce F / Willcutt, Erik G / McGrath, Lauren M

    Journal of learning disabilities

    2022  Volume 56, Issue 5, Page(s) 343–358

    Abstract: This study examined whether domain-general cognitive weaknesses in processing speed (PS) or executive functioning (EF) moderate the relation between word reading scores and anxiety such that lower word reading scores in combination with lower cognitive ... ...

    Abstract This study examined whether domain-general cognitive weaknesses in processing speed (PS) or executive functioning (EF) moderate the relation between word reading scores and anxiety such that lower word reading scores in combination with lower cognitive scores are associated with higher anxiety symptoms. The sample consisted of 755 youth ages 8-16 who were recruited as part of the Colorado Learning Disabilities Research Center twins study. Lower scores on PS (
    Language English
    Publishing date 2022-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217619-1
    ISSN 1538-4780 ; 0022-2194
    ISSN (online) 1538-4780
    ISSN 0022-2194
    DOI 10.1177/00222194221098719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: ADHD and Psychological Need Fulfillment in College Students.

    Serrano, Judah W / Abu-Ramadan, Tamara M / Vasko, John M / Leopold, Daniel R / Canu, Will H / Willcutt, Erik G / Hartung, Cynthia M

    Journal of attention disorders

    2023  Volume 27, Issue 8, Page(s) 912–924

    Abstract: Objective: Self-determination theory suggests that the satisfaction and frustration of basic psychological needs-autonomy, competence, relatedness-are uniquely associated with overall well-being. Undergraduates with attention-deficit/hyperactivity ... ...

    Abstract Objective: Self-determination theory suggests that the satisfaction and frustration of basic psychological needs-autonomy, competence, relatedness-are uniquely associated with overall well-being. Undergraduates with attention-deficit/hyperactivity disorder (ADHD) experience more academic-related impairment and are less likely to graduate. Thus, well-being is important to understand and aim to improve in these students.
    Method: Students at four universities (
    Results: The ADHD group reported lower satisfaction and higher frustration across all psychological needs. Inattention and hyperactivity/impulsivity were uniquely associated with aspects of need fulfillment beyond the impact of comorbid symptoms. Sex differences emerged such that women with ADHD had the lowest overall need satisfaction.
    Conclusions: Addressing need fulfillment, both satisfaction and frustration, in interventions with undergraduates with clinical/subclinical levels of ADHD may optimize treatment effectiveness.
    MeSH term(s) Humans ; Male ; Female ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Students/psychology ; Personal Satisfaction ; Surveys and Questionnaires ; Cognition ; Universities
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231161530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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