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  1. Book ; Thesis: Die Prävalenz der Helicobacter pylori-Infektion in der Bundesrepublik Deutschland und speziell in der Population der an der Universität Bielefeld tätigen Studierenden und Beschäftigten

    Wille, Lutz

    (Berichte aus der Medizin)

    2001  

    Author's details Lutz Wille
    Series title Berichte aus der Medizin
    Keywords Deutschland ; Helicobacter-pylori-Infektion ; Prävalenz ; Universität Bielefeld
    Subject Campylobacter-pylori-Infektion ; Campylobacter-pyloridis-Infektion ; Helicobacter pylori
    Language German
    Size XII, 284 S. : Ill., graph. Darst., 21 cm
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bielefeld, Univ., Diss., 2001
    HBZ-ID HT013222764
    ISBN 3-8265-9468-1 ; 978-3-8265-9468-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 267 order for loan Magazin

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  2. Article ; Conference proceedings: The use of discharge criteria to optimize patient discharge after gastrointestinal operations

    Müssle, B. / Wille, L. / Weitz, J. / Welsch, T.

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 08

    Event/congress Viszeralmedizin 2023 77. Jahrestagung der DGVS mit Sektion Endoskopie Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie mit den Arbeitsgemeinschaften der DGAV und Jahrestagung der CACP, Erst online. Dann Hamburg., 2023-09-11
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1772112
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.A 111/X: Show issues Location:
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  3. Thesis ; Online: The root rot complex of pea - Screening for resistance and quantification of microbial key players in the rhizosphere

    Wille, Lukas

    2020  

    Abstract: Pea (Pisum sativum L.) is a valuable and healthy protein source for food and feed. In addition to the nutritional benefits, pea is an invaluable agro-ecological asset for sustainable cropping systems through positive effects on soil fertility and soil ... ...

    Abstract Pea (Pisum sativum L.) is a valuable and healthy protein source for food and feed. In addition to the nutritional benefits, pea is an invaluable agro-ecological asset for sustainable cropping systems through positive effects on soil fertility and soil microbial diversity. The symbiosis with nitrogen-fixing bacteria allows pea and other legume crops to supply the soil with nitrogen and, therefore, to significantly reduce the application of external nitrogen fertilisers. Therefore, pea plays an important role especially in low-input farming systems. The growing market for plant- based protein supply is likely to promote pea cultivation in the near future. However, pea production is severely challenged by various soil-borne pathogens that form a Pea Root Rot Complex (PRRC) causing root-rot diseases. Despite considerable progress in resistance breeding against individual pathogens, current pea varieties lack resistance against multiple interacting pathogens. The overall goal of this thesis was to contribute to the understanding of resistance against root rot pathogen complexes in pea. Chapter 1 gives an overview of the importance of pea as a future key player in agricultural systems and the food sector before introducing the pea root rot complex concept and its relevance for research on resistance. Furthermore, the most recent developments in molecular biology relevant for molecular plant breeding of pea are briefly summarised and an overview of quantitative real-time PCR relevant for research on microbial interactions in the pea root rot complex is given. Chapter 2 reviews the current knowledge of resistance against root- rot pathogens in major grain legumes, highlights the importance of the host genotype in determining the composition of plant-associated microbial communities and how the root associated microbiome relates to plant health. In addition, major findings on the role of root exudation in disease susceptibility and resistance of grain legumes are summarised. Finally, it delineates how this knowledge ...
    Keywords Plant-microbe interaction ; disease resistance ; plant breeding ; Sustainable agriculture ; info:eu-repo/classification/ddc/500 ; Natural sciences
    Subject code 580
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Thesis ; Online: The root rot complex of pea - Screening for resistance and quantification of microbial key players in the rhizosphere

    Wille, Lukas

    2020  

    Abstract: Pea (Pisum sativum L.) is a valuable and healthy protein source for food and feed. In addition to the nutritional benefits, pea is an invaluable agro-ecological asset for sustainable cropping systems through positive effects on soil fertility and soil ... ...

    Abstract Pea (Pisum sativum L.) is a valuable and healthy protein source for food and feed. In addition to the nutritional benefits, pea is an invaluable agro-ecological asset for sustainable cropping systems through positive effects on soil fertility and soil microbial diversity. The symbiosis with nitrogen-fixing bacteria allows pea and other legume crops to supply the soil with nitrogen and, therefore, to significantly reduce the application of external nitrogen fertilisers. Therefore, pea plays an important role especially in low-input farming systems. The growing market for plant- based protein supply is likely to promote pea cultivation in the near future. However, pea production is severely challenged by various soil-borne pathogens that form a Pea Root Rot Complex (PRRC) causing root-rot diseases. Despite considerable progress in resistance breeding against individual pathogens, current pea varieties lack resistance against multiple interacting pathogens. The overall goal of this thesis was to contribute to the understanding of resistance against root rot pathogen complexes in pea. Chapter 1 gives an overview of the importance of pea as a future key player in agricultural systems and the food sector before introducing the pea root rot complex concept and its relevance for research on resistance. Furthermore, the most recent developments in molecular biology relevant for molecular plant breeding of pea are briefly summarised and an overview of quantitative real-time PCR relevant for research on microbial interactions in the pea root rot complex is given. Chapter 2 reviews the current knowledge of resistance against root- rot pathogens in major grain legumes, highlights the importance of the host genotype in determining the composition of plant-associated microbial communities and how the root associated microbiome relates to plant health. In addition, major findings on the role of root exudation in disease susceptibility and resistance of grain legumes are summarised. Finally, it delineates how this knowledge ...
    Keywords Farming Systems ; Soil biology ; Biodiversity and ecosystem services ; Farm nutrient management
    Subject code 580
    Language English
    Publishing country dk
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Heterosexual Self-Presentation, Identity Management, and Sexual Functioning Among Men Who Have Sex with Men.

    Parent, Mike C / Wille, Lexie

    Archives of sexual behavior

    2021  Volume 50, Issue 7, Page(s) 3155–3162

    Abstract: Research and clinical work on sexual functioning in men has traditionally focused on the presence or absence of erectile dysfunction (ED) or the inability to maintain an erection sufficient for satisfactory sexual performance. However, for men who have ... ...

    Abstract Research and clinical work on sexual functioning in men has traditionally focused on the presence or absence of erectile dysfunction (ED) or the inability to maintain an erection sufficient for satisfactory sexual performance. However, for men who have sex with men (MSM), receptive anal intercourse is a common form of sexual expression. Existing work on men's sexual dysfunction does not effectively address receptive anal sex functioning, and there is a need to understand how stressors can impact this common sexual behavior. The goal of the present study was to understand how stressors can impact erective and receptive anal sex functioning among MSM. In the present study, we hypothesized that minority stress (as operationalized by integrating identity management and heterosexual self-presentation) would have an impact on MSM's sexual functioning overall and adapted a previous measure of sexual dysfunction (International Index of Erectile Functioning) to better assess this relationship. Data were collected from 228 men (M
    MeSH term(s) Adult ; Heterosexuality ; Homosexuality, Male ; Humans ; Male ; Men ; Sexual Behavior ; Sexual and Gender Minorities
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-021-01968-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1106: Show issues Location:
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  6. Article ; Online: Online Prescriptions to HIV Pre-Exposure Prophylaxis and Pre-Exposure Prophylaxis Uptake.

    Wille, Lexie / Parent, Mike C

    AIDS patient care and STDs

    2020  Volume 34, Issue 12, Page(s) 499–501

    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2020.0196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2328: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Association of No Promotion of Homosexuality Laws and Electronic Cigarette Use Disparities for Sexual Minority Youth.

    Wille, Lexie / Parent, Mike C

    JAMA pediatrics

    2019  Volume 173, Issue 10, Page(s) 991–993

    Language English
    Publishing date 2019-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2019.2729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Quantitative Systems Pharmacology Model Describing the Cellular Kinetic-Pharmacodynamic Relationship for a Live Biotherapeutic Product to Support Microbiome Drug Development.

    Renardy, Marissa / Prokopienko, Alexander J / Maxwell, Joseph R / Flusberg, Deborah A / Makaryan, Sahak / Selimkhanov, Jangir / Vakilynejad, Majid / Subramanian, Kalyanasundaram / Wille, Lucia

    Clinical pharmacology and therapeutics

    2023  Volume 114, Issue 3, Page(s) 633–643

    Abstract: Live biotherapeutic products (LBPs) are human microbiome therapies showing promise in the clinic for a range of diseases and conditions. Describing the kinetics and behavior of LBPs poses a unique modeling challenge because, unlike traditional therapies, ...

    Abstract Live biotherapeutic products (LBPs) are human microbiome therapies showing promise in the clinic for a range of diseases and conditions. Describing the kinetics and behavior of LBPs poses a unique modeling challenge because, unlike traditional therapies, LBPs can expand, contract, and colonize the host digestive tract. Here, we present a novel cellular kinetic-pharmacodynamic quantitative systems pharmacology model of an LBP. The model describes bacterial growth and competition, vancomycin effects, binding and unbinding to the epithelial surface, and production and clearance of butyrate as a therapeutic metabolite. The model is calibrated and validated to published data from healthy volunteers. Using the model, we simulate the impact of treatment dose, frequency, and duration as well as vancomycin pretreatment on butyrate production. This model enables model-informed drug development and can be used for future microbiome therapies to inform decision making around antibiotic pretreatment, dose selection, loading dose, and dosing duration.
    MeSH term(s) Humans ; Vancomycin ; Kinetics ; Network Pharmacology ; Drug Development ; Microbiota
    Chemical Substances Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.2952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Conference proceedings ; Online: Utilising plant-microbiome interactions to enhance resistance breeding against pathogen complexes

    Hohmann, Pierre / Wille, Lukas / Messmer, Monika

    2021  

    Abstract: Concepts and results on how to utilise plant-microbiome interactions to enhance resistance breeding against pathogen ... ...

    Abstract Concepts and results on how to utilise plant-microbiome interactions to enhance resistance breeding against pathogen complexes
    Keywords Breeding ; genetics and propagation ; Crop health ; quality ; protection
    Language English
    Publishing country dk
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Audio / Video ; Online: Teaming up with soil microbes

    Wille, Lukas / Messmer, Monika / Studer, Bruno / Hohmann, Pierre

    2021  

    Abstract: Soil-borne diseases in legumes, especially in peas, cause severe damage and can lead up to total yield loss. New science is providing solutions. ...

    Abstract Soil-borne diseases in legumes, especially in peas, cause severe damage and can lead up to total yield loss. New science is providing solutions.
    Keywords Cereals ; pulses and oilseeds ; Breeding ; genetics and propagation ; Crop health ; quality ; protection
    Language English
    Publishing date 2021-05-25
    Publishing country dk
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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