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  1. AU="Willems, M"
  2. AU="Jane Ru Choi"
  3. AU="Nepal, Gaurav"
  4. AU=Pietrobelli Angelo AU=Pietrobelli Angelo
  5. AU="Lopeztello-Santillan, Adriana L"
  6. AU="Iaquinta, Angela"
  7. AU="Layne, Diana M"
  8. AU=Nadesalingam Ajantha
  9. AU=Kieser D C
  10. AU=Borthwick L. A.
  11. AU="Ding, Yiming"
  12. AU="Sid Ahmed, Mazen A"
  13. AU="Bermudez-Lekerika, Paola"
  14. AU="Ter Hoeve, Natalie D"
  15. AU="Yang, X-D"
  16. AU="Jerry J Shih"
  17. AU=Kapil Vikas
  18. AU="Sanda Cosarca"
  19. AU=Murthy J M K
  20. AU="Ward Chiasson, Stephanie"
  21. AU="Kinsella, Paul"
  22. AU="Alyaqout, Khaled"
  23. AU="J Joshua Smith"
  24. AU="Kotak, Dinesh"
  25. AU="Michael Holland"
  26. AU="Pauline, Staelen"
  27. AU="Mouna Esmaeilzadeh"
  28. AU=Congreve Miles
  29. AU="Li, Yunfeng" AU="Li, Yunfeng"
  30. AU="Shankar, Ganesh"
  31. AU="Ruginsk, Silvia G"
  32. AU="Aquilante, Francesco"
  33. AU="Dillon, Robert C"
  34. AU="Yuan Qu"
  35. AU="Dufour, A"
  36. AU="Hannus, Jill"
  37. AU="Rieber, Julia"
  38. AU="Gulmuradov, Tashpulat"
  39. AU="Romeu Fontanillas, Teresa"
  40. AU="Fleming, Renée"
  41. AU="Cao, Fang"
  42. AU="Sally J L Moore"
  43. AU="Moreno, Yolanda"
  44. AU="Vasiliy Ya. Kolyuchkin"

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  1. Buch ; Online: Pour l'amour des mots : Glanures lexicales, dictionnairiques, grammaticales et syntaxiques. Hommage à Michèle Lenoble-Pinson

    Willems, Martine

    2009  

    Abstract: Ce volume est offert à Michèle Lenoble-Pinson à loccasion de son accession à léméritat, en hommage à sa carrière exemplaire denseignante et de spécialiste internationalement reconnue de la grammaire et de la lexicologie françaises. Dix-huit personnalités ...

    Abstract Ce volume est offert à Michèle Lenoble-Pinson à loccasion de son accession à léméritat, en hommage à sa carrière exemplaire denseignante et de spécialiste internationalement reconnue de la grammaire et de la lexicologie françaises. Dix-huit personnalités belges et étrangères ont glané pour elle dans les champs de la langue française des réflexions sur la norme et lusage - notamment le Bon Usage -, sur des tournures syntaxiques récentes, sur lanalyse grammaticale traditionnelle de certains mots

    sur la maîtrise de lorthographe, sur sa rationalisation

    sur la féminisation des titres, des noms de métiers et de fonctions

    sur la terminologie, sur lélaboration des dictionnaires, sur lapprentissage du vocabulaire, sur les tabous lexicaux

    sur la variation de la forme des proverbes à travers le temps et sur le vocabulaire de la chasse au volume Ces contributions riches et variées ont été rassemblées pour lamour des mots, en référence à lattachement que Michèle Lenoble-Pinson a toujours porté à la discipline à laquelle elle a consacré toute sa vie professionnelle et lensemble de ses publications
    Schlagwörter Language and Literature
    Umfang 1 electronic resource ( pages)
    Verlag Presses de l'Université Saint-Louis
    Dokumenttyp Buch ; Online
    Anmerkung French ; Open Access
    HBZ-ID HT020323547
    ISBN 9782802805007 ; 2802805002
    DOI 10.4000/books.pusl.23113
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Exploring the genetic causes of isolated short stature. What has happened to idiopathic short stature?

    Willems, M / Amouroux, C / Barat-Houari, M / Salles, J-P / Edouard, T

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2023  Band 28, Heft 8S1, Seite(n) 8S27–8S32

    Abstract: Statural growth is underpinned by development of the growth plate during the process of endochondral ossification, which is strongly regulated by numerous local factors (intracellular, paracrine and extracellular matrix factors) and systemic factors ( ... ...

    Abstract Statural growth is underpinned by development of the growth plate during the process of endochondral ossification, which is strongly regulated by numerous local factors (intracellular, paracrine and extracellular matrix factors) and systemic factors (nutrition, hormones, proinflammatory cytokines and extracellular fluids). This explains why growth retardation can be associated with numerous pathologies, particularly genetic syndromes, hormonal or inflammatory conditions, or gastrointestinal disorders having a nutritional impact. However, in most cases (80%), no specific aetiology is found after clinical investigation and conventional additional tests have been carried out. In such cases, "idiopathic" short stature is diagnosed, which includes patients presenting with constitutional delay of growth and development and familial short stature, but also patients with very subtle constitutional skeletal dysplasia which are not easily identifiable. In recent years, new methods of genetic investigation (e.g. gene panels, exome or genome sequencing) have made it possible to identify many genetic variants associated with apparently isolated short stature. Indeed, it is still difficult to estimate the proportion of patients presenting with idiopathic short stature for which a molecular diagnosis of monogenic conditions could be made. This estimate varies hugely depending on the thoroughness of the clinical, laboratory and radiological assessments performed prior to molecular analysis, since retrospective analysis of positive cases usually reveals subtle signs of underlying syndromes or rare skeletal disorders. Molecular diagnosis in children is important to be able to offer genetic counselling and to organise patient management. Moreover, improved understanding of the molecular basis of these cases of short stature opens up numerous possibilities for more specific treatments targeting the growth plate. © 2022 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
    Sprache Englisch
    Erscheinungsdatum 2023-10-23
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/S0929-693X(22)00040-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Éducation thérapeutique et mucoviscidose.

    Boulay, M / Ramelot, L / Willems, M / Bauwens, N / Thimmesch, M

    Revue medicale de Liege

    2021  Band 76, Heft 11, Seite(n) 794–798

    Abstract: Therapeutic education is defined as all the tools taught to patients with the aim of improving their compliance to treatments. In a chronic disease, such as cystic fibrosis, this education should be done during the first months of child's life with the ... ...

    Titelübersetzung Therapeutic education and cystic fibrosis.
    Abstract Therapeutic education is defined as all the tools taught to patients with the aim of improving their compliance to treatments. In a chronic disease, such as cystic fibrosis, this education should be done during the first months of child's life with the collaboration of parents and then gradually given to children from the age of 6 until they are autonomous in the management of their treatment during adolescence. The tools used for therapeutic education should be playful, varied and adapted to the child's development, while respecting a standard for competences. In this article, we will define the main approaches of therapeutic education in patients with cystic fibrosis.
    Mesh-Begriff(e) Adolescent ; Child ; Chronic Disease ; Cystic Fibrosis/therapy ; Humans ; Parents ; Patient Compliance
    Sprache Französisch
    Erscheinungsdatum 2021-11-05
    Erscheinungsland Belgium
    Dokumenttyp Journal Article
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Should we perform oocyte accumulation to preserve fertility in women with Turner syndrome? A multicenter study and systematic review of the literature.

    Brouillet, S / Ranisavljevic, N / Sonigo, C / Haquet, E / Bringer-Deutsch, S / Loup-Cabaniols, V / Hamamah, S / Willems, M / Anahory, T

    Human reproduction (Oxford, England)

    2023  Band 38, Heft 9, Seite(n) 1733–1745

    Abstract: Study question: Should we perform oocyte accumulation to preserve fertility in women with Turner syndrome (TS)?: Summary answer: The oocyte cryopreservation strategy is not well adapted for all TS women as their combination of high basal FSH with low ...

    Abstract Study question: Should we perform oocyte accumulation to preserve fertility in women with Turner syndrome (TS)?
    Summary answer: The oocyte cryopreservation strategy is not well adapted for all TS women as their combination of high basal FSH with low basal AMH and low percentage of 46,XX cells in the karyotype significantly reduces the chances of freezing sufficient mature oocytes for fertility preservation.
    What is known already: An oocyte cryopreservation strategy requiring numerous stimulation cycles is needed to preserve fertility in TS women, to compensate for the low ovarian response, the possible oocyte genetic alterations, the reduced endometrial receptivity, and the increased rate of miscarriage, observed in this specific population. The validation of reliable predictive biomarkers of ovarian response to hormonal stimulation in TS patients is necessary to help practitioners and patients choose the best-personalized fertility preservation strategy.
    Study design, size, duration: A retrospective bicentric study was performed from 1 January 2011 to 1 January 2023. Clinical and biological data from all TS women who have received from ovarian stimulation for fertility preservation were collected. A systematic review of the current literature on oocyte retrieval outcomes after ovarian stimulation in TS women was also performed (PROSPERO registration number: CRD42022362352).
    Participants/materials, setting, methods: A total of 14 TS women who had undergone ovarian stimulation for fertility preservation were included, representing the largest cohort of TS patients published to date (n = 14 patients, 24 cycles). The systematic review of the literature identified 34 additional TS patients with 47 oocyte retrieval outcomes after ovarian stimulation in 14 publications (n = 48 patients, n = 71 cycles in total).
    Main results and the role of chance: The number of cryopreserved mature oocytes on the first cycle for TS patients was low (4.0 ± 3.7). Oocyte accumulation was systematically proposed to increase fertility potential and was accepted by 50% (7/14) of patients (2.4 ± 0.5 cycles), leading to an improved total number of 10.9 ± 7.2 cryopreserved mature oocytes per patient. In the group who refused the oocyte accumulation strategy, only one patient exceeded the threshold of 10 mature cryopreserved oocytes. In contrast, 57.1% (4/7) and 42.9% (3/7) of patients who have underwent the oocyte accumulation strategy reached the threshold of 10 and 15 mature cryopreserved oocytes, respectively (OR = 8 (0.6; 107.0), P = 0.12; OR= 11 (0.5; 282.1), P = 0.13). By analyzing all the data published to date and combining it with our data (n = 48 patients, n = 71 cycles), low basal FSH and high AMH concentrations as well as a higher percentage of 46,XX cells in the karyotype were significantly associated with a higher number of cryopreserved oocytes after the first cycle. Moreover, the combination of low basal FSH concentration (<5.9 IU/l), high AMH concentration (>1.13 ng/ml), and the presence of 46,XX cells (>1%) was significantly predictive of obtaining at least six cryopreserved oocytes in the first cycle, representing objective criteria for identifying patients with real chances of preserving an adequate fertility potential by oocyte cryopreservation.
    Limitations, reasons for caution: Our results should be analyzed with caution, as the optimal oocyte number needed for successful live birth in TS patients is still unknown due to the low number of reports their oocyte use in the literature to date.
    Wider implications of the findings: TS patients should benefit from relevant clinical evaluation, genetic counseling and psychological support to make an informed choice regarding their fertility preservation technique, as numerous stimulation cycles would be necessary to preserve a high number of oocytes.
    Study funding/competing interest(s): This research received no external funding. The authors declare no conflict of interest.
    Trial registration number: N/A.
    Mesh-Begriff(e) Humans ; Female ; Turner Syndrome/complications ; Turner Syndrome/therapy ; Retrospective Studies ; Fertility Preservation/methods ; Oocytes ; Cryopreservation/methods ; Follicle Stimulating Hormone ; Ovulation Induction/methods ; Multicenter Studies as Topic
    Chemische Substanzen Follicle Stimulating Hormone (9002-68-0)
    Sprache Englisch
    Erscheinungsdatum 2023-06-28
    Erscheinungsland England
    Dokumenttyp Systematic Review ; Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/dead135
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Dissertation / Habilitation: Ein Lehr- und Lernsystem zur Klassifizierung von Diagnosen in medizinischen Texten

    Willems, Matthias

    1991  

    Verfasserangabe vorgelegt von Matthias Willems
    Umfang V, 122 S.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Ulm, Univ., Diss., 1991
    HBZ-ID HT003985369
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  6. Artikel ; Konferenzbeitrag: Simeticon bei gasbedingtem Symptomenkomplex: Prospektive nicht interventionelle Studie zeigt schnelle und anhaltende Besserung auch bei krampfartigen Bauchschmerzen und Oberbauchbeschwerden

    Willems, M

    Zeitschrift für Gastroenterologie

    2010  

    Abstract: Zwei Drittel der Bevölkerung gibt auf Befragen an, zeitweise unter stärkeren Blähungen zu leiden. Patienten beschreiben gasbedingte Beschwerden gerne mit der Umschreibung „Luft im Bauch“. Hinter dieser diffusen Beschreibung verbirgt sich ein ... ...

    Veranstaltung/Kongress 65. Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten - 4. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV - Viszeralmedizin 2010, Stuttgart, 2010
    Abstract Zwei Drittel der Bevölkerung gibt auf Befragen an, zeitweise unter stärkeren Blähungen zu leiden. Patienten beschreiben gasbedingte Beschwerden gerne mit der Umschreibung „Luft im Bauch“. Hinter dieser diffusen Beschreibung verbirgt sich ein Symptomenkomplex mit mehr oder weniger belastenden Beschwerden, die individuell unterschiedlich ausgeprägt sind. Am meisten belasten die Symptome, die mit einer ausgeprägten Schmerzsymptomatik verbunden sind, wie krampfartige Bauchschmerzen und Oberbauchschmerzen. Ziel dieser apothekenbasierten nicht interventionellen Studie war es, die Wirksamkeit, den Verlauf der Beschwerdelinderung, die Verträglichkeit und Utilisation von 3 verschiedenen Simeticon haltigen Präparaten in unterschiedlicher Dosierung und Darreichungsform unter Alltagsbedingungen zu untersuchen. Patienten, die in der Apotheke eines der drei Präparate kauften und sich bereit erklärten, an der Studie teilzunehmen, erhielten einen fünfseitigen Fragebogen, in dem neben den demographischen Daten, Art und Stärke der Beschwerden, deren Häufigkeit, sowie der Zeitpunkt der Simeticon-Einnahme und der Dosierung erhoben wurden. Das Ausmaß, der Eintritt und die Dauer der Symptomlinderung konnte für 10 potenzielle Symptome dokumentiert werden. Insgesamt wurden von 4000 ausgegebenen Fragebögen 1129 (25%) zurückgesandt. 1054 Fragebögen waren auswertbar. 499 Patienten nahmen Simeticon aufgrund von krampfartigen Bauchschmerzen ein, wobei mehr als die Hälfte (50,5%) unter starken und sehr starken Schmerzen litt. Nach 90 Minuten hatten 89% dieser Patienten nur noch leichte oder gar keine Bauchkrämpfe mehr. Ähnlich verhielt sich das Beschwerdebild der 299 Patienten mit Oberbauchschmerzen, von denen die Hälfte starke und sehr starke Schmerzen angaben. Nach einer Stunde waren 83% der Verwender beschwerdefrei oder hatten nur noch leichte Schmerzen. Die Intensität der Bauchkrämpfe und Oberbauchschmerzen ging parallel zum Gesamtscore über alle zehn Symptome, verglichen zum Ausgangswert signifikant zu allen Messzeitpunkten zurück und lag nach 2 Stunden auf einem mittleren Score von 0,5, was einer Beschwerdefreiheit bzw. sehr leichten Beschwerden entspricht. Der Entschäumer Simeticon wirkt sich rasch positiv auf gasbedingte Symptome inklusive Bauchkrämpfe und Oberbauchschmerzen aus.
    Sprache Deutsch
    Erscheinungsdatum 2010-08-03
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0030-1263719
    Datenquelle Thieme Verlag

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  7. Buch ; Dissertation / Habilitation: Wachstumsfaktoren in Magenkarzinomen

    Willems, Maike

    1995  

    Verfasserangabe vorgelegt von Maike Willems geb. Hillen
    Sprache Deutsch
    Umfang 80 S. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Aachen, Techn. Hochsch., Diss., 1995
    HBZ-ID HT007168603
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  8. Buch ; Dissertation / Habilitation: Medizinische Universitätskliniken im deutschen Sprachgebiet

    Willems, Michael

    (1753 - 1914)

    1983  

    Umfang 194 S. : zahlr. Ill. u. graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Köln, Univ., Diss., 1983
    HBZ-ID HT002823002
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  9. Artikel: Intake of New Zealand Blackcurrant Powder Affects Skin-Borne Volatile Organic Compounds in Middle-Aged and Older Adults

    Willems, M. E. T. / Todaka, M. / Banic, M. / Cook, M. D. / Sekine, Y.

    Journal of dietary supplements. 2022 Sept. 3, v. 19, no. 5

    2022  

    Abstract: Skin volatile organic compounds (VOCs) can cause body odor or reveal human disease and may result from lipid peroxidation or activity by skin bacteria. We examined the effect of intake of New Zealand blackcurrant (NZBC) powder for 77 skin VOCs in middle- ... ...

    Abstract Skin volatile organic compounds (VOCs) can cause body odor or reveal human disease and may result from lipid peroxidation or activity by skin bacteria. We examined the effect of intake of New Zealand blackcurrant (NZBC) powder for 77 skin VOCs in middle-aged and older adults in a crossover design. Fourteen adults (nine males, age: 55 ± 5 yrs) consumed NZBC powder for 7 days (6 g·day⁻¹ with 138.6 mg anthocyanins). Two hours after the last intake, a passive flux sampler with trapping media was applied in the base of the neck for 1 hour. Gas chromatography-mass spectrometry was used for media analysis. Habitual anthocyanin intake was quantified using a food frequency questionnaire. Compared to control (i.e., no intake of NZBC powder), emission of six skin VOCs (i.e., 2-nonenal, acetic acid, 2-hexanone, 6-methyl-5-hepten-2-one, benzaldehyde, allyl methyl sulfide) were lower by more than 25%. Increases were observed for γ-octanolactone (+184%) and γ-decanolactone (+89%). A trend for a decrease for isovaleraldehyde, hexanal, and 2-pentanone, and an increase for heptanoic acid and γ-nonanolactone was observed. There was a significant correlation with daily habitual dietary anthocyanin intake for control values of hexanal and percentage change of γ-octanolactone. NZBC powder can change emanation of some VOCs in human skin. Analysis of skin VOCs following specific polyphenol intake may address the impact of dietary components to affect internal metabolic processes, body odor, and health.
    Schlagwörter acetic acid ; anthocyanins ; benzaldehyde ; black currants ; cross-over studies ; dimethyl sulfide ; food frequency questionnaires ; gas chromatography-mass spectrometry ; human diseases ; lipid peroxidation ; neck ; odors ; polyphenols ; skin (animal) ; volatile organic compounds ; New Zealand
    Sprache Englisch
    Erscheinungsverlauf 2022-0903
    Umfang p. 603-620.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2460305-3
    ISSN 1939-022X ; 1939-0211
    ISSN (online) 1939-022X
    ISSN 1939-0211
    DOI 10.1080/19390211.2021.1908479
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Buch: Chemische und pharmakologische Untersuchungen über Abbauprodukte des Valtrats

    Willems, Michael

    1980  

    Umfang 80 S. : GRAPH. DARST.
    Dokumenttyp Buch
    Anmerkung FRANKFURT (MAIN), UNIV., FACHBEREICH 15 - BIOCHEMIE, PHARMAZIE U. LEBENSMITTELCHEMIE, DISS., 1980
    HBZ-ID HT002599344
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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