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  1. Article ; Online: Reader response: Lower carotid revascularization rates after stroke in racial/ethnic minority-serving US hospitals.

    Willey, Joshua Z

    Neurology

    2020  Volume 94, Issue 20, Page(s) 896–897

    MeSH term(s) Continental Population Groups ; Ethnic Groups ; Hospitals ; Humans ; Minority Groups ; Stroke
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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    Zs.MO 374: Show issues

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  2. Article ; Online: Bleeding From Antiplatelet Agents in Patients With Stroke and Transient Ischemic Attack: How Important Is It?

    Willey, Joshua Zebadiah / Chaturvedi, Seemant

    Neurology

    2022  Volume 99, Issue 6, Page(s) 223–224

    MeSH term(s) Drug Therapy, Combination ; Hemorrhage ; Humans ; Ischemic Attack, Transient/complications ; Ischemic Attack, Transient/drug therapy ; Platelet Aggregation Inhibitors/adverse effects ; Stroke/drug therapy
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of the Vulnerable Carotid Plaque in Embolic Stroke of Unknown Source.

    Willey, Joshua Z / Pasterkamp, Gerard

    Journal of the American College of Cardiology

    2022  Volume 79, Issue 22, Page(s) 2200–2202

    MeSH term(s) Carotid Arteries ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Embolic Stroke ; Humans ; Magnetic Resonance Imaging ; Plaque, Atherosclerotic/diagnosis ; Plaque, Atherosclerotic/diagnostic imaging ; Stroke/etiology
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reader response: ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms.

    Willey, Joshua Z

    Neurology

    2018  Volume 90, Issue 22, Page(s) 1038–1039

    MeSH term(s) Aneurysm, Ruptured ; Humans ; Intracranial Aneurysm ; Risk Factors
    Language English
    Publishing date 2018-05-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000005595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Racial-Ethnic disparities in stroke prevalence among patients with heart failure.

    Ibeh, Chinwe / Tom, Sarah E / Marshall, Randolph S / Elkind, Mitchell S V / Willey, Joshua Z

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2024  Volume 123, Page(s) 173–178

    Abstract: Racial-ethnic disparities exist in the prevalence and outcomes of heart failure (HF) and are presumed to be related to differences in cardiovascular risk factor burden and control. There is little data on stroke disparities among patients with HF or the ... ...

    Abstract Racial-ethnic disparities exist in the prevalence and outcomes of heart failure (HF) and are presumed to be related to differences in cardiovascular risk factor burden and control. There is little data on stroke disparities among patients with HF or the factors responsible. We hypothesized disparities in stroke prevalence exist among patients with HF in a manner not fully explained by burden of cardiovascular disease. We analyzed data from the National Health and Nutrition Examination Survey (1999-2014). Cardiovascular profiles were compared by race/ethnicity. Using survey-weighted models, effect modification of the relationship between HF and stroke by race/ethnicity was examined adjusting for cardiovascular profiles. Of 40,437 participants, 2.5 % had HF. The HF cohort had a greater proportion of White and Black participants (77 % vs 74 % and 15 % vs 12 %, respectively) and fewer participants of Hispanic ethnicity (8 % vs 14 %). Stroke was 8 times more prevalent in HF (19.6 % vs 2.3 %, <0.001). Among individuals with HF, race-ethnic differences were identified in the prevalence and mean values of vascular risk factors but were largely driven by higher rates in Black participants. There was significant interaction between HF and race/ethnicity; HF increased the odds of stroke over 7-fold in participants of Hispanic ethnicity (aOR: 7.84; 95 % CI: 4.11-15.0) but to a lesser extent in Black and White participants (Black aOR: 2.49; 95 % CI: 1.72-3.60; White aOR: 3.36; 95 % CI: 2.57-4.40). People of Hispanic ethnicity with HF have a disproportionately higher risk of stroke in a manner not fully explained by differences in vascular risk profiles.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Black or African American/statistics & numerical data ; Ethnicity/statistics & numerical data ; Health Status Disparities ; Heart Failure/ethnology ; Heart Failure/epidemiology ; Hispanic or Latino/statistics & numerical data ; Nutrition Surveys ; Prevalence ; Risk Factors ; Stroke/ethnology ; Stroke/epidemiology ; United States/epidemiology ; White
    Language English
    Publishing date 2024-04-06
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2024.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hemorrhagic Stroke Risk in Armed Forces Veterans: The Role of Post-Traumatic Stress Disorder and Its Treatment.

    Willey, Joshua Z / Chang, Bernard P

    Stroke

    2020  Volume 52, Issue 1, Page(s) 130–131

    MeSH term(s) Hemorrhagic Stroke ; Humans ; Military Personnel ; Stress Disorders, Post-Traumatic ; Veterans
    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.032669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  7. Article ; Online: Blood pressure and stroke risk in left ventricular assist devices.

    Willey, Joshua Z

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2015  Volume 34, Issue 4, Page(s) 497–498

    MeSH term(s) Female ; Heart-Assist Devices ; Humans ; Hypertension/complications ; Male ; Postoperative Complications/etiology ; Stroke/etiology
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2014.11.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2056: Show issues Location:
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  8. Article ; Online: Dolichoectasia: a brain arterial disease with an elusive treatment.

    Lopez-Navarro, Edgar R / Park, Soojin / Willey, Joshua Z / Gutierrez, Jose

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 8, Page(s) 4901–4908

    Abstract: Introduction: Dolichoectasia is a form of brain large artery disease associated with a high risk of mortality and morbidity. Progressive enlargement of arterial size is a predictor of mortality, but there are no specific treatments for arresting or ... ...

    Abstract Introduction: Dolichoectasia is a form of brain large artery disease associated with a high risk of mortality and morbidity. Progressive enlargement of arterial size is a predictor of mortality, but there are no specific treatments for arresting or slowing down dilatation. Additionally, dilated brain arteries can cause flow stagnation, which can trigger thrombosis and cause stroke. Pathology and genetic studies indicate a possible role for increased matrix metalloproteinase activation in arterial dilatation and thus in the pathophysiology of dolichoectasia. Therefore, therapeutic interventions aimed at slowing down arterial dilatation and preventing thrombosis could hypothetically play a role in treating patients with dolichoectasia.
    Methods: We present four patients with dolichoectasia that exemplify therapeutic challenges worth discussing in the context of the current literature. Two patients were treated off-label with doxycycline (based on its antiMMP properties) and with apixaban, one patient was put on warfarin and later switched to aspirin, and the fourth patient underwent endovascular treatment.
    Results: We report four cases, all men 50 years or older. Of the two patients treated with doxycycline, we noted a slowdown of the basilar artery (BA) growth, but the BA continued to grow in the other patient. Of the two patients who received apixaban, none had a subsequent stroke in 5 and 4 years of follow-up, respectively. One patient was admitted with a fatal BA thrombosis and rupture, and pathological examination of the brain arteries demonstrated advanced arterial wall degeneration but no atherosclerosis.
    Discussion: These cases exemplify the challenges of treating people with dolichoectasia and highlight the need for better evidence regarding the best possible treatment for this population.
    MeSH term(s) Basilar Artery ; Dilatation, Pathologic/complications ; Doxycycline ; Humans ; Intracranial Arterial Diseases/complications ; Intracranial Arterial Diseases/pathology ; Male ; Stroke/complications ; Vertebrobasilar Insufficiency/complications ; Vertebrobasilar Insufficiency/diagnostic imaging ; Vertebrobasilar Insufficiency/drug therapy
    Chemical Substances Doxycycline (N12000U13O)
    Language English
    Publishing date 2022-04-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-06078-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Letter by Willey and Williams Regarding Article, "Racial and Ethnic Disparities in the Utilization of Thrombectomy for Acute Stroke: Analysis of Data From 2016 to 2018".

    Willey, Joshua Z / Williams, Olajide

    Stroke

    2019  Volume 50, Issue 11, Page(s) e339

    MeSH term(s) Continental Population Groups ; Ethnic Groups ; Humans ; Stroke ; Thrombectomy
    Language English
    Publishing date 2019-10-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.119.027577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Stroke and Mechanical Circulatory Support in Adults.

    Bae, David J / Willey, Joshua Z / Ibeh, Chinwe / Yuzefpolskaya, Melana / Colombo, Paolo C

    Current cardiology reports

    2023  Volume 25, Issue 12, Page(s) 1665–1675

    Abstract: Purpose of the review: Short-term and durable mechanical circulatory support (MCS) devices represent life-saving interventions for patients with cardiogenic shock and end-stage heart failure. This review will cover the epidemiology, risk factors, and ... ...

    Abstract Purpose of the review: Short-term and durable mechanical circulatory support (MCS) devices represent life-saving interventions for patients with cardiogenic shock and end-stage heart failure. This review will cover the epidemiology, risk factors, and treatment of stroke in this patient population.
    Recent findings: Short-term devices such as intra-aortic balloon pump, Impella, TandemHeart, and Venoatrial Extracorporal Membrane Oxygenation, as well as durable continuous-flow left ventricular assist devices (LVADs), improve cardiac output and blood flow to the vital organs. However, MCS use is associated with high rates of complications, including ischemic and hemorrhagic strokes which carry a high risk for death and disability. Improvements in MCS technology have reduced but not eliminated the risk of stroke. Mitigation strategies focus on careful management of anti-thrombotic therapies. While data on therapeutic options for stroke are limited, several case series reported favorable outcomes with thrombectomy for ischemic stroke patients with large vessel occlusions, as well as with reversal of anticoagulation for those with hemorrhagic stroke. Stroke in patients treated with MCS is associated with high morbidity and mortality. Preventive strategies are targeted based on the specific form of MCS. Improvements in the design of the newest generation device have reduced the risk of ischemic stroke, though hemorrhagic stroke remains a serious complication.
    MeSH term(s) Adult ; Humans ; Heart Failure ; Hemorrhagic Stroke/complications ; Shock, Cardiogenic/therapy ; Heart-Assist Devices/adverse effects ; Intra-Aortic Balloon Pumping ; Stroke/prevention & control ; Stroke/complications ; Ischemic Stroke/complications ; Treatment Outcome
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-023-01985-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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