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  1. AU="William King"
  2. AU="Selivanov, A N"
  3. AU="Jae-Seung Yun"
  4. AU=Bartoletti Angelo
  5. AU=Morita Megumi
  6. AU="Ji, Yinjie" AU="Ji, Yinjie"
  7. AU="Abbadessa, Anna"
  8. AU="Liu, Tai-Hang"
  9. AU="Najt, Pablo"
  10. AU="Meng Ning"
  11. AU="Zhang, Zhiqun"
  12. AU="Jakobsen, Ingrid"
  13. AU="Ren, Aolin"
  14. AU="Chegni, Hamid"
  15. AU=Singer Eugenia
  16. AU=Narayan P
  17. AU="Daniele Coraci" AU="Daniele Coraci"
  18. AU=Ahn Anthony K
  19. AU="Pétrequin, Pierre"
  20. AU=Smit Cornelis AU=Smit Cornelis
  21. AU="Goyal, Sheenam"
  22. AU="Trullàs, Joan Carles"
  23. AU=Bedrood Sahar
  24. AU="Dharmaraj, Santhosh Kumar"

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  1. Buch: Muscle aging, inclusion body myositis and myopathies

    Askanas, Valerie / Engel, William King

    2012  

    Titelvarianten Muscle aging, inclusion-body myositis and myopathies
    Verfasserangabe ed. by Valerie Askanas and W. King Engel
    Schlagwörter Myositis, Inclusion Body / physiopathology ; Aging
    Sprache Englisch
    Umfang XII, 250 S. : Ill., graph. Darst., Kt.
    Verlag Wiley-Blackwell
    Erscheinungsort Oxford u.a.
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references and index
    HBZ-ID HT017129985
    ISBN 978-1-4051-9646-8 ; 1-4051-9646-7
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Valuing selected WAItE health states using the Time Trade-Off methodology

    Tomos Robinson / Sarah Hill / Giovany Orozco-Leal / Ashleigh Kernohan / William King / Yemi Oluboyede

    Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-

    findings from an online interviewer-assisted remote survey

    2024  Band 9

    Abstract: Abstract Purpose The Weight-Specific Adolescent Instrument for Economic Evaluation (WAItE) is a physical weight-specific patient reported outcome measure for use in adolescence. The purpose of this study was to use the Time Trade-Off (TTO) methodology, ... ...

    Abstract Abstract Purpose The Weight-Specific Adolescent Instrument for Economic Evaluation (WAItE) is a physical weight-specific patient reported outcome measure for use in adolescence. The purpose of this study was to use the Time Trade-Off (TTO) methodology, administered using an online interviewer-assisted remote survey, to obtain utility values for several health states from the WAItE descriptive system from a sample of the UK adult general population. Methods The adult sample was gathered using a market research company and a sample of local residents. All participants completed the same interviewer-assisted remote survey, which included rating WAItE states of varying impairment using the TTO. Results 42 adults completed the survey. Utility values were gathered for four health states, ranging from low impairment to the most severe health from the WAItE descriptive system (the Pits state). Consistent orderings of the WAItE health states were observed; the health state with the lowest level of impairment was valued highest and the Pits state was valued lowest. Several respondents (n = 7, 17%) considered the Pits state to be worse than death; however, the mean value of this health state was 0.23. Conclusions The utility value of the Pits state relative to death generated from this study will be used to anchor latent values for WAItE health states generated from a Discrete Choice Experiment onto the 0 = death, 1 = full health Quality Adjusted Life Year (QALY) scale as part of a valuation study for the WAItE in the UK population. This study also provides further evidence that interviewer-assisted digital studies are feasible for collecting TTO data.
    Schlagwörter Time Trade Off ; Patient reported outcome measures ; Obesity ; Adolescence ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Buch ; Online: Managerial Competencies Driving Successful Change Initiatives

    selsor, william king

    Walden Dissertations and Doctoral Studies

    A Multiple Case Study of Healthcare Administrators

    2020  

    Abstract: Healthcare administrators’ competencies for driving successful strategic change initiatives in healthcare organizations remain outdated and limited in the management literature. The purpose of this qualitative, multiple case study was to explore the ... ...

    Abstract Healthcare administrators’ competencies for driving successful strategic change initiatives in healthcare organizations remain outdated and limited in the management literature. The purpose of this qualitative, multiple case study was to explore the perceptions of healthcare administrators on the specific nature of management competencies needed to drive successful strategic change initiatives within healthcare organizations. To address the research problem and purpose of the study, qualitative data were collected from multiple sources of evidence, including semi-structured interviews with seven healthcare administrators, archival data, and reflective journaling notes. This study was framed by Kash, Spaulding, Johnson, and Gamm’s conceptual framework, the comparison of success factors for change model, developed to identify success factors for strategic change initiatives in healthcare organizations. Ten themes emerged from the data analysis (textual data and cross-case synthesis), with five coding categories grounded in the conceptual framework: (a) critical evaluation of daily problems, (b) train and develop strong healthcare administrator skills, (c) attention to multiple healthcare technologies, (d) develop foresight capabilities, and (e) network management. Patient quality of care has always been a central axiom of healthcare’s social responsibility mission within local communities and society at large. Implementation of new insights from this study addressing cutting-edge challenges faced by healthcare administrators in the post-COVID-19 environment may lead to improved quality of patient care and thus contribute to positive social change across various sized healthcare facilities.
    Schlagwörter Change Initiatives ; Organizational Change ; Strategic change initiatives ; Health and Medical Administration ; covid19
    Thema/Rubrik (Code) 650 ; 360
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T08:00:00Z
    Verlag ScholarWorks
    Erscheinungsland us
    Dokumenttyp Buch ; Online
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  4. Artikel ; Online: Potential Mechanism of Action of Current Point-of-Care Autologous Therapy Treatments for Osteoarthritis of the Knee—A Narrative Review

    Jennifer Woodell-May / Kathleen Steckbeck / William King

    International Journal of Molecular Sciences, Vol 22, Iss 2726, p

    2021  Band 2726

    Abstract: Osteoarthritis (OA) is a progressive degenerative disease that manifests as pain and inflammation and often results in total joint replacement. There is significant interest in understanding how intra-articular injections made from autologous blood or ... ...

    Abstract Osteoarthritis (OA) is a progressive degenerative disease that manifests as pain and inflammation and often results in total joint replacement. There is significant interest in understanding how intra-articular injections made from autologous blood or bone marrow could alleviate symptoms and potentially intervene in the progression of the disease. There is in vitro an in vivo evidence that suggests that these therapies, including platelet-rich plasma (PRP), autologous anti-inflammatories (AAIs), and concentrated bone marrow aspirate (cBMA), can interrupt cartilage matrix degradation driven by pro-inflammatory cytokines. This review analyzes the evidence for and against inclusion of white blood cells, the potential role of platelets, and the less studied potential role of blood plasma when combining these components to create an autologous point-of-care therapy to treat OA. There has been significant focus on the differences between the various autologous therapies. However, evidence suggests that there may be more in common between groups and perhaps we should be thinking of these therapies on a spectrum of the same technology, each providing significant levels of anti-inflammatory cytokines that can be antagonists against the inflammatory cytokines driving OA symptoms and progression. While clinical data have demonstrated symptom alleviation, more studies will need to be conducted to determine whether these preclinical disease-modifying findings translate into clinical practice.
    Schlagwörter platelet-rich plasma ; autologous anti-inflammatory ; concentrated bone marrow aspirate ; osteoarthritis ; intra-articular injection ; mechanism of action ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 616 ; 610
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
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  5. Artikel ; Online: Up-regulation of Osh6 boosts an anti-aging membrane trafficking pathway toward vacuoles

    Ilham Kadhim / Nazneen Begum / William King / Licheng Xu / Fusheng Tang

    Microbial Cell, Vol 9, Iss 8, Pp 145-

    2022  Band 157

    Abstract: Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners. We previously found that a 2-fold up-regulation of Osh6, one of seven yeast oxysterol-binding ... ...

    Abstract Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners. We previously found that a 2-fold up-regulation of Osh6, one of seven yeast oxysterol-binding proteins, remedies vacuolar morphology defects in mid-aged cells, partly down-regulates the target of rapamycin complex 1 (TORC1), and increases the replicative lifespan. At the molecular level, Osh6 transports phosphatidylserine (PS) and phosphatidylinositol-4-phosphate (PI4P) between the endoplasmic reticulum (ER) and the plasma membrane (PM). To decipher how an ER-PM working protein controls vacuolar morphology, we tested genetic interactions between OSH6 and DRS2, whose protein flips PS from the lumen to the cytosolic side of the Golgi, the organelle between ER and vacuoles in many pathways. Up-regulated OSH6 complemented vacuolar morphology of drs2∆ and enriched PI4P on the Golgi, indicating that Osh6 also works on the Golgi. This altered PI4P-enrichment led to a delay in the secretion of the proton ATPase Pma1 to the PM and a rerouting of Pma1 to vacuoles in a manner dependent on the trans-Golgi network (TGN) to late endosome (LE) trafficking pathway. Since the TGN-LE pathway controls endosomal and vacuolar TORC1, it may be the anti-aging pathway boosted by up-regulated Osh6.
    Schlagwörter osh6 ; pi4p ; golgi ; vacuole ; longevity ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571 ; 570
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Shared Science Publishers OG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: 3 A/B testing in healthcare

    Simon Jones / Leora Horwitz / William King / Holly Krelle / Kyra Rosen / Sara Tsuruo / Nate Klapheke / Jay Stadelman

    BMJ Open Quality, Vol 12, Iss Suppl

    how you can apply tech industry methods to improve quality in your system

    2023  Band 4

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag BMJ Publishing Group
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  7. Artikel ; Online: Evaluating teen driving knowledge and behaviors following educational outreach

    Kathy Monroe / Michele Nichols / Marie Crew / Leslie Brown / William King

    Injury Epidemiology, Vol 7, Iss S1, Pp 1-

    2020  Band 6

    Abstract: Abstract Background Teen driving educational events are an effective strategy to increase adolescent drivers’ awareness of safe driving practices. The objectives of this study were to evaluate changing rates of self-reported driving practices and ... ...

    Abstract Abstract Background Teen driving educational events are an effective strategy to increase adolescent drivers’ awareness of safe driving practices. The objectives of this study were to evaluate changing rates of self-reported driving practices and knowledge of the state Graduated Driver Licensing laws (GDL) by teens over a nine-year period in a single state. Methods This was a prospective observational study of high school students ages 14 to 19 years old. Paper surveys were sent to the high schools participating in teen driving educational events (9 schools in 2009 and 4 schools in 2018). Students in those schools completed surveys prior to the events. Students completing the anonymous survey were invited to the event. Questions evaluated awareness of state GDL and safe and risky driving behaviors. Statistical comparisons of survey answers from 2009 to 2018 were analyzed using the z test of proportions (2 tailed, alpha 0.05). Results A total of 397 students participated in 2018 with ages ranging from 14 to 19 years. Racial distribution was 81% white, 14% black, and there were 57% female participants. Only 69% (n = 273) reported “always” wearing their seatbelt. When asked about high risk behaviors, 78% (n = 309) of adolescents reported they personally “never” text while driving; 97% (385); never drive after drinking, and 87% (n = 344) never ride with someone who has been drinking. Compared to 2009 participants (1304 students, 9 schools from central part of state), the students in 2018 (4 schools scattered across state) reported wearing seatbelts “always” (n = 69% vs 39%; p < 0.001); “never texting while driving” (78% vs 33%; p < 0.001); and “never drinking and driving” (97% vs 88%; p < 0.001). No significant difference in rates of students having taken a driving education class nor driving over speed limit were reported. Conclusion Results are encouraging that participants in 2018 report more use of seatbelts, less texting while driving, less drinking while driving and lower numbers of being in MVC than ...
    Schlagwörter Teen driving ; Education ; Risky behaviors ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag BMC
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies

    William King / Krista Toler / Jennifer Woodell-May

    BioMed Research International, Vol

    2018  Band 2018

    Abstract: There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory. Misconceptions in the practice of biologic orthopedics result in the simplified ... ...

    Abstract There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory. Misconceptions in the practice of biologic orthopedics result in the simplified principle that platelets deliver growth factors, WBCs cause inflammation, and the singular value of bone marrow is the stem cells. The aim of this review is to address these common misconceptions which will enable better development of future orthopedic medical devices. WBC behavior is adaptive in nature and, depending on their environment, WBCs can hinder or induce healing. Successful tissue repair occurs when platelets arrive at a wound site, degranulate, and release growth factors and cytokines which, in turn, recruit WBCs to the damaged tissue. Therefore, a key role of even pure platelet-rich plasma is to recruit WBCs to a wound. Bone marrow contains a complex mixture of vascular cells, white blood cells present at much greater concentrations than in blood, and a small number of progenitor cells and stem cells. The negative results observed for WBC-containing autologous therapies in vitro have not translated to human clinical studies. With an enhanced understanding of the complex WBC biology, the next generation of biologics will be more specific, likely resulting in improved effectiveness.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Hindawi Limited
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  9. Artikel ; Online: Socioeconomic inequality in medication persistence in primary and secondary prevention of coronary heart disease - A population-wide electronic cohort study.

    William King / Arron Lacey / James White / Daniel Farewell / Frank Dunstan / David Fone

    PLoS ONE, Vol 13, Iss 3, p e

    2018  Band 0194081

    Abstract: BACKGROUND:Coronary heart disease (CHD) mortality in England fell by 36% between 2000 and 2007 and it is estimated that approximately 50% of the fall was due to improved treatment uptake. Marked socio-economic inequalities in CHD mortality in the United ... ...

    Abstract BACKGROUND:Coronary heart disease (CHD) mortality in England fell by 36% between 2000 and 2007 and it is estimated that approximately 50% of the fall was due to improved treatment uptake. Marked socio-economic inequalities in CHD mortality in the United Kingdom (UK) remain, with higher age-adjusted rates in more deprived groups. Inequalities in the persistence of medication for primary and secondary prevention of CHD may contribute to the observed social gradient and we investigated this possibility in the population of Wales (UK). METHODS AND FINDINGS:An electronic cohort of individuals aged over 20 (n = 1,199,342) in Wales (UK) was formed using linked data from primary and secondary care and followed for six years (2004-2010). We identified indications for medication (statins, aspirin, ACE inhibitors, clopidogrel) recommended in UK National Institute for Clinical Excellence (NICE) guidance for CHD (high risk, stable angina, stable angina plus diabetes, unstable angina, and myocardial infarction) and measured the persistence of indicated medication (time from initiation to discontinuation) across quintiles of the Welsh Index of Multiple Deprivation, an area-based measure of socio-economic inequality, using Cox regression frailty models. In models adjusted for demographic factors, CHD risk and comorbidities across 15 comparisons for persistence of the medications, none favoured the least deprived quintile, two favoured the most deprived quintile and 13 showed no significant differences. CONCLUSIONS:During our study period (2004-2010) we found no significant evidence of socio-economic inequality in the persistence of recommended medication for primary and secondary prevention of CHD.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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  10. Artikel ; Online: Identification of two glycerophosphodiester phosphodiesterase genes in maize leaf phosphorus remobilization

    Jingxin Wang / Wenbo Pan / Alexiy Nikiforov / William King / Wanting Hong / Weiwei Li / Yang Han / Jana Patton-Vogt / Jianbo Shen / Lingyun Cheng

    Crop Journal, Vol 9, Iss 1, Pp 95-

    2021  Band 108

    Abstract: Phosphate deficiency is one of the leading causes of crop productivity loss. Phospholipid degradation liberates phosphate to cope with phosphate deficiency. Glycerophosphodiester phosphodiesterases (GPX-PDEs) hydrolyse the intermediate products of ... ...

    Abstract Phosphate deficiency is one of the leading causes of crop productivity loss. Phospholipid degradation liberates phosphate to cope with phosphate deficiency. Glycerophosphodiester phosphodiesterases (GPX-PDEs) hydrolyse the intermediate products of phospholipid catabolism glycerophosphodiesters into glycerol-3-phosphate, a precursor of phosphate. However, the function of GPX-PDEs in phosphate remobilization in maize remains unclear. In the present study, we characterized two phosphate deficiency-inducible GPX-PDE genes, ZmGPX-PDE1 and ZmGPX-PDE5, in maize leaves. ZmGPX-PDE1 and ZmGPX-PDE5 were transcriptionally regulated by ZmPHR1, a well-described phosphate starvation-responsive transcription factor of the MYB family. Complementation of the yeast GPX-PDE mutant gde1∆ indicated that ZmGPX-PDE1 and ZmGPX-PDE5 functioned as GPX-PDEs, suggesting their roles in phosphate recycling from glycerophosphodiesters. In vitro enzyme assays showed that ZmGPX-PDE1 and ZmGPX-PDE5 catalysed glycerophosphodiester degradation with different substrate preferences for glycerophosphoinositol and glycerophosphocholine, respectively. ZmGPX-PDE1 was upregulated during leaf senescence, and more remarkably, loss of ZmGPX-PDE1 in maize compromised the remobilization of phosphorus from senescing leaves to young leaves, resulting in a stay-green phenotype under phosphate starvation. These results suggest that ZmGPX-PDE1 catalyses the degradation of glycerophosphodiesters in maize, promoting phosphate recycling from senescing leaves to new leaves. This mechanism is crucial for improving phosphorus utilization efficiency in crops.
    Schlagwörter Glycerophosphodiester phosphodiesterases ; Maize ; Phosphate deficiency ; Phosphorus remobilization ; Phospholipid ; Agriculture ; S ; Agriculture (General) ; S1-972
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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