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  1. Article ; Online: Polymeric biomaterials for biophotonic applications

    Dingying Shan / Ethan Gerhard / Chenji Zhang / John William Tierney / Daniel Xie / Zhiwen Liu / Jian Yang

    Bioactive Materials, Vol 3, Iss 4, Pp 434-

    2018  Volume 445

    Abstract: With the growing importance of optical techniques in medical diagnosis and treatment, there exists a pressing need to develop and optimize materials platform for biophotonic applications. Particularly, the design of biocompatible and biodegradable ... ...

    Abstract With the growing importance of optical techniques in medical diagnosis and treatment, there exists a pressing need to develop and optimize materials platform for biophotonic applications. Particularly, the design of biocompatible and biodegradable materials with desired optical, mechanical, chemical, and biological properties is required to enable clinically relevant biophotonic devices for translating in vitro optical techniques into in situ and in vivo use. This technological trend propels the development of natural and synthetic polymeric biomaterials to replace traditional brittle, nondegradable silica glass based optical materials. In this review, we present an overview of the advances in polymeric optical material development, optical device design and fabrication techniques, and the accompanying applications to imaging, sensing and phototherapy. Keywords: Biophotonics, Biomaterials, Imaging, Sensing, Phototherapy
    Keywords Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Reciprocal innovation

    Thomas Sors, PhD / Kara Wools-Kaloustian, MD / Rishika Chauhan O'Brien, MPA / Li Yuan Bermel, PhD / Ibrahim Chikowe, MPhil / Adrian Gardner, MD / Jepchirchir Kiplagat, PhD / Marya Lieberman, ProfPhD / Sharon Moe, MD / Nydia Morales-Soto, PhD / Winstone Nyandiko, ProfMMed / David Plater, MPA / Betsy C Rono, MPH / Michael Scanlon, MPH / William Tierney, MD / Rachel Vreeman, ProfMD / Sarah Wiehe, MD / Debra Litzelman, ProfMD

    The Lancet Global Health, Vol 10, Iss , Pp S30- (2022)

    a new approach to equitable and mutually beneficial global health research and partnerships

    2022  

    Abstract: Background: The Indiana University Center for Global Health coined the term reciprocal innovation to describe bidirectional, mutually beneficial research and translational research within long-term global health partnerships. Inspired by a 30-year global ...

    Abstract Background: The Indiana University Center for Global Health coined the term reciprocal innovation to describe bidirectional, mutually beneficial research and translational research within long-term global health partnerships. Inspired by a 30-year global health partnership between Indiana University (Indianapolis, IN, USA) and Moi University College of Health Sciences (Eldoret, Kenya), we developed a reciprocal innovation programme based at the Indiana Clinical and Translational Sciences Institute (Indianapolis, IN, USA). We describe early lessons in building this programme and its potential as a transformative approach to address systemic inequities across high-income and low/middle-income countries. Methods: The reciprocal innovation programme, established in 2016, aims to identify and support research on the design, testing, replication, and dissemination of health technologies and interventions that have applicability across high-income and low-income and middle-income countries. Central to this process is the building of equitable, mutually beneficial global health partnerships. Programme activities, informed by an environmental scan of stakeholders in Indiana, USA and Kenya, included funding a competitive research grants programme, hosting workshops for community-based and global health researchers, and creating educational and training videos on reciprocal innovation approaches. Findings: To date, the programme has awarded more than 30 grants totalling US$ 610 000 for research in nine countries. Examples of funded cross-continent reciprocal innovation projects include the application of rapid testing for falsified drug detection in Malawi and for use by harm reduction organisations in the USA, and the adoption of a Kenyan community health-worker model to reduce infant mortality in Indiana. These projects, among others, are resulting in measurable improvements in health outcomes in both Indiana and abroad, and continue to expand. Three global reciprocal innovation workshops have been held and an online database has been created to showcase research in this area. Interpretation: In the first 5 years of the programme, we have engaged investigators and launched projects internationally in reciprocal innovation, illustrating a new approach to global health research, translation, and partnerships. Although this programme is in early stages and still developing metrics to assess its success, reciprocal innovation has the potential to help to address systemic inequities and global challenges in both high-income and low-income and middle-income settings through long-term, equitable, and mutually beneficial partnerships. Funding: This work is partly supported by the National Center for Advancing Translational Sciences at the National Institutes of Health (Bethesda, MD, USA) grant number UL1TR00252.
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 306
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders

    Nicola Marchi / William Tierney / Andreas V. Alexopoulos / Vikram Puvenna / Tiziana Granata / Damir Janigro

    Cardiovascular Psychiatry and Neurology, Vol

    2011  Volume 2011

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; DOAJ:Cardiovascular
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-brain Barrier

    Luca Cucullo / Vikram Puvenna / Mohammed Hossain / Peter Mazzone / William Tierney / Damir Janigro

    International Journal of Environmental Research and Public Health, Vol 7, Iss 12, Pp 4111-

    Expanding the Awareness of Smoking Toxicity in an Underappreciated Area

    2010  Volume 4126

    Abstract: Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, ... ...

    Abstract Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, significantly increasing the risk for ischemic manifestations such as acute coronary syndrome and stroke. Despite the strong evidence for an association between smoking and vascular impairment, the impact of TS exposure on the blood-brain barrier (BBB) has only been marginally addressed. This is a major problem given that the BBB is crucial in the maintenance of brain homeostasis. Recent data have also shown that chronic smokers have a higher incidence of small vessel ischemic disease (SVID), a pathological condition characterized by leaky brain microvessels and loss of BBB integrity. In the brain TS increases the risk of silent cerebral infarction (SCI) and stroke owing to the pro-coagulant and atherogenic effects of smoking. In this article we provide a detailed review and analysis of current knowledge of the pathophysiology of tobacco smoke toxicity at the cerebrovascular levels. We also discuss the potential toxicity of recently marketed “potential-reduced exposure products”.
    Keywords tobacco smoke ; alternative ; blood-brain barrier ; central nervous system ; inflammation ; endothelial cells ; white blood cells ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2010-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book: An Account ... of the "Suspension bridge across the river Danube, uniting Pesth with Buda and the adjacent country" in the kingdom of Hungary ... under the councils of Stephen Szechenyi [u.a.]

    Clark, William Tierney

    1852  

    Author's details By William Tierney Clark
    Dates of publication 1852-1853
    Size 8
    Publisher Weale
    Publishing place London
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: An Account ... of the "Suspension bridge across the river Danube, uniting Pesth with Buda and the adjacent country" in the kingdom of Hungary ... under the councils of Stephen Szechenyi [u.a.]

    Clark, William Tierney

    1852  

    Author's details By William Tierney Clark
    Size 8
    Publisher Weale
    Publishing place London
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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    Inter-library loan at ZB MED

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  7. Book: An Account ... of the "Suspension bridge across the river Danube, uniting Pesth with Buda and the adjacent country" in the kingdom of Hungary ... under the councils of Stephen Szechenyi [u.a.]

    Clark, William Tierney

    1851  

    Author's details By William Tierney Clark
    Dates of publication 1851-1853
    Size 8
    Publisher Weale
    Publishing place London
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Book: An Account ... of the "Suspension bridge across the river Danube, uniting Pesth with Buda and the adjacent country" in the kingdom of Hungary ... under the councils of Stephen Szechenyi [u.a.]

    Clark, William Tierney
    Author's details By William Tierney Clark
    Publisher Weale
    Publishing place London
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-brain Barrier: Expanding the Awareness of Smoking Toxicity in an Underappreciated Area

    Peter Mazzone / William Tierney / Mohammed Hossain / Vikram Puvenna / Damir Janigro / Luca Cucullo

    International Journal of Environmental Research and Public Health

    Issue (12)

    Abstract: Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, ... ...

    Abstract Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, significantly increasing the risk for ischemic manifestations such as acute coronary syndrome and stroke. Despite the strong evidence for an association between smoking and vascular impairment, the impact of TS exposure on the blood-brain barrier (BBB) has only been marginally addressed. This is a major problem given that the BBB is crucial in the maintenance of brain homeostasis. Recent data have also shown that chronic smokers have a higher incidence of small vessel ischemic disease (SVID), a pathological condition characterized by leaky brain microvessels and loss of BBB integrity. In the brain TS increases the risk of silent cerebral infarction (SCI) and stroke owing to the pro-coagulant and atherogenic effects of smoking. In this article we provide a detailed review and analysis of current knowledge of the pathophysiology of tobacco smoke toxicity at the cerebrovascular levels. We also discuss the potential toxicity of recently marketed “potential-reduced exposure products”.
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-brain Barrier: Expanding the Awareness of Smoking Toxicity in an Underappreciated Area

    Peter Mazzone / William Tierney / Mohammed Hossain / Vikram Puvenna / Damir Janigro / Luca Cucullo

    International Journal of Environmental Research and Public Health

    Issue (12)

    Abstract: Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, ... ...

    Abstract Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, significantly increasing the risk for ischemic manifestations such as acute coronary syndrome and stroke. Despite the strong evidence for an association between smoking and vascular impairment, the impact of TS exposure on the blood-brain barrier (BBB) has only been marginally addressed. This is a major problem given that the BBB is crucial in the maintenance of brain homeostasis. Recent data have also shown that chronic smokers have a higher incidence of small vessel ischemic disease (SVID), a pathological condition characterized by leaky brain microvessels and loss of BBB integrity. In the brain TS increases the risk of silent cerebral infarction (SCI) and stroke owing to the pro-coagulant and atherogenic effects of smoking. In this article we provide a detailed review and analysis of current knowledge of the pathophysiology of tobacco smoke toxicity at the cerebrovascular levels. We also discuss the potential toxicity of recently marketed “potential-reduced exposure products”.
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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