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  1. Article ; Online: A New Dawn for Aldosterone as a Therapeutic Target in Hypertension.

    Williams, Bryan

    JAMA

    2023  Volume 330, Issue 12, Page(s) 1138–1139

    MeSH term(s) Humans ; Aldosterone ; Hypertension/drug therapy ; Molecular Targeted Therapy
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.17087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Evaluation of the utility of NEWS2 during the COVID-19 pandemic.

    Williams, Bryan

    Clinical medicine (London, England)

    2022  Volume 22, Issue 6, Page(s) 539–543

    Abstract: The emergence of the COVID-19 pandemic resulted in a dramatic increase in acutely ill patients presenting to hospitals with life-threatening acute respiratory disease. There was an immediate need for effective triage systems to facilitate clinical ... ...

    Abstract The emergence of the COVID-19 pandemic resulted in a dramatic increase in acutely ill patients presenting to hospitals with life-threatening acute respiratory disease. There was an immediate need for effective triage systems to facilitate clinical decision making. This review assesses the performance of the National Early Warning Score 2 (NEWS2) in two contexts. Firstly, the ability to detect acute illness severity and likely clinical deterioration in patients presenting to hospitals with COVID-19. Secondly, the use of NEWS2 in the longitudinal monitoring to detect acute clinical deterioration in hospitalised patients with COVID-19. NEWS2 appeared to be at least comparable and, often, superior to other scoring systems (such as qSOFA and CURB-65), and provided an earlier alert of deterioration. A NEWS2 of 5 had high short-term sensitivity within and was unlikely to miss patients with COVID-19 who go on to deteriorate, but this comes with moderate specificity. However, the specificity of these systems is likely underestimated because preventing deterioration is their purpose.NEWS2 is an adjunct to clinical decision making and has served that purpose during the COVID-19 pandemic, playing an important role in communicating illness severity, clinical deterioration, triaging patients to appropriate levels of care and prompting completion of treatment escalation plans for those with high scores and at imminent risk of deterioration.
    MeSH term(s) Humans ; COVID-19 ; Pandemics ; Clinical Deterioration ; Triage/methods
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2022-news-covid
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The National Early Warning Score: from concept to NHS implementation.

    Williams, Bryan

    Clinical medicine (London, England)

    2022  Volume 22, Issue 6, Page(s) 499–505

    Abstract: This year is the 10th anniversary since the launch of the National Early Warning Score (NEWS) by the Royal College of Physicians in 2012. This review reflects on the journey, from the nascent concept of a standardised system to detect acute illness ... ...

    Abstract This year is the 10th anniversary since the launch of the National Early Warning Score (NEWS) by the Royal College of Physicians in 2012. This review reflects on the journey, from the nascent concept of a standardised system to detect acute illness severity and clinical deterioration through to the adoption of NEWS2 by the NHS and, ultimately, its incorporation into quality indicators of acute care provision. The impact of NEWS/NEWS2 on the transformation of provision and configuration and training of acute care teams in hospitals is reviewed. User feedback has been key in iterating guidance on the use of NEWS/NEWS2 and key elements of this are discussed. The ultimate aim of NEWS was to improve patient outcomes with acute illness or deterioration and the impact on outcomes is now becoming apparent but, paradoxically, an effective response can eliminate the link between the score and the ultimate outcome. This review concludes with a reflection on what the next 10 years may bring, particularly with the digital transformation of healthcare and its potential impact on scoring systems, as well as the necessary permeation of NEWS2 beyond the acute hospital setting into emergency response triage in primary and community care settings.Ten years on, via NEWS/NEWS2, the NHS is the first healthcare system globally with a 'common language' of illness severity and a standardised early warning system for acute clinical illness and deterioration, a system that is now being replicated in many other areas of the world.
    MeSH term(s) Humans ; Early Warning Score ; State Medicine ; Critical Care ; Educational Status ; Hospitals
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2022-news-concept
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Renin-angiotensin system inhibitors in hospitalised patients with COVID-19.

    Williams, Bryan

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 3, Page(s) 221–222

    MeSH term(s) Angiotensin Receptor Antagonists ; COVID-19 ; Hospitals ; Humans ; Prospective Studies ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00003-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Hypertension in diabetes

    Williams, Bryan

    2003  

    Author's details ed. by Bryan Williams
    Keywords Diabetes Mellitus / complications ; Hypertension / complications
    Language English
    Size XVI, 359 S. : Ill., graph. Darst.
    Publisher Dunitz
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013614088
    ISBN 1-85317-552-8 ; 978-1-85317-552-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 A 935 order for loan Magazin

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  6. Book ; Conference proceedings: Consensus Conference on Early Chronic Kidney Disease

    Williams, Bryan

    [6 and 7 February 2007, Edinburgh]

    (Nephrology, dialysis, transplantation ; 22, Suppl. 9)

    2007  

    Event/congress Consensus Conference on Early Chronic Kidney Disease (2007, Edinburgh)
    Author's details guest ed. Bryan Williams
    Series title Nephrology, dialysis, transplantation ; 22, Suppl. 9
    Collection
    Language English
    Size ix62 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015366053
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2198 -22,Suppl.9- not available for loan Zeitschriften-Lesesaal

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  7. Book ; Online: Mamã, porque sou uma ave?

    Wells, Anne Marie / Azul, Anabela Marisa / Williams, Bryan

    2015  

    Abstract: Uma ave, curiosa, ... ...

    Abstract Uma ave, curiosa, pergunta
    Size 1 electronic resource (55 pages)
    Publisher Coimbra University Press
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020589221
    ISBN 9789892607368 ; 9892607368
    DOI 10.14195/978-989-26-0736-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Conference proceedings: Diabetes and cardiovascular disease

    Williams, Bryan

    Titanic and the iceberg ; proceedings of a satellite symposium held during the 34th meeting of the European Association for the Study of Diabetes, 8 - 12th September 1998, Barcelona

    (Journal of human hypertension ; 13, Suppl. 2)

    1999  

    Institution European Association for the Study of Diabetes
    Author's details scientific organiser: Bryan Williams
    Series title Journal of human hypertension ; 13, Suppl. 2
    Collection
    Language English
    Size S28 S. : graph. Darst.
    Publisher Stockton
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT010405756
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2380 -13,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  9. Book ; Conference proceedings: Diabetes mellitus and cardiovascular disease

    Williams, Bryan

    proceedings of a satellite symposium held during the 34th meeting of the European Association for the Study of Diabetes, 8 - 12th September 1998, Barcelona

    (Acta diabetologica ; 36,1/2, Suppl.)

    1999  

    Institution European Association for the Study of Diabetes
    Author's details guest ed. B. Williams
    Series title Acta diabetologica ; 36,1/2, Suppl.
    Collection
    Language English
    Size A4, S24 S. : graph. Darst.
    Publisher Springer
    Publishing place Milano
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT011256071
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 611 -36,1/2,Suppl.- not available for loan Zeitschriften-Lesesaal

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  10. Article: Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas.

    Fernando, Dasun / Ahmed, Afsar U / Williams, Bryan R G

    Frontiers in oncology

    2024  Volume 14, Page(s) 1347694

    Abstract: Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central nervous system's glial support cells, affecting children, adolescents, and young adults. Tumors of the central nervous system account for the leading cause of ... ...

    Abstract Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central nervous system's glial support cells, affecting children, adolescents, and young adults. Tumors of the central nervous system account for the leading cause of pediatric mortality of which high-grade gliomas present a significantly grim prognosis. While the past few decades have seen many pediatric cancers experiencing significant improvements in overall survival, the prospect of survival for patients diagnosed with pHGGs has conversely remained unchanged. This can be attributed in part to tumor heterogeneity and the existence of the blood-brain barrier. Advances in discovery research have substantiated the existence of unique subgroups of pHGGs displaying alternate responses to different therapeutics and varying degrees of overall survival. This highlights a necessity to approach discovery research and clinical management of the disease in an alternative subtype-dependent manner. This review covers traditional approaches to the therapeutic management of pHGGs, limitations of such methods and emerging alternatives. Novel mutations which predominate the pHGG landscape are highlighted and the therapeutic potential of targeting them in a subtype specific manner discussed. Collectively, this provides an insight into issues in need of transformative progress which arise during the management of pHGGs.
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1347694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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