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Book ; Online ; E-Book: Yen and Jaffe's reproductive endocrinology

Strauss, Jerome F. / Barbieri, Robert L. / Dokras, Anuja / Williams, Carmen J. / Williams, S. Zev

physiology, pathophysiology, and clinical management

2024

Title variant	Reprodctive endocrinology
Author's details	Jerome F. Strauss, Robert L. Barbieri, Anuja Dokras, Carmen J. Williams, Zev S. Williams editors
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (2155 Seiten), Illustrationen, Diagramme
Edition	Ninth edition
Publisher	Elsevier
Publishing place	Philadelphia, PA
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030019187
ISBN	978-0-323-81008-1 ; 9780323810074 ; 0-323-81008-X ; 0323810071
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Developmental exposure to phytoestrogens found in soy: New findings and clinical implications.

Suen, Alisa A / Kenan, Anna C / Williams, Carmen J

Biochemical pharmacology

2021 Volume 195, Page(s) 114848

Abstract: Exposure to naturally derived estrogen receptor activators, such as the phytoestrogen genistein, can occur at physiologically relevant concentrations in the human diet. Soy-based infant formulas are of particular concern because infants consuming these ... ...

Abstract	Exposure to naturally derived estrogen receptor activators, such as the phytoestrogen genistein, can occur at physiologically relevant concentrations in the human diet. Soy-based infant formulas are of particular concern because infants consuming these products have serum genistein levels almost 20 times greater than those seen in vegetarian adults. Comparable exposures in animal studies have adverse physiologic effects. The timing of exposure is particularly concerning because infants undergo a steroid hormone-sensitive period termed "minipuberty" during which estrogenic chemical exposure may alter normal reproductive tissue patterning and function. The delay between genistein exposure and reproductive outcomes poses a unique challenge to collecting epidemiological data. In 2010, the U.S. National Toxicology Program monograph on the safety of the use of soy formula stated that the use of soy-based infant formula posed minimal concern and emphasized a lack of data from human subjects. Since then, several new human and animal studies have advanced our epidemiological and mechanistic understanding of the risks and benefits of phytoestrogen exposure. Here we aim to identify clinically relevant findings regarding phytoestrogen exposure and female reproductive outcomes from the past 10 years, with a focus on the phytoestrogen genistein, and explore the implications of these findings for soy infant formula recommendations. Research presented in this review will inform clinical practice and dietary recommendations for infants based on evidence from both clinical epidemiology and basic research advances in endocrinology and developmental biology from mechanistic in vitro and animal studies.
MeSH term(s)	Animals ; Child Development/drug effects ; Child Development/physiology ; Female ; Genistein/administration & dosage ; Genistein/pharmacology ; Humans ; Infant ; Infant Formula/analysis ; Phytoestrogens/administration & dosage ; Phytoestrogens/pharmacology ; Reproduction/drug effects ; Reproduction/physiology ; Soy Foods/analysis
Chemical Substances	Phytoestrogens ; Genistein (DH2M523P0H)
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2021.114848
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Article ; Online: PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.

Savy, Virginia / Stein, Paula / Shi, Min / Williams, Carmen J

Biology of reproduction

2022 Volume 107, Issue 6, Page(s) 1439–1451

Abstract: Egg activation in mammals is triggered by oscillations in egg intracellular calcium (Ca2+) level. Ca2+ oscillation patterns can be modified in vitro by changing the ionic composition of culture media or in vivo by conditions affecting mitochondrial ... ...

Abstract	Egg activation in mammals is triggered by oscillations in egg intracellular calcium (Ca2+) level. Ca2+ oscillation patterns can be modified in vitro by changing the ionic composition of culture media or in vivo by conditions affecting mitochondrial function, such as obesity and inflammation. In mice, disruption of Ca2+ oscillations in vitro impacts embryo development and offspring growth. Here we tested the hypothesis that, even without in vitro manipulation, abnormal Ca2+ signaling following fertilization impacts offspring growth. Plasma membrane Ca2+ ATPases (PMCA) extrude cytosolic Ca2+ to restore Ca2+ homeostasis. To disrupt Ca2+ signaling in vivo, we conditionally deleted PMCA1 (cKO) in oocytes. As anticipated, in vitro fertilized cKO eggs had increased Ca2+ exposure relative to controls. To assess the impact on offspring growth, cKO females were mated to wild type males to generate pups that had high Ca2+ exposure at fertilization. Because these offspring would be heterozygous, we also tested the impact of global PMCA1 heterozygosity on offspring growth. Control heterozygous pups that had normal Ca2+ at fertilization were generated by mating wild type females to heterozygous males; these control offspring weighed significantly less than their wild type siblings. However, heterozygous offspring from cKO eggs (and high Ca2+ exposure) were larger than heterozygous controls at 12 week-of-age and males had altered body composition. Our results show that global PMCA1 haploinsufficiency impacts growth and support that abnormal Ca2+ signaling after fertilization in vivo has a long-term impact on offspring weight. These findings are relevant for environmental and medical conditions affecting Ca2+ handling and for design of culture conditions and procedures for domestic animal and human assisted reproduction.
MeSH term(s)	Male ; Female ; Mice ; Humans ; Animals ; Calcium Signaling/physiology ; Calcium/metabolism ; Fertilization/physiology ; Zygote/metabolism ; Oocytes/metabolism ; Mammals/metabolism
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioac180
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Zs.A 551: Show issues

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Article: Superovulation Does Not Alter Calcium Oscillations Following Fertilization.

Savy, Virginia / Stein, Paula / Shi, Min / Williams, Carmen J

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 762057

Abstract: Superovulation is a common approach to maximize the number of eggs available for either clinical assisted reproductive technologies or experimental animal studies. This procedure provides supraphysiological amounts of gonadotropins to promote continued ... ...

Abstract	Superovulation is a common approach to maximize the number of eggs available for either clinical assisted reproductive technologies or experimental animal studies. This procedure provides supraphysiological amounts of gonadotropins to promote continued growth and maturation of ovarian follicles that otherwise would undergo atresia. There is evidence in mice, cows, sheep, and humans that superovulation has a detrimental impact on the quality of the resulting ovulated eggs or embryos. Here we tested the hypothesis that eggs derived from superovulation have a reduced capacity to support calcium oscillations, which are a critical factor in the success of embryo development. Eggs were obtained from mice that were either naturally cycling or underwent a standard superovulation protocol. The eggs were either parthenogenetically activated using strontium or fertilized
Language	English
Publishing date	2021-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.762057
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Article ; Online: Modulators of calcium signalling at fertilization.

Stein, Paula / Savy, Virginia / Williams, Audrey M / Williams, Carmen J

Open biology

2020 Volume 10, Issue 7, Page(s) 200118

Abstract: ... Calcium ( ... ...

Abstract	Calcium (Ca
MeSH term(s)	Calcium/metabolism ; Calcium Release Activated Calcium Channels/genetics ; Calcium Signaling/genetics ; Endoplasmic Reticulum/genetics ; Fertilization/genetics ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics
Chemical Substances	Calcium Release Activated Calcium Channels ; Inositol 1,4,5-Trisphosphate Receptors ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-07-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2630944-0
ISSN	2046-2441 ; 2046-2441
ISSN (online)	2046-2441
ISSN	2046-2441
DOI	10.1098/rsob.200118
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mouse strain-dependent egg factors regulate calcium signals at fertilization.

McDonough, Caitlin E / Bernhardt, Miranda L / Williams, Carmen J

Molecular reproduction and development

2020 Volume 87, Issue 2, Page(s) 284–292

Abstract: ... Calcium ( ... ...

Abstract	Calcium (Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Embryonic Development/physiology ; Endoplasmic Reticulum/metabolism ; Female ; Fertilization in Vitro/methods ; Male ; Mice ; Mice, Inbred Strains ; Oocytes/metabolism ; Spermatozoa/metabolism
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.23316
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Zs.A 2759: Show issues

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Article ; Online: LUTs of blastocyst nuclei cell for quantification.

Gambini, Andrés / Williams, Carmen J

Molecular reproduction and development

2016 Volume 83, Issue 7, Page(s) 575

Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.22677
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Article ; Online: Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.

Jefferson, Tanner B / Wang, Tianyuan / Jefferson, Wendy N / Li, Yin / Hamilton, Katherine J / Wade, Paul A / Williams, Carmen J / Korach, Kenneth S

Epigenetics

2022 Volume 18, Issue 1, Page(s) 2139986

Abstract: Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male ... ...

Abstract	Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male and female mice. Previously, we reported that neonatal DES exposure causes ERα-mediated aberrations in the transcriptome and in DNA methylation in seminal vesicles (SVs) of adult mice. However, only a subset of DES-altered genes could be explained by changes in DNA methylation. We hypothesized that alterations in histone modification may also contribute to the altered transcriptome during SV development. To test this idea, we performed a series of genome-wide analyses of mouse SVs at pubertal and adult developmental stages in control and DES-exposed wild-type and ERα knockout mice. Neonatal DES exposure altered ERα-mediated mRNA and lncRNA expression in adult SV, including genes encoding chromatin-modifying proteins that can impact histone H3K27ac modification. H3K27ac patterns, particularly at enhancers, and DNA methylation were reprogrammed over time during normal SV development and after DES exposure. Some of these reprogramming changes were ERα-dependent, but others were ERα-independent. A substantial number of DES-altered genes had differential H3K27ac peaks at nearby enhancers. Comparison of gene expression changes, H3K27ac marks and DNA methylation marks between adult SV and adult uterine tissue from ovariectomized mice neonatally exposed to DES revealed that most of the epigenetic changes and altered genes were distinct in the two tissues. These findings indicate that the effects of developmental DES exposure cause reprogramming of reproductive tract tissue differentiation through multiple epigenetic mechanisms.
MeSH term(s)	Animals ; Mice ; Male ; Female ; Diethylstilbestrol/pharmacology ; Estrogen Receptor alpha/genetics ; DNA Methylation ; Genome-Wide Association Study ; Epigenesis, Genetic ; Gene Expression
Chemical Substances	Diethylstilbestrol (731DCA35BT) ; Estrogen Receptor alpha
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.1080/15592294.2022.2139986
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical Exposure.

Suen, Alisa A / Jefferson, Wendy N / Wood, Charles E / Williams, Carmen J

Molecular cancer research : MCR

2019 Volume 17, Issue 12, Page(s) 2369–2382

Abstract: Early-life exposure to estrogenic chemicals can increase cancer risk, likely by disrupting normal patterns of cellular differentiation. Female mice exposed neonatally to the synthetic estrogen diethylstilbestrol (DES) develop metaplastic and neoplastic ... ...

Abstract	Early-life exposure to estrogenic chemicals can increase cancer risk, likely by disrupting normal patterns of cellular differentiation. Female mice exposed neonatally to the synthetic estrogen diethylstilbestrol (DES) develop metaplastic and neoplastic uterine changes as adults. Abnormal endometrial glands express the oncofetal protein sine oculis homeobox 1 (SIX1) and contain cells with basal [cytokeratin (CK)14
MeSH term(s)	Animals ; Animals, Newborn ; Carcinogenesis/drug effects ; Cell Differentiation/drug effects ; Corn Oil/pharmacology ; Diethylstilbestrol/pharmacology ; Diethylstilbestrol/toxicity ; Disease Models, Animal ; Endometrial Hyperplasia/chemically induced ; Endometrial Hyperplasia/genetics ; Endometrial Hyperplasia/pathology ; Endometrial Neoplasms/chemically induced ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Endometrium/drug effects ; Endometrium/pathology ; Epithelial Cells/drug effects ; Estrogens/pharmacology ; Estrogens/toxicity ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Homeodomain Proteins/genetics ; Humans ; Keratin-14/genetics ; Mice
Chemical Substances	Estrogens ; Homeodomain Proteins ; Keratin-14 ; Krt14 protein, mouse ; Six1 protein, mouse ; Diethylstilbestrol (731DCA35BT) ; Corn Oil (8001-30-7)
Language	English
Publishing date	2019-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-19-0475
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Zs.A 5744: Show issues

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Article ; Online: Broadening the Environmental Lens to Include Social and Structural Determinants of Women's Health Disparities.

Smarr, Melissa M / Avakian, Megan / Lopez, Adeline R / Onyango, Brenda / Amolegbe, Sara / Boyles, Abee / Fenton, Suzanne E / Harmon, Quaker E / Jirles, Bill / Lasko, Denise / Moody, Rosemary / Schelp, John / Sutherland, Vicki / Thomas, Laura / Williams, Carmen J / Dixon, Darlene

Environmental health perspectives

2024 Volume 132, Issue 1, Page(s) 15002

Abstract: Background: Due to the physical, metabolic, and hormonal changes before, during, and after pregnancy, women-defined here as people assigned female at birth-are particularly susceptible to environmental insults. Racism, a driving force of social ... ...

Abstract	Background: Due to the physical, metabolic, and hormonal changes before, during, and after pregnancy, women-defined here as people assigned female at birth-are particularly susceptible to environmental insults. Racism, a driving force of social determinants of health, exacerbates this susceptibility by affecting exposure to both chemical and nonchemical stressors to create women's health disparities. Objectives: To better understand and address social and structural determinants of women's health disparities, the National Institute of Environmental Health Sciences (NIEHS) hosted a workshop focused on the environmental impacts on women's health disparities and reproductive health in April 2022. This commentary summarizes foundational research and unique insights shared by workshop participants, who emphasized the need to broaden the definition of the environment to include upstream social and structural determinants of health. We also summarize current challenges and recommendations, as discussed by workshop participants, to address women's environmental and reproductive health disparities. Discussion: The challenges related to women's health equity, as identified by workshop attendees, included developing research approaches to better capture the social and structural environment in both human and animal studies, integrating environmental health principles into clinical care, and implementing more inclusive publishing and funding approaches. Workshop participants discussed recommendations in each of these areas that encourage interdisciplinary collaboration among researchers, clinicians, funders, publishers, and community members. https://doi.org/10.1289/EHP12996.
MeSH term(s)	United States ; Animals ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Environmental Health ; Health Equity ; National Institute of Environmental Health Sciences (U.S.) ; Publishing ; Health Inequities
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP12996
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Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

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