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  1. Book ; Online: Chapter 2 Viking camps: A historiographical overview

    Williams, Gareth

    2023  

    Keywords Archaeology ; Viking Camps, Ireland, England, Sweden, Frankia, Iberia, winter camps, Viking military camps, Viking Encampment, viking economy, archaeology, Viking archaeology, history, Viking Studies
    Language English
    Size 1 electronic resource (56 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030649414
    ISBN 9781032389530 ; 1032389532
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Biomedical applications of inorganic materials

    Williams, Gareth R.

    (Inorganic materials series ; 10)

    2022  

    Author's details edited by Gareth R. Williams
    Series title Inorganic materials series ; 10
    Collection
    Language English
    Size 1 Online-Ressource (xi, 379 Seiten), Illustrationen, Diagramme
    Publisher Royal Society of Chemistry
    Publishing place Croydon
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021261992
    ISBN 978-1-78801-929-3 ; 978-1-78801-930-9 ; 9781788016063 ; 1-78801-929-6 ; 1-78801-930-X ; 1788016068
    DOI 10.1039/9781788019293
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Paralysed with fear

    Williams, Gareth

    the story of polio

    2013  

    Author's details Gareth Williams
    Keywords Poliomyelitis--History ; Poliomyelitis vaccine--History
    Language English
    Size XVII, 354 S. : Ill., graph. Darst., Kt., 20 cm
    Publisher Palgrave Macmillan
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017698787
    ISBN 978-1-137-29975-8 ; 1-137-29975-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1944 available for loan (reading room) Lesesaal EG

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  4. Book ; Online: Electrospun and Electrosprayed Formulations for Drug Delivery

    Blagbrough, Ian S. / Williams, Gareth R.

    2019  

    Abstract: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in ... ...

    Abstract This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer
    Keywords Medicine (General) ; Therapeutics. Pharmacology
    Size 1 electronic resource (190 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020195800
    ISBN 9783038979128 ; 9783038979135 ; 3038979120 ; 3038979139
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Angel of death

    Williams, Gareth

    the story of smallpox

    2010  

    Author's details by Gareth Williams
    Language English
    Size XIX, 425 S., [4] Bl. : Ill., graph. Darst.
    Publisher Palgrave Macmillan
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016377842
    ISBN 978-0-230-27471-6 ; 0-230-27471-4 ; 9780230293199 ; 0230293190
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3409 order for loan Magazin

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  6. Book: Obesity

    Williams, Gareth / Frühbeck, Gema

    science to practice

    2009  

    Author's details Gareth Williams ; Gema Frühbeck
    Keywords Obesity ; Obesity/Prevention ; Obesity/Treatment
    Subject code 616.398
    Language English
    Size XVII, 585 S. : zahlr. Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015900445
    ISBN 978-0-470-01911-5 ; 0-470-01911-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 1633 order for loan Magazin

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  7. Book ; Online: Nanofibres in Drug Delivery

    Luo, C.J. / Raimi-Abraham, Bahijja T. / Williams, Gareth R.

    2018  

    Abstract: In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, ...

    Abstract In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory.The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects
    Keywords Medicine (General) ; Pharmacy and materia medica ; Wirkstofffreisetzung ; Nanofaser
    Subject Nanofibers ; Nanofibres ; Arzneimittelfreigabe ; Arzneimittelfreisetzung ; Freigabe ; Arzneistofffreisetzung ; Liberation ; Drug delivery ; Medikamentenfreigabe
    Size 1 electronic resource (242 p.)
    Publisher UCL Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101412
    ISBN 9781787350182 ; 1787350185
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Influence of upwelling on coral reef benthic communities: a systematic review and meta-analysis.

    Spring, Danielle L / Williams, Gareth J

    Proceedings. Biological sciences

    2023  Volume 290, Issue 1995, Page(s) 20230023

    Abstract: Highly competitive coral reef benthic communities are acutely sensitive to changes in environmental parameters such as temperature and nutrient concentrations. Physical oceanographic processes that induce upwelling therefore act as drivers of community ... ...

    Abstract Highly competitive coral reef benthic communities are acutely sensitive to changes in environmental parameters such as temperature and nutrient concentrations. Physical oceanographic processes that induce upwelling therefore act as drivers of community structure on tropical reefs. How upwelling impacts coral communities, however, is not fully understood; upwelling may provide a natural buffer against climate impacts and could potentially enhance the efficacy of spatial management and reef conservation efforts. This study employed a systematic review to assess existing literature linking upwelling with reef community structure, and a meta-analysis to quantify upwelling impact on the percentage cover of coral reef benthic groups. We show that upwelling has context-dependant effects on the cover of hard coral and fleshy macroalgae, with effect size and direction varying with depth, region and remoteness. Fleshy macroalgae were found to increase by 110% on inhabited reefs yet decrease by 56% around one well-studied remote island in response to upwelling. Hard coral cover was not significantly impacted by upwelling on inhabited reefs but increased by 150% when direct local human pressures were absent. By synthesizing existing evidence, this review facilitates adaptive and nuanced reef management which considers the influence of upwelling on reef assemblages.
    MeSH term(s) Animals ; Humans ; Coral Reefs ; Anthozoa/physiology ; Seaweed ; Climate ; Nutrients
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2023.0023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Shape complementarity at protein interfaces via global docking optimisation.

    Williams, Gareth

    Journal of molecular graphics & modelling

    2018  Volume 84, Page(s) 69–73

    Abstract: Protein complexes are characterised by shape complementarity at the interface. Here we present a simple fast global shape fitting algorithm to investigate the extent to which interfaces are global minima of complementarity. The algorithm is applied to a ... ...

    Abstract Protein complexes are characterised by shape complementarity at the interface. Here we present a simple fast global shape fitting algorithm to investigate the extent to which interfaces are global minima of complementarity. The algorithm is applied to a varied set of hetero and homo complexes and complexes between complexes showing that over 90% of large interfaces are global maxima in the space of shape complementarity.
    MeSH term(s) Algorithms ; Binding Sites ; Models, Molecular ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Proteins/chemistry
    Chemical Substances Proteins
    Language English
    Publishing date 2018-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2018.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3491: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Advanced Formulation Approaches for Proteins.

    Schlosser, Corinna S / Williams, Gareth R / Dziemidowicz, Karolina

    Handbook of experimental pharmacology

    2023  Volume 284, Page(s) 69–91

    Abstract: Proteins and peptides are highly desirable as therapeutic agents, being highly potent and specific. However, there are myriad challenges with processing them into patient-friendly formulations: they are often unstable and have a tendency to aggregate or ... ...

    Abstract Proteins and peptides are highly desirable as therapeutic agents, being highly potent and specific. However, there are myriad challenges with processing them into patient-friendly formulations: they are often unstable and have a tendency to aggregate or degrade upon storage. As a result, the vast majority of protein actives are delivered parenterally as solutions, which has a number of disadvantages in terms of cost, accessibility, and patient experience. Much work has been undertaken to develop new delivery systems for biologics, but to date this has led to relatively few products on the market. In this chapter, we review the challenges faced when developing biologic formulations, discuss the technologies that have been explored to try to overcome these, and consider the different delivery routes that can be applied. We further present an overview of the currently marketed products and assess the likely direction of travel in the next decade.
    MeSH term(s) Humans ; Drug Delivery Systems ; Proteins
    Chemical Substances Proteins
    Language English
    Publishing date 2023-04-08
    Publishing country Germany
    Document type Review ; Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2023_647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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