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Article ; Online: Towards the reduction of surgical site infection rates in colorectal surgery.

Reeves, Nicola / Williams, Gethin

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 24, Issue 2, Page(s) 238–239

MeSH term(s)	Colorectal Surgery ; Digestive System Surgical Procedures ; Humans ; Risk Factors ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control
Language	English
Publishing date	2021-11-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15970
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Article ; Online: Minimizing the risk of early symptomatic parastomal herniation.

Herbert, Geraint / Williams, Gethin L / Stephenson, Brian M

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 7, Page(s) 1931–1932

MeSH term(s)	Hernia, Ventral ; Humans
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Letter
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15679
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Article ; Online: Prolapsing mass in the caecum: learning point for the colonoscopist.

James, Osian / Williams, Gethin Llewellyn

BMJ case reports

2019 Volume 12, Issue 4

MeSH term(s)	Cecum/diagnostic imaging ; Cecum/pathology ; Colonic Polyps/diagnostic imaging ; Colonoscopy ; Endometriosis/diagnosis ; Female ; Humans ; Middle Aged
Language	English
Publishing date	2019-04-20
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-229811
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Article ; Online: Strangulated right-sided diaphragmatic hernia presenting and treated as lung empyema: beware of the differential diagnosis.

Gupta, Sapna / Warrell, Daniel / Smith, Laurie / Williams, Gethin Llewellyn

BMJ case reports

2020 Volume 13, Issue 7

Abstract: A 78-year-old man with no surgical history or recent trauma presented to the emergency department with sudden onset right-sided chest pain and dyspnoea. He was admitted under the physicians for investigations and was subsequently diagnosed with empyema ... ...

Abstract	A 78-year-old man with no surgical history or recent trauma presented to the emergency department with sudden onset right-sided chest pain and dyspnoea. He was admitted under the physicians for investigations and was subsequently diagnosed with empyema of the right thorax. After no improvement with intravenous antibiotics, a chest drain was inserted; no pus was drained. He worsened clinically; a repeated CT scan demonstrated an incarcerated loop of small bowel within the right thoracic cavity secondary to a diaphragmatic hernia (DH). The patient had emergency surgery to remove necrotic small bowel and to lavage the thorax. Strangulated DH should be considered as a differential diagnosis where presentation is unusual and empyema does not improve after initial management.
MeSH term(s)	Aged ; Diagnosis, Differential ; Empyema, Pleural/diagnosis ; Hernia, Diaphragmatic/complications ; Hernia, Diaphragmatic/diagnosis ; Humans ; Intestine, Small/pathology ; Male ; Necrosis/diagnosis ; Necrosis/etiology ; Thoracic Cavity/pathology
Language	English
Publishing date	2020-07-08
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-233440
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Response: Impact and outcomes of postoperative anaemia in colorectal cancer patients: a systematic review.

Froud, Joseph L J / Poacher, Arwel T / Whittaker, Thomas M / Williamson, Jeremy S / Williams, Gethin L

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 9, Page(s) 2478

MeSH term(s)	Anemia/etiology ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/surgery ; Humans ; Postoperative Period
Language	English
Publishing date	2021-06-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15752
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Book ; Online: Why the Gospel of Thomas Matters

Abraham-Williams, Gethin

The Spirituality Of Incertainties

2015

Abstract: ... In a world of religious intolerance and bigotry, the case for embracing doubt and questioning through the Gospel of Thomas ... ...

Abstract	In a world of religious intolerance and bigotry, the case for embracing doubt and questioning through the Gospel of Thomas.
Language	English
Size	Online-Ressource (188 p)
Publisher	John Hunt Publishing
Publishing place	Lanham
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781782799290 ; 178279929X
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research.

Nickerson, Aidan P / Newton, Graeme W T / O'Sullivan, James H / Martinez-Perez, Manuel / Sales, Anna C / Williams, Gethin / Pickering, Anthony E / Dunham, James P

Journal of visualized experiments : JoVE

2023 , Issue 194

Abstract: Nociceptors are a class of primary afferent neurons that signal potentially harmful noxious stimuli. An increase in nociceptor excitability occurs in acute and chronic pain conditions. This produces abnormal ongoing activity or reduced activation ... ...

Abstract	Nociceptors are a class of primary afferent neurons that signal potentially harmful noxious stimuli. An increase in nociceptor excitability occurs in acute and chronic pain conditions. This produces abnormal ongoing activity or reduced activation thresholds to noxious stimuli. Identifying the cause of this increased excitability is required for the development and validation of mechanism-based treatments. Single-neuron electrical threshold tracking can quantify nociceptor excitability. Therefore, we have developed an application to allow such measurements and demonstrate its use in humans and rodents. APTrack provides real-time data visualization and action potential identification using a temporal raster plot. Algorithms detect action potentials by threshold crossing and monitor their latency after electrical stimulation. The plugin then modulates the electrical stimulation amplitude using an up-down method to estimate the electrical threshold of the nociceptors. The software was built upon the Open Ephys system (V0.54) and coded in C++ using the JUCE framework. It runs on Windows, Linux, and Mac operating systems. The open-source code is available (https://github.com/Microneurography/APTrack). The electrophysiological recordings were taken from nociceptors in both a mouse skin-nerve preparation using the teased fiber method in the saphenous nerve and in healthy human volunteers using microneurography in the superficial peroneal nerve. Nociceptors were classified by their response to thermal and mechanical stimuli, as well as by monitoring the activity-dependent slowing of the conduction velocity. The software facilitated the experiment by simplifying the action potential identification through the temporal raster plot. We demonstrate real-time closed-loop electrical threshold tracking of single-neuron action potentials during in vivo human microneurography, for the first time, and during ex vivo mouse electrophysiological recordings of C-fibers and Aδ-fibers. We establish proof of principle by showing that the electrical threshold of a human heat-sensitive C-fiber nociceptor is reduced by heating the receptive field. This plugin enables the electrical threshold tracking of single-neuron action potentials and allows the quantification of changes in nociceptor excitability.
MeSH term(s)	Humans ; Mice ; Animals ; Nerve Fibers, Unmyelinated/physiology ; Action Potentials/physiology ; Nociceptors/physiology ; Electric Stimulation ; Pain ; Skin/innervation ; Pain Threshold/physiology
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/64898
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Delay to elective colorectal cancer surgery and implications for survival: a systematic review and meta-analysis.

Whittaker, Thomas M / Abdelrazek, Mohamed E G / Fitzpatrick, Aran J / Froud, Joseph L J / Kelly, Jack R / Williamson, Jeremy S / Williams, Gethin L

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 7, Page(s) 1699–1711

Abstract: Aim: The Covid-19 pandemic has delayed elective colorectal cancer (CRC) surgery. The aim of this study was to see whether or not this may affect overall survival (OS) and disease-free survival (DFS).: Method: A systematic review was carried out ... ...

Abstract	Aim: The Covid-19 pandemic has delayed elective colorectal cancer (CRC) surgery. The aim of this study was to see whether or not this may affect overall survival (OS) and disease-free survival (DFS). Method: A systematic review was carried out according to PRISMA guidelines (PROSPERO ID: CRD42020189158). Medline, EMBASE and Scopus were interrogated. Patients aged over 18 years with a diagnosis of colon or rectal cancer who received elective surgery as their primary treatment were included. Delay to elective surgery was defined as the period between CRC diagnosis and the day of surgery. Meta-analysis of the outcomes OS and DFS were conducted. Forest plots, funnel plots and tests of heterogeneity were produced. An estimated number needed to harm (NNH) was calculated for statistically significant pooled hazard ratios (HRs). Results: Of 3753 articles identified, seven met the inclusion criteria. Encompassing 314 560 patients, three of the seven studies showed that a delay to elective resection is associated with poorer OS or DFS. OS was assessed at a 1 month delay, the HR for six datasets was 1.13 (95% CI 1.02-1.26, p = 0.020) and at 3 months the pooled HR for three datasets was 1.57 (95% CI 1.16-2.12, p = 0.004). The estimated NNH for a delay at 1 month and 3 months was 35 and 10 respectively. Delay was nonsignificantly negatively associated with DFS on meta-analysis. Conclusion: This review recommends that elective surgery for CRC patients is not postponed longer than 4 weeks, as available evidence suggests extended delays from diagnosis are associated with poorer outcomes. Focused research is essential so patient groups can be prioritized based on risk factors in future delays or pandemics.
MeSH term(s)	Adult ; COVID-19 ; Colorectal Neoplasms/surgery ; Disease-Free Survival ; Humans ; Pandemics ; Prognosis ; Rectal Neoplasms ; SARS-CoV-2
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15625
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Clinical and health economic evaluation of a post-stroke arrhythmia monitoring service.

Muggeridge, David / Callum, Kara / Macpherson, Lynsey / Howard, Nick / Graune, Claudia / Megson, Ian / Giangreco, Adam / Gallacher, Susan / Campbell, Linda / Williams, Gethin / Macaden, Ashish / Leslie, Stephen J

The British journal of cardiology

2022 Volume 29, Issue 2, Page(s) 15

Abstract: Atrial fibrillation (AF) is a major cause of recurrent stroke and transient ischaemic attack (TIA) in the UK. As many patients can have asymptomatic paroxysmal AF, prolonged arrhythmia monitoring is advised in selected patients following a stroke or TIA. ...

Abstract	Atrial fibrillation (AF) is a major cause of recurrent stroke and transient ischaemic attack (TIA) in the UK. As many patients can have asymptomatic paroxysmal AF, prolonged arrhythmia monitoring is advised in selected patients following a stroke or TIA. This service evaluation assessed the clinical and potential health economic impact of prolonged arrhythmia monitoring post-stroke using R-TEST monitoring devices. This was a prospective, case-controlled, service evaluation in a single health board in the North of Scotland. Patients were included if they had a recent stroke or TIA, were in sinus rhythm, and did not have another indication for, or contraindication to, oral anticoagulation. A health economic model was developed to estimate the clinical and economic value delivered by the R-TEST monitoring. Approval to use anonymised patient data in this service evaluation was obtained. During the evaluation period, 100 consecutive patients were included. The average age was 70 ± 11 years, 46% were female. Stroke was the presenting complaint in 83% of patients with the other 17% having had a TIA. AF was detected in seven of 83 (8.4%) patients who had had a stroke and one of 17 (5.9%) patients with a TIA. Health economic modelling predicted that adoption of R-TEST monitoring has a high probability of demonstrating both clinical and economic benefits. In conclusion, developing a post-stroke arrhythmia monitoring service using R-TEST devices is feasible, effective at detecting AF, and represents a probable clinical and economic benefit.
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1354589-9
ISSN	1753-4313 ; 0969-6113
ISSN (online)	1753-4313
ISSN	0969-6113
DOI	10.5837/bjc.2022.015
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Zs.A 4578: Show issues

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Article ; Online: Elective Repair of Abdominal Aortic Aneurysm and the Risk of Colonic Ischaemia: Systematic Review and Meta-Analysis.

Williamson, Jeremy S / Ambler, Graeme K / Twine, Christopher P / Williams, Ian M / Williams, Gethin Ll

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2018 Volume 56, Issue 1, Page(s) 31–39

Abstract: Introduction: Colon ischaemia (CI) is a significant complication of open (OR) and endovascular (EVAR) repair of abdominal aortic aneurysm (AAA). With a rapid increase in EVAR uptake, contemporary data demonstrating the differing rates and outcomes of CI ...

Abstract	Introduction: Colon ischaemia (CI) is a significant complication of open (OR) and endovascular (EVAR) repair of abdominal aortic aneurysm (AAA). With a rapid increase in EVAR uptake, contemporary data demonstrating the differing rates and outcomes of CI between EVAR and OR, particularly in the elective setting, are lacking. The aim was to characterise the risk and consequences of CI in elective AAA repair comparing EVAR with OR. Methods: A systematic review and meta-analysis of the literature was performed using the Cochrane collaboration protocol and reported according to the PRISMA guidelines. PubMed, MedLine, and EMBASE were searched for studies reporting CI rates after elective AAA repair. Ruptured AAAs were excluded from analysis. Results: Thirteen studies reporting specific outcomes of CI after elective AAA repair, containing 162,750 evaluable patients (78,151 EVAR and 84,599 OR) were included. All studies found a higher risk of CI with OR than with EVAR. Three studies performed confounder adjustment with CI rates of 0.5-1% versus 2.1-3.6% (EVAR vs. OR) and combined odds ratio of 2.7 (2.0-3.5) for the development of CI with OR versus EVAR. The majority of cases of CI occurred within 30 days and were associated with variable mortality (0-73%) and re-intervention rates (27-54%). GRADE assessment of evidence strength was very low for all outcomes. There was a high degree of heterogeneity between studies both methodologically and in terms of CI rates, re-intervention, mortality, and time to development of CI. Conclusions: EVAR is associated with a reduced incidence of CI compared with OR.
MeSH term(s)	Aortic Aneurysm, Abdominal/surgery ; Aortic Rupture/surgery ; Colon/blood supply ; Elective Surgical Procedures/adverse effects ; Endovascular Procedures/adverse effects ; Humans ; Ischemia/etiology ; Ischemia/mortality ; Laparotomy/adverse effects ; Postoperative Complications/etiology ; Reoperation ; Risk Factors ; Time Factors
Language	English
Publishing date	2018-04-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2018.03.005
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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