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  1. Article ; Online: Evaluating the Effects of Early Pruning, Leaf Removal, and Shoot Thinning on ‘MidSouth’ Grapes over Two Consecutive Vintages in South Mississippi

    Williams, Haley N. / Stafne, Eric T. / Zhang, Yan / Chang, Sam K.C.

    Agronomy. 2023 Jan. 27, v. 13, no. 2

    2023  

    Abstract: Yield components and fruit composition of ‘MidSouth’, an interspecific hybrid bunch grape (Vitis spp.) with relatively low total soluble solids and high titratable acidity, was evaluated in south Mississippi to determine if treatments consisting of early ...

    Abstract Yield components and fruit composition of ‘MidSouth’, an interspecific hybrid bunch grape (Vitis spp.) with relatively low total soluble solids and high titratable acidity, was evaluated in south Mississippi to determine if treatments consisting of early pruning, early pruning with pre-bloom leaf removal, normal pruning with post-fruit set leaf removal, or normal pruning in one study, or post-fruit set leaf removal, post-fruit set shoot thinning, or neither leaf removal nor shoot thinning in a second study could improve these qualities. Early pruning with leaf removal reduced berries per cluster, cluster weights, yields, and Ravaz index. Early pruning treatments had inconsistent results from year to year, and normal pruning treatments were not often significantly different. Shoot thinned vines had lower yields and Ravaz index and higher total soluble solids. Second study leaf removal vines had lower juice pH in 2020 and lower yield per vine in 2021. These findings show that ‘MidSouth’ can be altered by these practices, but they did not appear to sufficiently alter ‘MidSouth’ quality. Thus, early pruning with or without leaf removal, normal pruning with leaf removal, and shoot thinning are not recommended for ‘MidSouth’ in south Mississippi, and normal pruning without these practices should be continued.
    Keywords Vitis ; agronomy ; fruit composition ; grapes ; hybrids ; juices ; leaves ; pH ; titratable acidity ; vines ; Mississippi
    Language English
    Dates of publication 2023-0127
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy13020368
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Design and operation of a molten salt electrochemical cell

    Consiglio, Anthony N. / Carotti, Francesco / Liu, Ertai / Williams, Haley / Scarlat, Raluca O.

    MethodsX. 2022, v. 9

    2022  

    Abstract: Molten salts such as 2LiF-BeF₂ (FLiBe) have been proposed as coolants for advanced nuclear fission and fusion reactors. Critical to the design, licensing and operation of these reactors is characterization and understanding of the chemical behavior and ... ...

    Abstract Molten salts such as 2LiF-BeF₂ (FLiBe) have been proposed as coolants for advanced nuclear fission and fusion reactors. Critical to the design, licensing and operation of these reactors is characterization and understanding of the chemical behavior and mass transport of activation and fission products, corrosion products, and other solutes in the coolant. Electrochemical techniques are a powerful suite of tools for probing these phenomena. The design of an experimental cell for molten salt electrochemistry is described herein. As a demonstration of this design, details of the experimental methods used to conduct electrochemical experiments with molten FLiBe with addition of LiH are provided. Decommissioning of the cell is considered from the point of view of decontamination and waste generated. Main features of the cell include:•Suitable for operation up to 800 °C; suitable for operation inside and outside of a glovebox.•Enables sweep gas, gas sampling and analysis; enables addition of solid and liquid materials during operation.•Supports a variety of electrode materials and arrangements.
    Keywords corrosion ; decontamination ; electrochemistry ; electrodes ; liquids ; mass transfer ; physicochemical properties ; wastes
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2022.101626
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Design and operation of a molten salt electrochemical cell.

    Consiglio, Anthony N / Carotti, Francesco / Liu, Ertai / Williams, Haley / Scarlat, Raluca O

    MethodsX

    2022  Volume 9, Page(s) 101626

    Abstract: Molten salts such as 2LiF- ... ...

    Abstract Molten salts such as 2LiF-BeF
    Language English
    Publishing date 2022-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2022.101626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.

    Tello, Judith A / Williams, Haley E / Eppler, Robert M / Steinhilb, Michelle L / Khanna, May

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 883358

    Abstract: Neurodegenerative diseases represent a formidable challenge to global health. As advances in other areas of medicine grant healthy living into later decades of life, aging diseases such as Alzheimer's disease (AD) and other neurodegenerative disorders ... ...

    Abstract Neurodegenerative diseases represent a formidable challenge to global health. As advances in other areas of medicine grant healthy living into later decades of life, aging diseases such as Alzheimer's disease (AD) and other neurodegenerative disorders can diminish the quality of these additional years, owed largely to the lack of efficacious treatments and the absence of durable cures. Alzheimer's disease prevalence is predicted to more than double in the next 30 years, affecting nearly 15 million Americans, with AD-associated costs exceeding $1 billion by 2050. Delaying onset of AD and other neurodegenerative diseases is critical to improving the quality of life for patients and reducing the burden of disease on caregivers and healthcare systems. Significant progress has been made to model disease pathogenesis and identify points of therapeutic intervention. While some researchers have contributed to our understanding of the proteins and pathways that drive biological dysfunction in disease using
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.883358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prevalence of COVID-19 in Louisiana and Its Association With Race, Concentrated Disadvantage, Chronic Disease Prevalence and Other Social Determinants of Health

    Ferguson, Tekeda F. / Williams, Haley A. / Danos, Denise

    Annals of Epidemiology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #893449
    Database COVID19

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  6. Article ; Online: Prevalence of COVID-19 in Louisiana and Its Association With Race, Concentrated Disadvantage, Chronic Disease Prevalence and Other Social Determinants of Health

    Ferguson, Tekeda F. / Williams, Haley A. / Danos, Denise

    Annals of Epidemiology ; ISSN 1047-2797

    2020  

    Keywords Epidemiology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.annepidem.2020.08.054
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Constant-potential molecular dynamics simulations of molten salt double layers for FLiBe and FLiNaK.

    Langford, Luke / Winner, Nicholas / Hwang, Andrea / Williams, Haley / Vergari, Lorenzo / Scarlat, Raluca O / Asta, Mark

    The Journal of chemical physics

    2022  Volume 157, Issue 9, Page(s) 94705

    Abstract: We report the results of constant-potential molecular dynamics simulations of the double layer interface between molten 2LiF- ... ...

    Abstract We report the results of constant-potential molecular dynamics simulations of the double layer interface between molten 2LiF-BeF
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0097697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.

    Tomalka, Jeffrey A / Owings, Anna / Galeas-Pena, Michelle / Ziegler, Carly G K / Robinson, Tanya O / Wichman, Thomas G / Laird, Hannah / Williams, Haley B / Dhaliwal, Neha S / Everman, Steven / Zafar, Yousaf / Shalek, Alex K / Horwitz, Bruce H / Ordovas-Montanes, Jose / Glover, Sarah C / Gibert, Yann

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that : Methods and findings: ... ...

    Abstract Background: Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that
    Methods and findings: We performed a total fatty acid panel on plasma and bulk RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) collected from 10 infected and 10 uninfected patients. Univariate comparison of lipid metabolites revealed that lipid metabolites were increased in SARS-CoV-2 patients including the lipid mediators Arachidonic Acid (AA) and Eicosapentaenoic Acid (EPA). AA, EPA and the fatty acids Docosahexaenoic acid (DHA) and Docosapentaenoic acid (DPA), were positively correlated to WHO disease severity score. Transcriptomic analysis demonstrated that COVID-19 patients can be segregated based on WHO scores. Ontology, KEGG and Reactome analysis identified pathways enriched for genes related to innate immunity, interactions between lymphoid and nonlymphoid cells, interleukin signaling and, cell cycling pathways.
    Conclusions: Our study offers an association between nasopharynx mucosa eicosanoid genes expression, specific serum inflammatory lipids and, subsequent DNA damage pathways activation in PBMCs to severity of COVID-19 infection.
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.14.23295549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.

    Ziegler, Carly G K / Owings, Anna H / Galeas-Pena, Michelle / Kazer, Samuel W / Miao, Vincent N / Navia, Andrew W / Tang, Ying / Bromley, Joshua D / Lotfy, Peter / Sloan, Meredith / Laird, Hannah / Williams, Haley B / George, Micayla / Drake, Riley S / Pride, Yilianys / Abraham, George E / Senitko, Michal / Robinson, Tanya O / Diamond, Gill /
    Lionakis, Michail S / Shalek, Alex K / Ordovas-Montanes, Jose / Horwitz, Bruce H / Glover, Sarah C

    Microbiology spectrum

    2024  , Page(s) e0351623

    Abstract: Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and associations with ... ...

    Abstract Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and associations with specific immune responses in the airways remain incompletely defined. We previously generated a single-cell RNA-sequencing data set characterizing the upper respiratory microenvironment during COVID-19 and mapped the relationship between disease severity and the local behavior of nasal epithelial cells and infiltrating immune cells. Our previous study, in agreement with findings from related human cohorts, demonstrated that a profound deficiency in host immunity, particularly in type I and type III interferon signaling in the upper respiratory tract, is associated with rapid progression to severe disease and worse clinical outcomes. We have now performed further analysis of this cohort and identified a subset of participants with severe COVID-19 and concurrent detection of
    Importance: In this paper, we present an analysis suggesting that symptomatic and asymptomatic fungal coinfections can impact patient disease progression during COVID-19 hospitalization. By looking into the presence of other pathogens and their effect on the host immune response during COVID-19 hospitalizations, we aim to offer insight into an underestimated scenario, furthering our current knowledge of determinants of severity that could be considered for future diagnostic and intervention strategies.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03516-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection

    Tomalka, Jeffrey A. / Owings, Anna / Galeas-Pena, Michelle / Ziegler, Carly G.K. / Robinson, Tanya O. / Wichman, Thomas G. / Laird, Hannah / Williams, Haley B. / Dhaliwal, Neha S. / Everman, Steven / Zafar, Yousaf / Shalek, Alex K. / Horwitz, Bruce H. / Ordovas-Montanes, Jose / Glover, Sarah C. / Gibert, Yann

    medRxiv

    Abstract: Abstract: Background Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that alox genes, involved ...

    Abstract Abstract: Background Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that alox genes, involved in eicosanoid synthesis, were up-regulated in high WHO score patients, especially in goblet cells. Herein, we aimed to further understand the roles played by eicosanoids during severe SARS-CoV-2 infection. Methods and findings We performed a total fatty acid panel on plasma and bulk RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) collected from 10 infected and 10 uninfected patients. Univariate comparison of lipid metabolites revealed that lipid metabolites were increased in SARS-CoV-2 patients including the lipid mediators Arachidonic Acid (AA) and Eicosapentaenoic Acid (EPA). AA, EPA and the fatty acids Docosahexaenoic acid (DHA) and Docosapentaenoic acid (DPA), were positively correlated to WHO disease severity score. Transcriptomic analysis demonstrated that COVID-19 patients can be segregated based on WHO scores. Ontology, KEGG and Reactome analysis identified pathways enriched for genes related to innate immunity, interactions between lymphoid and nonlymphoid cells, interleukin signaling and, cell cycling pathways. Conclusions Our study offers an association between nasopharynx mucosa eicosanoid genes expression, specific serum inflammatory lipids and, subsequent DNA damage pathways activation in PBMCs to severity of COVID-19 infection.
    Keywords covid19
    Language English
    Publishing date 2023-09-15
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.09.14.23295549
    Database COVID19

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