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  1. AU="Williams, Karen A."
  2. AU="Bayahia, Rabia"
  3. AU=Moriyama Yoko
  4. AU="Fanxuan Zhao"
  5. AU="Miller, Dylan"
  6. AU="Kabir, Eva Rahman"
  7. AU="Panter"
  8. AU="van Versendaal, Daniëlle"
  9. AU="Fletcher Samuel P"
  10. AU="Amici, Carla"
  11. AU=Chubb S A Paul
  12. AU="Hindi, Yousef"
  13. AU="Aljohani, Eman"
  14. AU=Jun Seah Ivan Yu
  15. AU="Pickavance, Georgia C"
  16. AU="Howard, Brittany L"
  17. AU="de Sousa Alves Neri, Julianna Lys"
  18. AU="Elizabeth Noble"
  19. AU="Nicole Shaver"
  20. AU=Siegel Vivian
  21. AU="Calméjane, Louis"
  22. AU="Lombardi, S."
  23. AU="Hartmann, H"
  24. AU="Furuya Junior, Carlos Kyoshi"
  25. AU="Bo, L J"
  26. AU="Baxter, J"
  27. AU="Liu, Zhenhong"
  28. AU="Xiaochun Deng"
  29. AU="Anderson, Ciorsdan"
  30. AU="Xiaofang Zhang"
  31. AU=Stincarelli Maria Alfreda AU=Stincarelli Maria Alfreda
  32. AU="McNabb, Warren C."
  33. AU="Seker, Demet"
  34. AU="Braman, Sidney S"
  35. AU="Yerke, Lisa"
  36. AU="Antonella Lettieri"
  37. AU="Valdiviezo, Jesús"

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  1. Artikel ; Online: Auricular Therapy for Migraine.

    Williams, Karen A

    Current pain and headache reports

    2024  

    Abstract: Purpose of review: Migraine brings hours or even days of disability, affecting 15% of the US population and one billion people worldwide. Migraine treatments have improved over the years and there is now a range of non-pharmacologic therapies that can ... ...

    Abstract Purpose of review: Migraine brings hours or even days of disability, affecting 15% of the US population and one billion people worldwide. Migraine treatments have improved over the years and there is now a range of non-pharmacologic therapies that can be administered as monotherapy, combined with pharmacologic therapy or combined with other non-pharmacologic therapies to give greater options for those who do not tolerate, do not respond to, or who wish to reduce or avoid pharmacologic treatments.
    Recent findings: We conducted a review of the literature on auricular therapy as acute or preventive treatment for migraine, searching the databases of MEDLINE and ClinicalTrials.gov from 2013 to 2023. A total of 43 articles contained at least one search term, with three studies specific to acute or prevention of migraine (one for acute only, one for prevention only and one for both acute and prevention). The population was limited to, adults with migraine ages 18 or older, with the administration of auricular therapy as the intervention. While there have been studies on the use of auricular therapy for pain on two specific standardized auricular therapies, Battlefield Acupuncture (BFA) and National Acupuncture Detoxification Association (NADA), neither of these protocols were utilized in any of the studies specific to migraine management. Each of the three studies used different techniques, with one using acupuncture needles and five specific points and two using semi-permanent needles (remained in for a few days) that were placed in areas that showed high activity. Each of these studies showed auricular therapy to have benefit for the management of migraine. However, the authors of each of the studies recommended further studies. Auricular therapy may be a helpful adjunctive treatment to abort a current migraine attack or aid in reducing the frequency or severity of migraine attacks.
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-024-01261-3
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  2. Artikel ; Online: Headache management in a Veteran population: First considerations.

    Williams, Karen A

    Journal of the American Association of Nurse Practitioners

    2020  Band 32, Heft 11, Seite(n) 758–763

    Abstract: It is estimated that almost half the general population has a headache disorder. The majority of these are considered tension-type headaches. Migraines and chronic daily headache (CDH) are not as common but are much more debilitating. Although CDH/ ... ...

    Abstract It is estimated that almost half the general population has a headache disorder. The majority of these are considered tension-type headaches. Migraines and chronic daily headache (CDH) are not as common but are much more debilitating. Although CDH/chronic migraine (CM) occurs in about 3% of the population, it has been found to be 20% or higher in the post 9/11 combat Veteran population. Data from the Veterans Health Administration show that more than 380,000 Veterans, younger than 50 years, received care for a headache in 2017. Approximately 75% of the headache care was from a primary care provider. The purpose of the article is to review physical examination for the veteran with a history of a headache disorder, discuss contributing factors and comorbid conditions, as well as give an overview of current treatment options, with a focus on the post-9/11 combat Veteran who has CDH/CM.
    Mesh-Begriff(e) Complementary Therapies/trends ; Disease Management ; Headache/psychology ; Headache/therapy ; Humans ; Prescription Drug Overuse/adverse effects ; Risk Factors ; Veterans/psychology ; Veterans/statistics & numerical data
    Sprache Englisch
    Erscheinungsdatum 2020-11-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2716317-9
    ISSN 2327-6924 ; 1745-7599 ; 2327-6886 ; 1041-2972
    ISSN (online) 2327-6924 ; 1745-7599
    ISSN 2327-6886 ; 1041-2972
    DOI 10.1097/JXX.0000000000000539
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  3. Artikel ; Online: Management of Chronic Migraine and Occipital Neuralgia in Post 9/11 Combat Veterans.

    Williams, Karen A / Lawson, Robin M / Perurena, Osvaldo H / Coppin, John D

    Military medicine

    2019  Band 184, Heft 7-8, Seite(n) e207–e211

    Abstract: Introduction: The rate of chronic migraine (CM) has been shown to be 20% or greater in the post 9/11 combat veteran population with a history of traumatic brain injury, while the rate is much lower at 3-5% in the general population. Studies have shown ... ...

    Abstract Introduction: The rate of chronic migraine (CM) has been shown to be 20% or greater in the post 9/11 combat veteran population with a history of traumatic brain injury, while the rate is much lower at 3-5% in the general population. Studies have shown that medications such as oral topiramate or intramuscular injections of onabotulinum toxin A (Botox) have been used for CM prevention, and occipital blocks have been shown to be helpful in treating occipital neuralgia and short-term relief of CM. However, there are no known studies that have specifically evaluated the use of Botox and occipital blocks for reducing headache frequency in the US veteran population. The purpose of this study was to evaluate the effectiveness of using occipital blocks and Botox as dual therapy for reducing headache frequency in post 9/11 combat veterans with CM, occipital neuralgia, and a history of TBI or neck trauma.
    Materials and methods: Following Institutional Review Board approval, a retrospective chart review was completed on post 9/11 combat veterans treated in a headache clinic located at the Central Texas Veteran Health Care System. The electronic medical record was used to retrieve the charts of post 9/11 combat veterans who (1) had a confirmed deployment-related history of TBI or neck trauma; (2) were diagnosed with CM and occipital neuralgia; and (3) were treated in the headache clinic between January 1, 2014 and December 31, 2015 with the administration of occipital blocks and Botox within the first six months. Of 282 charts that were reviewed, a total of 30 (N = 30) veterans fit the criteria. The mean number of self-reported headache days per month (28 days) for the month prior to starting treatment was compared to the number of headache days per month (28 days) 6 months after initiation of therapy.
    Results: Results revealed that the mean number of headache days in the month prior to treatment was 24.1 (22.0, 25.7). The mean number of headache days in the month post-treatment (6 months after the initiation of dual therapy with occipital blocks and Botox) was 12.9 (9.7, 16.4). The mean difference in the number of headache days from pre- to post-treatment (pre-treatment minus post-treatment) was 11.2 (8.2, 14.2).
    Conclusion: This study evaluated the effectiveness of using occipital blocks and Botox as dual therapy for reducing headache frequency for post 9/11 combat veterans with CM, occipital neuralgia, and a history of TBI or neck trauma. Results revealed a statistically significant reduction in the number of headache days per month after the dual therapy. There were multiple limitations to the study to include a small sample size, lack of a control group, self-reported headaches for only 1 month pre-and post-treatment, and no control for other interventions or events which may have influenced the outcome. There is a strong need for randomized, double blinded, placebo- controlled studies involving dual therapy in this population. This study, though small, may be helpful in stimulating additional studies and treatments in this veteran population.
    Mesh-Begriff(e) Adult ; Botulinum Toxins, Type A/standards ; Botulinum Toxins, Type A/therapeutic use ; Disease Management ; Female ; Humans ; Injections, Intramuscular ; Logistic Models ; Male ; Middle Aged ; Migraine Disorders/therapy ; Nerve Block/methods ; Nerve Block/standards ; Nerve Block/statistics & numerical data ; Neuralgia/therapy ; Occipital Lobe/abnormalities ; Occipital Lobe/physiopathology ; Retrospective Studies ; Texas ; Veterans/statistics & numerical data
    Chemische Substanzen Botulinum Toxins, Type A (EC 3.4.24.69)
    Sprache Englisch
    Erscheinungsdatum 2019-01-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usy405
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  4. Artikel ; Online: Wild Plant Genetic Resources in North America

    Greene, Stephanie L. / Khoury, Colin K. / Williams, Karen A.

    An Overview

    2019  

    Abstract: North America, including Canada, Mexico, and the United States, is rich in plant species used by humans in both ancient and modern times. A select number of these have become globally important domesticated crops, including maize, beans, cotton, and ... ...

    Abstract North America, including Canada, Mexico, and the United States, is rich in plant species used by humans in both ancient and modern times. A select number of these have become globally important domesticated crops, including maize, beans, cotton, and sunflower. Many other native and also naturalized species have potential for use, either directly or as genetic resources for breeding agricultural crops. However, despite increasing recognition of their potential value, deficiencies in information, conservation, and access to the diversity in these plants hinder their further use. This chapter provides an overview of the agriculturally relevant wild plant resources of North America, with focus on wild relatives of globally important major crops, as well as the wild cousins of regionally and locally important domesticates. The chapter concludes by providing an overview of strategies for conserving wild plant genetic resources, including the international regulatory frameworks affecting policies to various degrees in Canada, Mexico, and the United States.
    Schlagwörter germoplasm ; genetic resources ; wild species ; conservation ; crop resources ; nort america
    Sprache Englisch
    Erscheinungsdatum 2019-01-25T18:47:27Z
    Verlag Springer
    Erscheinungsland fr
    Dokumenttyp Artikel ; Online
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  5. Artikel: The Genetic Diversity of Cranberry Crop Wild Relatives, Vaccinium macrocarpon Aiton and V. oxycoccos L., in the US, with Special Emphasis on National Forests

    Rodriguez-Bonilla, Lorraine / Williams, Karen A / Rodríguez Bonilla, Fabian / Matusinec, Daniel / Maule, Andrew / Coe, Kevin / Wiesman, Eric / Diaz-Garcia, Luis / Zalapa, Juan

    Plants. 2020 Oct. 26, v. 9, no. 11

    2020  

    Abstract: Knowledge of the genetic diversity in populations of crop wild relatives (CWR) can inform effective strategies for their conservation and facilitate utilization to solve agricultural challenges. Two crop wild relatives of the cultivated cranberry are ... ...

    Abstract Knowledge of the genetic diversity in populations of crop wild relatives (CWR) can inform effective strategies for their conservation and facilitate utilization to solve agricultural challenges. Two crop wild relatives of the cultivated cranberry are widely distributed in the US. We studied 21 populations of Vaccinium macrocarpon Aiton and 24 populations of Vaccinium oxycoccos L. across much of their native ranges in the US using 32 simple sequence repeat (SSR) markers. We observed high levels of heterozygosity for both species across populations with private alleles ranging from 0 to 26. For V. macrocarpon, we found a total of 613 alleles and high levels of heterozygosity (HO = 0.99, HT = 0.75). We also observed high numbers of alleles (881) and levels of heterozygosity (HO = 0.71, HT = 0.80) in V. oxycoccos (4x). Our genetic analyses confirmed the field identification of a native population of V. macrocarpon on the Okanogan-Wenatchee National Forest in the state of Washington, far outside the previously reported range for the species. Our results will help to inform efforts of the United States Department of Agriculture Agricultural Research Service (USDA-ARS) and the United States Forest Service (USFS) to conserve the most diverse and unique wild cranberry populations through ex situ preservation of germplasm and in situ conservation in designated sites on National Forests.
    Schlagwörter Vaccinium macrocarpon ; Vaccinium oxycoccos ; alleles ; cranberries ; genetic analysis ; genetic variation ; heterozygosity ; microsatellite repeats ; national forests ; wild relatives ; Okanogan-Wenatchee National Forest ; Washington (state)
    Sprache Englisch
    Erscheinungsverlauf 2020-1026
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants9111446
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: Crop wild relatives of the United States require urgent conservation action

    Khoury, Colin K. / Carver, Daniel / Greene, Stephanie L. / Williams, Karen A. / Achicanoy, Harold A. / Schori, Melanie / León, Blanca / Wiersema, John H. / Frances, Anne

    Proceedings of the National Academy of Sciences. 2020 Dec. 14, v. 117, no. 52, p. 33351-33357

    2020  , Seite(n) 33351–33357

    Abstract: The contributions of crop wild relatives (CWR) to food security depend on their conservation and accessibility for use. The United States contains a diverse native flora of CWR, including those of important cereal, fruit, nut, oil, pulse, root and tuber, ...

    Abstract The contributions of crop wild relatives (CWR) to food security depend on their conservation and accessibility for use. The United States contains a diverse native flora of CWR, including those of important cereal, fruit, nut, oil, pulse, root and tuber, and vegetable crops, which may be threatened in their natural habitats and underrepresented in plant conservation repositories. To determine conservation priorities for these plants, we developed a national inventory, compiled occurrence information, modeled potential distributions, and conducted threat assessments and conservation gap analyses for 600 native taxa. We found that 7.1% of the taxa may be critically endangered in their natural habitats, 50% may be endangered, and 28% may be vulnerable. We categorized 58.8% of the taxa as of urgent priority for further action, 37% as high priority, and 4.2% as medium priority. Major ex situ conservation gaps were identified for 93.3% of the wild relatives (categorized as urgent or high priority), with 83 taxa absent from conservation repositories, while 93.1% of the plants were equivalently prioritized for further habitat protection. Various taxonomic richness hotspots across the US represent focal regions for further conservation action. Related needs include facilitating greater access to and characterization of these cultural-genetic-natural resources and raising public awareness of their existence, value, and plight.
    Schlagwörter biodiversity conservation ; botanical composition ; endangered species ; ex situ conservation ; flora ; fruit crops ; germplasm conservation ; grain crops ; habitat conservation ; indigenous species ; legumes ; nut crops ; oil crops ; phytogeography ; plant collections ; plant germplasm ; root crops ; species richness ; vegetable crops ; vulnerable species ; wild relatives ; United States
    Sprache Englisch
    Erscheinungsverlauf 2020-1229
    Umfang p. 33351-33357
    Erscheinungsort Proceedings of the National Academy of Sciences
    Dokumenttyp Artikel ; Online
    Anmerkung Resource is Open Access ; CHORUS License Information
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2007029117
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  7. Artikel: Toward integrated conservation of North America’s crop wild relatives

    Khoury, Colin K / Greene, Stephanie L / Krishnan, Sarada / Miller, Allison / Moreau, Tara / Williams, Karen A / Bonilla, Lorraine / Spurrier, Carol S / Zalapa, Juan Ernesto / Nabhan, Gary P

    Natural areas journal. 2020 Apr. 15, v. 40, no. 1

    2020  

    Abstract: North America harbors a rich native flora of crop wild relatives - the progenitors and closely related species of domesticated plants - as well as a range of culturally significant wild utilized plants. Despite their current and potential future value, ... ...

    Abstract North America harbors a rich native flora of crop wild relatives - the progenitors and closely related species of domesticated plants - as well as a range of culturally significant wild utilized plants. Despite their current and potential future value, they are rarely prioritized for conservation efforts, thus many species are threatened in their natural habitats, and most are under-represented in plant genebanks and botanical gardens. Further coordination of efforts among land management, botanical, and agricultural science organizations will lead to better protection and greater conservation practitioner as well as general public awareness with regard to these species. We present examples of productive collaborations focused on wild cranberries (Vaccinium macrocarpon Aiton and Vaccinium oxycoccos L.) and chile peppers (Capsicum annuum L. var. glabriusculum (Dunal) Heiser & Pickersgill). We then discuss five shared priorities for further action: 1) understand and document North America’s crop wild relatives and wild utilized plants, 2) protect threatened species in their natural habitats, 3) collect and conserve ex situ the diversity of prioritized species, 4) make this diversity accessible and attractive for plant breeding, research, and education, and 5) raise public awareness of their value and the threats to their persistence.
    Schlagwörter Capsicum annuum ; wild plants ; natural resources conservation ; Capsicum annuum var. glabriusculum ; Vaccinium macrocarpon ; Vaccinium oxycoccos ; botanical gardens ; cranberries ; education ; flora ; habitats ; hot peppers ; indigenous species ; land management ; plant breeding ; threatened species ; wild relatives ; North America
    Sprache Englisch
    Erscheinungsverlauf 2020-0415
    Umfang p. 96-100.
    Dokumenttyp Artikel
    ZDB-ID 2486532-1
    ISSN 2162-4399 ; 0885-8608
    ISSN (online) 2162-4399
    ISSN 0885-8608
    DOI 10.3375/043.040.0111
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  8. Artikel ; Online: Conservation and Use of the North American Plant Cornucopia

    Khoury, Colin K. / Greene, Stephanie L. / Williams, Karen A. / Kantar, Michael B. / Marek, Laura F.

    The Way Forward

    2019  

    Abstract: The pages of this extensive book document the potential of a great many North American plants to enhance the productivity, sustainability, and nutritional quality of crops or to be further developed into important cultivated species in their own right. ... ...

    Abstract The pages of this extensive book document the potential of a great many North American plants to enhance the productivity, sustainability, and nutritional quality of crops or to be further developed into important cultivated species in their own right. But this potential can only be realized if the plants are adequately conserved to ensure their survival and availability for research, invested in to promote their development, and marketed so as to be attractive to producers and consumers. We outline some of the key steps needed to boost the conservation and use of our regional cornucopia. In situ and ex situ conservation of North America’s useful plants are being accomplished by a variety of institutions with different mandates, but habitat destruction and other threats to wild populations continue to negatively impact many species. Information sharing, coordinating efforts, filling research gaps for wild plants, and increasing support for conservation will be necessary to more comprehensively safeguard these plants and to make them available for use. Technologies enabling more efficient exploration of the diversity within these species are rapidly advancing and offer the potential to contribute to quick advances in improvement of cultivars, but considerable further research and partnerships are needed to generate and share the results widely. Marketing of new crops can take advantage of the increasing public interest in diverse and nutritious foods, learning from successful collaborations between producers, researchers, and consumers. As a whole, North America already possesses a strong foundation from which the conservation and use of its flora can be enhanced. This includes many protected areas, strong conservation institutions, innovative research, and the willingness to collaborate across fields, institutions, and borders. There are still many silos that need to be broken down and reorganized through innovative partnerships to better conserve and benefit from the North American cornucopia. But given the ...
    Schlagwörter crop wild relatives ; food security
    Erscheinungsdatum 2019-03-14T19:57:00Z
    Verlag Springer
    Erscheinungsland fr
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Preface to North American Crop Wild Relatives, Volume 1

    Greene, Stephanie L. / Williams, Karen A. / Khoury, Colin K. / Kantar, Michael B. / Marek, Laura F.

    2019  

    Schlagwörter genetic resources ; conservation ; crop wild relatives
    Sprache Englisch
    Erscheinungsdatum 2019-01-25T19:29:13Z
    Verlag Springer
    Erscheinungsland fr
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  10. Buch ; Online: North American Crop Wild Relatives, Volume 1

    Greene, Stephanie L. / Williams, Karen A. / Khoury, Colin K. / Kantar, Michael B. / Marek, Laura F.

    2019  

    Abstract: The plant species that humans rely upon have an extended family of wild counterparts that are an important source of genetic diversity used to breed productive crops. These wild and weedy cousins are valuable as a resource for adapting our food, forage, ... ...

    Abstract The plant species that humans rely upon have an extended family of wild counterparts that are an important source of genetic diversity used to breed productive crops. These wild and weedy cousins are valuable as a resource for adapting our food, forage, industrial and other crops to climate change. Many wild plant species are also directly used, especially for revegetation, and as medicinal and ornamental plants. North America is rich in these wild plant genetic resources. This book is a valuable reference that describes the important crop wild relatives and wild utilized species found in Canada, the United States and Mexico. The book highlights efforts taken by these countries to conserve and use wild resources and provides essential information on best practices for collecting and conserving them. Numerous maps using up-to-date information and methods illustrate the distribution of important species, and supplement detailed description on the potential value these resources have to agriculture, as well as their conservation statuses and needs. There is broad recognition of the urgent need to conserve plant diversity; however, a small fraction of wild species is distinguished by their potential to support agricultural production. Many of these species are common, even weedy, and are easily overshadowed by rare or endangered plants. Nevertheless, because of their genetic proximity to agriculturally important crops or direct use, they deserve to be recognized, celebrated, conserved, and made available to support food and agricultural security. This comprehensive two-volume reference will be valuable for students and scientists interested in economic botany, and for practitioners at all levels tasked with conserving plant biodiversity
    Schlagwörter crop wild relatives ; plant genetic resources ; plant conservation ; crop adaptation ; climate change
    Sprache Englisch
    Erscheinungsdatum 2019-01-25T19:04:01Z
    Verlag Springer
    Erscheinungsland fr
    Dokumenttyp Buch ; Online
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